Family: Proteasome subunits

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b) [53931]
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: Ntn hydrolase-like [56234]
   4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
4. Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235]
   N-terminal residue provides two catalytic groups, nucleophile and proton donor
   uperfamily
5. Family: Proteasome subunits [56251]

Protein Domains:

1. Proteasome beta subunit (catalytic) [56252]
   1. Archaeon Thermoplasma acidophilum [TaxId: 2303] [56253] (50)
   2. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [90043] (1)
   3. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [56254] (112)
      The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)
   4. Cow (Bos taurus) [TaxId: 9913] [75567] (1)
   5. Rhodococcus erythropolis [TaxId: 1833] [103313] (9)
2. Proteasome alpha subunit (non-catalytic) [56255]
   contains an extension to the common fold at the N-terminus
   1. Archaeon Thermoplasma acidophilum [TaxId: 2303] [56256] (50)
   2. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [90044] (2)
   3. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [56257] (108)
      The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)
   4. Cow (Bos taurus) [TaxId: 9913] [75568] (1)
   5. Rhodococcus erythropolis [TaxId: 1833] [103314] (9)
3. HslV (ClpQ) protease [56258]
   dodecameric prokaryotic homologue of proteasome
   1. Escherichia coli [TaxId: 562] [56259] (7)
   2. Haemophilus influenzae [TaxId: 727] [56260] (6)
   3. Thermotoga maritima [TaxId: 2336] [90045] (1)
   4. Bacillus subtilis [TaxId: 1423] [160845] (26)
      SQ P39070 2-181

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk