Structural Classification of Proteins
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Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases)

N-terminal residue provides two catalytic groups, nucleophile and proton donor
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Ntn hydrolase-like [56234]
    4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
  4. Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235]
    N-terminal residue provides two catalytic groups, nucleophile and proton donor
    link to SUPERFAMILY database - Superfamily

Families:

  1. Class II glutamine amidotransferases [56236] (9)
    has slightly different topology than other families do
    1. Glucosamine 6-phosphate synthase, N-terminal domain [56237]
      1. Escherichia coli [TaxId: 562] [56238] (8) picpic
        SQ P17169 1-238
    2. Glutamine PRPP amidotransferase, N-terminal domain [56239]
      1. Bacillus subtilis [TaxId: 1423] [56240] (2) picpic
      2. Escherichia coli [TaxId: 562] [56241] (5) picpic
    3. Asparagine synthetase B, N-terminal domain [56242]
      1. Escherichia coli [TaxId: 562] [56243] (1) picpic
    4. beta-Lactam synthetase [69831]
      Asparagine synthetase B homologue
      1. Streptomyces clavuligerus [TaxId: 1901] [69832] (5) picpic
      2. Pectobacterium carotovorum [TaxId: 554] [103312] (2) picpic
        carbapenam synthetase CarA
    5. Alpha subunit of glutamate synthase, N-terminal domain [69833]
      1. Azospirillum brasilense [TaxId: 192] [69834] (7) picpic
      2. Synechocystis sp. [TaxId: 1143] [75566] (5) picpic
    6. Hypothetical protein YafJ (PA1307) [111217]
      1. Pseudomonas aeruginosa [TaxId: 287] [111218] (1) picpic
        SQ Q9I437
  2. Penicillin acylase, catalytic domain [56244] (4)
    1. Penicillin acylase [56245]
      also contains 2 all-alpha and a beta-barrel domains
      will be divided into domains in future release
      1. Escherichia coli [TaxId: 562] [56246] (24) picpic
      2. Providencia rettgeri [TaxId: 587] [56247] (1) picpic
    2. Cephalosporin acylase [64425]
      1. Brevundimonas diminuta [TaxId: 293] [64426] (4) picpic
      2. Pseudomonas sp., glutarylamidase [TaxId: 306] [69835] (5) picpic
  3. Penicillin V acylase [56248] (1)
    1. Penicillin V acylase [56249]
      1. Bacillus sphaericus [TaxId: 1421] [56250] (2) picpic
  4. Proteasome subunits [56251] (14)
    1. Proteasome beta subunit (catalytic) [56252]
      1. Archaeon Thermoplasma acidophilum [TaxId: 2303] [56253] (50) picpic
      2. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [90043] (1) picpic
      3. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [56254] (112) picpic
        The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)
      4. Cow (Bos taurus) [TaxId: 9913] [75567] (1) picpic
      5. Rhodococcus erythropolis [TaxId: 1833] [103313] (9) picpic
    2. Proteasome alpha subunit (non-catalytic) [56255]
      contains an extension to the common fold at the N-terminus
      1. Archaeon Thermoplasma acidophilum [TaxId: 2303] [56256] (50) picpic
      2. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [90044] (2) picpic
      3. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [56257] (108) picpic
        The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)
      4. Cow (Bos taurus) [TaxId: 9913] [75568] (1) picpic
      5. Rhodococcus erythropolis [TaxId: 1833] [103314] (9) picpic
    3. HslV (ClpQ) protease [56258]
      dodecameric prokaryotic homologue of proteasome
      1. Escherichia coli [TaxId: 562] [56259] (7) picpic
      2. Haemophilus influenzae [TaxId: 727] [56260] (6) picpic
      3. Thermotoga maritima [TaxId: 2336] [90045] (1) picpic
      4. Bacillus subtilis [TaxId: 1423] [160845] (26) picpic
        SQ P39070 2-181
  5. (Glycosyl)asparaginase [56261] (3)
    1. Glycosylasparaginase (aspartylglucosaminidase, AGA) [56262]
      the precursor chain is cleaved onto 2 fragments by autoproteolysis
      1. Human (Homo sapiens) [TaxId: 9606] [56263] (2) picpic
      2. Flavobacterium meningosepticum [TaxId: 238] [56264] (8) picpic
      3. Escherichia coli [TaxId: 562] [103315] (3) picpic
        SQ P37595
        isoaspartyl peptidase with L-asparaginase activity
        putative L-asparaginase YbiK
  6. Gamma-glutamyltranspeptidase-like [143906] (4)
    Pfam 01019
    1. Hypothetical protein Ta0994 [143907]
      1. Thermoplasma acidophilum [TaxId: 2303] [143908] (4) picpic
        SQ Q9HJH4 1-516
    2. Cephalosporin acylase [143909]
      1. Bacillus halodurans [TaxId: 86665] [143910] (4) picpic
        SQ Q9KEI5 3-539
    3. Gamma-glutamyltranspeptidase, GGT [143911]
      1. Helicobacter pylori [TaxId: 210] [143912] (1) picpic
        SQ O25743 29-375,380-565
      2. Escherichia coli [TaxId: 562] [143913] (14) picpic
        SQ P18956 29-387,391-580! SQ P18956 29-580
  7. SPO2555-like [160846] (1)
    Pfam 06267; DUF1028
    1. Hypothetical protein SPO2555 [160847]
      1. Silicibacter pomeroyi [TaxId: 89184] [160848] (1) picpic
        SQ Q5LQD5 1-229
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk