Structural Classification of Proteins
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Family: Ras-binding domain, RBD

contains Pfam 00788 and Pfam 02196

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: beta-Grasp (ubiquitin-like) [54235]
    core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
  4. Superfamily: Ubiquitin-like [54236]
    link to SUPERFAMILY database - Superfamily
  5. Family: Ras-binding domain, RBD [54263]
    contains Pfam 00788 and Pfam 02196

Protein Domains:

  1. c-Raf1 RBD [54264]
    1. Human (Homo sapiens) [TaxId: 9606] [54265] (3)
      1. 1c1y picpicxref
        complexed with ca, gtp, mg
        1. chain b [37618] picpiclink
      2. 1gua picpicxref
        complexed with ca, gnp, mg; mutant
        1. chain b [37619] picpiclink
      3. 1rfa picpic
        1. chain a [37620] picpiclink
    2. Rat (Rattus norvegicus) [TaxId: 10116] [54266] (1)
      1. 1rrb picpic
        1. chain a [37621] picpiclink
  2. Ral guanosine-nucleotide exchange factor, RalGDS [54267]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [54268] (2)
      1. 1lfd picpicxref
        complexed with gnp, mg; mutant
        1. chain a [37622] picpiclink
        2. chain c [37623] picpiclink
      2. 1lxd picpic
        mutant
        1. chain a [37624] picpiclink
        2. chain b [37625] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [54269] (3)
      1. 2b3a picpic
        automatically matched to d2rgf__
        1. region a:11-97 [127785] picpiclink
      2. 1rax picpic
        1. chain a [37626] picpiclink
      3. 2rgf picpic
        1. chain a [37627] picpiclink
  3. RalGDS-like factor, Rlf [54270]
    1. Mouse (Mus musculus) [TaxId: 10090] [54271] (1)
      1. 1rlf picpic
        1. chain a [37628] picpiclink
  4. Rgl [54272]
    1. Mouse (Mus musculus) [TaxId: 10090] [54273] (1)
      1. 1ef5 picpic
        1. chain a [37629] picpiclink
  5. Phoshoinositide 3-kinase (PI3K) [54274]
    includes parts of the flanking linkers
    1. Pig (Sus scrofa) [TaxId: 9823] [54275] (5)
      1. 1e7u picpicxrefxrefxref
        complexed with kwt; mutant
        1. region a:143-321 [37630] picpiclink
      2. 1e8x picpicxrefxrefxref
        complexed with atp, lu; mutant
        1. region a:142-321 [37631] picpiclink
      3. 1e7v picpicxrefxrefxref
        complexed with ly2; mutant
        1. region a:143-321 [37632] picpiclink
      4. 1e90 picpicxrefxrefxref
        complexed with myc; mutant
        1. region a:143-321 [37633] picpiclink
      5. 1e8w picpicxrefxrefxref
        complexed with que; mutant
        1. region a:143-321 [37634] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [54276] (3)
      1. 1e8y picpicxrefxrefxref
        mutant
        1. region a:143-322 [37635] picpiclink
      2. 1e8z picpicxrefxrefxref
        complexed with stu; mutant
        1. region a:144-322 [37636] picpiclink
      3. 1he8 picpicxrefxrefxrefxref
        complexed with gnp, mg; mutant
        1. region a:144-321 [37637] picpiclink
  6. Protein kinase byr2 [69662]
    1. Fission yeast (Schizosaccharomyces pombe) [TaxId: 4896] [69663] (2)
      1. 1k8r picpicxref
        complex with Ras
        complexed with gnp, mg
        1. chain b [72180] picpiclink
      2. 1i35 picpic
        1. chain a [66017] picpiclink
  7. Regulator of G-protein signaling 14, RGS14 [117821]
    1. Mouse (Mus musculus) [TaxId: 10090] [117822] (1)
      SQ P97492 366-456
      1. 1wfy picpic
        Structural genomics target
        1. chain a [114597] picpiclink
  8. Growth factor receptor-bound protein 7, GRB-7 [117823]
    1. Human (Homo sapiens) [TaxId: 9606] [117824] (1)
      SQ Q14451 100-186
      1. 1wgr picpic
        Structural genomics target
        1. chain a [114621] picpiclink
  9. Rap guanine nucleotide exchange factor 5, RapGEF5 [117825]
    1. Human (Homo sapiens) [TaxId: 9606] [117826] (1)
      SQ Q92565 241-331
      1. 1wgy picpic
        Structural genomics target
        1. chain a [114627] picpiclink
  10. Ras association domain-containing protein 8 [142962]
    1. Human (Homo sapiens) [TaxId: 9606] [142963] (1)
      SQ Q8NHQ8 1-83
      1. 2cs4 picpic
        1. region a:8-91 [130746] picpiclink
  11. Afadin [142964]
    1. Mouse (Mus musculus) [TaxId: 10090] [142965] (1)
      SQ Q9QZQ1 246-348
      The FHA domain structure is also known (PDB 1wln)
      1. 1wxa picpic
        1. region a:8-110 [121395] picpiclink
  12. Phospholipase C-epsilon-1 [142966]
    contains several Ras-binding domains; some are 'hidden' in the sequence
    1. Human (Homo sapiens) [TaxId: 9606] [142967] (4)
      SQ Q9P212 2006-2114! SQ Q9P212 2131-2246! SQ Q9P212 2134-2239
      1. 2c5l picpicxrefxref
        complexed with gol, gtp, mg; mutant
        1. region c:2134-2239 [129924] picpiclink
      2. 2c5l picpicxrefxref
        automatically matched to 2C5L C:2134-2239
        complexed with gol, gtp, mg; mutant
        1. region d:2134-2238 [129925] picpiclink
      3. 2bye picpic
        1. region a:2-110 [129478] picpiclink
      4. 2byf picpic
        mutant
        1. region a:1-116 [129479] picpiclink
  13. A-Raf proto-oncogene serine/threonine-protein kinase [142968]
    1. Human (Homo sapiens) [TaxId: 9606] [142969] (1)
      SQ P10398 19-91
      1. 1wxm picpic
        1. region a:8-80 [121402] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk