Fold: beta-Grasp (ubiquitin-like)

core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b) [53931]
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: beta-Grasp (ubiquitin-like) [54235]
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

Superfamilies:

1. Ubiquitin-like [54236] (8)
   uperfamily
   1. Ubiquitin-related [54237] (47)
      Pfam 00240
   2. UBX domain [54250] (5)
      Pfam 00789
   3. GABARAP-like [54253] (5)
      intracellular membrane trafficking and fusion proteins
   4. First domain of FERM [54256] (7)
   5. Ras-binding domain, RBD [54263] (16)
      contains Pfam 00788 and Pfam 02196
   6. BM-002-like [75362] (3)
      Pfam 03671; UPF0185; this family comprises small uncharacterized proteins including human protein BM-002
   7. APG12-like [142972] (1)
      Pfam 04110
   8. DIX domain [159926] (1)
      Pfam 00778
2. CAD & PB1 domains [54277] (2)
   contain extra helix; similar heterodimerization modes; possibly related to the ubiquitin-like superfamily
   uperfamily
   1. CAD domain [54278] (5)
   2. PB1 domain [64225] (11)
      Pfam 00564
      forms heterodimers, although not all PB1 domain pairs associate.
3. MoaD/ThiS [54285] (4)
   possible link between the ubiquitin-like and 2Fe-2S ferredoxin-like superfamilies
   uperfamily
   1. MoaD [54286] (3)
   2. ThiS [54289] (5)
   3. C9orf74 homolog [117833] (1)
   4. HI0395-like [159931] (1)
      Pfam 03658; UPF0125
4. TGS-like [81271] (2)
   possibly related to the ubiquitin-like and MoaD/ThiS superfamilies; some similarity to the alpha-L RNA-binding motif
   uperfamily
   1. TGS domain [81270] (2)
   2. G domain-linked domain [82583] (3)
5. 2Fe-2S ferredoxin-like [54292] (2)
   uperfamily
   1. 2Fe-2S ferredoxin-related [54293] (19)
   2. 2Fe-2S ferredoxin domains from multidomain proteins [54312] (16)
6. Staphylokinase/streptokinase [54328] (1)
   uperfamily
   1. Staphylokinase/streptokinase [54329] (2)
7. Doublecortin (DC) [89837] (1)
   possibly related to the ubiquitin-like superfamily
   uperfamily
   1. Doublecortin (DC) [89838] (2)
8. Superantigen toxins, C-terminal domain [54334] (1)
   uperfamily
   1. Superantigen toxins, C-terminal domain [54335] (15)
9. Immunoglobulin-binding domains [54358] (1)
   uperfamily
   1. Immunoglobulin-binding domains [54359] (2)
10. Translation initiation factor IF3, N-terminal domain [54364] (1)
    uperfamily
    1. Translation initiation factor IF3, N-terminal domain [54365] (1)
11. Glutamine synthetase, N-terminal domain [54368] (1)
    uperfamily
    1. Glutamine synthetase, N-terminal domain [54369] (2)
12. TmoB-like [110814] (1)
    possibly related to the ubiquitin-like and/or 2Fe-2S ferredoxin-like superfamilies
    uperfamily
    1. TmoB-like [110815] (1)
       Pfam 06234
13. Nqo1 middle domain-like [142984] (1)
    possibly evolved from 2Fe-2S ferredoxins; contains no iron-sulfur cluster
    uperfamily
    1. Nqo1 middle domain-like [142985] (1)
       C-terminal part of Pfam 01512
14. NSP3A-like [159936] (1)
    short helical inserions in the common fold
    1. NSP3A-like [159937] (1)

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk