Structural Classification of Proteins
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Fold: Cysteine proteinases

consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Cysteine proteinases [54000]
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

Superfamilies:

  1. Cysteine proteinases [54001] (22)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
    link to SUPERFAMILY database - Superfamily
    1. Papain-like [54002] (30)
      1. Actinidin [54003]
        1. Chinese gooseberry or kiwifruit (Actinidia chinensis) [TaxId: 3625] [54004] (2) picpic
      2. Papain [54005]
        1. Papaya (Carica papaya) [TaxId: 3649] [54006] (18) picpic
      3. Caricain (protease omega) [54007]
        1. Papaya (Carica papaya) [TaxId: 3649] [54008] (3) picpic
      4. Chymopapain [54009]
        1. Papaya (Carica papaya) [TaxId: 3649] [54010] (1) picpic
      5. Glycyl endopeptidase [54011]
        1. Papaya (Carica papaya) [TaxId: 3649] [54012] (1) picpic
      6. Proline-specific cysteine protease [54013]
        1. Ginger rhizome (Zingiber officinale) [TaxId: 94328] [54014] (1) picpic
      7. Ervatamin B [89803]
        1. Adam's apple (Ervatamia coronaria) [TaxId: 52861] [89804] (1) picpic
      8. Ervatamin C [102717]
        1. East indian rosebay (Ervatamia coronaria) [TaxId: 52861] [102718] (1) picpic
      9. Vignain (bean endopeptidase) [102719]
        1. Castor bean (Ricinus communis) [TaxId: 3988] [102720] (1) picpic
      10. Bleomycin hydrolase [54017]
        DNA-binding protease that has more insertions in the papain-like fold
        1. Baker's yeast (Saccharomyces cerevisiae), Gal6 [TaxId: 4932] [54018] (3) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [54019] (2) picpic
      11. Cruzain [54020]
        1. Trypanosoma cruzi [TaxId: 5693] [54021] (17) picpic
      12. (Pro)cathepsin B [54022]
        1. Human (Homo sapiens) [TaxId: 9606] [54023] (6) picpic
        2. Rat (Rattus norvegicus) [TaxId: 10116] [54024] (4) picpic
        3. Cow (Bos taurus) [TaxId: 9913] [54025] (11) picpic
      13. Cathepsin C (dipeptidyl peptidase I), catalytic domain [75330]
        1. Human (Homo sapiens) [TaxId: 9606] [75331] (1) picpic
        2. Rat (Rattus norvegicus) [TaxId: 10116] [82565] (1) picpic
      14. Cathepsin F [89805]
        1. Human (Homo sapiens) [TaxId: 9606] [89806] (1) picpic
      15. Cathepsin H [81637]
        also contains a disulfide-bound minicathepsin H chain
        1. Pig (Sus scrofa) [TaxId: 9823] [81636] (3) picpic
      16. (Pro)cathepsin K [54028]
        1. Human (Homo sapiens) [TaxId: 9606] [54029] (32) picpic
          SQ P43235 116-329 ! SQ P43235 115-329
        2. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [142845] (1) picpic
          SQ P43236 115-329
      17. (Pro)cathepsin L [54026]
        1. Human (Homo sapiens) [TaxId: 9606] [54027] (4) picpic
      18. (Pro)cathepsin S [82566]
        1. Human (Homo sapiens) [TaxId: 9606] [82567] (36) picpic
      19. (Pro)cathepsin V [64202]
        1. Human (Homo sapiens) [TaxId: 9606] [64203] (1) picpic
      20. (Pro)cathepsin X [54031]
        1. Human (Homo sapiens) [TaxId: 9606] [54032] (2) picpic
      21. Staphopain StpA [54033]
        1. Staphylococcus aureus [TaxId: 1280] [54034] (1) picpic
      22. Staphopain SspB [102721]
        1. Staphylococcus aureus [TaxId: 1280] [102722] (4) picpic
          SQ Q70UQ9 41-393
      23. Streptococcal pyrogenic exotoxin B [54035]
        1. Streptococcus pyogenes [TaxId: 1314] [54036] (2) picpic
          SQ P00788 31-398
      24. Falcipain 2 [142846]
        1. Plasmodium falciparum [TaxId: 5833] [142847] (6) picpic
          SQ Q9N6S8 244-484
      25. Major mite fecal allergen der p 1 [142848]
        1. House-dust mite (Dermatophagoides pteronyssinus) [TaxId: 6956] [142849] (3) picpic
          SQ P08176 19-320! SQ P08176 99-320
    2. Avirulence protein Avrpph3 [102723] (1)
      1. Avirulence protein Avrpph3 [102724]
        1. Pseudomonas syringae pv. phaseolicola [TaxId: 319] [102725] (1) picpic
    3. FMDV leader protease [54037] (1)
      1. FMDV leader protease [54038]
        1. Foot-and-mouth disease virus [TaxId: 12110] [54039] (5) picpic
    4. Calpain large subunit, catalytic domain (domain II) [54040] (5)
      1. Calpain large subunit, catalytic domain (domain II) [54041]
        includes the N-terminal 'sequence' domain I
        1. Human (Homo sapiens), M-type [TaxId: 9606] [54042] (2) picpic
        2. Rat (Rattus norvegicus), M-type [TaxId: 10116] [54043] (3) picpic
        3. Rat (Rattus norvegicus), mu-type [TaxId: 10116] [75332] (10) picpic
          SQ P97571 33-353
        4. Human (Homo sapiens), calpain 9 [TaxId: 9606] [142850] (1) picpic
          SQ O14815 28-337
        5. Human(Homo sapiens), mu type [TaxId: 9606] [142851] (3) picpic
          SQ P07384 33-353! SQ P07384 33-354
    5. Transglutaminase core [54044] (6)
      1. Transglutaminase catalytic domain [54045]
        1. Human (Homo sapiens), blood isozyme [TaxId: 9606] [54046] (8) picpic
          Coagulation factor XIII
        2. Human (Homo sapiens), tissue isozyme [TaxId: 9606] [75333] (2) picpic
          GDP-binding protein
        3. Human (Homo sapiens), TGase E3 [TaxId: 9606] [75334] (8) picpic
        4. Red sea bream (Chrysophrys major) [TaxId: 143350] [64204] (1) picpic
      2. Peptide:N-glycanase 1, PNG1 [142852]
        1. Baker's yeast(Saccharomyces cerevisiae) [TaxId: 4932] [142853] (2) picpic
          SQ Q02890 8-327
        2. Mouse (Mus musculus) [TaxId: 10090] [159840] (2) picpic
          SQ Q9JI78 164-450
    6. Arylamine N-acetyltransferase [54047] (4)
      fold similar to that of the factor XIII catalytic domain
      1. Arylamine N-acetyltransferase [54048]
        1. Salmonella typhimurium [TaxId: 90371] [54049] (1) picpic
        2. Mycobacterium smegmatis [TaxId: 1772] [75335] (7) picpic
        3. Rhizobium loti [TaxId: 381] [142854] (2) picpic
          SQ Q98D42 6-275
        4. Pseudomonas aeruginosa [TaxId: 287] [142855] (1) picpic
          SQ Q9HUY3 1-277
    7. Ubiquitin carboxyl-terminal hydrolase UCH-L [54050] (3)
      1. Ubiquitin carboxyl-terminal hydrolase UCH-l3 [54051]
        1. Human (Homo sapiens) [TaxId: 9606] [54052] (2) picpic
          SQ P15374
        2. Synthetic, based on Saccharomyces cerevisiae sequence [54053] (1) picpic
      2. Ubiquitin carboxyl-terminal hydrolase isozyme l1 [142856]
        1. Human (Homo sapiens) [TaxId: 9606] [142857] (2) picpic
          SQ P09936 1-223
    8. Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (5)
      Pfam 00443
      1. Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP) [82569]
        1. Human (Homo sapiens) [TaxId: 9606] [82570] (2) picpic
      2. Ubiquitin carboxyl-terminal hydrolase 6 [110769]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110770] (1) picpic
          SQ P43593 103-499
      3. Ubiquitin carboxyl-terminal hydrolase 8 [142858]
        1. Human (Homo sapiens) [TaxId: 9606] [142859] (1) picpic
          SQ P40818 762-1109
      4. Ubiquitin carboxyl-terminal hydrolase 14 [142860]
        1. Human (Homo sapiens) [TaxId: 9606] [142861] (4) picpic
          SQ P54578 100-482
      5. Ubiquitin carboxyl-terminal hydrolase 2, USP2 [159841]
        1. Human (Homo sapiens) [TaxId: 9606] [159842] (2) picpic
          SQ O75604 263-600! SQ O75604 264-599
    9. Adenain-like [54054] (5)
      Pfam 02902; Ulp1 protease family
      1. Human adenovirus 2 proteinase, adenain [54055]
        1. Mastadenovirus H2 [TaxId: 10515] [54056] (2) picpic
      2. Ulp1 protease C-terminal domain [54057]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [54058] (4) picpic
      3. Sentrin-specific protease 2, SENP2 [110771]
        1. Human (Homo sapiens) [TaxId: 9606] [110772] (8) picpic
          SQ Q9HC62 366-589
      4. Sentrin-specific protease 8, SENP8 [117760]
        1. Human (Homo sapiens) [TaxId: 9606] [117761] (6) picpic
          SQ Q96LD8
      5. Sentrin-specific protease 1 [142862]
        1. Human (Homo sapiens) [TaxId: 9606] [142863] (6) picpic
          SQ Q9P0U3 419-643
    10. Microbial transglutaminase [75336] (1)
      inverted positions of the catalytic triad Asp and His residues
      1. Microbial transglutaminase [75337]
        1. Streptoverticillium mobaraense [TaxId: 35621] [75338] (1) picpic
    11. Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [110773] (1)
      probably the same as Pfam 02338, OTU-like cysteine protease, but 1TFF (SQ Q96DC9) was not detected by the Pfam model
      1. Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [110774]
        1. Human (Homo sapiens) [TaxId: 9606] [110775] (1) picpic
          SQ Q96DC9
    12. IgG-specific endopeptidase IdeS (Sib38) [117762] (1)
      1. IgG-specific endopeptidase IdeS (Sib38) [117763]
        1. Streptococcus pyogenes [TaxId: 1314] [117764] (1) picpic
          SQ Q9F1R7 38-339 # SPy0861
    13. Lpg0564-like [142864] (1)
      Pfam 07313, DUF1460; contains new PDB entry 2p1g, annotated as putative xylanase
      1. Hypothetical protein Lpg0564 [142865]
        1. Legionella pneumophila [TaxId: 446] [142866] (1) picpic
          SQ Q5ZY11 49-352
    14. Phytochelatin synthase [142867] (1)
      Pfam 05023; assosiated Pfam 09328 (DUF1984) is a part of the same functional unit
      1. Primitive phytochelatin synthase [142868]
        1. Nostoc sp. pcc 7120 [TaxId: 103690] [142869] (4) picpic
          SQ Q8YY76 29-238
    15. CHAP domain [142870] (1)
      Pfam 05257
      1. Glutathionylspermidine synthase, amidase domain [142871]
        1. Escherichia coli [TaxId: 562] [142872] (10) picpic
          SQ P0AES0 10-200
    16. NlpC/P60 [142873] (1)
      Pfam 00877
      1. Cell wall-associated hydrolase Spr C-terminal domain [142874]
        1. Nostoc punctiforme [TaxId: 272131] [142875] (3) picpic
          SQ Q8YRR4 87-234
    17. PMT C-terminal domain like [159843] (1)
      displays a minimal thiol-protease fold and its catalytic triad; potential redox regulation: the catalytic cysteine can form a disulfide bond with an N-terminal cysteine
      1. Dermonecrotic toxin, ToxA [159844]
        Synonym: Mitogenic toxin PMT
        1. Pasteurella multocida [TaxId: 747] [159845] (4) picpic
          SQ P17452 1094-1285
    18. MOA C-terminal domain-like [159846] (1)
      PfamB 070855
      1. Agglutinin MOA [159847]
        1. Fairy-ring mushroom (Marasmius oreades) [TaxId: 181124] [159848] (1) picpic
          SQ Q8X123 156-293
    19. Atu2299-like [159849] (1)
      Pfam 09641; DUF2026; putative Cys/Ser-His-Asp catalytic triad
      1. Hypothetical protein Atu2299 [159850]
        Serine catalytic nucleophile
        1. Agrobacterium tumefaciens [TaxId: 358] [159851] (1) picpic
          SQ Q8UD29 1-202
    20. M48USP-like [159852] (1)
      Pfam 04843; Herpesvirus tegument protein, N-terminal conserved region
      1. Tegument protein M48; N-terminal domain [159853]
        1. Murine cytomegalovirus (MCMV) [TaxId: 10366] [159854] (2) picpic
          SQ A8E1C4 1-232
    21. YiiX-like [159855] (1)
      Pfam 06520; DUF1105; circularly permuted active site residues compare to papain
      1. Hypothetical protein YiiX [159856]
        1. Escherichia coli [TaxId: 562] [159857] (2) picpic
          SQ Q8X778 19-200
    22. Autophagin-like [159858] (2)
      Pfam 03416
      1. Cysteine protease ATG4A [159859]
        Autophagin-2
        1. Human (Homo sapiens) [TaxId: 9606] [159860] (4) picpic
          SQ Q8WYN0 26-359
      2. Cysteine protease ATG4B [159861]
        Autophagin-1
        1. Human (Homo sapiens) [TaxId: 9606] [159862] (5) picpic
          SQ Q9Y4P1 10-373! SQ Q9Y4P1 5-354
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
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