Structural Classification of Proteins

Fold: Acyl-CoA N-acyltransferases (Nat)

: 3 layers: a/b/a; contains mixed beta-sheet

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: Acyl-CoA N-acyltransferases (Nat) [55728]
3 layers: a/b/a; contains mixed beta-sheet

Superfamilies:

Acyl-CoA N-acyltransferases (Nat) [55729] (10)
uperfamily
1. N-acetyl transferase, NAT [55730] (60)
  1. Aminoglycoside 6'-N-acetyltransferase [55731]
    1. Enterococcus faecium [TaxId: 1352] [55732] (4)
  2. Aminoglycoside 3-N-acetyltransferase [55733]
    1. Serratia marcescens [TaxId: 615] [55734] (1)
  3. Aminoglycoside 2'-N-acetyltransferase [75506]
    1. Mycobacterium tuberculosis [TaxId: 1773] [75507] (4)
  4. Tabtoxin resistance protein [82747]
    possesses HAT activity
    1. Pseudomonas syringae [TaxId: 317] [82748] (2)
  5. Histone acetyltransferase domain of P300/CBP associating factor, PCAF [55735]
    1. Human (Homo sapiens) [TaxId: 9606] [55736] (1)
  6. Catalytic domain of GCN5 histone acetyltransferase [55737]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [55738] (1)
    2. Tetrahymena thermophila [TaxId: 5911] [55739] (9)
      SQ Q27198 49-209
    3. Human (Homo sapiens) [TaxId: 9606] [143647] (1)
      SQ Q92830 497-658
  7. Histone acetyltransferase HPA2 [55740]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [55741] (2)
  8. Histone acetyltransferase HAT1 [55742]
    contains additional N- and C-terminal (sub)domains
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [55743] (1)
  9. Histone acetyltransferase ESA1 [55744]
    most similar to HAT1 including the N- and C-terminal (sub)domains; the N-terminal domain contains a rudiment CCHC zinc-finger (res. 191-220); the C-terminal domain (res. 351-434) has "winged helix" DNA-binding fold
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [55745] (4)
  10. Serotonin N-acetyltranferase [55746]
    1. Sheep (Ovis aries) [TaxId: 9940] [55747] (7)
  11. Glucosamine-phosphate N-acetyltransferase GNA1 [64351]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [64352] (3)
  12. Putative acetyltransferase YycN [90011]
    1. Bacillus subtilis [TaxId: 1423] [90012] (2)
  13. Hypothetical protein YqiY [90013]
    1. Bacillus subtilis [TaxId: 1423] [90014] (1)
  14. Probable acetyltransferase YdaF [90015]
    1. Bacillus subtilis [TaxId: 1423] [90016] (1)
  15. Probable acetyltransferase YjcF [103169]
    1. Bacillus subtilis [TaxId: 1423] [103170] (1)
  16. Putative phosphinothricin acetyltransferase YwnH [103171]
    1. Bacillus subtilis [TaxId: 1423] [103172] (1)
  17. Hypothetical protein SA2309 [103173]
    1. Staphylococcus aureus [TaxId: 1280] [103174] (2)
  18. Mycothiol synthase MshD [103175]
    duplication: consists of two NAT domains swapped with the C-terminal strands with both domains binding acetyl-CoA; structural link with the other families
    1. Mycobacterium tuberculosis [TaxId: 1773] [103176] (3)
      Rv0819
  19. Aminoglycoside N-acetyltransferase AAC(6')-IY [111098]
    1. Salmonella enteritidis [TaxId: 149539] [111099] (3)
      SQ Q9R381
    2. Salmonella choleraesuis [TaxId: 28901] [160639] (2)
  20. Protease synthase and sporulation negative regulatory protein PaiA [111100]
    1. Bacillus subtilis [TaxId: 1423] [111101] (1)
      SQ P21340
  21. Hypothetical protein AT1g77540 [118064]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [118065] (3)
      SQ Q8LEN2
  22. Hypothetical protein PA0115 [118066]
    1. Pseudomonas aeruginosa [TaxId: 287] [118067] (1)
      SQ Q9I717
  23. Probable acetyltransferase TTHA1209 [118068]
    1. Thermus thermophilus [TaxId: 274] [118069] (2)
      SQ Q5SJ05
  24. Putative acetyltransferase EF0945 [118070]
    1. Enterococcus faecalis [TaxId: 1351] [118071] (1)
      SQ Q836Z8
  25. Putative acetyltransferase PF0028 [118072]
    1. Pyrococcus furiosus [TaxId: 2261] [118073] (1)
      SQ Q8U4Q2
  26. Hypothetical protein PH1933 [143648]
    1. Pyrococcus horikoshii [TaxId: 53953] [143649] (2)
      SQ O59596 1-157
  27. Probable acetyltransferase BC2806 [143650]
    1. Bacillus cereus [TaxId: 1396] [143651] (2)
      SQ Q81CG1 1-140
  28. Diamine acetyltransferase 1 [143652]
    1. Human (Homo sapiens) [TaxId: 9606] [143653] (18)
      SQ P21673 2-170! SQ P21673 3-169
  29. Hypothetical protein YsnE [143654]
    1. Bacillus subtilis [TaxId: 1423] [143655] (1)
      SQ P94562 1-151
  30. Probable acetyltransferase Atu2258 [143656]
    1. Agrobacterium tumefaciens [TaxId: 358] [143657] (1)
      SQ Q7CXI0 1-137
  31. Transcriptional regulator BH1968 [143658]
    1. Bacillus halodurans [TaxId: 86665] [143659] (2)
      SQ Q9KBG0 4-153
  32. Probable acetyltransferase Atu2290 [143660]
    1. Agrobacterium tumefaciens [TaxId: 358] [143661] (4)
      SQ Q8UD38 6-169
  33. Probable acetyltransferase EF1919 [143662]
    1. Enterococcus faecalis [TaxId: 1351] [143663] (2)
      SQ Q833M5 1-157
  34. Putative acetyltransferase EF0244 [143664]
    1. Enterococcus faecalis [TaxId: 1351] [143665] (4)
      SQ Q839D1 1-161
  35. Hypothetical protein PH0736 [143666]
    1. Pyrococcus horikoshii [TaxId: 53953] [143667] (2)
      SQ O58467 1-182
  36. Hypothetical protein Rv1347c/MT1389 [143668]
    1. Mycobacterium tuberculosis [TaxId: 1773] [143669] (8)
      SQ P64819 10-207
  37. Probable acetyltransferase YitI [143670]
    1. Bacillus licheniformis [TaxId: 1402] [143671] (3)
      SQ Q65LG7 2-146
  38. Probable histone acetyltransferase MYST1 [143672]
    ESA1 orthologue
    1. Human (Homo sapiens) [TaxId: 9606] [143673] (1)
      SQ Q9H7Z6 178-448
  39. Hypothetical protein SA2161 [143674]
    1. Staphylococcus aureus [TaxId: 1280] [143675] (2)
      SQ Q7A3W2 1-133
  40. Probable N-acetyltransferase PA0478 [143676]
    1. Pseudomonas aeruginosa [TaxId: 287] [143677] (2)
      SQ Q9I640 3-158
  41. L7/L12-Ribosomal-protein-serine acetyltransferase RimL [143678]
    1. Salmonella typhimurium [TaxId: 90371] [143679] (9)
      SQ Q8ZPC0 1-176
  42. Probable acetyltransferase SP0256 [143680]
    probable SA2161 ortholog
    1. Streptococcus pneumoniae [TaxId: 1313] [143681] (1)
      SQ Q97SR8 1-137
  43. Probable spermine/spermidine acetyltransferase EF1086 [143682]
    1. Enterococcus faecalis [TaxId: 1351] [143683] (1)
      SQ Q836M4 1-146
  44. Putative ribosomal-protein-serine acetyltransferase VC1889 [143684]
    similar to RimL and RimJ
    1. Vibrio cholerae [TaxId: 666] [143685] (1)
      SQ Q9KQV9 1-178
  45. Hypothetical protein PA3270 [143686]
    1. Pseudomonas aeruginosa [TaxId: 287] [143687] (4)
      SQ Q9HYX1 11-193
  46. Diamine acetyltransferase 2 [143688]
    1. Human (Homo sapiens) [TaxId: 9606] [143689] (4)
      SQ Q96F10 3-169
  47. Hypothetical protein MW0638 [143690]
    SA0631 ortholog
    1. Staphylococcus aureus [TaxId: 1280] [143691] (1)
      SQ Q8NXQ8 1-118
  48. Probable acetyltransferase PA4026 [143692]
    1. Pseudomonas aeruginosa [TaxId: 287] [143693] (4)
      SQ Q9HX01 1-153
  49. Hypothetical protein PA4866 [143694]
    Putative phosphinothricin acetyltransferase
    1. Pseudomonas aeruginosa [TaxId: 287] [143695] (3)
      SQ Q9HUU7 3-172! SQ Q9HUU7 4-172
  50. IAA acetyltransferase [143696]
    YvbK ortholojg
    1. Bacillus cereus [TaxId: 1396] [143697] (4)
      SQ Q81FK8 1-152
  51. Phosphinothricin acetyltransferase [143698]
    1. Agrobacterium tumefaciens [TaxId: 358] [143699] (4)
      SQ Q8UGX8 2-164
  52. Putative acetyltransferase PA4794 [143700]
    1. Pseudomonas aeruginosa [TaxId: 287] [143701] (1)
      SQ Q9HV14 1-160
  53. Histone acetyltransferase MYST3 [143702]
    ESA1 orthologue
    1. Human (Homo sapiens) [TaxId: 9606] [143703] (2)
      SQ Q92794 507-776
      solution structure of the zinc-binding motif have been determined in isolation (PDB 1m36, scop_sp 103600)
  54. Probable acetyltranferase Atu2435 [143704]
    1. Agrobacterium tumefaciens [TaxId: 358] [143705] (1)
      SQ Q8UCP8 4-167
  55. Hypothetical protein YvbK (BSu33890) [143706]
    1. Bacillus subtilis [TaxId: 1423] [143707] (4)
      SQ O32248 5-156
  56. Probable N-acetyltransferase RPA1999 [143708]
    1. Rhodopseudomonas palustris [TaxId: 1076] [143709] (1)
      SQ Q6N8A5 2-157
  57. Hypothetical protein TTHA1254 [160640]
    1. Thermus thermophilus [TaxId: 274] [160641] (2)
      SQ Q5SIW0 1-130
2. N-myristoyl transferase, NMT [55748] (3)
  duplication: consists of two NAT-like domains swapped with the C-terminal strands
  1. N-myristoyl transferase, NMT [55749]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [55750] (3)
    2. Yeast (Candida albicans) [TaxId: 5476] [55751] (3)
    3. Human (Homo sapiens) [TaxId: 9606] [143710] (8)
      SQ P30419 155-294! SQ P30419 295-496
3. Autoinducer synthetase [75508] (2)
  Pfam 00765
  1. Acyl-homoserinelactone synthase EsaI [75509]
    1. Pantoea stewartii subsp. stewartii [TaxId: 66271] [75510] (2)
  2. Autoinducer synthesis protein LasI [111102]
    1. Pseudomonas aeruginosa [TaxId: 287] [111103] (1)
      SQ P33883
4. FemXAB nonribosomal peptidyltransferases [82749] (3)
  duplication: consists of two NAT-like domains swapped with the C-terminal strands
  1. Methicillin resistance protein FemA [82750]
    transfer glycyl residue from tRNA-Gly
    1. Staphylococcus aureus [TaxId: 1280] [82751] (1)
  2. Peptidyltransferase FemX [103177]
    1. Weissella viridescens [TaxId: 1629] [103178] (8)
  3. Hypothetical protein BT3689 [160642]
    1. Bacteroides thetaiotaomicron [TaxId: 818] [160643] (4)
      SQ Q8A1H2 1-134! SQ Q8A1H2 135-298
5. Hypothetical protein cg14615-pa [103179] (1)
  duplication: consists of two NAT-like domains swapped with the C-terminal strands
  1. Hypothetical protein cg14615-pa [103180]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [103181] (1)
6. LFTR-like [143711] (1)
  Pfam 03588; closer relative to the nonribosomal peptidyltransferases (scop_fa 82749); deletion of the N-terminal half of the N-terminal NAT-like domain after the domain duplication/swapping events
  1. Leucyl/phenylalanyl-tRNA-protein transferase, LFTR (Aat) [143712]
    1. Escherichia coli [TaxId: 562] [143713] (1)
      SQ P0A8P1 1-232
7. Ornithine decarboxylase antizyme-like [143714] (1)
  Pfam 02100; may have evolved different function; putative active site maps to the same location in the common fold
  1. Ornithine decarboxylase antizyme [143715]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [143716] (1)
      SQ P54370 93-218
8. AstA-like [143717] (1)
  Pfam 04958; contains extra C-terminal domain, similar to the double psi beta-barrel fold (scop_cf 50684) with missing one strand and untangled psi-loops
  1. Arginine N-succinyltransferase, alpha chain, AstA [143718]
    1. Pseudomonas aeruginosa [TaxId: 287] [143719] (1)
      SQ P80357 1-338
9. Aq_1966-like [143720] (1)
  Pfam 06557; DUF1122; probable biological unit is homotrimeric; may have evolved different function; putative active site maps to the same location in the common fold
  1. Hypothetical protein Aq_1966 [143721]
    1. Aquifex aeolicus [TaxId: 63363] [143722] (3)
      SQ O67778 1-196
10. EF1021-like [160644] (3)
  duplication: consists of two NAT domains swapped with the C-terminal strands; overall structural similarity to Mycothiol synthase and N-myristoyl transferase (NMT); the similarity to NMT extends to the participation of the protein C-terminus (after the SCP2-like C-terminal domain) in the active site
  1. Putative acetyltransferase EF2353 [160645]
    1. Enterococcus faecalis [TaxId: 1351] [160646] (6)
      SQ Q831Y9 10-300
  2. Putative acetyltransferase Ava4977 [160647]
    1. Anabaena variabilis [TaxId: 1172] [160648] (1)
      SQ Q3M362 8-290
  3. Hypothetical protein EF1021 [160649]
    1. Enterococcus faecalis [TaxId: 1351] [160650] (6)
      SQ Q836T6 2-286