Structural Classification of Proteins
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Family: Matrix metalloproteases, catalytic domain

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Zincin-like [55485]
    contains mixed beta sheet with connection over free side of the sheet
  4. Superfamily: Metalloproteases ("zincins"), catalytic domain [55486]
    link to SUPERFAMILY database - Superfamily
  5. Family: Matrix metalloproteases, catalytic domain [55528]

Protein Domains:

  1. Fibroblast collagenase (MMP-1) [55529]
    1. Human (Homo sapiens) [TaxId: 9606] [55530] (14)
      SQ P03956 32-466
      1. 1hfc picpic
        complexed with ca, hap, zn
        1. chain a [40335] picpiclink
      2. 2tcl picpic
        complexed with ca, ro4, sm, zn
        1. chain a [40337] picpiclink
      3. 1cge picpic
        complexed with ca, zn
        1. chain a [40336] picpiclink
      4. 1su3 picpicxrefxref
        complexed with ca, cl, epe, na, so4, zn
        1. region a:107-270 [112119] picpiclink
        2. region b:107-270 [112122] picpiclink
      5. 966c picpic
        complexed with ca, rs2, zn
        1. chain a [40338] picpiclink
      6. 1cgf picpic
        complexed with ca, zn
        1. chain a [40339] picpiclink
        2. chain b [40340] picpiclink
      7. 1cgl picpic
        complexed with ca, cbz, emr, zn
        1. chain a [40341] picpiclink
        2. chain b [40342] picpiclink
      8. 2j0t picpicxrefxrefxref
        automatically matched to d1ayk__
        complexed with ca, zn
        1. region a:105-265 [137917] picpiclink
      9. 2j0t picpicxrefxrefxref
        automatically matched to d1ayk__
        complexed with ca, zn
        1. region b:105-265 [137918] picpiclink
      10. 2j0t picpicxrefxrefxref
        automatically matched to d1ayk__
        complexed with ca, zn
        1. region c:105-263 [137919] picpiclink
      11. 1ayk picpic
        complexed with ca, zn
        1. chain a [40345] picpiclink
      12. 4ayk picpic
        complexed with ca, cgs, zn
        1. chain a [40346] picpiclink
      13. 2ayk picpic
        complexed with ca, zn
        1. chain a [40344] picpiclink
      14. 3ayk picpic
        complexed with ca, cgs, zn
        1. chain a [40343] picpiclink
    2. Pig (Sus scrofa) [TaxId: 9823] [55531] (3)
      1. 2clt picpicxrefxref
        automatically matched to d1fbl_2
        complexed with ca, zn; mutant
        1. region a:81-252 [130587] picpiclink
      2. 2clt picpicxrefxref
        automatically matched to d1fbl_2
        complexed with ca, zn; mutant
        1. region b:81-252 [130589] picpiclink
      3. 1fbl picpicxref
        complexed with ca, hta, zn
        1. region a:100-271 [40347] picpiclink
  2. MMP-2 [69778]
    1. Human (Homo sapiens) [TaxId: 9606] [69779] (1)
      1. 1hov picpic
        complexed with ca, i52, zn
        1. chain a [65897] picpiclink
  3. Neutrophil collagenase (MMP-8) [55532]
    1. Human (Homo sapiens) [TaxId: 9606] [55533] (21)
      1. 1i76 picpic
        complexed with bsi, ca, zn
        1. chain a [61877] picpiclink
      2. 1i73 picpic
        complexed with ca, pat, zn
        1. chain a [61866] picpiclink
      3. 2oy2 picpic
        automatically matched to d1bzsa_
        complexed with ca, zn
        1. region a:86-242 [139428] picpiclink
      4. 2oy2 picpic
        automatically matched to d1bzsa_
        complexed with ca, zn
        1. region f:86-242 [139429] picpiclink
      5. 1zs0 picpic
        automatically matched to d1bzsa_
        complexed with ca, ein, mes, zn
        1. region a:80-242 [125570] picpiclink
      6. 1bzs picpic
        complexed with bsi, ca, epe, zn
        1. chain a [40348] picpiclink
      7. 1jap picpic
        complexed with ca, hoa, zn
        1. chain a [40349] picpiclink
      8. 2oy4 picpic
        automatically matched to d1bzsa_
        complexed with ca, zn
        1. region a:86-242 [139430] picpiclink
      9. 2oy4 picpic
        automatically matched to d1bzsa_
        complexed with ca, zn
        1. region f:86-242 [139431] picpiclink
      10. 1kbc picpic
        complexed with ca, hle, rin, zn
        1. chain a [40350] picpiclink
        2. chain b [40351] picpiclink
      11. 1zp5 picpic
        automatically matched to d1bzsa_
        complexed with 2ni, ca, zn
        1. region a:80-242 [125455] picpiclink
      12. 1zvx picpic
        automatically matched to d1bzsa_
        complexed with ca, fin, zn
        1. region a:80-242 [125733] picpiclink
      13. 1mmb picpic
        complexed with bat, ca, zn
        1. chain a [40352] picpiclink
      14. 1mnc picpic
        complexed with ca, plh, zn
        1. chain a [40353] picpiclink
      15. 1jj9 picpic
        complexed with bbt, ca, zn
        1. chain a [63115] picpiclink
      16. 1a85 picpic
        complexed with ca, hmi, zn
        1. chain a [40355] picpiclink
      17. 1a86 picpic
        complexed with ca, hmi, zn
        1. chain a [40354] picpiclink
      18. 1jao picpic
        complexed with btp, ca, gm1, zn
        1. chain a [40357] picpiclink
      19. 1jan picpic
        complexed with ca, hoa, zn
        1. chain a [40358] picpiclink
      20. 1jaq picpic
        complexed with ca, gm1, hmp, zn
        1. chain a [40356] picpiclink
      21. 1jh1 picpic
        complexed with ca, jst, zn
        1. chain a [66696] picpiclink
  4. Gelatinase A [55534]
    1. Human (Homo sapiens) [TaxId: 9606] [55535] (4)
      1. 1qib picpic
        1. chain a [40359] picpiclink
      2. 1eak picpicxrefxref
        complexed with ca, so4, zn; mutant
        1. region a:108-216,a:394-452 [70094] picpiclink
        2. region b:108-216,b:394-450 [70099] picpiclink
        3. region c:108-216,c:394-449 [70104] picpiclink
        4. region d:108-216,d:394-450 [70109] picpiclink
      3. 1ck7 picpicxrefxrefxref
        complexed with ca, cl, na, so4, zn; mutant
        1. region a:108-216,a:394-449 [58970] picpiclink
      4. 1gxd picpicxrefxrefxrefxref
        complexed with ca, so4, zn; mutant
        1. region a:79-187,a:365-421 [70693] picpiclink
        2. region b:79-187,b:365-421 [70699] picpiclink
  5. Stromelysin-1 (MMP-3) [55536]
    1. Human (Homo sapiens), fibroblast [TaxId: 9606] [55537] (36)
      1. 1hy7 picpic
        complexed with ca, mbs, zn
        1. chain a [65957] picpiclink
        2. chain b [65958] picpiclink
      2. 1hfs picpic
        complexed with ca, l04, zn
        1. chain a [40370] picpiclink
      3. 1ciz picpic
        complexed with ca, dps, so4, zn
        1. chain a [40371] picpiclink
      4. 1usn picpic
        complexed with ca, in9, zn
        1. chain a [40372] picpiclink
      5. 2d1o picpic
        automatically matched to d1b3db_
        complexed with ca, fa4, zn
        1. region a:83-253 [131134] picpiclink
      6. 2d1o picpic
        automatically matched to d1b3db_
        complexed with ca, fa4, zn
        1. region b:83-250 [131135] picpiclink
      7. 1caq picpic
        complexed with ca, dps, oc1, oc2, so4, zn
        1. chain a [40375] picpiclink
      8. 1c3i picpic
        complexed with ca, tr1, zn
        1. chain a [40373] picpiclink
        2. chain b [40374] picpiclink
      9. 1g49 picpic
        complexed with 111, ca, zn
        1. chain a [65140] picpiclink
        2. chain b [65141] picpiclink
      10. 2usn picpic
        complexed with ca, in8, zn
        1. chain a [40376] picpiclink
      11. 1qia picpic
        complexed with ca, zn
        1. chain a [81258] picpiclink
        2. chain b [81259] picpiclink
        3. chain c [81260] picpiclink
        4. chain d [81261] picpiclink
      12. 1b8y picpic
        complexed with ca, in7, so4, zn
        1. chain a [40377] picpiclink
      13. 1cqr picpic
        complexed with ca, zn
        1. chain a [40378] picpiclink
        2. chain b [40379] picpiclink
      14. 1d7x picpic
        complexed with ca, spc, zn
        1. chain a [40380] picpiclink
        2. chain b [40381] picpiclink
      15. 1g4k picpic
        complexed with ca, gol, hqq, zn
        1. chain a [60242] picpiclink
        2. chain b [60243] picpiclink
        3. chain c [60244] picpiclink
      16. 1sln picpic
        complexed with ca, inh, zn
        1. chain a [40362] picpiclink
      17. 1qic picpic
        complexed with ca, zn
        1. chain a [81262] picpiclink
        2. chain b [81263] picpiclink
        3. chain c [81264] picpiclink
        4. chain d [81265] picpiclink
      18. 1bqo picpic
        complexed with ca, n25, zn
        1. chain a [40363] picpiclink
        2. chain b [40364] picpiclink
      19. 1b3d picpic
        1. chain a [40382] picpiclink
        2. chain b [40383] picpiclink
      20. 1g05 picpic
        complexed with bbh, ca, zn
        1. chain a [65076] picpiclink
        2. chain b [65077] picpiclink
      21. 1d8m picpic
        complexed with bbh, ca, zn
        1. chain a [40392] picpiclink
        2. chain b [40393] picpiclink
      22. 1d8f picpic
        complexed with ca, spi, zn
        1. chain a [40388] picpiclink
        2. chain b [40389] picpiclink
      23. 1d5j picpic
        complexed with ca, mm3, zn
        1. chain a [40386] picpiclink
        2. chain b [40387] picpiclink
      24. 1biw picpic
        complexed with ca, s80, zn
        1. chain a [40384] picpiclink
        2. chain b [40385] picpiclink
      25. 1uea picpicxref
        complexed with ca, zn; mutant
        1. chain a [40365] picpiclink
        2. chain c [40366] picpiclink
      26. 1c8t picpic
        complexed with ca, tr1, zn; mutant
        1. chain a [40390] picpiclink
        2. chain b [40391] picpiclink
      27. 3usn picpic
        complexed with att, ca, zn
        1. chain a [40394] picpiclink
      28. 1oo9 picpicxref
        1. chain a [87190] picpiclink
      29. 2srt picpic
        complexed with inh, zn
        1. chain a [40367] picpiclink
      30. 1umt picpic
        complexed with ca, hae, mop, nh2, zn
        1. chain a [40369] picpiclink
      31. 2jnp picpic
        automatically matched to d1b3db_
        complexed with ca, ngh, zn
        1. region a:88-248 [148151] picpiclink
      32. 2jt6 picpic
        automatically matched to d1b3db_
        complexed with ca, jt6, zn
        1. region a:88-248 [148200] picpiclink
      33. 1ums picpic
        complexed with ca, hae, mop, nh2, zn
        1. chain a [40368] picpiclink
      34. 2jt5 picpic
        automatically matched to d1b3db_
        complexed with ca, jt5, zn
        1. region a:88-248 [148199] picpiclink
      35. 1bm6 picpic
        complexed with 3mp, ca, hav, msb, zn
        1. chain a [40395] picpiclink
      36. 1slm picpicxref
        truncated proenzyme
        complexed with ca, zn
        1. region a:81-250 [59043] picpiclink
  6. Matrilysin (MMP-7) [55538]
    1. Human (Homo sapiens) [TaxId: 9606] [55539] (4)
      1. 1mmq picpic
        complexed with ca, rrs, zn
        1. chain a [40396] picpiclink
      2. 1mmp picpic
        complexed with ca, rss, zn
        1. chain a [40397] picpiclink
        2. chain b [40398] picpiclink
      3. 1mmr picpic
        complexed with ca, srs, zn
        1. chain a [40399] picpiclink
      4. 2ddy picpic
        automatically matched to d1mmr__
        complexed with ca, mdw, zn
        1. region a:1-167 [131408] picpiclink
  7. Gelatinase B (MMP-9) [75496]
    1. Human (Homo sapiens) [TaxId: 9606] [75497] (13)
      1. 2ovx picpic
        automatically matched to d1gkda_
        complexed with 4mr, ca, cl, zn; mutant
        1. region a:110-443 [139388] picpiclink
      2. 2ovx picpic
        automatically matched to d1gkda_
        complexed with 4mr, ca, cl, zn; mutant
        1. region b:110-443 [139389] picpiclink
      3. 2ovz picpic
        automatically matched to d1gkda_
        complexed with 5mr, ca, cl, zn; mutant
        1. region a:110-443 [139390] picpiclink
      4. 2ovz picpic
        automatically matched to d1gkda_
        complexed with 5mr, ca, cl, zn; mutant
        1. region b:114-443 [139391] picpiclink
      5. 2ow0 picpic
        automatically matched to d1gkda_
        complexed with 6mr, ca, cl, zn; mutant
        1. region a:110-443 [139392] picpiclink
      6. 2ow0 picpic
        automatically matched to d1gkda_
        complexed with 6mr, ca, cl, zn; mutant
        1. region b:114-443 [139393] picpiclink
      7. 1gkd picpic
        complexed with bum, ca, stn, zn; mutant
        1. chain a [70217] picpiclink
        2. chain b [70218] picpiclink
      8. 2ow1 picpic
        automatically matched to d1gkda_
        complexed with 7mr, ca, cl, zn; mutant
        1. region a:110-443 [139394] picpiclink
      9. 2ow1 picpic
        automatically matched to d1gkda_
        complexed with 7mr, ca, cl, zn; mutant
        1. region b:114-443 [139395] picpiclink
      10. 1gkc picpic
        complexed with bum, ca, stn, zn
        1. chain a [70215] picpiclink
        2. chain b [70216] picpiclink
      11. 1l6j picpicxrefxref
        complexed with ca, zn
        1. region a:106-215,a:391-444 [73620] picpiclink
      12. 2ow2 picpic
        automatically matched to d1gkda_
        complexed with 8mr, ca, cl, zn; mutant
        1. region a:113-443 [139396] picpiclink
      13. 2ow2 picpic
        automatically matched to d1gkda_
        complexed with 8mr, ca, cl, zn; mutant
        1. region b:114-443 [139397] picpiclink
  8. Stromelysin-2 (MMP-10) [103128]
    1. Human (Homo sapiens) [TaxId: 9606] [103129] (1)
      1. 1q3a picpic
        complexed with ca, ngh, zn; mutant
        1. chain a [95664] picpiclink
        2. chain b [95665] picpiclink
        3. chain c [95666] picpiclink
  9. Stromelysin-3 (MMP-11) [64341]
    1. Mouse (Mus musculus) [TaxId: 10090] [64342] (1)
      1. 1hv5 picpic
        complexed with ca, cps, rxp, zn
        1. chain a [61288] picpiclink
        2. chain b [61289] picpiclink
        3. chain c [61290] picpiclink
        4. chain d [61291] picpiclink
        5. chain e [61292] picpiclink
        6. chain f [61293] picpiclink
  10. Macrophage elastase (MMP-12) [69780]
    1. Human (Homo sapiens) [TaxId: 9606] [69781] (18)
      SQ P39900 106-263 ! SQ P39900 106-264
      1. 1y93 picpic
        automatically matched to d1os2a_
        complexed with ca, hae, zn; mutant
        1. region a:106-263 [122772] picpiclink
      2. 1jk3 picpic
        complexed with bat, ca, zn; mutant
        1. chain a [66790] picpiclink
      3. 2oxw picpic
        automatically matched to d1os2a_
        complexed with ca, zn; mutant
        1. region a:106-263 [139426] picpiclink
      4. 2oxu picpic
        automatically matched to d1os2a_
        complexed with ca, zn; mutant
        1. region a:106-263 [139425] picpiclink
      5. 2hu6 picpic
        automatically matched to d1os2a_
        complexed with 37a, ca, hae, zn; mutant
        1. region a:106-263 [136767] picpiclink
      6. 1rmz picpic
        complexed with ca, ngh, zn; mutant
        1. chain a [111896] picpiclink
      7. 1os9 picpic
        complexed with ca, zn; mutant
        1. chain a [93482] picpiclink
        2. chain b [93483] picpiclink
        3. chain c [93484] picpiclink
        4. chain d [93485] picpiclink
        5. chain e [93486] picpiclink
        6. chain f [93487] picpiclink
      8. 1ros picpic
        complexed with ca, deo, zn
        1. chain a [111903] picpiclink
        2. chain b [111904] picpiclink
      9. 2oxz picpic
        automatically matched to d1os2a_
        complexed with ca, zn; mutant
        1. region a:106-263 [139427] picpiclink
      10. 1utt picpic
        complexed with ca, cp8, hae, zn
        1. chain a [113430] picpiclink
      11. 1os2 picpic
        complexed with act, azi, ca, hae, zn; mutant
        1. chain a [93469] picpiclink
        2. chain b [93470] picpiclink
        3. chain c [93471] picpiclink
        4. chain d [93472] picpiclink
        5. chain e [93473] picpiclink
        6. chain f [93474] picpiclink
      12. 1utz picpic
        complexed with ca, hae, pf3, zn
        1. chain a [113431] picpiclink
        2. chain b [113432] picpiclink
      13. 1jiz picpic
        complexed with ca, cgs, zn
        1. chain a [71693] picpiclink
        2. chain b [71694] picpiclink
      14. 2k2g picpic
        automatically matched to d1jiza_
        complexed with dsv, zn
        1. region a:100-263 [148260] picpiclink
      15. 1ycm picpic
        automatically matched to d1os2a_
        complexed with ca, ngh, zn; mutant
        1. region a:106-263 [122969] picpiclink
      16. 1z3j picpic
        automatically matched to d1os2a_
        complexed with ca, ngh, zn; mutant
        1. region a:106-263 [124408] picpiclink
      17. 2poj picpic
        automatically matched to d1jk3a_
        complexed with ca, zn; mutant
        1. region a:106-263 [149722] picpiclink
      18. 2z2d picpic
        automatically matched to d1jiza_
        complexed with ca, hsi, zn
        1. region a:106-263 [153936] picpiclink
  11. Collagenase-3 (MMP-13) [55540]
    1. Human (Homo sapiens) [TaxId: 9606] [55541] (34)
      1. 1xuc picpic
        automatically matched to d1euba_
        complexed with ca, pb3, zn
        1. region a:104-272 [122332] picpiclink
      2. 1xuc picpic
        automatically matched to d1euba_
        complexed with ca, pb3, zn
        1. region b:104-269 [122333] picpiclink
      3. 2ow9 picpic
        automatically matched to d1euba_
        complexed with ca, hae, so4, sp6, zn
        1. region a:83-249 [139419] picpiclink
      4. 2ow9 picpic
        automatically matched to d1euba_
        complexed with ca, hae, so4, sp6, zn
        1. region b:83-248 [139420] picpiclink
      5. 1xud picpic
        automatically matched to d1euba_
        complexed with ca, pb4, zn
        1. region a:104-272 [122334] picpiclink
      6. 1xud picpic
        automatically matched to d1euba_
        complexed with ca, pb4, zn
        1. region b:104-269 [122335] picpiclink
      7. 830c picpic
        complexed with ca, rs1, zn
        1. chain a [40400] picpiclink
        2. chain b [40401] picpiclink
      8. 1xur picpic
        automatically matched to d1euba_
        complexed with ca, pb5, zn
        1. region a:104-272 [122338] picpiclink
      9. 1xur picpic
        automatically matched to d1euba_
        complexed with ca, pb5, zn
        1. region b:104-269 [122339] picpiclink
      10. 2e2d picpicxref
        automatically matched to d1euba_
        complexed with ca, zn
        1. region a:104-268 [131979] picpiclink
      11. 1ztq picpic
        automatically matched to d1euba_
        complexed with 033, ca, zn
        1. region a:79-243 [125651] picpiclink
      12. 1ztq picpic
        automatically matched to d1euba_
        complexed with 033, ca, zn
        1. region b:79-243 [125652] picpiclink
      13. 1ztq picpic
        automatically matched to d1euba_
        complexed with 033, ca, zn
        1. region c:79-243 [125653] picpiclink
      14. 1ztq picpic
        automatically matched to d1euba_
        complexed with 033, ca, zn
        1. region d:79-243 [125654] picpiclink
      15. 2d1n picpic
        automatically matched to d1euba_
        complexed with ca, fa4, zn
        1. region a:104-269 [131132] picpiclink
      16. 2d1n picpic
        automatically matched to d1euba_
        complexed with ca, fa4, zn
        1. region b:104-269 [131133] picpiclink
      17. 1you picpic
        automatically matched to d1euba_
        complexed with ca, pfd, so4, zn
        1. region a:104-271 [123783] picpiclink
      18. 1you picpic
        automatically matched to d1euba_
        complexed with ca, pfd, so4, zn
        1. region b:104-268 [123784] picpiclink
      19. 2ozr picpic
        automatically matched to d1euba_
        complexed with ca, gg1, hae, zn
        1. region a:83-249 [149119] picpiclink
      20. 2ozr picpic
        automatically matched to d1euba_
        complexed with ca, gg1, hae, zn
        1. region b:83-249 [149120] picpiclink
      21. 2ozr picpic
        automatically matched to d1euba_
        complexed with ca, gg1, hae, zn
        1. region c:83-249 [149121] picpiclink
      22. 2ozr picpic
        automatically matched to d1euba_
        complexed with ca, gg1, hae, zn
        1. region d:84-249 [149122] picpiclink
      23. 2ozr picpic
        automatically matched to d1euba_
        complexed with ca, gg1, hae, zn
        1. region e:83-249 [149123] picpiclink
      24. 2ozr picpic
        automatically matched to d1euba_
        complexed with ca, gg1, hae, zn
        1. region f:83-249 [149124] picpiclink
      25. 2ozr picpic
        automatically matched to d1euba_
        complexed with ca, gg1, hae, zn
        1. region g:83-248 [149125] picpiclink
      26. 2ozr picpic
        automatically matched to d1euba_
        complexed with ca, gg1, hae, zn
        1. region h:83-248 [149126] picpiclink
      27. 456c picpic
        complexed with 345, ca, zn
        1. chain a [40402] picpiclink
        2. chain b [40403] picpiclink
      28. 2pjt picpic
        automatically matched to d1euba_
        complexed with 347, ca, zn
        1. region a:79-243 [149575] picpiclink
      29. 2pjt picpic
        automatically matched to d1euba_
        complexed with 347, ca, zn
        1. region b:79-243 [149576] picpiclink
      30. 2pjt picpic
        automatically matched to d1euba_
        complexed with 347, ca, zn
        1. region c:79-243 [149577] picpiclink
      31. 2pjt picpic
        automatically matched to d1euba_
        complexed with 347, ca, zn
        1. region d:79-243 [149578] picpiclink
      32. 1fm1 picpic
        complexed with ca, way, zn
        1. chain a [59876] picpiclink
      33. 1fls picpic
        complexed with ca, way, zn
        1. chain a [59875] picpiclink
      34. 1eub picpic
        complexed with 3mp, ca, hav, msb, zn
        1. chain a [59503] picpiclink
    2. Mouse (Mus musculus) [TaxId: 10090] [55542] (1)
      1. 1cxv picpic
        complexed with ca, cbp, zn
        1. chain a [40404] picpiclink
        2. chain b [40405] picpiclink
  12. Membrane-type matrix metalloproteinase (CDMT1-MMP) [55543]
    1. Human (Homo sapiens) [TaxId: 9606] [55544] (2)
      1. 1bqq picpicxref
        complexed with k, zn
        1. chain m [40406] picpiclink
      2. 1buv picpicxref
        complexed with ca, zn
        1. chain m [40407] picpiclink
  13. Matrix metalloproteinase-16 (MMP-16) [103130]
    1. Human (Homo sapiens) [TaxId: 9606] [103131] (1)
      1. 1rm8 picpic
        complexed with bat, ca, zn
        1. chain a [97660] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk