Family: Ubiquitin activating enzymes (UBA)

the common fold is elaborated with additional (sub)domains

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Activating enzymes of the ubiquitin-like proteins [69571]
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
4. Superfamily: Activating enzymes of the ubiquitin-like proteins [69572]
   transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
   the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
   uperfamily
5. Family: Ubiquitin activating enzymes (UBA) [89763]
   the common fold is elaborated with additional (sub)domains

Protein Domains:

1. UBA3 [89764]
   a subunit of the heterodimeric E1 enzyme for NEDD8; contains an all-alpha insert subdomain of the FF-like fold (residues 210-288) and an extra C-terminal alpha+beta subdomain (partly disordered)
   1. Human (Homo sapiens) [TaxId: 9606] [89765] (11)
      SQ Q8TBC4 33-458
      1. 1yov
         automatically matched to d1ngvb_
         complexed with zn
         1. region b:12-437 [123786]
      2. 1yov
         automatically matched to d1ngvb_
         complexed with zn
         1. region d:19-436 [123788]
      3. 1y8x
         C-terminal, E2 binding domain only; (this domain belongs to Pfam 08825)
         1. region b:349-440 [144607]
      4. 1tt5
         complexed with zn
         1. chain b [107292]
         2. chain d [107294]
      5. 2nvu
         automatically matched to d1ngvb_
         complexed with atp, mg, zn; mutant
         1. region b:2012-2441 [138661]
      6. 1r4m
         complexed with zn; mutant
         1. chain b [97000]
         2. chain d [97002]
         3. chain f [97004]
         4. chain h [97006]
      7. 3dbl
         automatically matched to d1r4mb_
         complexed with zn; mutant
         1. region b:12-441 [157474]
      8. 3dbl
         automatically matched to d1r4mb_
         complexed with zn; mutant
         1. region d:12-441 [157476]
      9. 3dbl
         automatically matched to d1r4mb_
         complexed with zn; mutant
         1. region f:12-441 [157478]
      10. 3dbl
          automatically matched to d1r4mb_
          complexed with zn; mutant
          1. region h:12-441 [157480]
      11. 1r4n
          complexed with atp, zn; mutant
          1. chain b [97012]
          2. chain d [97014]
          3. chain f [97016]
          4. chain h [97018]
2. Amyloid beta precursor protein-binding protein 1, APPBP1 [89766]
   a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion
   1. Human (Homo sapiens) [TaxId: 9606] [89767] (18)
      SQ Q13564
      1. 1yov
         automatically matched to d1ngva_
         complexed with zn
         1. region a:6-534 [123785]
      2. 1yov
         automatically matched to d1ngva_
         complexed with zn
         1. region c:9-534 [123787]
      3. 1tt5
         complexed with zn
         1. chain a [107291]
         2. chain c [107293]
      4. 2nvu
         automatically matched to d1ngva_
         complexed with atp, mg, zn; mutant
         1. region a:6-534 [138660]
      5. 1r4m
         complexed with zn; mutant
         1. chain a [96999]
         2. chain c [97001]
         3. chain e [97003]
         4. chain g [97005]
      6. 3dbh
         automatically matched to d1tt5a_
         complexed with zn; mutant
         1. region a:6-534 [157468]
      7. 3dbh
         automatically matched to d1tt5a_
         complexed with zn; mutant
         1. region c:6-534 [157469]
      8. 3dbh
         automatically matched to d1tt5a_
         complexed with zn; mutant
         1. region e:6-534 [157470]
      9. 3dbh
         automatically matched to d1tt5a_
         complexed with zn; mutant
         1. region g:6-534 [157471]
      10. 3dbl
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region a:6-534 [157473]
      11. 3dbl
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region c:6-534 [157475]
      12. 3dbl
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region e:6-534 [157477]
      13. 3dbl
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region g:6-534 [157479]
      14. 3dbr
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region a:6-534 [157482]
      15. 3dbr
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region c:6-534 [157483]
      16. 3dbr
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region e:6-534 [157484]
      17. 3dbr
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region g:6-534 [157485]
      18. 1r4n
          complexed with atp, zn; mutant
          1. chain a [97011]
          2. chain c [97013]
          3. chain e [97015]
          4. chain g [97017]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk