Family: Ubiquitin activating enzymes (UBA)

the common fold is elaborated with additional (sub)domains

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Activating enzymes of the ubiquitin-like proteins [69571]
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
4. Superfamily: Activating enzymes of the ubiquitin-like proteins [69572]
   transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
   the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
   uperfamily
5. Family: Ubiquitin activating enzymes (UBA) [89763]
   the common fold is elaborated with additional (sub)domains

Protein Domains:

1. UBA3 [89764]
   a subunit of the heterodimeric E1 enzyme for NEDD8; contains an all-alpha insert subdomain of the FF-like fold (residues 210-288) and an extra C-terminal alpha+beta subdomain (partly disordered)
   1. Human (Homo sapiens) [TaxId: 9606] [89765] (11)
      SQ Q8TBC4 33-458
2. Amyloid beta precursor protein-binding protein 1, APPBP1 [89766]
   a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion
   1. Human (Homo sapiens) [TaxId: 9606] [89767] (18)
      SQ Q13564

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk