Structural Classification of Proteins
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Superfamily: Activating enzymes of the ubiquitin-like proteins

transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Activating enzymes of the ubiquitin-like proteins [69571]
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
  4. Superfamily: Activating enzymes of the ubiquitin-like proteins [69572]
    transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
    the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
    link to SUPERFAMILY database - Superfamily

Families:

  1. Molybdenum cofactor biosynthesis protein MoeB [69573] (1)
    1. Molybdenum cofactor biosynthesis protein MoeB [69574]
      1. Escherichia coli [TaxId: 562] [69575] (3)
        1. 1jw9 picpicxref
          complexed with so4, zn
          1. chain b [67377] picpiclink
        2. 1jwb picpicxref
          complexed with amp, so4, zn
          1. chain b [67381] picpiclink
        3. 1jwa picpicxref
          complexed with atp
          1. chain b [67379] picpiclink
  2. Ubiquitin activating enzymes (UBA) [89763] (2)
    the common fold is elaborated with additional (sub)domains
    1. UBA3 [89764]
      a subunit of the heterodimeric E1 enzyme for NEDD8; contains an all-alpha insert subdomain of the FF-like fold (residues 210-288) and an extra C-terminal alpha+beta subdomain (partly disordered)
      1. Human (Homo sapiens) [TaxId: 9606] [89765] (11)
        SQ Q8TBC4 33-458
        1. 1yov picpicxrefxref
          automatically matched to d1ngvb_
          complexed with zn
          1. region b:12-437 [123786] picpiclink
        2. 1yov picpicxrefxref
          automatically matched to d1ngvb_
          complexed with zn
          1. region d:19-436 [123788] picpiclink
        3. 1y8x picpicxref
          C-terminal, E2 binding domain only; (this domain belongs to Pfam 08825)
          1. region b:349-440 [144607] picpiclink
        4. 1tt5 picpicxref
          complexed with zn
          1. chain b [107292] picpiclink
          2. chain d [107294] picpiclink
        5. 2nvu picpicxrefxrefxrefxrefxref
          automatically matched to d1ngvb_
          complexed with atp, mg, zn; mutant
          1. region b:2012-2441 [138661] picpiclink
        6. 1r4m picpicxrefxref
          complexed with zn; mutant
          1. chain b [97000] picpiclink
          2. chain d [97002] picpiclink
          3. chain f [97004] picpiclink
          4. chain h [97006] picpiclink
        7. 3dbl picpicxrefxrefxrefxrefxref
          automatically matched to d1r4mb_
          complexed with zn; mutant
          1. region b:12-441 [157474] picpiclink
        8. 3dbl picpicxrefxrefxrefxrefxref
          automatically matched to d1r4mb_
          complexed with zn; mutant
          1. region d:12-441 [157476] picpiclink
        9. 3dbl picpicxrefxrefxrefxrefxref
          automatically matched to d1r4mb_
          complexed with zn; mutant
          1. region f:12-441 [157478] picpiclink
        10. 3dbl picpicxrefxrefxrefxrefxref
          automatically matched to d1r4mb_
          complexed with zn; mutant
          1. region h:12-441 [157480] picpiclink
        11. 1r4n picpicxrefxref
          complexed with atp, zn; mutant
          1. chain b [97012] picpiclink
          2. chain d [97014] picpiclink
          3. chain f [97016] picpiclink
          4. chain h [97018] picpiclink
    2. Amyloid beta precursor protein-binding protein 1, APPBP1 [89766]
      a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion
      1. Human (Homo sapiens) [TaxId: 9606] [89767] (18)
        SQ Q13564
        1. 1yov picpicxrefxref
          automatically matched to d1ngva_
          complexed with zn
          1. region a:6-534 [123785] picpiclink
        2. 1yov picpicxrefxref
          automatically matched to d1ngva_
          complexed with zn
          1. region c:9-534 [123787] picpiclink
        3. 1tt5 picpicxref
          complexed with zn
          1. chain a [107291] picpiclink
          2. chain c [107293] picpiclink
        4. 2nvu picpicxrefxrefxrefxrefxref
          automatically matched to d1ngva_
          complexed with atp, mg, zn; mutant
          1. region a:6-534 [138660] picpiclink
        5. 1r4m picpicxrefxref
          complexed with zn; mutant
          1. chain a [96999] picpiclink
          2. chain c [97001] picpiclink
          3. chain e [97003] picpiclink
          4. chain g [97005] picpiclink
        6. 3dbh picpicxref
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region a:6-534 [157468] picpiclink
        7. 3dbh picpicxref
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region c:6-534 [157469] picpiclink
        8. 3dbh picpicxref
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region e:6-534 [157470] picpiclink
        9. 3dbh picpicxref
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region g:6-534 [157471] picpiclink
        10. 3dbl picpicxrefxrefxrefxrefxref
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region a:6-534 [157473] picpiclink
        11. 3dbl picpicxrefxrefxrefxrefxref
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region c:6-534 [157475] picpiclink
        12. 3dbl picpicxrefxrefxrefxrefxref
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region e:6-534 [157477] picpiclink
        13. 3dbl picpicxrefxrefxrefxrefxref
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region g:6-534 [157479] picpiclink
        14. 3dbr picpic
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region a:6-534 [157482] picpiclink
        15. 3dbr picpic
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region c:6-534 [157483] picpiclink
        16. 3dbr picpic
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region e:6-534 [157484] picpiclink
        17. 3dbr picpic
          automatically matched to d1tt5a_
          complexed with zn; mutant
          1. region g:6-534 [157485] picpiclink
        18. 1r4n picpicxrefxref
          complexed with atp, zn; mutant
          1. chain a [97011] picpiclink
          2. chain c [97013] picpiclink
          3. chain e [97015] picpiclink
          4. chain g [97017] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk