Structural Classification of Proteins

Superfamily: S-adenosyl-L-methionine-dependent methyltransferases

: uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: S-adenosyl-L-methionine-dependent methyltransferases [53334]
core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
Superfamily: S-adenosyl-L-methionine-dependent methyltransferases [53335]
uperfamily

Families:

COMT-like [53336] (3)
1. Catechol O-methyltransferase, COMT [53337]
  1. Rat (Rattus norvegicus) [TaxId: 10116] [53338] (6)
    1. 2cl5
      automatically matched to d1h1da_
      complexed with bie, bu3, mes, mg, sam
      1. region a:3-216 [130570]
    2. 2cl5
      automatically matched to d1h1da_
      complexed with bie, bu3, mes, mg, sam
      1. region b:3-215 [130571]
    3. 1h1d
      complexed with bia, mg, sam
      1. chain a [83452]
    4. 1vid
      complexed with dnc, mg, sam
      1. chain a [34178]
    5. 2zlb
      automatically matched to d1h1da_
      complexed with so4
      1. region a:3-214 [154628]
    6. 1jr4
      complexed with cl4, mg
      1. chain a [71820]
2. COMT domain-containing protein 1, COMTD1 [142571]
  1. Human (Homo sapiens) [TaxId: 9606] [142572] (2)
    SQ Q86VU5 44-262
    1. 2avd
      complexed with sam
      1. region a:44-262 [127377]
    2. 2avd
      automatically matched to 2AVD A:44-262
      complexed with sam
      1. region b:44-262 [127378]
3. Caffeoyl-CoA O-methyltransferase [142573]
  1. Alfalfa (Medicago sativa) [TaxId: 3879] [142574] (8)
    SQ Q40313 21-247
    1. 1sus
      automatically matched to 1SUI A:21-247
      complexed with ca, sah, spf
      1. region a:21-247 [119053]
    2. 1sus
      automatically matched to 1SUI A:21-247
      complexed with ca, sah, spf
      1. region b:21-247 [119054]
    3. 1sus
      automatically matched to 1SUI A:21-247
      complexed with ca, sah, spf
      1. region c:21-247 [119055]
    4. 1sus
      automatically matched to 1SUI A:21-247
      complexed with ca, sah, spf
      1. region d:21-247 [119056]
    5. 1sui
      complexed with ca, fre, sah
      1. region a:21-247 [119049]
    6. 1sui
      automatically matched to 1SUI A:21-247
      complexed with ca, fre, sah
      1. region b:21-247 [119050]
    7. 1sui
      automatically matched to 1SUI A:21-247
      complexed with ca, fre, sah
      1. region c:21-247 [119051]
    8. 1sui
      automatically matched to 1SUI A:21-247
      complexed with ca, fre, sah
      1. region d:21-247 [119052]
Plant O-methyltransferase, C-terminal domain [64111] (5)
1. Chalcone O-methyltransferase [64112]
  1. Alfalfa (Medicago sativa) [TaxId: 3879] [64113] (2)
    1. 1fp1
      complexed with hcc, sah
      1. region d:129-372 [59940]
    2. 1fpq
      complexed with sam
      1. region a:129-372 [59948]
2. Isoflavone O-methyltransferase [64114]
  1. Alfalfa (Medicago sativa) [TaxId: 3879] [64115] (2)
    1. 1fp2
      complexed with hmo, sah
      1. region a:109-352 [59942]
    2. 1fpx
      complexed with sam
      1. region a:109-352 [59951]
3. Caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase [75259]
  1. Alfalfa (Medicago sativa) [TaxId: 3879] [75260] (2)
    1. 1kyz
      complexed with fer, sah
      1. region a:120-362 [73313]
      2. region c:120-365 [73315]
      3. region e:120-365 [73317]
    2. 1kyw
      complexed with hfl, sah
      1. region a:120-362 [73297]
      2. region c:120-365 [73299]
      3. region f:120-365 [73301]
4. Aclacinomycin-10-hydroxylase RdmB [102554]
  evolved a different function; binds SAM and SAH
  1. Streptomyces purpurascens [TaxId: 1924] [102555] (4)
    SQ Q54527
    1. 1qzz
      complexed with act, sam
      1. region a:102-357 [96720]
    2. 1r00
      complexed with act, sah
      1. region a:102-357 [96722]
    3. 1xds
      complexed with dra, sam
      1. region a:102-357 [115175]
      2. region b:102-357 [115177]
    4. 1xdu
      complexed with act, sfg
      1. region a:102-357 [115179]
5. Carminomycin 4-O-methyltransferase [110660]
  1. Streptomyces peucetius [TaxId: 1950] [110661] (2)
    SQ Q06528
    1. 1tw3
      complexed with ert, sah
      1. region a:99-351 [107374]
      2. region b:99-351 [107376]
    2. 1tw2
      complexed with ert, sah
      1. region a:99-351 [107370]
      2. region b:99-351 [107372]
RNA methyltransferase FtsJ [53339] (1)
1. RNA methyltransferase FtsJ [53340]
  1. Escherichia coli [TaxId: 562] [53341] (2)
    1. 1ej0
      complexed with hg, sam
      1. chain a [34179]
    2. 1eiz
      complexed with sam
      1. chain a [34180]
Fibrillarin homologue [53342] (3)
1. Fibrillarin homologue [53343]
  1. Archaeon Methanococcus jannaschii [TaxId: 2190] [53344] (2)
    1. 1g8s
      structural genomics
      complexed with met
      1. chain a [90507]
    2. 1fbn
      structural genomics
      1. chain a [34181]
  2. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [89737] (1)
    AF2087
    1. 1nt2
      structural genomics; complex with Nop5p (AF2088)
      complexed with sam
      1. chain a [86149]
  3. Archaeon Pyrococcus horikoshii [TaxId: 53953] [102556] (2)
    1. 1g8a
      structural genomics
      1. chain a [90506]
    2. 1pry
      structural genomics
      1. chain a [95063]
rRNA methyltransferase RlmA [102557] (1)
1. rRNA methyltransferase RlmA [102558]
  23S rRNA N1-G745 methyltransferase
  1. Escherichia coli [TaxId: 562] [102559] (1)
    1. 1p91
      structural genomics; NESG target ER19
      complexed with sam, so4, zn
      1. chain a [94378]
      2. chain b [94379]
rRNA methyltransferase AviRa [89738] (1)
1. rRNA methyltransferase AviRa [89739]
  1. Streptomyces viridochromogenes [TaxId: 1938] [89740] (2)
    1. 1o9g
      complexed with mse; mutant
      1. chain a [86692]
    2. 1o9h
      1. chain a [86693]
rRNA adenine dimethylase-like [88784] (5)
1. rRNA adenine dimethylase [53363]
  contains additional all-alpha C-terminal domain (res.181-248)
  1. Streptococcus pneumoniae, Ermam [TaxId: 1313] [53364] (1)
    1. 1yub
      mutant
      1. chain a [34219]
  2. Bacillus subtilis, Ermc' [TaxId: 1423] [53365] (5)
    1. 1qam
      complexed with act
      1. chain a [34220]
    2. 1qan
      complexed with act, sah
      1. chain a [34221]
    3. 1qao
      complexed with sam
      1. chain a [34222]
    4. 1qaq
      complexed with sfg
      1. chain a [34223]
    5. 2erc
      1. chain a [34224]
      2. chain b [34225]
2. Transcription factor sc-mtTFB [69555]
  overall structure is very similar to those of Ermc' and Ermam
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [69556] (1)
    1. 1i4w
      complexed with xe
      1. chain a [66028]
3. High level kasugamycin resistance protein KsgA [110662]
  1. Escherichia coli [TaxId: 562] [110663] (1)
    SQ P06992
    1. 1qyr
      1. chain a [104657]
      2. chain b [104658]
4. Probable dimethyladenosine transferase [142575]
  1. Human (Homo sapiens) [TaxId: 9606] [142576] (2)
    SQ Q9UNQ2 36-313
    1. 1zq9
      complexed with sam
      1. region a:36-313 [125505]
    2. 1zq9
      automatically matched to 1ZQ9 A:36-313
      complexed with sam
      1. region b:36-313 [125506]
mRNA cap methylase [88785] (3)
1. Polymerase regulatory subunit VP39 [53361]
  1. Vaccinia virus [TaxId: 10245] [53362] (19)
    1. 1vpt
      complexed with sam; mutant
      1. chain a [34207]
    2. 3mag
      complexed with 3ma, sah; mutant
      1. chain a [34205]
    3. 4dcg
      complexed with mg7, sah; mutant
      1. chain a [34208]
    4. 1v39
      complexed with mdg, sah; mutant
      1. chain a [34206]
    5. 1vp3
      complexed with sah
      1. chain a [34209]
    6. 1jsz
      complexed with ndm, sah
      1. chain a [71849]
    7. 1vp9
      complexed with sah; mutant
      1. chain a [34210]
    8. 1p39
      complexed with mgt, sah; mutant
      1. chain a [34213]
    9. 2vp3
      complexed with mdg, sah; mutant
      1. chain a [34211]
    10. 1eam
      complexed with sah; mutant
      1. chain a [34212]
    11. 1bky
      complexed with 1mc, sah; mutant
      1. chain a [34214]
    12. 1jte
      complexed with sah; mutant
      1. chain a [71860]
    13. 3mct
      complexed with 3mc, sah; mutant
      1. chain a [34215]
    14. 2ga9
      automatically matched to d1vpt__
      complexed with ca, sap; mutant
      1. region a:1-297 [134885]
    15. 1b42
      complexed with m1a, sah; mutant
      1. chain a [34217]
    16. 1eqa
      complexed with mg7, sah; mutant
      1. chain a [34216]
    17. 2gaf
      automatically matched to d1vpt__
      mutant
      1. region a:1-297 [134888]
    18. 1av6
      protein/RNA complex; complexed with mgt, sah; mutant
      1. chain a [34218]
    19. 1jtf
      complexed with mdg, sah; mutant
      1. chain a [71861]
2. An RNA cap (nucleoside-2'-O-)-methyltransferase domain of RNA polymerase NS5 [89741]
  structurally and functionally similar to VP39
  1. Flavivirus (Dengue virus type 2) [TaxId: 12637] [89742] (3)
    SQ P12823 2495-2756
    1. 1l9k
      complexed with sah, so4; mutant
      1. chain a [84569]
    2. 1r6a
      complexed with rvp, sah, so4
      1. chain a [104817]
    3. 2p1d
      automatically matched to d1l9ka_
      complexed with 5gp, sah, so4
      1. region a:7-265 [139456]
  2. Dengue virus 2 [TaxId: 11060] [159679] (5)
    1. 2p41
      automatically matched to d1l9ka_
      complexed with cit, g1g, gol, sah, so4
      1. region a:8-264 [149193]
    2. 2p3l
      automatically matched to d1l9ka_
      complexed with cit, g3a, gol, sah, so4
      1. region a:8-264 [149180]
    3. 2p3o
      automatically matched to d1l9ka_
      complexed with cit, gta, sah, so4
      1. region a:8-264 [149182]
    4. 2p40
      automatically matched to d1l9ka_
      complexed with gtg, so4
      1. region a:8-264 [149192]
    5. 2p3q
      automatically matched to d1l9ka_
      complexed with gp3, sah, so4
      1. region a:8-264 [149185]
mRNA cap (Guanine N-7) methyltransferase [102560] (1)
mRNA capping enzyme
1. mRNA cap (Guanine N-7) methyltransferase [102561]
  1. Fungus (Encephalitozoon cuniculi) [TaxId: 6035] [102562] (7)
    1. 1ri5
      1. chain a [97502]
    2. 1z3c
      automatically matched to d1ri1a_
      complexed with sa8
      1. region a:41-292 [124398]
    3. 1ri4
      complexed with sam
      1. chain a [97501]
    4. 1ri1
      complexed with gtg, sah
      1. chain a [97498]
    5. 1ri3
      complexed with sah
      1. chain a [97500]
    6. 2hv9
      automatically matched to d1ri1a_
      complexed with sfg
      1. region a:41-292 [136799]
    7. 1ri2
      complexed with gtg
      1. chain a [97499]
Hypothetical protein MJ0882 [53345] (1)
1. Hypothetical protein MJ0882 [53346]
  1. Archaeon Methanococcus jannaschii [TaxId: 2190] [53347] (1)
    1. 1dus
      structural genomics
      1. chain a [34182]
Hypothetical protein HI0319 (YecO) [69544] (1)
1. Hypothetical protein HI0319 (YecO) [69545]
  1. Haemophilus influenzae [TaxId: 727] [69546] (1)
    structural genomics
    1. 1im8
      CASP4
      complexed with cl, sai
      1. chain a [66212]
      2. chain b [66213]
Glycine N-methyltransferase [53348] (3)
1. Glycine N-methyltransferase [53349]
  1. Rat (Rattus norvegicus) [TaxId: 10116] [53350] (16)
    1. 1xva
      complexed with act, sam
      1. chain a [34183]
      2. chain b [34184]
    2. 2idj
      automatically matched to d1bhja_
      complexed with ca
      1. region a:2-292 [137276]
    3. 2idj
      automatically matched to d1bhja_
      complexed with ca
      1. region b:2-292 [137277]
    4. 2idj
      automatically matched to d1bhja_
      complexed with ca
      1. region c:2-292 [137278]
    5. 2idj
      automatically matched to d1bhja_
      complexed with ca
      1. region d:2-292 [137279]
    6. 1d2c
      1. chain a [34185]
      2. chain b [34186]
    7. 2idk
      automatically matched to d1bhja_
      complexed with c2f
      1. region a:2-292 [137280]
    8. 2idk
      automatically matched to d1bhja_
      complexed with c2f
      1. region b:2-292 [137281]
    9. 2idk
      automatically matched to d1bhja_
      complexed with c2f
      1. region c:2-292 [137282]
    10. 2idk
      automatically matched to d1bhja_
      complexed with c2f
      1. region d:2-292 [137283]
    11. 1d2g
      mutant
      1. chain a [34187]
      2. chain b [34188]
    12. 1nbh
      complexed with act, sam
      1. chain a [85516]
      2. chain b [85517]
      3. chain c [85518]
      4. chain d [85519]
    13. 1bhj
      1. chain a [34189]
      2. chain b [34190]
    14. 1kia
      complexed with act, sam
      1. chain a [84407]
      2. chain b [84408]
      3. chain c [84409]
      4. chain d [84410]
    15. 1nbi
      complexed with sam; mutant
      1. chain a [85520]
      2. chain b [85521]
      3. chain c [85522]
      4. chain d [85523]
    16. 1d2h
      complexed with sah; mutant
      1. chain a [34191]
      2. chain b [34192]
      3. chain c [34193]
      4. chain d [34194]
  2. Human (Homo sapiens) [TaxId: 9606] [110664] (1)
    SQ Q14749
    1. 1r74
      complexed with bme, cit
      1. chain a [104828]
      2. chain b [104829]
  3. Mouse (Mus musculus) [TaxId: 10090] [110665] (2)
    SQ Q9QXF8
    1. 1r8y
      complexed with bme
      1. chain a [104857]
      2. chain b [104858]
      3. chain c [104859]
      4. chain d [104860]
      5. chain e [104861]
      6. chain f [104862]
      7. chain g [104863]
      8. chain h [104864]
    2. 1r8x
      complexed with bme, trs
      1. chain a [104855]
      2. chain b [104856]
Arylamine N-methyltransferase [69547] (2)
1. Phenylethanolamine N-methyltransferase, PNMTase [69548]
  1. Human (Homo sapiens) [TaxId: 9606] [69549] (21)
    1. 2g72
      automatically matched to d1hnnb_
      complexed with f21, sam
      1. region a:18-280 [134724]
    2. 2g72
      automatically matched to d1hnnb_
      complexed with f21, sam
      1. region b:18-280 [134725]
    3. 2g8n
      automatically matched to d1hnnb_
      complexed with f83, sah
      1. region a:23-280 [134777]
    4. 2g8n
      automatically matched to d1hnnb_
      complexed with f83, sah
      1. region b:18-280 [134778]
    5. 2g71
      automatically matched to d1hnnb_
      complexed with fts, gol, sah
      1. region a:21-280 [134722]
    6. 2g71
      automatically matched to d1hnnb_
      complexed with fts, gol, sah
      1. region b:18-280 [134723]
    7. 2an3
      automatically matched to d1hnnb_
      complexed with ctl, sah
      1. region a:23-280 [127027]
    8. 2an3
      automatically matched to d1hnnb_
      complexed with ctl, sah
      1. region b:518-780 [127028]
    9. 2an4
      automatically matched to d1hnnb_
      complexed with otr, po4, sah
      1. region a:24-280 [127029]
    10. 2an4
      automatically matched to d1hnnb_
      complexed with otr, po4, sah
      1. region b:18-280 [127030]
    11. 1yz3
      automatically matched to d1hnnb_
      complexed with sah, ska
      1. region a:18-280 [124268]
    12. 1yz3
      automatically matched to d1hnnb_
      complexed with sah, ska
      1. region b:18-280 [124269]
    13. 2an5
      automatically matched to d1hnnb_
      complexed with po4, sah, ttl
      1. region a:23-280 [127031]
    14. 2an5
      automatically matched to d1hnnb_
      complexed with po4, sah, ttl
      1. region b:18-280 [127032]
    15. 2ony
      automatically matched to d1hnnb_
      complexed with po4, sah, tmj
      1. region a:24-280 [148915]
    16. 2ony
      automatically matched to d1hnnb_
      complexed with po4, sah, tmj
      1. region b:524-780 [148916]
    17. 2g70
      automatically matched to d1hnnb_
      complexed with hnt, po4, sam
      1. region a:20-280 [134720]
    18. 2g70
      automatically matched to d1hnnb_
      complexed with hnt, po4, sam
      1. region b:18-280 [134721]
    19. 1hnn
      complexed with sah, skf
      1. chain a [65895]
      2. chain b [65896]
    20. 1n7j
      complexed with idi, sah
      1. chain a [91696]
      2. chain b [91697]
    21. 1n7i
      complexed with ly1, sah
      1. chain a [91694]
      2. chain b [91695]
2. Indolethylamine N-methyltransferase, INMT [142577]
  1. Human (Homo sapiens) [TaxId: 9606] [142578] (1)
    SQ O95050 5-261
    1. 2a14
      complexed with sah, so4
      1. region a:5-261 [125972]
Histamine methyltransferase [75261] (1)
1. Histamine methyltransferase [75262]
  1. Human (Homo sapiens) [TaxId: 9606] [75263] (12)
    1. 1jqe
      complexed with qun, sah, unx
      1. chain a [71789]
      2. chain b [71790]
    2. 2aot
      automatically matched to d1jqda_
      complexed with 2pm, sah
      1. region a:5-292 [127098]
    3. 2aot
      automatically matched to d1jqda_
      complexed with 2pm, sah
      1. region b:5-292 [127099]
    4. 1jqd
      complexed with hsm, sah
      1. chain a [71787]
      2. chain b [71788]
    5. 2aou
      automatically matched to d1jqda_
      complexed with cqa
      1. region a:5-292 [127100]
    6. 2aou
      automatically matched to d1jqda_
      complexed with cqa
      1. region b:5-292 [127101]
    7. 2aov
      automatically matched to d1jqda_
      complexed with 4di, c2m
      1. region a:5-292 [127102]
    8. 2aov
      automatically matched to d1jqda_
      complexed with 4di, c2m
      1. region b:5-292 [127103]
    9. 2aow
      automatically matched to d1jqea_
      complexed with tha; mutant
      1. region a:13-292 [127104]
    10. 2aow
      automatically matched to d1jqea_
      complexed with tha; mutant
      1. region b:13-292 [127105]
    11. 2aox
      automatically matched to d1jqda_
      complexed with tha
      1. region a:5-292 [127106]
    12. 2aox
      automatically matched to d1jqda_
      complexed with tha
      1. region b:5-292 [127107]
Hypothetical Protein YjhP [82469] (1)
1. Hypothetical Protein YjhP [82470]
  1. Escherichia coli [TaxId: 562] [82471] (1)
    1. 1nkv
      structural genomics
      CASP5
      complexed with mse
      1. chain a [80577]
      2. chain b [80578]
      3. chain c [80579]
Salicylic acid carboxyl methyltransferase (SAMT) [102563] (1)
1. Salicylic acid carboxyl methyltransferase (SAMT) [102564]
  1. Clarkia breweri [TaxId: 36903] [102565] (1)
    1. 1m6e
      complexed with lu, sah, sal
      1. chain x [91188]
Thiopurine S-methyltransferase [102566] (2)
1. Thiopurine S-methyltransferase [102567]
  1. Pseudomonas syringae [TaxId: 317] [102568] (1)
    1. 1pjz
      1. chain a [94794]
  2. Human (Homo sapiens) [TaxId: 9606] [142579] (3)
    SQ P51580 17-245
    1. 2bzg
      complexed with b3p, sah
      1. region a:17-245 [129559]
    2. 2h11
      automatically matched to 2BZG A:17-245
      complexed with b3p, sah, scn; mutant
      1. region a:17-245 [135941]
    3. 2h11
      automatically matched to 2BZG A:17-245
      complexed with b3p, sah, scn; mutant
      1. region b:17-245 [135942]
Leucine carboxy methyltransferase Ppm1 [102569] (1)
1. Leucine carboxy methyltransferase Ppm1 [102570]
  involved in the regulation of protein phosphatase 2a activity
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [102571] (7)
    1. 1rjd
      complexed with bme, sam, so4
      1. chain a [97558]
      2. chain b [97559]
      3. chain c [97560]
    2. 1rje
      complexed with bme, sah, so4
      1. chain a [97561]
      2. chain b [97562]
      3. chain c [97563]
    3. 2ob2
      automatically matched to d1rjdc_
      complexed with gol, po4, sah
      1. region a:2-328 [139001]
    4. 2ob2
      automatically matched to d1rjdc_
      complexed with gol, po4, sah
      1. region b:2-328 [139002]
    5. 2ob2
      automatically matched to d1rjdc_
      complexed with gol, po4, sah
      1. region c:2-328 [139003]
    6. 1rjf
      complexed with bme, gol
      1. chain a [97564]
      2. chain b [97565]
      3. chain c [97566]
    7. 1rjg
      complexed with sah
      1. chain a [97567]
Precorrin-6Y methyltransferase (CbiT) [82472] (1)
1. Precorrin-6Y methyltransferase (CbiT) [82473]
  1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [82474] (5)
    MTH146
    1. 1l3i
      structural genomics
      complexed with mse, sah
      1. chain a [77676]
      2. chain b [77677]
      3. chain c [77678]
      4. chain d [77679]
      5. chain e [77680]
      6. chain f [77681]
    2. 1l3c
      structural genomics
      complexed with mse
      1. chain a [77671]
      2. chain b [77672]
      3. chain c [77673]
      4. chain d [77674]
    3. 1f38
      complexed with mse
      1. chain a [83240]
      2. chain b [83241]
      3. chain c [83242]
      4. chain d [83243]
    4. 1kxz
      structural genomics
      complexed with mse
      1. chain a [77604]
      2. chain b [77605]
      3. chain c [77606]
      4. chain d [77607]
      5. chain e [77608]
      6. chain f [77609]
      7. chain g [77610]
      8. chain h [77611]
    5. 1l3b
      structural genomics
      complexed with mse
      1. chain a [77663]
      2. chain b [77664]
      3. chain c [77665]
      4. chain d [77666]
      5. chain e [77667]
      6. chain f [77668]
      7. chain g [77669]
      8. chain h [77670]
MraW-like putative methyltransferases [82475] (2)
1. TM0872, methyltransferase domain [82476]
  contains an inserted alpha helical subdomain
  1. Thermotoga maritima [TaxId: 2336] [82477] (2)
    1. 1m6y
      CASP5
      complexed with mse, sah, so4
      1. region a:2-114,a:216-294 [78717]
      2. region b:8-114,b:216-292 [78719]
    2. 1n2x
      complexed with mse, sam, so4
      1. region a:8-114,a:216-294 [79861]
      2. region b:8-114,b:216-292 [79863]
  2. Thermus thermophilus [TaxId: 274] [117678] (1)
    SQ Q5SJD8
    1. 1wg8
      Structural genomics target
      complexed with sam
      1. region a:5-108,a:207-284 [114606]
      2. region b:5-108,b:207-284 [114608]
N5-glutamine methyltransferase, HemK [89743] (2)
1. N5-glutamine methyltransferase, HemK [89744]
  contains an N-terminal alpha helical subdomain; res. 13-84
  1. Thermotoga maritima [TaxId: 2336] [89745] (5)
    SQ Q9WYV8
    1. 1nv8
      complexed with meq, sam
      1. chain a [86224]
      2. chain b [86225]
    2. 1sg9
      Structural genomics target
      complexed with gln, sam
      1. chain a [105526]
      2. chain b [105527]
      3. chain c [105528]
    3. 1vq1
      automatically matched to d1sg9a_
      complexed with sam
      1. region a:12-281 [120067]
    4. 1vq1
      automatically matched to d1sg9a_
      complexed with sam
      1. region b:12-281 [120068]
    5. 1nv9
      complexed with sah
      1. chain a [86226]
  2. Escherichia coli [TaxId: 562] [110666] (2)
    SQ P37186
    1. 2b3t
      automatically matched to d1t43a_
      complexed with sah
      1. region a:2-275 [127796]
    2. 1t43
      complexed with sah
      1. chain a [106392]
Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2)
1. Catalytic, N-terminal domain of histone methyltransferase Dot1l [89747]
  a non-SET domain nucleosomal histone methyltransferase
  1. Human (Homo sapiens) [TaxId: 9606] [89748] (1)
    1. 1nw3
      complexed with act, sam, so4
      1. chain a [86288]
  2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110667] (1)
    SQ Q04089 176-581
    1. 1u2z
      complexed with sah
      1. chain a [107626]
      2. chain b [107627]
      3. chain c [107628]
Guanidinoacetate methyltransferase [69550] (2)
1. Guanidinoacetate methyltransferase [69551]
  a template structure of protein arginine methyltransferase
  1. Rat (Rattus norvegicus) [TaxId: 10116] [69552] (5)
    SQ P10868
    1. 1xcl
      complexed with gai, sah
      1. chain a [115127]
    2. 1xcj
      complexed with nmg, sah
      1. chain a [115126]
    3. 1p1c
      complexed with gd3, sah
      1. chain a [87669]
      2. chain b [87670]
    4. 1khh
      complexed with sah
      1. chain a [68615]
      2. chain b [68616]
    5. 1p1b
      complexed with sah
      1. chain a [87665]
      2. chain b [87666]
      3. chain c [87667]
      4. chain d [87668]
  2. Human (Homo sapiens) [TaxId: 9606] [142580] (3)
    SQ Q14353 8-236
    1. 1zx0
      complexed with sah
      1. region a:8-236 [125757]
    2. 1zx0
      automatically matched to 1ZX0 A:8-236
      complexed with sah
      1. region b:8-236 [125758]
    3. 1zx0
      automatically matched to 1ZX0 A:8-236
      complexed with sah
      1. region c:8-236 [125759]
Arginine methyltransferase [53351] (4)
lacks the last two strands of the common fold replaced with a beta-sandwich oligomerisation subdomain
1. Arginine methyltransferase, HMT1 [53352]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [53353] (1)
    1. 1g6q
      mutant
      1. chain 1 [34195]
      2. chain 2 [34196]
      3. chain 3 [34197]
      4. chain 4 [34198]
      5. chain 5 [34199]
      6. chain 6 [34200]
  2. Rat (Rattus norvegicus) [TaxId: 10116] [64116] (1)
    1. 1f3l
      complexed with sah
      1. chain a [59630]
2. Protein arginine N-methyltransferase 1, PRMT1 [89749]
  1. Rat (Rattus norvegicus) [TaxId: 10116] [89750] (3)
    1. 1ori
      complexed with sah
      1. chain a [87339]
    2. 1orh
      complexed with substrate peptide, chain B
      complexed with gol, sah; mutant
      1. chain a [93455]
    3. 1or8
      complexed with substrate peptide, chains B,C, D and E
      complexed with gol, sah
      1. chain a [93451]
3. Protein arginine N-methyltransferase 3, PRMT3 [142581]
  1. Human (Homo sapiens) [TaxId: 9606] [142582] (1)
    SQ O60678 221-531
    1. 2fyt
      complexed with sah
      1. region a:238-548 [134391]
Protein-L-isoaspartyl O-methyltransferase [53354] (5)
topological variant; strand order 3214567; strand 6 is antiparallel to the rest
1. Protein-L-isoaspartyl O-methyltransferase [68927]
  1. Thermotoga maritima [TaxId: 2336] [68928] (1)
    1. 1dl5
      complexed with cd, cl, sah
      1. region a:1-213 [64720]
      2. region b:1-213 [64722]
  2. Archaeon Pyrococcus furiosus [TaxId: 2261] [69553] (4)
    1. 1jg1
      complexed with sah
      1. chain a [66661]
    2. 1jg4
      complexed with sam
      1. chain a [66665]
    3. 1jg2
      complexed with adn, na
      1. chain a [66662]
    4. 1jg3
      complexed with adn, asi, cl, na
      1. chain a [66663]
      2. chain b [66664]
  3. Human (Homo sapiens) [TaxId: 9606] [69554] (2)
    1. 1i1n
      complexed with sah
      1. chain a [71102]
    2. 1kr5
      complexed with sah
      1. chain a [68847]
  4. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [102572] (1)
    1. 1r18
      complexed with sah
      1. chain a [96800]
  5. Sulfolobus tokodaii [TaxId: 111955] [110668] (1)
    SQ Q972K9
    1. 1vbf
      1. chain a [108475]
      2. chain b [108476]
      3. chain c [108477]
      4. chain d [108478]
Glucose-inhibited division protein B (GidB) [75264] (2)
1. Glucose-inhibited division protein B (GidB) [75265]
  function unknown
  1. Escherichia coli [TaxId: 562] [75266] (1)
    1. 1jsx
      structural genomics
      1. chain a [71846]
  2. Bacillus subtilis [TaxId: 1423] [117679] (1)
    SQ P25813
    1. 1xdz
      1. chain a [115196]
tRNA(1-methyladenosine) methyltransferase-like [64117] (4)
contains additional N-terminal beta-sandwich domain
1. Probable methyltransferase Rv2118c [64118]
  1. Mycobacterium tuberculosis [TaxId: 1773] [64119] (1)
    1. 1i9g
      structural genomics
      complexed with sam
      1. chain a [62090]
2. Hypothetical protein TM0748 [102573]
  1. Thermotoga maritima [TaxId: 2336] [102574] (1)
    1. 1o54
      structural genomics
      complexed with cl
      1. chain a [92482]
3. Hypothetical protein FLJ20628 [142583]
  1. Human (Homo sapiens) [TaxId: 9606] [142584] (2)
    SQ Q9BVS5 149-472
    1. 2b25
      complexed with sam, unx
      1. region a:6-329 [127699]
    2. 2b25
      automatically matched to 2B25 A:6-329
      complexed with sam, unx
      1. region b:6-329 [127700]
4. Hypothetical protein Ta0852 [142585]
  forms dimer similar to half-tetramer of the other members but with swapped N-terminal domains; variant topology of the N-terminal domain
  1. Thermoplasma acidophilum [TaxId: 2303] [142586] (1)
    SQ Q9HJW1 6-255
    1. 1yb2
      1. region a:6-255 [122868]
NOL1/NOP2/sun [102575] (3)
Pfam 01189; contains additional N-terminal 3-helical and ferredoxin-like domains
1. Hypothetical methyltransferase PH1374 [102576]
  1. Archaeon Pyrococcus horikoshii [TaxId: 53953] [102577] (1)
    1. 1ixk
      1. chain a [90716]
2. Ribosomal RNA small subunit methyltransferase B, RsmB (Sun, Fmu/Fmv), C-terminal domain [110669]
  1. Escherichia coli [TaxId: 562] [110670] (2)
    SQ P36929
    1. 1sqg
      1. region a:145-428 [105913]
    2. 1sqf
      complexed with sam
      1. region a:145-429 [105911]
3. NOL1R [142587]
  1. Human (Homo sapiens) [TaxId: 9606] [142588] (1)
    SQ Q96P11 133-425
    1. 2b9e
      complexed with sam
      1. region a:133-425 [128124]
Ribosomal protein L11 methyltransferase PrmA [102578] (1)
contains additional N-terminal ferredoxin-like domain
1. PrmA-like protein TTHA0656 (TT0836) [102579]
  1. Thermus thermophilus [TaxId: 274] [102580] (12)
    1. 2nxc
      automatically matched to d1ufka_
      1. region a:1-254 [138739]
    2. 3egv
      automatically matched to d1ufka_
      complexed with 4mm, cl, gol, iod, sah; mutant
      1. region a:1-254 [158148]
    3. 2nxe
      automatically matched to d1ufka_
      complexed with sam
      1. region a:1-254 [138740]
    4. 2nxe
      automatically matched to d1ufka_
      complexed with sam
      1. region b:1-254 [138741]
    5. 1ufk
      structural genomics
      1. chain a [99340]
    6. 3cjr
      automatically matched to d1ufka_
      complexed with sfg; mutant
      1. region a:1-254 [156711]
    7. 2nxj
      automatically matched to d1ufka_
      1. region a:1-254 [138742]
    8. 2nxj
      automatically matched to d1ufka_
      1. region b:1-254 [138743]
    9. 2nxn
      automatically matched to d1ufka_
      1. region a:1-254 [138744]
    10. 3cjq
      automatically matched to d1ufka_
      complexed with 2mm, iod, sah; mutant
      1. region a:1-254 [156702]
    11. 3cjq
      automatically matched to d1ufka_
      complexed with 2mm, iod, sah; mutant
      1. region d:1-254 [156705]
    12. 3cjq
      automatically matched to d1ufka_
      complexed with 2mm, iod, sah; mutant
      1. region g:1-254 [156708]
(Uracil-5-)-methyltransferase [102581] (1)
Pfam 05958
1. rRNA (Uracil-5-)-methyltransferase RumA, catalytic domain [102582]
  includes an iron-sulfur cluster-binding, alpha+beta sudbomain
  1. Escherichia coli [TaxId: 562] [102583] (3)
    1. 1uwv
      complexed with cl, fs4, ni, po4
      1. region a:75-432 [100129]
    2. 2bh2
      automatically matched to d1uwva2
      complexed with fmu, sah, sf4
      1. region a:75-432 [128511]
    3. 2bh2
      automatically matched to d1uwva2
      complexed with fmu, sah, sf4
      1. region b:75-431 [128513]
Chemotaxis receptor methyltransferase CheR, C-terminal domain [53357] (1)
contains additional N-terminal all-alpha domain, res. 11-91
1. Chemotaxis receptor methyltransferase CheR, C-terminal domain [53358]
  1. Salmonella typhimurium [TaxId: 90371] [53359] (2)
    1. 1af7
      complexed with sah
      1. region a:92-284 [34203]
    2. 1bc5
      complexed with ace, co, sah
      1. region a:92-284 [34204]
C5 cytosine-specific DNA methylase, DCM [88786] (3)
1. DNA methylase HhaI [53367]
  1. Haemophilus haemolyticus [TaxId: 726] [53368] (20)
    SQ P05102
    1. 2c7p
      automatically matched to d10mha_
      complexed with 5cm, a1p, cit, epe, sah, so4
      1. region a:1-327 [130080]
    2. 2c7q
      automatically matched to d10mha_
      complexed with 5cm, a1p, cit, sah, so4
      1. region a:1-327 [130081]
    3. 2c7o
      automatically matched to d10mha_
      complexed with 5cm, a1p, sah, so4
      1. region a:1-327 [130079]
    4. 2c7r
      automatically matched to d1fjxa_
      complexed with 5cm, a1p, gol, sah, so4; mutant
      1. region a:1-327 [130082]
    5. 1skm
      complexed with hcx, sah
      1. chain a [105675]
    6. 6mht
      protein/DNA complex; complexed with 4sc, 5mc, sam
      1. chain a [34226]
    7. 2hr1
      automatically matched to d10mha_
      complexed with sah
      1. region a:1-327 [136677]
    8. 9mht
      protein/DNA complex; complexed with ap, sah
      1. chain a [34227]
    9. 1m0e
      complexed with sah, z
      1. chain a [78332]
    10. 1fjx
      protein/DNA complex; complexed with sah, so4; mutant
      1. chain a [34228]
    11. 1mht
      protein/DNA complex; complexed with ch3, flo, sah, thm
      1. chain a [34236]
    12. 7mht
      protein/DNA complex; complexed with sah
      1. chain a [34231]
    13. 4mht
      protein/DNA complex; complexed with ch3, sah
      1. chain a [34230]
    14. 10mh
      protein/DNA complex; complexed with 5mc, 5nc, sah
      1. chain a [34232]
    15. 1hmy
      complexed with sam
      1. chain a [34229]
    16. 8mht
      protein/DNA complex; complexed with 2up, sah
      1. chain a [34233]
    17. 3mht
      protein/DNA complex; complexed with sah
      1. chain a [34234]
    18. 5mht
      protein/DNA complex; complexed with 5cm, sah
      1. chain a [34237]
    19. 2hmy
      complexed with sam
      1. chain b [34235]
    20. 1svu
      complexed with sah, so4, unx; mutant
      1. chain a [106052]
      2. chain b [106053]
2. DNA methylase HaeIII [53371]
  1. Haemophilus aegyptius [TaxId: 197575] [53372] (1)
    1. 1dct
      protein/DNA complex; complexed with ca, ch3, flo
      1. chain a [34244]
      2. chain b [34245]
3. DNMT2 [53375]
  an enigmatic DNA methyltransferase homologue from mitochondria
  1. Human (Homo sapiens) [TaxId: 9606] [53376] (1)
    1. 1g55
      complexed with bme, cry, sah, so4; mutant
      1. chain a [34247]
DNA methylase TaqI, N-terminal domain [88787] (1)
1. DNA methylase TaqI, N-terminal domain [53369]
  1. Thermus aquaticus [TaxId: 271] [53370] (18)
    1. 2ih2
      automatically matched to d1aqia1
      complexed with 5py, 6ma, gol, nea
      1. region a:21-243 [147669]
    2. 2ih2
      automatically matched to d1aqia1
      complexed with 5py, 6ma, gol, nea
      1. region d:21-243 [147671]
    3. 2ibt
      automatically matched to d1aqia1
      complexed with 2pr, 3dr, 6ma, gol, nea
      1. region a:21-243 [137205]
    4. 2ibt
      automatically matched to d1aqia1
      complexed with 2pr, 3dr, 6ma, gol, nea
      1. region d:21-243 [137207]
    5. 2ih5
      automatically matched to d1aqia1
      complexed with 3dr, 6ma, gol, nea
      1. region a:21-243 [147677]
    6. 2np7
      automatically matched to d1aqia1
      complexed with 3dr, 4pc, 6ma, gol, nea
      1. region a:21-243 [148336]
    7. 2jg3
      automatically matched to d1aqia1
      complexed with ba2, gol, k
      1. region a:23-243 [148035]
    8. 2jg3
      automatically matched to d1aqia1
      complexed with ba2, gol, k
      1. region d:23-243 [148037]
    9. 1g38
      complexed with ch3, nea
      1. region a:21-243 [111567]
      2. region d:21-243 [111569]
    10. 2ih4
      automatically matched to d1aqia1
      complexed with 4pc, 6ma, gol, nea
      1. region a:21-243 [147673]
    11. 2ih4
      automatically matched to d1aqia1
      complexed with 4pc, 6ma, gol, nea
      1. region d:21-243 [147675]
    12. 2ibs
      automatically matched to d1aqia1
      complexed with 2pr, 6ma, nea
      1. region a:21-243 [137201]
    13. 2ibs
      automatically matched to d1aqia1
      complexed with 2pr, 6ma, nea
      1. region d:21-243 [137203]
    14. 2np6
      automatically matched to d1aqia1
      complexed with 3dr, 6ma, gol, ipa, nea
      1. region a:21-243 [148332]
    15. 2np6
      automatically matched to d1aqia1
      complexed with 3dr, 6ma, gol, ipa, nea
      1. region d:21-243 [148334]
    16. 2adm
      complexed with sam
      1. region a:21-243 [111611]
      2. region b:21-243 [111613]
    17. 1aqi
      complexed with sah
      1. region a:21-243 [111559]
      2. region b:21-243 [111561]
    18. 1aqj
      complexed with sfg
      1. region a:21-243 [111563]
      2. region b:21-243 [111565]
N6 adenine-specific DNA methylase, DAM [88788] (2)
1. DNA methylase DpnM [53373]
  1. Streptococcus pneumoniae [TaxId: 1313] [53374] (1)
    1. 2dpm
      complexed with hg, sam
      1. chain a [34246]
2. DNA methylase T4DAM [102584]
  1. Bacteriophage T4 [TaxId: 10665] [102585] (14)
    1. 1yf3
      complexed with gol, sah
      1. region a:1-259 [123046]
    2. 1yf3
      automatically matched to 1YF3 A:1-259
      complexed with gol, sah
      1. region b:1-259 [123047]
    3. 1q0s
      complexed with sah
      1. chain a [95509]
    4. 1yfj
      complexed with ca, cl, sah
      1. region a:1-259 [123070]
    5. 1yfj
      automatically matched to 1YFJ A:1-259
      complexed with ca, cl, sah
      1. region b:1-259 [123071]
    6. 1yfj
      automatically matched to 1YFJ A:1-259
      complexed with ca, cl, sah
      1. region c:1-259 [123072]
    7. 1yfj
      automatically matched to 1YFJ A:1-259
      complexed with ca, cl, sah
      1. region d:1-259 [123073]
    8. 1yfj
      automatically matched to 1YFJ A:1-259
      complexed with ca, cl, sah
      1. region e:1-259 [123074]
    9. 1yfj
      automatically matched to 1YFJ A:1-259
      complexed with ca, cl, sah
      1. region f:1-259 [123075]
    10. 1yfl
      automatically matched to 1YFJ A:1-259
      complexed with sfg
      1. region a:1-259 [123076]
    11. 1yfl
      automatically matched to 1YFJ A:1-259
      complexed with sfg
      1. region b:1-259 [123077]
    12. 1yfl
      automatically matched to 1YFJ A:1-259
      complexed with sfg
      1. region d:1-259 [123078]
    13. 1yfl
      automatically matched to 1YFJ A:1-259
      complexed with sfg
      1. region e:1-259 [123079]
    14. 1q0t
      complexed with DNA
      complexed with iod, sah
      1. chain a [95510]
      2. chain b [95511]
Type II DNA methylase [53377] (3)
circularly permuted version of the common fold
1. m.PvuII N4 cytosine-specific DNA methyltransferase [53378]
  1. Proteus vulgaris [TaxId: 585] [53379] (1)
    1. 1boo
      complexed with sah; mutant
      1. chain a [34248]
2. m.RsrI N6 adenosine-specific DNA methyltransferase [53380]
  1. Rhodobacter sphaeroides [TaxId: 1063] [53381] (5)
    1. 1eg2
      complexed with mta
      1. chain a [34249]
    2. 1nw6
      complexed with cl, sfg
      1. chain a [86290]
    3. 1nw5
      complexed with cl, sam
      1. chain a [86289]
    4. 1nw7
      complexed with cl, sah
      1. chain a [86291]
    5. 1nw8
      complexed with cl; mutant
      1. chain a [86292]
3. Methyltransferase mboII [75267]
  1. Moraxella bovis [TaxId: 476] [75268] (1)
    1. 1g60
      complexed with na, sam
      1. chain a [70151]
      2. chain b [70152]
Spermidine synthase [69557] (7)
contains additional N-terminal tetramerisation all-beta domain, res. 1-71
1. Spermidine synthase [69558]
  polyamine aminopropyltransferase
  1. Thermus thermophilus [TaxId: 274] [102586] (1)
    1. 1uir
      1. chain a [99429]
      2. chain b [99430]
  2. Thermotoga maritima [TaxId: 2336] [69559] (2)
    1. 1inl
      1. chain a [66220]
      2. chain b [66221]
      3. chain c [66222]
      4. chain d [66223]
    2. 1jq3
      complexed with aat
      1. chain a [67079]
      2. chain b [67080]
      3. chain c [67081]
      4. chain d [67082]
  3. Bacillus subtilis [TaxId: 1423] [82478] (1)
    1. 1iy9
      CASP5
      1. chain a [76943]
      2. chain b [76944]
      3. chain c [76945]
      4. chain d [76946]
  4. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117680] (5)
    SQ Q9ZUB3
    1. 1xj5
      1. chain a [115378]
      2. chain b [115379]
      3. chain c [115380]
      4. chain d [115381]
    2. 2q41
      automatically matched to d1xj5b_
      1. region a:41-330 [139815]
    3. 2q41
      automatically matched to d1xj5b_
      1. region b:41-330 [139816]
    4. 2q41
      automatically matched to d1xj5b_
      1. region c:41-330 [139817]
    5. 2q41
      automatically matched to d1xj5b_
      1. region d:41-330 [139818]
  5. Caenorhabditis elegans [TaxId: 6239] [142589] (2)
    SQ Q9U2F0 3-314
    1. 2b2c
      1. region a:3-314 [127706]
    2. 2b2c
      automatically matched to 2B2C A:3-314
      1. region b:3-314 [127707]
  6. Human (Homo sapiens) [TaxId: 9606] [142590] (8)
    SQ P19623 15-300
    1. 2o07
      automatically matched to 2O05 A:15-300
      complexed with mta, spd
      1. region a:16-300 [138862]
    2. 2o07
      automatically matched to 2O05 A:15-300
      complexed with mta, spd
      1. region b:15-299 [138863]
    3. 2o06
      automatically matched to 2O05 A:15-300
      complexed with mg, mta, put
      1. region a:15-300 [138860]
    4. 2o06
      automatically matched to 2O05 A:15-300
      complexed with mg, mta, put
      1. region b:15-300 [138861]
    5. 2o0l
      automatically matched to 2O05 A:15-300
      complexed with s4m
      1. region a:16-300 [138864]
    6. 2o0l
      automatically matched to 2O05 A:15-300
      complexed with s4m
      1. region b:15-299 [138865]
    7. 2o05
      complexed with mta
      1. region a:15-300 [138858]
    8. 2o05
      automatically matched to 2O05 A:15-300
      complexed with mta
      1. region b:15-300 [138859]
2. Putative spermidine synthetase PF0127 (SpeE) [82479]
  1. Archaeon Pyrococcus furiosus [TaxId: 2261] [82480] (1)
    1. 1mjf
      structural genomics
      1. chain a [79198]
      2. chain b [79199]
Mycolic acid cyclopropane synthase [69560] (6)
1. CmaA1 [69561]
  1. Mycobacterium tuberculosis [TaxId: 1773] [69562] (3)
    1. 1kpg
      complexed with 16a, co3, sah
      1. chain a [68735]
      2. chain b [68736]
      3. chain c [68737]
      4. chain d [68738]
    2. 1kph
      complexed with 10a, co3, sah
      1. chain a [68739]
      2. chain b [68740]
      3. chain c [68741]
      4. chain d [68742]
    3. 1kp9
      complexed with acy
      1. chain a [68733]
      2. chain b [68734]
2. CmaA2 [116723]
  1. Mycobacterium tuberculosis [TaxId: 1773] [116724] (1)
    1. 1kpi
      complexed with 10a, co3, sah, so4
      1. chain a [68743]
3. PccA [75269]
  1. Mycobacterium tuberculosis [TaxId: 1773] [75270] (1)
    1. 1l1e
      complexed with co3, sah
      1. chain a [73454]
      2. chain b [73455]
4. Methoxy mycolic acid synthase 2, Mma2 [117681]
  1. Mycobacterium tuberculosis [TaxId: 1773] [117682] (1)
    SQ P72026 33-317
    1. 1tpy
      complexed with 16a, co3, sah
      1. chain a [112608]
5. Methoxy mycolic acid synthase 4, Mma4 [142591]
  1. Mycobacterium tuberculosis [TaxId: 1773] [142592] (2)
    SQ Q79FX8 22-301
    1. 2fk8
      automatically matched to 2FK7 A:22-301
      complexed with sam
      1. region a:22-301 [133648]
    2. 2fk7
      1. region a:22-301 [133647]
6. Putative sarcosine dimethylglycine methyltransferase [159680]
  sequence similarity to other families with less structural similarity
  1. Red algae (Galdieria sulphuraria) [TaxId: 130081] [159681] (1)
    1. 2o57
      1. region a:16-297 [148591]
Ta1320-like [89751] (2)
1. Hypothetical protein Ta1320 [89752]
  1. Archaeon Thermoplasma acidophilum [TaxId: 2303] [89753] (1)
    1. 1ne2
      structural genomics
      complexed with fmt, mse
      1. chain a [85586]
      2. chain b [85587]
2. Hypothetical protein PH1948 [142593]
  1. Archaeon Pyrococcus horikoshii [TaxId: 53953] [142594] (4)
    SQ O59611 4-204
    1. 1wy7
      complexed with sah
      1. region a:4-204 [121433]
    2. 1wy7
      automatically matched to 1WY7 A:4-204
      complexed with sah
      1. region b:4-204 [121434]
    3. 1wy7
      automatically matched to 1WY7 A:4-204
      complexed with sah
      1. region c:4-204 [121435]
    4. 1wy7
      automatically matched to 1WY7 A:4-204
      complexed with sah
      1. region d:4-204 [121436]
UbiE/COQ5-like [110671] (5)
Pfam 01209
1. Hypothetical protein BH2331 [110672]
  1. Bacillus halodurans [TaxId: 86665] [110673] (1)
    SQ Q9KAF6
    1. 1vl5
      Structural genomics target
      1. chain a [108720]
      2. chain b [108721]
      3. chain c [108722]
      4. chain d [108723]
2. Possible histamine N-methyltransferase TM1293 [110674]
  1. Thermotoga maritima [TaxId: 2336] [110675] (1)
    SQ Q9X119
    1. 1vlm
      Structural genomics target
      complexed with na; mutant
      1. chain a [108836]
      2. chain b [108837]
3. Hypothetical protein YcgJ [117683]
  1. Bacillus subtilis [TaxId: 1423] [117684] (3)
    SQ O31474
    1. 1xxl
      complexed with so4
      1. chain a [116203]
      2. chain b [116204]
    2. 2glu
      complexed with sam, so4
      1. region a:2-228 [135346]
    3. 2glu
      automatically matched to 2GLU A:2-228
      complexed with sam, so4
      1. region b:2-228 [135347]
4. Hypothetical methyltransferase TM1389 [142595]
  1. Thermotoga maritima [TaxId: 2336] [142596] (2)
    SQ Q9X1A9 1-246
    1. 2avn
      complexed with po4, sai
      1. region a:1-246 [127380]
    2. 2avn
      automatically matched to 2AVN A:1-246
      complexed with po4, sai
      1. region b:1-246 [127381]
5. Hypothetical protein ECA1738 [159682]
  1. Erwinia carotovora [TaxId: 554] [159683] (6)
    SQ Q6D6E7 21-249
    1. 2p7i
      automatically matched to 2P7H A:21-249
      complexed with cl, mpd, na, trs
      1. region a:22-246 [149285]
    2. 2p7i
      automatically matched to 2P7H A:21-249
      complexed with cl, mpd, na, trs
      1. region b:21-249 [149286]
    3. 2p7h
      complexed with cl, edo, na, trs
      1. region a:21-249 [149281]
    4. 2p7h
      automatically matched to 2P7H A:21-249
      complexed with cl, edo, na, trs
      1. region b:21-246 [149282]
    5. 2p7h
      automatically matched to 2P7H A:21-249
      complexed with cl, edo, na, trs
      1. region c:21-249 [149283]
    6. 2p7h
      automatically matched to 2P7H A:21-249
      complexed with cl, edo, na, trs
      1. region d:21-246 [149284]
AD-003 protein-like [117685] (2)
Pfam 05891; DUF858
1. Hypothetical protein Lmaj004091aaa (LmjF30.0810) [117686]
  1. Leishmania major [TaxId: 5664] [117687] (1)
    SQ Q4Q7M2
    1. 1xtp
      Structural genomics target
      complexed with sai
      1. chain a [116031]
2. Adrenal gland protein AD-003 (C9orf32) [142597]
  1. Human (Homo sapiens) [TaxId: 9606] [142598] (2)
    SQ Q9BV86 1-222
    1. 2ex4
      complexed with sah
      1. region a:2-224 [132516]
    2. 2ex4
      automatically matched to 2EX4 A:2-224
      complexed with sah
      1. region b:2-224 [132517]
CAC2371-like [117688] (3)
similar overall fold to the Glycine N-methyltransferase (scop_fa 53348) and mRNA cap (Guanine N-7) methyltransferase (scop_fa 102560) families
1. Putative methyltransferase CAC2371 [117689]
  1. Clostridium acetobutylicum [TaxId: 1488] [117690] (1)
    SQ Q97GJ5
    1. 1y8c
      Structural genomics target
      complexed with so4
      1. chain a [116563]
2. Hypothetical protein PH0226 [142599]
  1. Archaeon Pyrococcus horikoshii [TaxId: 53953] [142600] (2)
    SQ O57965 2-227
    1. 1ve3
      complexed with sam
      1. region a:2-227 [120010]
    2. 1ve3
      automatically matched to 1VE3 A:2-227
      complexed with sam
      1. region b:2-227 [120011]
3. Hypothetical methyltransferase PH1305 [142601]
  the beta-sheet insertion makes trimerization subdomain
  1. Archaeon Pyrococcus horikoshii [TaxId: 53953] [142602] (3)
    SQ O59000 1-251
    1. 1wzn
      complexed with mg, sah, so4
      1. region a:1-251 [121525]
    2. 1wzn
      automatically matched to 1WZN A:1-251
      complexed with mg, sah, so4
      1. region b:1-251 [121526]
    3. 1wzn
      automatically matched to 1WZN A:1-251
      complexed with mg, sah, so4
      1. region c:1-251 [121527]
TehB-like [142603] (1)
Pfam 03848; overall structural similarity to Thiopurine S-methyltransferase (Pfam 05724)
1. Putative methyltransferase TehB [142604]
  Tellurite resistance protein
  1. Salmonella typhimurium [TaxId: 90371] [142605] (2)
    SQ Q8ZPC3 1-198
    sequence similarity to Hypothetical methyltransferase PH1305 of the CAC2371-like family (scop_fa 117688)
    1. 2i6g
      complexed with acy, cl, edo, mly
      1. region a:1-198 [137096]
    2. 2i6g
      automatically matched to 2I6G A:1-198
      complexed with acy, cl, edo, mly
      1. region b:1-198 [137097]
N-6 DNA Methylase-like [142606] (3)
Pfam 02384; contains C-terminal extension to the canonical fold and extra N-terminal all-alpha domain similar to the insert domain of the DAM family (scop_fa 88788)
1. Hypothetical protein Lmo1582 [142607]
  1. Listeria monocytogenes [TaxId: 1639] [142608] (1)
    SQ Q8Y6U9 2-329
    1. 2f8l
      complexed with cl, gol, sam, so4
      1. region a:2-329 [133132]
2. M.EcoKI [142609]
  contains extra C-terminal structured region
  1. Escherichia coli [TaxId: 562] [142610] (2)
    SQ P08957 4-527
    1. 2ar0
      complexed with unx; mutant
      1. region a:6-529 [127185]
    2. 2ar0
      automatically matched to 2AR0 A:6-529
      complexed with unx; mutant
      1. region b:6-527 [127186]
3. Type I restriction enzyme StySJI M protein [159684]
  1. Bacteroides thetaiotaomicron [TaxId: 818] [159685] (2)
    SQ Q89Z59 9-433
    1. 2okc
      complexed with cl, gol, ipa, sam
      1. region a:9-433 [148801]
    2. 2okc
      automatically matched to 2OKC A:9-433
      complexed with cl, gol, ipa, sam
      1. region b:9-432 [148802]
YhhF-like [142611] (5)
Pfam 03602
1. Putative methylase EF2452 [142612]
  1. Enterococcus faecalis [TaxId: 1351] [142613] (2)
    SQ Q831P8 1-182
    1. 2fhp
      1. region a:1-182 [133495]
    2. 2fhp
      automatically matched to 2FHP A:1-182
      1. region b:1-182 [133496]
2. Methyltransferase TTHA0928 [142614]
  1. Thermus thermophilus [TaxId: 274] [142615] (1)
    SQ Q5SJT0 15-185
    1. 1ws6
      1. region a:15-185 [121222]
3. Putative methylase HI0767 [142616]
  YhhF homologue
  1. Haemophilus influenzae [TaxId: 727] [142617] (1)
    SQ P44869 11-193
    1. 2ift
      1. region a:11-193 [137347]
4. Putative methyltransferase SPy1538 [142618]
  1. Streptococcus pyogenes [TaxId: 1314] [142619] (2)
    SQ Q99YU1 28-179
    1. 2esr
      complexed with glc
      1. region a:28-179 [132344]
    2. 2esr
      automatically matched to 2ESR A:28-179
      complexed with glc
      1. region b:28-179 [132345]
5. Methylase YhhF [142620]
  1. Escherichia coli [TaxId: 562] [142621] (6)
    SQ P0ADX9 10-192
    1. 2fpo
      complexed with cl, edo
      1. region a:10-192 [133909]
    2. 2fpo
      automatically matched to 2FPO A:10-192
      complexed with cl, edo
      1. region b:10-192 [133910]
    3. 2fpo
      automatically matched to 2FPO A:10-192
      complexed with cl, edo
      1. region c:10-192 [133911]
    4. 2fpo
      automatically matched to 2FPO A:10-192
      complexed with cl, edo
      1. region d:10-192 [133912]
    5. 2fpo
      automatically matched to 2FPO A:10-192
      complexed with cl, edo
      1. region e:10-192 [133913]
    6. 2fpo
      automatically matched to 2FPO A:10-192
      complexed with cl, edo
      1. region f:10-192 [133914]
Met-10+ protein-like [142622] (1)
Pfam 02475; contains extra N-terminal alpha+beta domain: beta(2)-alpha-beta(2); mixed beta-sheet; order: 1234; cf scop_fold 102740
1. Hypothetical protein PH0793 [142623]
  1. Pyrococcus horikoshii [TaxId: 53953] [142624] (1)
    SQ O58523 19-278
    1. 2frn
      complexed with edo
      1. region a:19-278 [133993]
Nsp15 N-terminal domain-like [142625] (2)
rudiment methyltransferase fold that probably has lost the enzymatic activity; contains extra N-terminal alpha+beta subdomain
1. Nsp15 [142626]
  1. Murine hepatitis virus, MHV [TaxId: 11138] [142627] (2)
    SQ P16342 6504-6697! SQ P16342 6697-6872
    1. 2gti
      complexed with gol, so4; mutant
      1. region a:1-194 [135652]
    2. 2gth
      1. region a:1-194 [135650]
  2. SARS coronavirus [TaxId: 227859] [142628] (11)
    SQ Q6VA80 6619-6774
    1. 2h85
      mutant
      1. region a:1-190 [136233]
    2. 2rhb
      automatically matched to d2h85a1
      mutant
      1. region a:1-190 [152036]
    3. 2rhb
      automatically matched to d2h85a1
      mutant
      1. region b:1-190 [152038]
    4. 2rhb
      automatically matched to d2h85a1
      mutant
      1. region c:1-190 [152040]
    5. 2rhb
      automatically matched to d2h85a1
      mutant
      1. region d:1-190 [152042]
    6. 2rhb
      automatically matched to d2h85a1
      mutant
      1. region e:1-190 [152044]
    7. 2rhb
      automatically matched to d2h85a1
      mutant
      1. region f:1-190 [152046]
    8. 2ozk
      1. region a:27-190 [149107]
    9. 2ozk
      automatically matched to 2OZK A:27-190
      1. region b:28-190 [149109]
    10. 2ozk
      automatically matched to 2OZK A:27-190
      1. region c:29-190 [149111]
    11. 2ozk
      automatically matched to 2OZK A:27-190
      1. region d:29-190 [149113]
BC2162-like [142629] (1)
contains extra helical regions inserted after strands 5 and 6 of the canonical fold
1. Methyltransferase BC2162 [142630]
  1. Bacillus cereus [TaxId: 1396] [142631] (2)
    SQ Q81E32 13-293
    1. 2gh1
      complexed with act, gol
      1. region a:13-293 [135170]
    2. 2gh1
      automatically matched to 2GH1 A:13-293
      complexed with act, gol
      1. region b:13-293 [135171]
CmcI-like [142632] (1)
Pfam 04989; may have evolved different enzymatic activity
1. Cephalosporin hydroxylase CmcI [142633]
  1. Streptomyces clavuligerus [TaxId: 1901] [142634] (34)
    SQ O85726 2-233
    1. 2bm8
      mutant
      1. region a:2-233 [128771]
    2. 2bm8
      automatically matched to 2BM8 A:2-233
      mutant
      1. region b:2-233 [128772]
    3. 2bm8
      automatically matched to 2BM8 A:2-233
      mutant
      1. region c:2-233 [128773]
    4. 2bm8
      automatically matched to 2BM8 A:2-233
      mutant
      1. region d:2-233 [128774]
    5. 2bm8
      automatically matched to 2BM8 A:2-233
      mutant
      1. region e:2-233 [128775]
    6. 2bm8
      automatically matched to 2BM8 A:2-233
      mutant
      1. region f:2-233 [128776]
    7. 2bm8
      automatically matched to 2BM8 A:2-233
      mutant
      1. region g:3-233 [128777]
    8. 2bm8
      automatically matched to 2BM8 A:2-233
      mutant
      1. region h:2-233 [128778]
    9. 2bm8
      automatically matched to 2BM8 A:2-233
      mutant
      1. region i:2-233 [128779]
    10. 2bm8
      automatically matched to 2BM8 A:2-233
      mutant
      1. region j:2-233 [128780]
    11. 2bm8
      automatically matched to 2BM8 A:2-233
      mutant
      1. region k:3-233 [128781]
    12. 2bm8
      automatically matched to 2BM8 A:2-233
      mutant
      1. region l:2-233 [128782]
    13. 2br4
      automatically matched to 2BR3 A:2-233
      complexed with mg, p4c, peg, sam; mutant
      1. region a:3-233 [128982]
    14. 2br4
      automatically matched to 2BR3 A:2-233
      complexed with mg, p4c, peg, sam; mutant
      1. region b:3-233 [128983]
    15. 2br4
      automatically matched to 2BR3 A:2-233
      complexed with mg, p4c, peg, sam; mutant
      1. region c:2-233 [128984]
    16. 2br4
      automatically matched to 2BR3 A:2-233
      complexed with mg, p4c, peg, sam; mutant
      1. region d:2-231 [128985]
    17. 2br4
      automatically matched to 2BR3 A:2-233
      complexed with mg, p4c, peg, sam; mutant
      1. region e:2-233 [128986]
    18. 2br4
      automatically matched to 2BR3 A:2-233
      complexed with mg, p4c, peg, sam; mutant
      1. region f:2-232 [128987]
    19. 2br3
      complexed with 15p, mg, peg; mutant
      1. region a:2-233 [128976]
    20. 2br3
      automatically matched to 2BR3 A:2-233
      complexed with 15p, mg, peg; mutant
      1. region b:3-233 [128977]
    21. 2br3
      automatically matched to 2BR3 A:2-233
      complexed with 15p, mg, peg; mutant
      1. region c:3-233 [128978]
    22. 2br3
      automatically matched to 2BR3 A:2-233
      complexed with 15p, mg, peg; mutant
      1. region d:2-231 [128979]
    23. 2br3
      automatically matched to 2BR3 A:2-233
      complexed with 15p, mg, peg; mutant
      1. region e:2-233 [128980]
    24. 2br3
      automatically matched to 2BR3 A:2-233
      complexed with 15p, mg, peg; mutant
      1. region f:2-233 [128981]
    25. 2br5
      automatically matched to 2BM8 A:2-233
      complexed with sah; mutant
      1. region a:8-233 [128988]
    26. 2br5
      automatically matched to 2BM8 A:2-233
      complexed with sah; mutant
      1. region b:2-233 [128989]
    27. 2br5
      automatically matched to 2BM8 A:2-233
      complexed with sah; mutant
      1. region c:8-233 [128990]
    28. 2br5
      automatically matched to 2BM8 A:2-233
      complexed with sah; mutant
      1. region e:3-232 [128991]
    29. 2bm9
      automatically matched to 2BM8 A:2-233
      complexed with sam; mutant
      1. region a:2-233 [128783]
    30. 2bm9
      automatically matched to 2BM8 A:2-233
      complexed with sam; mutant
      1. region b:4-233 [128784]
    31. 2bm9
      automatically matched to 2BM8 A:2-233
      complexed with sam; mutant
      1. region c:3-233 [128785]
    32. 2bm9
      automatically matched to 2BM8 A:2-233
      complexed with sam; mutant
      1. region d:2-233 [128786]
    33. 2bm9
      automatically matched to 2BM8 A:2-233
      complexed with sam; mutant
      1. region e:3-233 [128787]
    34. 2bm9
      automatically matched to 2BM8 A:2-233
      complexed with sam; mutant
      1. region f:3-233 [128788]
hypothetical RNA methyltransferase [142635] (4)
C-terminal part of Pfam 03602; similar to (Uracil-5-)-methyltransferase (Pfam 05958)
1. Putative methyltransferase Atu0340 [142636]
  there is no associated PUA domain; rudiment extra N-terminal subdomain
  1. Agrobacterium tumefaciens [TaxId: 358] [142637] (3)
    SQ Q8UIF7 1-309
    1. 2igt
      complexed with acy, fmt, gol, sam
      1. region a:1-309 [137401]
    2. 2igt
      automatically matched to 2IGT A:1-309
      complexed with acy, fmt, gol, sam
      1. region b:1-309 [137402]
    3. 2igt
      automatically matched to 2IGT A:1-309
      complexed with acy, fmt, gol, sam
      1. region c:1-309 [137403]
2. Hypothetical protein TTHA1280, middle and C-terminal domains [142638]
  1. Thermus thermophilus [TaxId: 274] [142639] (10)
    SQ Q5SIT4 65-382
    1. 1wxx
      automatically matched to 1WXW A:65-382
      complexed with k, po4
      1. region a:65-382 [121419]
    2. 1wxx
      automatically matched to 1WXW A:65-382
      complexed with k, po4
      1. region b:65-382 [121421]
    3. 1wxx
      automatically matched to 1WXW A:65-382
      complexed with k, po4
      1. region c:65-382 [121423]
    4. 1wxx
      automatically matched to 1WXW A:65-382
      complexed with k, po4
      1. region d:65-382 [121425]
    5. 1wxw
      complexed with hez
      1. region a:65-382 [121411]
    6. 1wxw
      automatically matched to 1WXW A:65-382
      complexed with hez
      1. region b:65-382 [121413]
    7. 1wxw
      automatically matched to 1WXW A:65-382
      complexed with hez
      1. region c:65-382 [121415]
    8. 1wxw
      automatically matched to 1WXW A:65-382
      complexed with hez
      1. region d:65-382 [121417]
    9. 2cww
      automatically matched to 1WXW A:65-382
      complexed with acy, gol, sah
      1. region a:65-382 [130953]
    10. 2cww
      automatically matched to 1WXW A:65-382
      complexed with acy, gol, sah
      1. region b:65-382 [130955]
3. Hypothetical protein SMu776, middle and C-terminal domains [142640]
  1. Streptococcus mutans [TaxId: 1309] [142641] (1)
    SQ Q8DUW5 69-385
    1. 2b78
      1. region a:69-385 [128026]
4. Hypothetical protein PH1915, middle and C-terminal domains [142642]
  1. Archaeon Pyrococcus horikoshii [TaxId: 53953] [142643] (2)
    SQ O59578 73-396
    1. 2as0
      1. region a:73-396 [127228]
    2. 2as0
      automatically matched to 2AS0 A:73-396
      1. region b:73-396 [127230]
RPA4359-like [142644] (1)
Pfam 02636; DUF185
1. Hypothetical protein RPA4359 [142645]
  1. Rhodopseudomonas palustris [TaxId: 1076] [142646] (2)
    SQ Q6N1P6 2-366
    1. 1zkd
      1. region a:2-366 [125184]
    2. 1zkd
      automatically matched to 1ZKD A:2-366
      1. region b:2-366 [125185]
TrmB-like [142647] (2)
Pfam 02390
1. tRNA (guanine-N(7)-)-methyltransferase TrmB [142648]
  1. Streptococcus pneumoniae [TaxId: 1313] [142649] (2)
    SQ P67506 8-211
    1. 1yzh
      complexed with gol
      1. region a:8-211 [124277]
    2. 1yzh
      automatically matched to 1YZH A:8-211
      complexed with gol
      1. region b:8-211 [124278]
  2. Bacillus subtilis [TaxId: 1423] [142650] (2)
    SQ O34522 10-213
    1. 2fca
      complexed with k
      1. region a:10-213 [133262]
    2. 2fca
      automatically matched to 2FCA A:10-213
      complexed with k
      1. region b:11-213 [133263]
Methyltransferase 10 domain [142651] (1)
Pfam 05971; DUF890
1. Methyltransferase 10 domain containing protein METT10D [142652]
  1. Human (Homo sapiens) [TaxId: 9606] [142653] (3)
    SQ Q86W50 42-291
    1. 2h00
      complexed with cl, dtu, sah
      1. region a:5-254 [135925]
    2. 2h00
      automatically matched to 2H00 A:5-254
      complexed with cl, dtu, sah
      1. region b:8-253 [135926]
    3. 2h00
      automatically matched to 2H00 A:5-254
      complexed with cl, dtu, sah
      1. region c:7-254 [135927]
YhiQ-like [159686] (3)
Pfam 04445; DUF548; contains extra N-terminal alpha+beta subdomain [beta-alpha-beta(4)]
1. Hypothetical protein YhiQ [159687]
  1. Escherichia coli [TaxId: 562] [159688] (1)
    SQ P68568 1-250
    1. 2pgx
      1. region a:1-250 [149463]
  2. Salmonella typhimurium [TaxId: 90371] [159689] (1)
    SQ Q9X6G2 1-252
    1. 2pkw
      complexed with trs
      1. region a:1-252 [149605]
  3. Shigella flexneri [TaxId: 623] [159690] (1)
    SQ Q7UAV7 1-250
    1. 2oyr
      complexed with sah
      1. region a:1-250 [149078]
FkbM-like [159691] (1)
contains extra N-terminal alpha/beta and all-alpha subdomains
1. Methyltransferase FkbM [159692]
  1. Methylobacillus flagellatus [TaxId: 405] [159693] (1)
    SQ Q1GXX6 14-408
    1. 2py6
      complexed with cl, edo, peg, unl
      1. region a:14-408 [149932]
ML2640-like [159694] (1)
Pfam 02409; O-methyltransferase N-terminus (DUF142); most similar structure to the Leucine carboxy methyltransferase Ppm1 family
1. Putative methyltransferase ML2640 [159695]
  1. Mycobacterium leprae [TaxId: 1769] [159696] (4)
    SQ Q9CCZ4 8-310
    1. 2uyo
      automatically matched to 2CKD A:8-310
      1. region a:14-310 [152321]
    2. 2uyq
      automatically matched to 2CKD A:8-310
      complexed with sam
      1. region a:14-310 [152322]
    3. 2ckd
      1. region a:8-310 [146409]
    4. 2ckd
      automatically matched to 2CKD A:8-310
      1. region b:13-310 [146410]
TRM1-like [159697] (1)
Pfam 02005; contains extra C-terminal alpha+beta subdomain
1. N(2),N(2)-dimethylguanosine tRNA methyltransferase Trm1 [159698]
  1. Pyrococcus horikoshii [TaxId: 53953] [159699] (5)
    SQ O59493 3-377
    1. 2dul
      complexed with gol; mutant
      1. region a:3-377 [146588]
    2. 2eju
      automatically matched to 2DUL A:3-377
      complexed with gol, sah; mutant
      1. region a:3-377 [146881]
    3. 2ejt
      automatically matched to 2DUL A:3-377
      complexed with gol, sam; mutant
      1. region a:3-377 [146880]
    4. 2ytz
      automatically matched to 2DUL A:3-377
      complexed with sah, so4; mutant
      1. region a:3-377 [153776]
    5. 2ytz
      automatically matched to 2DUL A:3-377
      complexed with sah, so4; mutant
      1. region b:3-376 [153777]
LPG1296-like [159700] (1)
Pfam 04378; DUF519
1. Uncharacterized protein LPG1296 [159701]
  involved in catabolism of external DNA
  1. Legionella pneumophila [TaxId: 446] [159702] (1)
    SQ Q5ZVZ2 14-284
    1. 2oo3
      complexed with so4
      1. region a:9-279 [148918]