Structural Classification of Proteins
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Superfamily: S-adenosyl-L-methionine-dependent methyltransferases

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: S-adenosyl-L-methionine-dependent methyltransferases [53334]
    core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
  4. Superfamily: S-adenosyl-L-methionine-dependent methyltransferases [53335]
    link to SUPERFAMILY database - Superfamily

Families:

  1. COMT-like [53336] (3) picpic
  2. Plant O-methyltransferase, C-terminal domain [64111] (5) picpic
  3. RNA methyltransferase FtsJ [53339] (1) picpic
  4. Fibrillarin homologue [53342] (3) picpic
  5. rRNA methyltransferase RlmA [102557] (1) picpic
  6. rRNA methyltransferase AviRa [89738] (1) picpic
  7. rRNA adenine dimethylase-like [88784] (5) picpic
  8. mRNA cap methylase [88785] (3) picpic
  9. mRNA cap (Guanine N-7) methyltransferase [102560] (1) picpic
    mRNA capping enzyme
  10. Hypothetical protein MJ0882 [53345] (1) picpic
  11. Hypothetical protein HI0319 (YecO) [69544] (1) picpic
  12. Glycine N-methyltransferase [53348] (3) picpic
  13. Arylamine N-methyltransferase [69547] (2) picpic
  14. Histamine methyltransferase [75261] (1) picpic
  15. Hypothetical Protein YjhP [82469] (1) picpic
  16. Salicylic acid carboxyl methyltransferase (SAMT) [102563] (1) picpic
  17. Thiopurine S-methyltransferase [102566] (2) picpic
  18. Leucine carboxy methyltransferase Ppm1 [102569] (1) picpic
  19. Precorrin-6Y methyltransferase (CbiT) [82472] (1) picpic
  20. MraW-like putative methyltransferases [82475] (2) picpic
  21. N5-glutamine methyltransferase, HemK [89743] (2) picpic
  22. Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2) picpic
  23. Guanidinoacetate methyltransferase [69550] (2) picpic
  24. Arginine methyltransferase [53351] (4) picpic
    lacks the last two strands of the common fold replaced with a beta-sandwich oligomerisation subdomain
  25. Protein-L-isoaspartyl O-methyltransferase [53354] (5) picpic
    topological variant; strand order 3214567; strand 6 is antiparallel to the rest
  26. Glucose-inhibited division protein B (GidB) [75264] (2) picpic
  27. tRNA(1-methyladenosine) methyltransferase-like [64117] (4) picpic
    contains additional N-terminal beta-sandwich domain
  28. NOL1/NOP2/sun [102575] (3) picpic
    Pfam 01189; contains additional N-terminal 3-helical and ferredoxin-like domains
  29. Ribosomal protein L11 methyltransferase PrmA [102578] (1) picpic
    contains additional N-terminal ferredoxin-like domain
  30. (Uracil-5-)-methyltransferase [102581] (1) picpic
    Pfam 05958
  31. Chemotaxis receptor methyltransferase CheR, C-terminal domain [53357] (1) picpic
    contains additional N-terminal all-alpha domain, res. 11-91
  32. C5 cytosine-specific DNA methylase, DCM [88786] (3) picpic
  33. DNA methylase TaqI, N-terminal domain [88787] (1) picpic
  34. N6 adenine-specific DNA methylase, DAM [88788] (2) picpic
  35. Type II DNA methylase [53377] (3) picpic
    circularly permuted version of the common fold
  36. Spermidine synthase [69557] (7) picpic
    contains additional N-terminal tetramerisation all-beta domain, res. 1-71
  37. Mycolic acid cyclopropane synthase [69560] (6) picpic
  38. Ta1320-like [89751] (2) picpic
  39. UbiE/COQ5-like [110671] (5) picpic
    Pfam 01209
  40. AD-003 protein-like [117685] (2) picpic
    Pfam 05891; DUF858
  41. CAC2371-like [117688] (3) picpic
    similar overall fold to the Glycine N-methyltransferase (scop_fa 53348) and mRNA cap (Guanine N-7) methyltransferase (scop_fa 102560) families
  42. TehB-like [142603] (1) picpic
    Pfam 03848; overall structural similarity to Thiopurine S-methyltransferase (Pfam 05724)
  43. N-6 DNA Methylase-like [142606] (3) picpic
    Pfam 02384; contains C-terminal extension to the canonical fold and extra N-terminal all-alpha domain similar to the insert domain of the DAM family (scop_fa 88788)
  44. YhhF-like [142611] (5) picpic
    Pfam 03602
  45. Met-10+ protein-like [142622] (1) picpic
    Pfam 02475; contains extra N-terminal alpha+beta domain: beta(2)-alpha-beta(2); mixed beta-sheet; order: 1234; cf scop_fold 102740
  46. Nsp15 N-terminal domain-like [142625] (2) picpic
    rudiment methyltransferase fold that probably has lost the enzymatic activity; contains extra N-terminal alpha+beta subdomain
  47. BC2162-like [142629] (1) picpic
    contains extra helical regions inserted after strands 5 and 6 of the canonical fold
  48. CmcI-like [142632] (1) picpic
    Pfam 04989; may have evolved different enzymatic activity
  49. hypothetical RNA methyltransferase [142635] (4) picpic
    C-terminal part of Pfam 03602; similar to (Uracil-5-)-methyltransferase (Pfam 05958)
  50. RPA4359-like [142644] (1) picpic
    Pfam 02636; DUF185
  51. TrmB-like [142647] (2) picpic
    Pfam 02390
  52. Methyltransferase 10 domain [142651] (1) picpic
    Pfam 05971; DUF890
  53. YhiQ-like [159686] (3) picpic
    Pfam 04445; DUF548; contains extra N-terminal alpha+beta subdomain [beta-alpha-beta(4)]
  54. FkbM-like [159691] (1) picpic
    contains extra N-terminal alpha/beta and all-alpha subdomains
  55. ML2640-like [159694] (1) picpic
    Pfam 02409; O-methyltransferase N-terminus (DUF142); most similar structure to the Leucine carboxy methyltransferase Ppm1 family
  56. TRM1-like [159697] (1) picpic
    Pfam 02005; contains extra C-terminal alpha+beta subdomain
  57. LPG1296-like [159700] (1) picpic
    Pfam 04378; DUF519
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk