Structural Classification of Proteins
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Family: RNA helicase

duplication: consists of two similar domains, one binds NTP and the other binds RNA; also contains an all-alpha subdomain in the C-terminal extension

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: P-loop containing nucleoside triphosphate hydrolases [52539]
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. Superfamily: P-loop containing nucleoside triphosphate hydrolases [52540]
    division into families based on beta-sheet topologies
    link to SUPERFAMILY database - Superfamily
  5. Family: RNA helicase [52724]
    duplication: consists of two similar domains, one binds NTP and the other binds RNA; also contains an all-alpha subdomain in the C-terminal extension

Protein Domains:

  1. HCV helicase domain [52725]
    1. Human hepatitis C virus (HCV), different isolates [TaxId: 11103] [52726] (6)
      1. 1a1v picpic
        protein/DNA complex; complexed with so4; mutant
        1. region a:190-325 [32467] picpiclink
        2. region a:326-624 [32468] picpiclink
      2. 1hei picpic
        complexed with ca
        1. region a:187-325 [32463] picpiclink
        2. region a:326-629 [32464] picpiclink
        3. region b:188-325 [32465] picpiclink
        4. region b:326-628 [32466] picpiclink
      3. 8ohm picpic
        1. region a:190-325 [32469] picpiclink
        2. region a:326-624 [32470] picpiclink
      4. 1cu1 picpicxref
        complexed with po4, zn
        1. region a:187-325 [32471] picpiclink
        2. region a:326-631 [32472] picpiclink
        3. region b:1187-1325 [32473] picpiclink
        4. region b:1326-1631 [32474] picpiclink
      5. 1onb picpic
        an engineered arginine-rich subdomain 2
        1. chain a [87137] picpiclink
      6. 1jr6 picpic
        an engineered arginine-rich subdomain 2
        1. chain a [71821] picpiclink
  2. Dengue virus helicase [142328]
    1. Dengue virus type 2 [TaxId: 11060] [142329] (8)
      SQ Q91H74 1653-1957! SQ Q91H74 1958-2093
      1. 2bmf picpic
        automatically matched to 2BHR A:483-618
        1. region a:483-618 [128791] picpiclink
      2. 2bmf picpic
        automatically matched to 2BHR A:178-482
        1. region a:178-482 [128792] picpiclink
      3. 2bmf picpic
        automatically matched to 2BHR A:483-618
        1. region b:483-618 [128793] picpiclink
      4. 2bmf picpic
        automatically matched to 2BHR A:178-482
        1. region b:178-482 [128794] picpiclink
      5. 2bhr picpic
        complexed with so4
        1. region a:483-618 [128542] picpiclink
      6. 2bhr picpic
        complexed with so4
        1. region a:178-482 [128543] picpiclink
      7. 2bhr picpic
        automatically matched to 2BHR A:483-618
        complexed with so4
        1. region b:483-618 [128544] picpiclink
      8. 2bhr picpic
        automatically matched to 2BHR A:178-482
        complexed with so4
        1. region b:178-482 [128545] picpiclink
  3. YFV helicase domain [142330]
    1. Yellow fever virus [TaxId: 11089] [142331] (2)
      SQ P19901 1669-1842! SQ P19901 1843-2107
      1. 1yks picpic
        1. region a:185-324 [123561] picpiclink
      2. 1yks picpic
        1. region a:325-623 [123562] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk