Family: Transhydrogenase domain III (dIII)

binds NADP, shares with the pyruvate oxidase FAD-binding domain a common ADP-binding mode

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: DHS-like NAD/FAD-binding domain [52466]
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
4. Superfamily: DHS-like NAD/FAD-binding domain [52467]
   binds cofactor molecules in the opposite direction than classical Rossmann fold
   uperfamily
5. Family: Transhydrogenase domain III (dIII) [52484]
   binds NADP, shares with the pyruvate oxidase FAD-binding domain a common ADP-binding mode

Protein Domains:

1. Transhydrogenase domain III (dIII) [52485]
   1. Human (Homo sapiens) [TaxId: 9606] [52486] (4)
      1. 1djl
         complexed with gol, nap, so4
         1. chain a [31746]
         2. chain b [31747]
      2. 1u31
         automatically matched to d1djla_
         complexed with gol, nap, so4
         1. region a:23-204 [119491]
      3. 1u31
         automatically matched to d1djla_
         complexed with gol, nap, so4
         1. region b:23-204 [119492]
      4. 1pt9
         complexed with gol, so4, tap
         1. chain a [95097]
         2. chain b [95098]
   2. Cow (Bos taurus) [TaxId: 9913] [52487] (1)
      1. 1d4o
         1. chain a [31748]
   3. Rhodospirillum rubrum [TaxId: 1085] [52488] (17)
      1. 1pno
         complexed with nap
         1. chain a [94953]
         2. chain b [94954]
      2. 2fsv
         complexed with gol, nad, nap; mutant
         1. region c:30-203 [134041]
      3. 1u2g
         automatically matched to d1pnoa_
         complexed with apr, gol, ndp
         1. region c:33-203 [119484]
      4. 1pnq
         complexed with ndp
         1. chain a [94955]
         2. chain b [94956]
      5. 2oor
         automatically matched to d1pnoa_
         complexed with gol, nad, txp
         1. region c:33-202 [139175]
      6. 1u28
         automatically matched to d1pnoa_
         complexed with gol, nad, nap
         1. region c:33-203 [119472]
      7. 2oo5
         automatically matched to d1pnoa_
         complexed with nap, so4, txd
         1. region c:33-203 [139166]
      8. 2fr8
         automatically matched to d1pnoa_
         complexed with nad, nap; mutant
         1. region c:33-203 [133977]
      9. 1ptj
         complexed with dI component
         complexed with gol, nap, snd
         1. chain c [95103]
      10. 1nm5
          complexed with dI component
          complexed with gol, nad, nap; mutant
          1. chain c [91972]
      11. 1hzz
          complexed with dI component
          complexed with nad, nap
          1. chain c [61474]
      12. 1u2d
          automatically matched to d1pnoa_
          complexed with gol, nad, ndp
          1. region c:33-203 [119479]
      13. 2frd
          automatically matched to d1pnoa_
          complexed with nad, nap; mutant
          1. region c:33-203 [133984]
      14. 1xlt
          automatically matched to d1pnoa_
          complexed with na, nad, ndp, suc
          1. region c:291-464 [122126]
      15. 1xlt
          automatically matched to d1pnoa_
          complexed with na, nad, ndp, suc
          1. region f:292-464 [122131]
      16. 1xlt
          automatically matched to d1pnoa_
          complexed with na, nad, ndp, suc
          1. region i:292-464 [122136]
      17. 1e3t
          complexed with nap
          1. chain a [31749]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk