Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like

the constituent families form similar dimers
uperfamily

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Isocitrate/Isopropylmalate dehydrogenase-like [53658]
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
4. Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like [53659]
   the constituent families form similar dimers
   uperfamily

Families:

1. Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (13)
   the active site is between the two identical subunits
   1. 3-isopropylmalate dehydrogenase, IPMDH [53661]
      1. Thermus thermophilus [TaxId: 274] [53662] (14)
      2. Chimera (Thermus thermophilus) and (Bacillus subtilis) [TaxId: 274] [53663] (2)
      3. Bacillus coagulans [TaxId: 1398] [53664] (3)
      4. Thiobacillus ferrooxidans [TaxId: 920] [53665] (1)
      5. Salmonella typhimurium [TaxId: 90371] [53666] (1)
      6. Escherichia coli [TaxId: 562] [53667] (1)
      7. Thermotoga maritima [TaxId: 2336] [110714] (1)
         SQ Q9WZ26
      8. Sulfolobus tokodaii [TaxId: 111955] [117724] (1)
         SQ P50455
      9. Mycobacterium tuberculosis [TaxId: 1773] [117725] (5)
         SQ P95313
   2. Isocitrate dehydrogenase, ICDH [53668]
      1. Escherichia coli [TaxId: 562] [53669] (26)
      2. Bacillus subtilis [TaxId: 1423] [64171] (1)
   3. NADP-dependent isocitrate dehydrogenase [82524]
      1. Pig (Sus scrofa) [TaxId: 9823] [82525] (2)
      2. Human (Homo sapiens) [TaxId: 9606] [110715] (2)
         SQ O75874
2. PdxA-like [102656] (2)
   Pfam 04166; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PlsX-like and phosphotransacetylase families
   1. 4-hydroxythreonine-4-phosphate dehydrogenase PdxA [102657]
      pyridoxal phosphate biosynthetic protein
      1. Escherichia coli [TaxId: 562] [102658] (3)
      2. Salmonella typhimurium [TaxId: 90371] [102659] (1)
3. PlsX-like [102660] (2)
   Pfam 02504; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PdxA-like and phosphotransacetylase families
   1. Fatty acid/phospholipid synthesis protein PlsX [102661]
      1. Bacillus subtilis [TaxId: 1423] [102662] (1)
      2. Enterococcus faecalis [TaxId: 1351] [110716] (1)
         SQ Q82ZE8
4. Phosphotransacetylase [102663] (4)
   Pfam 01515; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PdxA-like and PlsX-like families
   1. Phosphotransacetylase Pta [110717]
      1. Methanosarcina thermophila [TaxId: 2210] [110718] (5)
         SQ P38503
      2. Streptococcus pyogenes [TaxId: 1314] [102665] (1)
      3. Bacillus subtilis [TaxId: 1423] [117726] (2)
         SQ P39646
   2. Ethanolamine utilization protein EutD [117727]
      1. Escherichia coli [TaxId: 562] [117728] (1)
         SQ P77218 2-323
5. Monomeric isocitrate dehydrogenase [82526] (1)
   the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion
   1. Monomeric isocitrate dehydrogenase [82527]
      1. Azotobacter vinelandii [TaxId: 354] [82528] (1)
         the insert region spans residues 150-404

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk