Structural Classification of Proteins
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Superfamily: PH domain-like

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: PH domain-like barrel [50728]
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. Superfamily: PH domain-like [50729]
    link to SUPERFAMILY database - Superfamily

Families:

  1. Pleckstrin-homology domain (PH domain) [50730] (51)
    Pfam 00169
    1. Phospholipase C delta-1 [50731]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [50732] (1)
        1. 1mai picpic
          complexed with i3p
          1. chain a [26951] picpiclink
    2. beta-spectrin [50733]
      1. Mouse (Mus musculus), brain [TaxId: 10090] [50734] (2)
        1. 1btn picpic
          complexed with i3p
          1. chain a [26952] picpiclink
        2. 1mph picpic
          1. chain a [26953] picpiclink
      2. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [50735] (1)
        1. 1dro picpic
          1. chain a [26954] picpiclink
      3. Human (Homo sapiens), brain 2 isoform [TaxId: 9606] [117243] (1)
        SQ O15020 2219-2324
        1. 1wjm picpic
          Structural genomics target
          1. chain a [114702] picpiclink
    3. Dynamin [50736]
      1. Human (Homo sapiens) [TaxId: 9606] [50737] (2)
        1. 2dyn picpic
          1. chain a [26957] picpiclink
          2. chain b [26958] picpiclink
        2. 1dyn picpic
          1. chain a [26955] picpiclink
          2. chain b [26956] picpiclink
    4. Bruton's tyrosine kinase [50738]
      contains Btk zinc-binding motif
      1. Human (Homo sapiens) [TaxId: 9606] [50739] (7)
        1. 1btk picpic
          complexed with na, zn; mutant
          1. chain a [26959] picpiclink
          2. chain b [26960] picpiclink
        2. 1bwn picpic
          complexed with 4ip, zn; mutant
          1. chain a [26961] picpiclink
          2. chain b [26962] picpiclink
        3. 2z0p picpic
          automatically matched to d1b55a_
          complexed with 4pt, zn
          1. region a:2-168 [153912] picpiclink
        4. 2z0p picpic
          automatically matched to d1b55a_
          complexed with 4pt, zn
          1. region b:2-168 [153913] picpiclink
        5. 2z0p picpic
          automatically matched to d1b55a_
          complexed with 4pt, zn
          1. region c:2-168 [153914] picpiclink
        6. 2z0p picpic
          automatically matched to d1b55a_
          complexed with 4pt, zn
          1. region d:2-168 [153915] picpiclink
        7. 1b55 picpic
          complexed with its, zn
          1. chain a [26963] picpiclink
          2. chain b [26964] picpiclink
    5. Pleckstrin [50740]
      1. Human (Homo sapiens) [TaxId: 9606] [50741] (9)
        1. 2i5f picpic
          automatically matched to d1xx0a1
          complexed with 5ip
          1. region a:244-347 [147512] picpiclink
        2. 2i5c picpic
          automatically matched to d1xx0a1
          complexed with ip5
          1. region a:244-347 [147507] picpiclink
        3. 2i5c picpic
          automatically matched to d1xx0a1
          complexed with ip5
          1. region b:244-347 [147508] picpiclink
        4. 2i5c picpic
          automatically matched to d1xx0a1
          complexed with ip5
          1. region c:244-347 [147509] picpiclink
        5. 1zm0 picpic
          2nd PH domain
          1. region a:243-347 [125276] picpiclink
        6. 1zm0 picpic
          automatically matched to 1ZM0 A:243-347
          1. region b:243-347 [125277] picpiclink
        7. 1xx0 picpic
          2nd PH domain
          1. region a:234-350 [122412] picpiclink
        8. 1x05 picpic
          2nd PH domain
          1. region a:8-123 [121543] picpiclink
        9. 1pls picpic
          mutant
          1. chain a [26965] picpiclink
    6. Son of sevenless-1 (sos-1) [50742]
      1. Mouse (Mus musculus) [TaxId: 10090] [50743] (1)
        1. 1pms picpic
          mutant
          1. chain a [26966] picpiclink
      2. Human (Homo sapiens) [TaxId: 9606] [50744] (4)
        SQ Q07889 189-1046
        1. 1dbh picpicxref
          1. region a:418-550 [26967] picpiclink
        2. 1xdv picpicxrefxref
          1. region a:419-549 [115182] picpiclink
          2. region b:419-549 [115185] picpiclink
        3. 1xd4 picpicxrefxref
          1. region a:419-549 [115151] picpiclink
          2. region b:419-549 [115154] picpiclink
        4. 1awe picpic
          1. chain a [26968] picpiclink
    7. GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745]
      1. Mouse (Mus musculus) [TaxId: 10090] [50746] (1)
        1. 1foe picpicxrefxref
          complexed with so4; mutant
          1. region a:1240-1401 [26969] picpiclink
          2. region c:1240-1401 [26970] picpiclink
          3. region e:1240-1401 [26971] picpiclink
          4. region g:1240-1401 [26972] picpiclink
    8. Dbl's big sister, Dbs [74989]
      1. Mouse (Mus musculus) [TaxId: 10090] [74990] (4)
        SQ Q64096 624-958 # 98% sequence identity; the rat sequence Q63406 region 499-833 is 100% identical to the PDB sequence
        1. 1kz7 picpicxrefxref
          complexed with mse; mutant
          1. region a:819-965 [73334] picpiclink
          2. region c:1819-1960 [73337] picpiclink
        2. 1kzg picpicxrefxref
          mutant
          1. region a:819-965 [73356] picpiclink
          2. region c:1819-1960 [73359] picpiclink
        3. 1lb1 picpicxrefxref
          mutant
          1. region a:819-953 [73785] picpiclink
          2. region c:819-953 [73788] picpiclink
          3. region e:819-953 [73791] picpiclink
          4. region g:819-953 [73794] picpiclink
        4. 1rj2 picpicxref
          1. region a:819-950 [104955] picpiclink
          2. region d:819-950 [104957] picpiclink
          3. region g:819-950 [104959] picpiclink
          4. region j:819-950 [104961] picpiclink
    9. GEF of intersectin [74991]
      1. Human (Homo sapiens) [TaxId: 9606] [74992] (1)
        1. 1ki1 picpicxrefxref
          complexed with so4; mutant
          1. region b:1439-1580 [72498] picpiclink
          2. region d:1439-1580 [72501] picpiclink
    10. G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747]
      1. Human (Homo sapiens) [TaxId: 9606] [50748] (1)
        1. 1bak picpic
          mutant
          1. chain a [26973] picpiclink
      2. Cow (Bos taurus) [TaxId: 9913] [89354] (6)
        1. 1omw picpicxrefxrefxrefxref
          complexed with cmt; mutant
          1. region a:550-668 [87087] picpiclink
        2. 2bcj picpicxrefxrefxrefxrefxrefxref
          automatically matched to d1omwa2
          complexed with ace, alf, gdp, mg; mutant
          1. region a:550-656 [128287] picpiclink
        3. 1ym7 picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1omwa2
          mutant
          1. region a:550-656 [123686] picpiclink
        4. 1ym7 picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1omwa2
          mutant
          1. region b:550-656 [123689] picpiclink
        5. 1ym7 picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1omwa2
          mutant
          1. region c:550-656 [123692] picpiclink
        6. 1ym7 picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1omwa2
          mutant
          1. region d:552-656 [123695] picpiclink
    11. Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749]
      1. Human (Homo sapiens) [TaxId: 9606] [50750] (2)
        1. 1fao picpic
          complexed with its
          1. chain a [26974] picpiclink
        2. 1fb8 picpic
          complexed with po4
          1. chain a [26975] picpiclink
    12. Grp1 [50751]
      ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
      1. Mouse (Mus musculus) [TaxId: 10090] [50752] (8)
        1. 1fgy picpic
          complexed with 4ip
          1. chain a [26976] picpiclink
        2. 2r09 picpicxrefxref
          automatically matched to d1fhwb_
          complexed with 4ip, pe5, pge, so4; mutant
          1. region a:266-391 [151493] picpiclink
        3. 2r09 picpicxrefxref
          automatically matched to d1fhwb_
          complexed with 4ip, pe5, pge, so4; mutant
          1. region b:266-391 [151495] picpiclink
        4. 1fhw picpic
          complexed with i5p, so4
          1. chain a [26977] picpiclink
          2. chain b [26978] picpiclink
        5. 2r0d picpicxrefxref
          automatically matched to d1fhwb_
          complexed with 4ip, peg, so4; mutant
          1. region a:266-391 [151497] picpiclink
        6. 2r0d picpicxrefxref
          automatically matched to d1fhwb_
          complexed with 4ip, peg, so4; mutant
          1. region b:266-391 [151499] picpiclink
        7. 1fgz picpic
          complexed with so4
          1. chain a [26979] picpiclink
        8. 1fhx picpic
          complexed with 4ip, so4
          1. chain a [26980] picpiclink
          2. chain b [26981] picpiclink
    13. UNC-89 [50753]
      1. Nematode (Caenorhabditis elegans) [TaxId: 6239] [50754] (1)
        1. 1fho picpic
          1. chain a [26982] picpiclink
    14. Tapp1 [74993]
      1. Human (Homo sapiens) [TaxId: 9606] [74994] (1)
        1. 1eaz picpic
          phosphoinositol (3,4)-bisphosphate binding PH domain
          complexed with cit
          1. chain a [70113] picpiclink
    15. Rac-alpha serine/threonine kinase [89355]
      1. Human (Homo sapiens) [TaxId: 9606] [89356] (5)
        SQ P31749 1-117
        1. 1unq picpic
          complexed with ace, its
          1. chain a [107968] picpiclink
        2. 1unr picpic
          complexed with so4
          1. chain a [107969] picpiclink
        3. 1h10 picpic
          complexed with ace, its, mse
          1. chain a [83446] picpiclink
        4. 1unp picpic
          1. chain a [107967] picpiclink
        5. 2uvm picpic
          automatically matched to d1unpa_
          complexed with gvf, na
          1. region a:3-116 [139979] picpiclink
    16. Rac-beta serine/threonine protein kinase (PKB/AKT) [110254]
      1. Human (Homo sapiens) [TaxId: 9606] [110255] (1)
        SQ P31751 1-111
        1. 1p6s picpic
          1. chain a [104075] picpiclink
    17. SH2 and PH domain-containing adapter protein APS [110256]
      1. Mouse (Mus musculus) [TaxId: 10090] [110257] (1)
        SQ Q9JID9 178-299
        1. 1v5m picpic
          Structural genomics target
          mutant
          1. chain a [108379] picpiclink
    18. Tapp2 [110258]
      1. Mouse (Mus musculus) [TaxId: 10090] [110259] (1)
        SQ Q9ERS5 1-113
        1. 1v5p picpic
          Structural genomics target
          1. chain a [108382] picpiclink
    19. SET binding factor 1, Sbf1 [110260]
      1. Mouse (Mus musculus) [TaxId: 10090] [110261] (1)
        SQ Q8K2Z0 256-367
        1. 1v5u picpic
          Structural genomics target
          1. chain a [108386] picpiclink
    20. Rac/CDC42 GEF 6, alpha-pix [110262]
      1. Mouse (Mus musculus) [TaxId: 10090] [110263] (1)
        SQ Q8K4I3 429-551
        1. 1v61 picpic
          Structural genomics target
          1. chain a [108389] picpiclink
    21. Triple functional domain protein TRIO [110264]
      1. Human (Homo sapiens) [TaxId: 9606] [110265] (2)
        SQ O75962 1231-1535
        1. 1nty picpicxref
          1. region a:1415-1535 [103874] picpiclink
        2. 2nz8 picpicxrefxref
          automatically matched to d1ntya2
          1. region b:1415-1535 [138839] picpiclink
    22. Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266]
      1. Human (Homo sapiens) [TaxId: 9606] [110267] (1)
        SQ Q9BZF1 149-265
        1. 1v88 picpic
          Structural genomics target
          1. chain a [108423] picpiclink
    23. Rho-GTPase-activating protein 25 (KIAA0053) [110268]
      1. Human (Homo sapiens) [TaxId: 9606] [110269] (1)
        SQ P42331 40-144
        1. 1v89 picpic
          Structural genomics target
          1. chain a [108424] picpiclink
    24. Rho guanine nucleotide exchange factor 12 [110270]
      1. Human (Homo sapiens), gamma isoform [TaxId: 9606] [110271] (2)
        SQ Q9NZN5 766-1138
        1. 1txd picpicxref
          1. region a:1020-1133 [107423] picpiclink
        2. 1x86 picpicxrefxref
          complexed with po4; mutant
          1. region a:1020-1133 [109505] picpiclink
          2. region c:1020-1133 [109508] picpiclink
          3. region e:1020-1133 [109511] picpiclink
          4. region g:1020-1133 [109514] picpiclink
    25. Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244]
      1. Human (Homo sapiens) [TaxId: 9606] [117245] (2)
        SQ Q9H4M7 47-153
        1. 1upq picpic
          complexed with so4
          1. chain a [113392] picpiclink
        2. 1upr picpic
          complexed with its
          1. chain a [113393] picpiclink
    26. 3-phosphoinositide dependent protein kinase-1 [117246]
      1. Human (Homo sapiens) [TaxId: 9606] [117247] (3)
        SQ O15530 409-550
        1. 1w1h picpic
          complexed with gol, so4
          1. chain a [114076] picpiclink
          2. chain b [114077] picpiclink
          3. chain c [114078] picpiclink
          4. chain d [114079] picpiclink
        2. 1w1d picpic
          complexed with 4ip, au, gol
          1. chain a [114074] picpiclink
        3. 1w1g picpic
          complexed with 4pt
          1. chain a [114075] picpiclink
    27. Dedicator of cytokinesis protein 9, DOCK9 [117248]
      1. Human (Homo sapiens) [TaxId: 9606] [117249] (1)
        SQ Q9BZ29 165-301
        1. 1wg7 picpic
          Structural genomics target
          1. chain a [114604] picpiclink
    28. FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250]
      1. Mouse (Mus musculus) [TaxId: 10090] [117251] (1)
        SQ Q69ZL1 1303-1389
        1. 1wgq picpic
          Structural genomics target
          1. chain a [114620] picpiclink
    29. Calcium-dependent activator protein for secretion, CAPS [117252]
      1. Human (Homo sapiens) [TaxId: 9606] [117253] (1)
        SQ Q8NFR0 522-634
        1. 1wi1 picpic
          Structural genomics target
          1. chain a [114658] picpiclink
    30. Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254]
      1. Human (Homo sapiens) [TaxId: 9606] [117255] (1)
        SQ O15085 714-1081
        1. 1xcg picpicxrefxref
          mutant
          1. region a:942-1081 [115121] picpiclink
          2. region e:942-1081 [115124] picpiclink
    31. Centaurin-delta 1 [141395]
      1. Human (Homo sapiens) [TaxId: 9606] [141396] (1)
        SQ Q8WZ64 483-584
        1. 2cod picpic
          1. region a:8-109 [130675] picpiclink
    32. Cytohesin 3 [141397]
      1. Mouse (Mus musculus) [TaxId: 10090] [141398] (1)
        SQ O08967 261-387
        1. 1u2b picpic
          complexed with so4
          1. region a:261-387 [119474] picpiclink
    33. Exocyst complex protein EXO84 [141399]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [141400] (4)
        SQ O54924 171-283
        1. 1zc3 picpicxrefxref
          automatically matched to 1ZC4 B:171-283
          complexed with gnp, mg; mutant
          1. region b:171-279 [124881] picpiclink
        2. 1zc3 picpicxrefxref
          automatically matched to 1ZC4 B:171-283
          complexed with gnp, mg; mutant
          1. region d:171-279 [124883] picpiclink
        3. 1zc4 picpicxrefxref
          complexed with gnp, mg; mutant
          1. region b:171-283 [124885] picpiclink
        4. 1zc4 picpicxrefxref
          automatically matched to 1ZC4 B:171-283
          complexed with gnp, mg; mutant
          1. region d:171-283 [124887] picpiclink
    34. Cytohesin 2 [141401]
      1. Mouse (Mus musculus) [TaxId: 10090] [141402] (2)
        SQ P63034 260-378
        1. 1u29 picpic
          automatically matched to 1U27 A:260-378
          complexed with i3p
          1. region a:260-378 [119473] picpiclink
        2. 1u27 picpic
          complexed with 4ip
          1. region a:260-378 [119467] picpiclink
    35. Src kinase-associated phosphoprotein SKAP55 (SCAP1) [141403]
      1. Human (Homo sapiens) [TaxId: 9606] [141404] (4)
        SQ O15268 108-213
        1. 1u5d picpic
          complexed with so4; mutant
          1. region a:108-213 [119536] picpiclink
        2. 1u5d picpic
          automatically matched to 1U5D A:108-213
          complexed with so4; mutant
          1. region b:108-212 [119537] picpiclink
        3. 1u5d picpic
          automatically matched to 1U5D A:108-213
          complexed with so4; mutant
          1. region c:108-212 [119538] picpiclink
        4. 1u5d picpic
          automatically matched to 1U5D A:108-213
          complexed with so4; mutant
          1. region d:108-213 [119539] picpiclink
    36. Signal-transducing adaptor protein 1, STAP-1 [141405]
      1. Human (Homo sapiens) [TaxId: 9606] [141406] (1)
        SQ Q9ULZ2 16-151
        1. 1x1f picpic
          1. region a:8-143 [121579] picpiclink
    37. KIAA1914 [141407]
      1. Human (Homo sapiens) [TaxId: 9606] [141408] (1)
        SQ Q8N4X5 354-448
        1. 2cof picpic
          1. region a:8-102 [130676] picpiclink
    38. Pleckstrin-2 [141409]
      1. Human (Homo sapiens) [TaxId: 9606] [141410] (1)
        SQ Q9NYT0 238-353
        1. 1x1g picpic
          2nd PH domain
          1. region a:8-123 [121580] picpiclink
    39. Alpha-1-syntrophin [141411]
      1. Mouse (Mus musculus) [TaxId: 10090] [141412] (1)
        SQ Q61234 2-44,203-264
        1. 2adz picpic
          split PH domain; excluded region 44-116 contains disordered bits of truncated PDZ domain-containing insert region
          1. region a:1-43,a:117-178 [126599] picpiclink
    40. Phosphoinositide phospholipase C, PLC-gamma-1 [141413]
      contains split PH domain
      1. Rat (Rattus norvegicus) [TaxId: 10116] [141414] (1)
        SQ P10686 489-525,870-933
        1. 2fjl picpic
          split PH domain; disordered bits of insert domains and an artificial linker are excluded
          1. region a:1-37,a:87-150 [133611] picpiclink
    41. FYVE, RhoGEF and PH domain containing protein 3, FGD3 [141415]
      1. Human (Homo sapiens) [TaxId: 9606] [141416] (1)
        SQ Q5JSP0 605-703
        1. 2coc picpic
          1. region a:8-106 [130674] picpiclink
    42. Src-associated adaptor protein Skap2 [141417]
      1. Mouse (Mus musculus) [TaxId: 10090] [141418] (9)
        SQ Q9Z2K4 105-212! SQ Q9Z2K4 109-219! SQ Q9Z2K4 14-222
        1. 1u5f picpic
          complexed with so4; mutant
          1. region a:109-219 [119542] picpiclink
        2. 1u5g picpic
          mutant
          1. region a:105-219 [119543] picpiclink
        3. 1u5g picpic
          automatically matched to 1U5G A:105-219
          mutant
          1. region b:105-219 [119544] picpiclink
        4. 1u5g picpic
          automatically matched to 1U5G A:105-219
          mutant
          1. region c:105-219 [119545] picpiclink
        5. 1u5g picpic
          automatically matched to 1U5G A:105-219
          mutant
          1. region d:105-219 [119546] picpiclink
        6. 1u5e picpic
          includes extra N-terminal alpha-hairpin, dimerisation subdomain
          mutant
          1. region a:14-222 [119540] picpiclink
        7. 1u5e picpic
          automatically matched to 1U5E A:14-222
          mutant
          1. region b:14-222 [119541] picpiclink
        8. 2otx picpic
          automatically matched to 1U5E A:14-222
          mutant
          1. region a:14-222 [139373] picpiclink
        9. 2otx picpic
          automatically matched to 1U5E A:14-222
          mutant
          1. region b:14-222 [139374] picpiclink
    43. Protein kinase c, d2 type [141419]
      1. Human (Homo sapiens) [TaxId: 9606] [141420] (1)
        SQ Q9BZL6 398-509
        1. 2coa picpic
          1. region a:8-119 [130672] picpiclink
    44. Phospholipase C-beta-2 [159207]
      1. Human (Homo sapiens) [TaxId: 9606] [159208] (2)
        SQ Q00722 11-141
        1. 2zkm picpicxrefxrefxref
          automatically matched to 2FJU B:11-141
          complexed with ca
          1. region x:11-141 [154589] picpiclink
        2. 2fju picpicxrefxrefxrefxref
          complexed with ca, gsp, mg
          1. region b:11-141 [145172] picpiclink
    45. Rho guanine nucleotide exchange factor 9, Collybistin [159209]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [159210] (1)
        SQ Q9QX73 300-461
        1. 2dfk picpicxrefxrefxref
          complexed with gol, so4
          1. region a:240-401 [145078] picpiclink
    46. DCC-interacting protein 13-alpha, APPL1 [159211]
      1. Human (Homo sapiens) [TaxId: 9606] [159212] (1)
        SQ Q9UKG1 274-374
        1. 2elb picpicxref
          1. region a:274-374 [146896] picpiclink
    47. Rho GTPase-activating protein 21 [159213]
      1. Human (Homo sapiens) [TaxId: 9606] [159214] (6)
        SQ Q5T5U3 931-1063
        1. 2j59 picpicxrefxrefxrefxrefxrefxref
          complexed with dio, edo, gtp, mg, so4; mutant
          1. region m:931-1063 [145656] picpiclink
        2. 2j59 picpicxrefxrefxrefxrefxrefxref
          automatically matched to 2J59 M:931-1063
          complexed with dio, edo, gtp, mg, so4; mutant
          1. region n:931-1063 [145657] picpiclink
        3. 2j59 picpicxrefxrefxrefxrefxrefxref
          automatically matched to 2J59 M:931-1063
          complexed with dio, edo, gtp, mg, so4; mutant
          1. region o:931-1061 [145658] picpiclink
        4. 2j59 picpicxrefxrefxrefxrefxrefxref
          automatically matched to 2J59 M:931-1063
          complexed with dio, edo, gtp, mg, so4; mutant
          1. region p:931-1063 [145659] picpiclink
        5. 2j59 picpicxrefxrefxrefxrefxrefxref
          automatically matched to 2J59 M:931-1063
          complexed with dio, edo, gtp, mg, so4; mutant
          1. region q:931-1063 [145660] picpiclink
        6. 2j59 picpicxrefxrefxrefxrefxrefxref
          automatically matched to 2J59 M:931-1063
          complexed with dio, edo, gtp, mg, so4; mutant
          1. region r:931-1063 [145661] picpiclink
  2. Phosphotyrosine-binding domain (PTB) [50755] (14)
    Pfam 00640
    1. X11 [50756]
      1. Human (Homo sapiens) [TaxId: 9606] [50757] (2)
        1. 1aqc picpic
          1. chain a [26983] picpiclink
          2. chain b [26984] picpiclink
        2. 1x11 picpic
          1. chain a [26985] picpiclink
          2. chain b [26986] picpiclink
    2. Insulin receptor substrate 1, IRS-1 [50758]
      duplication: contains two domains of this fold
      1. Human (Homo sapiens) [TaxId: 9606] [50759] (2)
        1. 1qqg picpic
          1. region a:12-114 [26987] picpiclink
          2. region a:159-262 [26988] picpiclink
          3. region b:11-114 [26989] picpiclink
          4. region b:159-264 [26990] picpiclink
        2. 1irs picpic
          second domain complexed with a IL-4 receptor phosphopeptide
          1. chain a [26991] picpiclink
    3. Shc adaptor protein [50760]
      1. Human (Homo sapiens) [TaxId: 9606] [50761] (3)
        1. 1oy2 picpic
          1. chain a [93717] picpiclink
        2. 1shc picpic
          1. chain a [26992] picpiclink
        3. 1n3h picpic
          1. chain a [91564] picpiclink
    4. Numb [50762]
      1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [50763] (2)
        1. 2nmb picpic
          complexed with a phosphotyrosine peptide
          1. chain a [26994] picpiclink
        2. 1ddm picpic
          complexed to a nak peptide
          1. chain a [26993] picpiclink
      2. Mouse (Mus musculus) [TaxId: 10090] [117256] (1)
        SQ Q9QZS3 19-172
        1. 1wj1 picpic
          Structural genomics target
          1. chain a [114688] picpiclink
    5. Disabled homolog 1 (Dab1) [89357]
      1. Mouse (Mus musculus) [TaxId: 10090] [89358] (3)
        1. 1ntv picpic
          complexed with apoer2 peptide
          complexed with po4
          1. chain a [86168] picpiclink
        2. 1nu2 picpic
          complexed with apoer2 peptide and PI-4,5P2
          complexed with i3p
          1. chain a [86169] picpiclink
        3. 1oqn picpic
          complexed with peptide and I3P
          complexed with i3p
          1. chain a [93420] picpiclink
          2. chain b [93421] picpiclink
    6. Disabled homolog 2 (Dab2) [101830]
      1. Mouse (Mus musculus) [TaxId: 10090] [101831] (2)
        1. 1p3r picpic
          1. chain a [94065] picpiclink
          2. chain b [94066] picpiclink
          3. chain c [94067] picpiclink
        2. 1m7e picpic
          complexed with peptide
          1. chain a [91220] picpiclink
          2. chain b [91221] picpiclink
          3. chain c [91222] picpiclink
    7. Downstream of tyrosine kinase 5, Dok-5 [101832]
      1. Human (Homo sapiens) [TaxId: 9606] [101833] (1)
        1. 1j0w picpic
          1. chain a [90748] picpiclink
          2. chain b [90749] picpiclink
    8. Docking protein 1, Dok1 [101834]
      1. Mouse (Mus musculus) [TaxId: 10090] [101835] (2)
        SQ P97465 152-254
        1. 1p5t picpic
          1. chain a [94148] picpiclink
          2. chain b [94149] picpiclink
        2. 1uef picpic
          complexed with po3
          1. chain a [107788] picpiclink
          2. chain b [107789] picpiclink
    9. FGFR substrate 2 (SNT-1) [117257]
      1. Human (Homo sapiens) [TaxId: 9606] [117258] (1)
        SQ Q7LDQ6 11-129
        1. 1xr0 picpic
          complexed with BFGFR-1 peptide (SQ Q04589 409-430), chain A
          1. chain b [115858] picpiclink
    10. Amyloid beta A4 precursor protein-binding family B member 2, Apbb2 [117259]
      1. Mouse (Mus musculus) [TaxId: 10090] [117260] (2)
        SQ Q9DBR4 582-704
        1. 1wgu picpic
          Structural genomics target
          1. chain a [114623] picpiclink
        2. 2roz picpic
          automatically matched to d1wgua_
          1. region b:1-136 [152178] picpiclink
    11. Tensin [141421]
      1. Human (Homo sapiens) [TaxId: 9606] [141422] (1)
        SQ Q9UPS7 1139-1285
        Tensin2
        1. 2dkq picpic
          1. region a:8-154 [131556] picpiclink
      2. Chicken (Gallus gallus) [TaxId: 9031] [141423] (1)
        SQ Q04205 1606-1738
        1. 1wvh picpic
          1. region a:1606-1738 [121341] picpiclink
    12. EPS8-like protein 1, EPS8L1 [141424]
      1. Mouse (Mus musculus) [TaxId: 10090] [141425] (2)
        SQ Q8R5F8 31-159
        1. 2cy5 picpic
          automatically matched to 2CY4 A:31-159
          complexed with ca
          1. region a:31-159 [131018] picpiclink
        2. 2cy4 picpic
          complexed with ca
          1. region a:31-159 [131017] picpiclink
  3. Ran-binding domain [50764] (4)
    1. Nuclear pore complex protein Nup358 [50765]
      1. Human (Homo sapiens) [TaxId: 9606] [50766] (1)
        1. 1rrp picpicxref
          complexed with gnp, mg
          1. chain b [26995] picpiclink
          2. chain d [26996] picpiclink
    2. Ran-binding protein 1, Ranbp1 [69292]
      1. Human (Homo sapiens) [TaxId: 9606] [69293] (2)
        1. 1k5d picpicxrefxref
          complexed with gnp, mg; mutant
          1. chain b [68169] picpiclink
          2. chain e [68172] picpiclink
          3. chain h [68175] picpiclink
          4. chain k [68178] picpiclink
        2. 1k5g picpicxrefxref
          complexed with af3, gdp, mg; mutant
          1. chain b [68181] picpiclink
          2. chain e [68184] picpiclink
          3. chain h [68187] picpiclink
          4. chain k [68190] picpiclink
    3. Ran binding protein 3 [141426]
      1. Human (Homo sapiens) [TaxId: 9606] [141427] (1)
        SQ Q9H6Z4 380-516
        1. 2crf picpic
          1. region a:8-144 [130738] picpiclink
    4. Ran-binding protein 2 [141428]
      1. Human (Homo sapiens) [TaxId: 9606] [141429] (1)
        SQ P49792 2027-2154
        1. 1xke picpic
          1. region a:7-124 [122076] picpiclink
  4. Enabled/VASP homology 1 domain (EVH1 domain) [50767] (8)
    1. Enabled [50768]
      1. Mouse (Mus musculus) [TaxId: 10090] [50769] (1)
        1. 1evh picpic
          complexed with ace
          1. chain a [26997] picpiclink
      2. Homo sapiens [TaxId: 9606] [159215] (4)
        1. 2iyb picpic
          automatically matched to d1evha_
          complexed with zn
          1. region a:2-112 [147836] picpiclink
        2. 2iyb picpic
          automatically matched to d1evha_
          complexed with zn
          1. region b:2-112 [147837] picpiclink
        3. 2iyb picpic
          automatically matched to d1evha_
          complexed with zn
          1. region c:2-112 [147838] picpiclink
        4. 2iyb picpic
          automatically matched to d1evha_
          complexed with zn
          1. region d:2-112 [147839] picpiclink
    2. Ena/vasp-like protein [50770]
      1. Mouse (Mus musculus) [TaxId: 10090] [50771] (1)
        1. 1qc6 picpic
          mutant
          1. chain a [26998] picpiclink
          2. chain b [26999] picpiclink
    3. Vasodilator-stimulated phosphoprotein (VASP) [50772]
      1. Human (Homo sapiens) [TaxId: 9606] [50773] (1)
        1. 1egx picpic
          1. chain a [27000] picpiclink
    4. Homer [50774]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [50775] (3)
        1. 1i2h picpic
          1. chain a [71103] picpiclink
        2. 1ddw picpic
          mutant
          1. chain a [27001] picpiclink
        3. 1ddv picpic
          1. chain a [27002] picpiclink
      2. Mouse (Mus musculus), 2b/vesl 2 [TaxId: 10090] [63800] (1)
        1. 1i7a picpic
          complexed with flc, phe
          1. chain a [61880] picpiclink
          2. chain b [61881] picpiclink
          3. chain c [61882] picpiclink
          4. chain d [61883] picpiclink
    5. Actin regulatory protein WASP [82140]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [82141] (1)
        1. 1mke picpic
          pseudo complex: fusion protein with a WIP peptide (res. 1-25) and a linker peptide (res. 26-30)
          1. region a:31-144 [79231] picpiclink
    6. Sprouty-related, EVH1 domain-containing protein 1, Spred-1 [141430]
      1. Western clawed frog (Xenopus tropicalis) [TaxId: 8364] [141431] (4)
        SQ Q66JG9 10-123! SQ Q66JG9 9-123
        1. 1xod picpic
          complexed with gol
          1. region a:10-123 [122202] picpiclink
        2. 1xod picpic
          automatically matched to 1XOD A:10-123
          complexed with gol
          1. region b:10-123 [122203] picpiclink
        3. 1tj6 picpic
          mutant
          1. region a:9-123 [119286] picpiclink
        4. 1tj6 picpic
          automatically matched to 1TJ6 A:9-123
          mutant
          1. region b:9-123 [119287] picpiclink
  5. Dcp1 [101836] (1)
    close structural similarity to EVH1 domain
    1. Dcp1 [101837]
      decapping protein involved in mRNA degradation
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [101838] (1)
        1. 1q67 picpic
          1. chain a [95960] picpiclink
          2. chain b [95961] picpiclink
  6. Third domain of FERM [50776] (9)
    1. Moesin [50777]
      1. Human (Homo sapiens) [TaxId: 9606] [50778] (3)
        SQ P26038 4-297
        1. 1ef1 picpicxrefxrefxref
          complexed with so4
          1. region a:199-297 [27003] picpiclink
          2. region b:199-297 [27004] picpiclink
        2. 1e5w picpicxrefxref
          includes first long helix
          1. region a:199-346 [59281] picpiclink
        3. 1sgh picpicxrefxrefxref
          1. region a:199-297 [105530] picpiclink
    2. Radixin [50779]
      1. Mouse (Mus musculus) [TaxId: 10090] [50780] (20)
        1. 2zpy picpicxrefxref
          automatically matched to d1gc6a2
          1. region a:199-297 [154759] picpiclink
        2. 1j19 picpicxrefxref
          1. region a:199-317 [83959] picpiclink
        3. 2d10 picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region a:199-297 [131098] picpiclink
        4. 2d10 picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region b:199-297 [131101] picpiclink
        5. 2d10 picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region c:199-297 [131104] picpiclink
        6. 2d10 picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region d:199-297 [131107] picpiclink
        7. 1gc7 picpicxrefxref
          1. region a:199-297 [27005] picpiclink
        8. 2d11 picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region a:199-296 [131110] picpiclink
        9. 2d11 picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region b:199-296 [131113] picpiclink
        10. 2d11 picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region c:199-296 [131116] picpiclink
        11. 2d11 picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region d:199-296 [131119] picpiclink
        12. 2d2q picpicxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region a:199-297 [131183] picpiclink
        13. 2d2q picpicxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region b:199-297 [131186] picpiclink
        14. 1gc6 picpicxrefxref
          complexed with i3p
          1. region a:199-297 [27006] picpiclink
        15. 2ems picpicxrefxref
          automatically matched to d1gc6a2
          1. region a:199-297 [146926] picpiclink
        16. 2emt picpicxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region a:199-297 [146929] picpiclink
        17. 2emt picpicxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region b:199-297 [146932] picpiclink
        18. 2yvc picpicxrefxrefxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region a:199-297 [140079] picpiclink
        19. 2yvc picpicxrefxrefxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region b:199-296 [140082] picpiclink
        20. 2yvc picpicxrefxrefxrefxrefxrefxref
          automatically matched to d1gc6a2
          1. region c:199-296 [140085] picpiclink
    3. Ezrin [82142]
      complexed with the icam-2 cytoplasmic peptide, chain B
      1. Human (Homo sapiens) [TaxId: 9606] [82143] (1)
        1. 1ni2 picpicxrefxref
          1. region a:199-297 [80526] picpiclink
          2. region b:199-297 [80529] picpiclink
    4. Erythroid membrane protein 4.1R [50781]
      1. Human (Homo sapiens) [TaxId: 9606] [50782] (1)
        1. 1gg3 picpicxrefxref
          1. region a:188-279 [27007] picpiclink
          2. region b:188-279 [27008] picpiclink
          3. region c:188-279 [27009] picpiclink
    5. Merlin [69294]
      the neurofibromatosis 2 tumor suppressor protein
      1. Human (Homo sapiens) [TaxId: 9606] [69295] (1)
        1. 1h4r picpicxrefxref
          complexed with so4
          1. region a:215-313 [65617] picpiclink
          2. region b:215-313 [65620] picpiclink
      2. Mouse (Mus musculus) [TaxId: 10090] [74995] (1)
        1. 1isn picpicxrefxref
          1. region a:215-340 [71401] picpiclink
    6. Talin [82144]
      1. Chicken (Gallus gallus) [TaxId: 9031] [82145] (6)
        1. 1mix picpicxref
          1. region a:309-400 [79167] picpiclink
        2. 2k00 picpic
          automatically matched to d1mixa2
          1. region a:309-400 [148252] picpiclink
        3. 2g35 picpic
          automatically matched to d1mixa2
          1. region a:5-96 [134548] picpiclink
        4. 1miz picpicxref
          1. region b:309-400 [79173] picpiclink
        5. 1mk7 picpicxref
          1. region b:309-400 [79220] picpiclink
          2. region d:309-400 [79222] picpiclink
        6. 1mk9 picpicxref
          1. region b:309-398 [79224] picpiclink
          2. region d:309-400 [79226] picpiclink
          3. region f:309-398 [79228] picpiclink
          4. region h:309-400 [79230] picpiclink
    7. Talin-1 [117261]
      1. Mouse (Mus musculus) [TaxId: 10090] [117262] (1)
        SQ P26039 209-410
        1. 1y19 picpicxref
          complexed with (covalently linked) peptide from PIP5KIgamma (SQ O70161 638-651), chains A, C, E, G, I and K
          1. region b:309-400 [116330] picpiclink
          2. region d:309-400 [116332] picpiclink
          3. region f:309-400 [116334] picpiclink
          4. region h:309-400 [116336] picpiclink
          5. region j:309-400 [116338] picpiclink
          6. region l:309-400 [116340] picpiclink
    8. Focal adhesion kinase 1 [141432]
      1. Chicken (Gallus gallus) [TaxId: 9031] [141433] (5)
        SQ Q00944 254-363
        1. 2al6 picpicxrefxrefxrefxref
          1. region a:254-363 [126967] picpiclink
        2. 2al6 picpicxrefxrefxrefxref
          automatically matched to 2AL6 A:254-363
          1. region b:254-363 [126970] picpiclink
        3. 2aeh picpicxrefxrefxrefxref
          automatically matched to 2AL6 A:254-363
          1. region a:254-363 [126626] picpiclink
        4. 2aeh picpicxrefxrefxrefxref
          automatically matched to 2AL6 A:254-363
          1. region b:254-363 [126629] picpiclink
        5. 2j0m picpicxrefxref
          automatically matched to d2aeha2
          complexed with 4st
          1. region a:254-359 [147846] picpiclink
  7. PreBEACH PH-like domain [82146] (2)
    1. PH-like domain of neurobeachin [82147]
      1. Human (Homo sapiens) [TaxId: 9606] [82148] (1)
        1. 1mi1 picpicxref
          complexed with mse
          1. region a:2140-2248 [79138] picpiclink
          2. region b:2140-2248 [79140] picpiclink
    2. Lipopolysaccharide-responsive and beige-like anchor protein LRBA [117263]
      1. Human (Homo sapiens) [TaxId: 9606] [117264] (1)
        SQ P50851 2076-2489
        1. 1t77 picpicxref
          1. region a:2076-2185 [112291] picpiclink
          2. region b:2076-2185 [112293] picpiclink
          3. region c:2076-2185 [112295] picpiclink
          4. region d:2076-2185 [112297] picpiclink
  8. GRAM domain [101839] (1)
    1. Myotubularin-related protein 2, N-terminal domain [101840]
      1. Human (Homo sapiens) [TaxId: 9606] [101841] (4)
        1. 1zsq picpicxref
          automatically matched to d1lw3a1
          complexed with edo, pib; mutant
          1. region a:74-198 [125616] picpiclink
        2. 1zvr picpicxref
          automatically matched to d1lw3a1
          complexed with 3pi, edo; mutant
          1. region a:74-198 [125723] picpiclink
        3. 1lw3 picpicxref
          complexed with po4; mutant
          1. region a:74-198 [91152] picpiclink
        4. 1m7r picpicxref
          complexed with po4; mutant
          1. region a:74-198 [91223] picpiclink
          2. region b:74-198 [91225] picpiclink
  9. TFIIH domain [110272] (2)
    1. TFIIH basal transcription factor complex p62 subunit (BTF2-p62), N-terminal domain [110273]
      1. Human (Homo sapiens) [TaxId: 9606] [110274] (2)
        SQ P32780 1-108
        1. 2rnr picpic
          automatically matched to d1pfja_
          1. region b:1-108 [152172] picpiclink
        2. 1pfj picpic
          1. chain a [104145] picpiclink
    2. RNA polymerase II transcription factor B 73 kDa, TFB1 [141434]
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141435] (3)
        SQ P32776 2-115
        1. 1y5o picpic
          mutant
          1. region a:2-115 [122650] picpiclink
        2. 2gs0 picpic
          automatically matched to 1Y5O A:2-115
          mutant
          1. region a:2-115 [135573] picpiclink
        3. 2k2u picpic
          automatically matched to d1y5oa1
          1. region a:2-115 [148262] picpiclink
  10. SSRP1-like [141436] (1)
    Pfam 03531; Structure-specific recognition protein family; duplication: comprises tandem repeat of two domains of this fold
    1. FACT complex subunit POB3, middle domain [141437]
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141438] (6)
        SQ Q04636 237-474! SQ Q04636 238-474
        1. 2gcl picpic
          complexed with cl
          1. region a:237-474 [134991] picpiclink
        2. 2gcl picpic
          automatically matched to 2GCL A:237-474
          complexed with cl
          1. region b:238-474 [134992] picpiclink
        3. 2gcj picpic
          mutant
          1. region a:238-474 [134987] picpiclink
        4. 2gcj picpic
          automatically matched to 2GCJ A:238-474
          mutant
          1. region b:238-474 [134988] picpiclink
        5. 2gcj picpic
          automatically matched to 2GCJ A:238-474
          mutant
          1. region c:238-474 [134989] picpiclink
        6. 2gcj picpic
          automatically matched to 2GCJ A:238-474
          mutant
          1. region d:238-474 [134990] picpiclink
  11. Necap1 N-terminal domain-like [141439] (1)
    Pfam 07933; DUF1681
    1. Necap1 [141440]
      1. Mouse (Mus musculus) [TaxId: 10090] [141441] (1)
        SQ Q9CR95 1-133
        1. 1tqz picpic
          1. region a:1-133 [119327] picpiclink
  12. VPS36 N-terminal domain-like [141442] (3)
    PfamB 030385
    1. Vacuolar protein sorting protein 36, VPS36 [141443]
      1. Human (Homo sapiens) [TaxId: 9606] [141444] (1)
        SQ Q86VN1 3-131
        1. 2hth picpicxref
          1. region b:3-131 [136743] picpiclink
      2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141445] (2)
        SQ Q06696 1-99,252-282
        1. 2cay picpic
          complexed with so4
          1. region a:1-99,a:252-282 [130167] picpiclink
        2. 2cay picpic
          automatically matched to 2CAY A:1-99,A:252-282
          complexed with so4
          1. region b:1-99,b:252-281 [130168] picpiclink
      3. Mouse (Mus musculus) [TaxId: 10090] [141446] (1)
        SQ Q91XD6 10-130
        1. 2dx5 picpicxref
          1. region a:10-130 [131866] picpiclink
  13. BPHL domain [159216] (2)
    Pfam 08000; DUF1696, bacterial proteins with PH-like domain
    1. Uncharacterized protein Exig2160 [159217]
      homododecameric ring assembly; olizomerization is mediated by the C-terminal alpha-hairpin extension
      1. Exiguobacterium sibiricum 255-15 [TaxId: 262543] [159218] (6)
        SQ B1YJX4 14-203
        1. 3b77 picpic
          1. region a:14-203 [154921] picpiclink
        2. 3b77 picpic
          automatically matched to 3B77 A:14-203
          1. region b:14-203 [154922] picpiclink
        3. 3b77 picpic
          automatically matched to 3B77 A:14-203
          1. region c:14-203 [154923] picpiclink
        4. 3b77 picpic
          automatically matched to 3B77 A:14-203
          1. region d:14-203 [154924] picpiclink
        5. 3b77 picpic
          automatically matched to 3B77 A:14-203
          1. region e:15-203 [154925] picpiclink
        6. 3b77 picpic
          automatically matched to 3B77 A:14-203
          1. region f:15-203 [154926] picpiclink
    2. Uncharacterized protein Shew0819 [159219]
      homopentameric ring assembly through the pairing of the beta-barrel edge strands
      1. Shewanella loihica [TaxId: 359303] [159220] (5)
        SQ A3QB43 9-124
        1. 3dcx picpic
          complexed with cl, mpd
          1. region a:9-124 [157541] picpiclink
        2. 3dcx picpic
          automatically matched to 3DCX A:9-124
          complexed with cl, mpd
          1. region b:12-124 [157542] picpiclink
        3. 3dcx picpic
          automatically matched to 3DCX A:9-124
          complexed with cl, mpd
          1. region c:10-124 [157543] picpiclink
        4. 3dcx picpic
          automatically matched to 3DCX A:9-124
          complexed with cl, mpd
          1. region d:12-124 [157544] picpiclink
        5. 3dcx picpic
          automatically matched to 3DCX A:9-124
          complexed with cl, mpd
          1. region e:13-124 [157545] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk