Structural Classification of Proteins
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Family: Pleckstrin-homology domain (PH domain)

Pfam 00169

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: PH domain-like barrel [50728]
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. Superfamily: PH domain-like [50729]
    link to SUPERFAMILY database - Superfamily
  5. Family: Pleckstrin-homology domain (PH domain) [50730]
    Pfam 00169

Protein Domains:

  1. Phospholipase C delta-1 [50731]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [50732] (1) picpic
  2. beta-spectrin [50733]
    1. Mouse (Mus musculus), brain [TaxId: 10090] [50734] (2) picpic
    2. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [50735] (1) picpic
    3. Human (Homo sapiens), brain 2 isoform [TaxId: 9606] [117243] (1) picpic
      SQ O15020 2219-2324
  3. Dynamin [50736]
    1. Human (Homo sapiens) [TaxId: 9606] [50737] (2) picpic
  4. Bruton's tyrosine kinase [50738]
    contains Btk zinc-binding motif
    1. Human (Homo sapiens) [TaxId: 9606] [50739] (7) picpic
  5. Pleckstrin [50740]
    1. Human (Homo sapiens) [TaxId: 9606] [50741] (9) picpic
  6. Son of sevenless-1 (sos-1) [50742]
    1. Mouse (Mus musculus) [TaxId: 10090] [50743] (1) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [50744] (4) picpic
      SQ Q07889 189-1046
  7. GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745]
    1. Mouse (Mus musculus) [TaxId: 10090] [50746] (1) picpic
  8. Dbl's big sister, Dbs [74989]
    1. Mouse (Mus musculus) [TaxId: 10090] [74990] (4) picpic
      SQ Q64096 624-958 # 98% sequence identity; the rat sequence Q63406 region 499-833 is 100% identical to the PDB sequence
  9. GEF of intersectin [74991]
    1. Human (Homo sapiens) [TaxId: 9606] [74992] (1) picpic
  10. G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747]
    1. Human (Homo sapiens) [TaxId: 9606] [50748] (1) picpic
    2. Cow (Bos taurus) [TaxId: 9913] [89354] (6) picpic
  11. Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749]
    1. Human (Homo sapiens) [TaxId: 9606] [50750] (2) picpic
  12. Grp1 [50751]
    ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
    1. Mouse (Mus musculus) [TaxId: 10090] [50752] (8) picpic
  13. UNC-89 [50753]
    1. Nematode (Caenorhabditis elegans) [TaxId: 6239] [50754] (1) picpic
  14. Tapp1 [74993]
    1. Human (Homo sapiens) [TaxId: 9606] [74994] (1) picpic
  15. Rac-alpha serine/threonine kinase [89355]
    1. Human (Homo sapiens) [TaxId: 9606] [89356] (5) picpic
      SQ P31749 1-117
  16. Rac-beta serine/threonine protein kinase (PKB/AKT) [110254]
    1. Human (Homo sapiens) [TaxId: 9606] [110255] (1) picpic
      SQ P31751 1-111
  17. SH2 and PH domain-containing adapter protein APS [110256]
    1. Mouse (Mus musculus) [TaxId: 10090] [110257] (1) picpic
      SQ Q9JID9 178-299
  18. Tapp2 [110258]
    1. Mouse (Mus musculus) [TaxId: 10090] [110259] (1) picpic
      SQ Q9ERS5 1-113
  19. SET binding factor 1, Sbf1 [110260]
    1. Mouse (Mus musculus) [TaxId: 10090] [110261] (1) picpic
      SQ Q8K2Z0 256-367
  20. Rac/CDC42 GEF 6, alpha-pix [110262]
    1. Mouse (Mus musculus) [TaxId: 10090] [110263] (1) picpic
      SQ Q8K4I3 429-551
  21. Triple functional domain protein TRIO [110264]
    1. Human (Homo sapiens) [TaxId: 9606] [110265] (2) picpic
      SQ O75962 1231-1535
  22. Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266]
    1. Human (Homo sapiens) [TaxId: 9606] [110267] (1) picpic
      SQ Q9BZF1 149-265
  23. Rho-GTPase-activating protein 25 (KIAA0053) [110268]
    1. Human (Homo sapiens) [TaxId: 9606] [110269] (1) picpic
      SQ P42331 40-144
  24. Rho guanine nucleotide exchange factor 12 [110270]
    1. Human (Homo sapiens), gamma isoform [TaxId: 9606] [110271] (2) picpic
      SQ Q9NZN5 766-1138
  25. Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244]
    1. Human (Homo sapiens) [TaxId: 9606] [117245] (2) picpic
      SQ Q9H4M7 47-153
  26. 3-phosphoinositide dependent protein kinase-1 [117246]
    1. Human (Homo sapiens) [TaxId: 9606] [117247] (3) picpic
      SQ O15530 409-550
  27. Dedicator of cytokinesis protein 9, DOCK9 [117248]
    1. Human (Homo sapiens) [TaxId: 9606] [117249] (1) picpic
      SQ Q9BZ29 165-301
  28. FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250]
    1. Mouse (Mus musculus) [TaxId: 10090] [117251] (1) picpic
      SQ Q69ZL1 1303-1389
  29. Calcium-dependent activator protein for secretion, CAPS [117252]
    1. Human (Homo sapiens) [TaxId: 9606] [117253] (1) picpic
      SQ Q8NFR0 522-634
  30. Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254]
    1. Human (Homo sapiens) [TaxId: 9606] [117255] (1) picpic
      SQ O15085 714-1081
  31. Centaurin-delta 1 [141395]
    1. Human (Homo sapiens) [TaxId: 9606] [141396] (1) picpic
      SQ Q8WZ64 483-584
  32. Cytohesin 3 [141397]
    1. Mouse (Mus musculus) [TaxId: 10090] [141398] (1) picpic
      SQ O08967 261-387
  33. Exocyst complex protein EXO84 [141399]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [141400] (4) picpic
      SQ O54924 171-283
  34. Cytohesin 2 [141401]
    1. Mouse (Mus musculus) [TaxId: 10090] [141402] (2) picpic
      SQ P63034 260-378
  35. Src kinase-associated phosphoprotein SKAP55 (SCAP1) [141403]
    1. Human (Homo sapiens) [TaxId: 9606] [141404] (4) picpic
      SQ O15268 108-213
  36. Signal-transducing adaptor protein 1, STAP-1 [141405]
    1. Human (Homo sapiens) [TaxId: 9606] [141406] (1) picpic
      SQ Q9ULZ2 16-151
  37. KIAA1914 [141407]
    1. Human (Homo sapiens) [TaxId: 9606] [141408] (1) picpic
      SQ Q8N4X5 354-448
  38. Pleckstrin-2 [141409]
    1. Human (Homo sapiens) [TaxId: 9606] [141410] (1) picpic
      SQ Q9NYT0 238-353
  39. Alpha-1-syntrophin [141411]
    1. Mouse (Mus musculus) [TaxId: 10090] [141412] (1) picpic
      SQ Q61234 2-44,203-264
  40. Phosphoinositide phospholipase C, PLC-gamma-1 [141413]
    contains split PH domain
    1. Rat (Rattus norvegicus) [TaxId: 10116] [141414] (1) picpic
      SQ P10686 489-525,870-933
  41. FYVE, RhoGEF and PH domain containing protein 3, FGD3 [141415]
    1. Human (Homo sapiens) [TaxId: 9606] [141416] (1) picpic
      SQ Q5JSP0 605-703
  42. Src-associated adaptor protein Skap2 [141417]
    1. Mouse (Mus musculus) [TaxId: 10090] [141418] (9) picpic
      SQ Q9Z2K4 105-212! SQ Q9Z2K4 109-219! SQ Q9Z2K4 14-222
  43. Protein kinase c, d2 type [141419]
    1. Human (Homo sapiens) [TaxId: 9606] [141420] (1) picpic
      SQ Q9BZL6 398-509
  44. Phospholipase C-beta-2 [159207]
    1. Human (Homo sapiens) [TaxId: 9606] [159208] (2) picpic
      SQ Q00722 11-141
  45. Rho guanine nucleotide exchange factor 9, Collybistin [159209]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [159210] (1) picpic
      SQ Q9QX73 300-461
  46. DCC-interacting protein 13-alpha, APPL1 [159211]
    1. Human (Homo sapiens) [TaxId: 9606] [159212] (1) picpic
      SQ Q9UKG1 274-374
  47. Rho GTPase-activating protein 21 [159213]
    1. Human (Homo sapiens) [TaxId: 9606] [159214] (6) picpic
      SQ Q5T5U3 931-1063
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk