Structural Classification of Proteins
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Fold: OB-fold

barrel, closed or partly opened n=5, S=10 or S=8; greek-key

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: OB-fold [50198]
    barrel, closed or partly opened n=5, S=10 or S=8; greek-key

Superfamilies:

  1. Staphylococcal nuclease [50199] (1)
    link to SUPERFAMILY database - Superfamily
    1. Staphylococcal nuclease [50200] (1)
      barrel, closed; n=5, S=10
      1. Staphylococcal nuclease [50201]
        1. Staphylococcus aureus [TaxId: 1280] [50202] (68) picpic
          SQ P00644 89-223
  2. Bacterial enterotoxins [50203] (2)
    link to SUPERFAMILY database - Superfamily
    1. Bacterial AB5 toxins, B-subunits [50204] (9)
      1. Heat-labile toxin [50205]
        1. Escherichia coli, type IB [TaxId: 562] [50206] (29) picpic
        2. Escherichia coli, type IIB [TaxId: 562] [50207] (3) picpic
      2. Cholera toxin [50208]
        barrel, partly opened; n*=5, S*=10
        1. Vibrio cholerae [TaxId: 666] [50209] (33) picpic
          SQ P01556 22-124
      3. Verotoxin-1/shiga-toxin, B-pentamer [50210]
        phage-borne toxin; bacteriophages H30 and H19B
        1. Escherichia coli [TaxId: 562] [50211] (22) picpic
        2. Shigella dysenteriae, toxin I [TaxId: 622] [50212] (3) picpic
          identical sequence with verotoxin-1 B
        3. Shigella dysenteriae, toxin II [TaxId: 622] [101755] (6) picpic
      4. Pertussis toxin S2/S3 subunits, C-terminal domain [50213]
        N-terminal domain in S2/S3 has C-lectin-like fold
        1. Bordetella pertussis [TaxId: 520] [50214] (3) picpic
      5. Pertussis toxin S4 subunit [50215]
        1. Bordetella pertussis [TaxId: 520] [50216] (3) picpic
      6. Pertussis toxin S5 subunit [50217]
        1. Bordetella pertussis [TaxId: 520] [50218] (3) picpic
    2. Superantigen toxins, N-terminal domain [50219] (15)
      1. Staphylococcal enterotoxin A, SEA [50220]
        1. Staphylococcus aureus [TaxId: 1280] [50221] (6) picpic
      2. Staphylococcal enterotoxin C2, SEC2 [50222]
        1. Staphylococcus aureus [TaxId: 1280] [50223] (8) picpic
      3. Toxic shock syndrome toxin-1 (TSST-1) [50224]
        1. Staphylococcus aureus [TaxId: 1280] [50225] (13) picpic
      4. Staphylococcal enterotoxin B, SEB [50226]
        1. Staphylococcus aureus [TaxId: 1280] [50227] (12) picpic
      5. Staphylococcal enterotoxin C3, SEC3 [50228]
        1. Staphylococcus aureus [TaxId: 1280] [50229] (11) picpic
          SQ P23313
      6. Staphylococcal enterotoxin H, SEH [50230]
        1. Staphylococcus aureus [TaxId: 1280] [50231] (4) picpic
      7. Superantigen-like protein SET3 [74946]
        1. Staphylococcus aureus [TaxId: 1280] [74947] (3) picpic
      8. Streptococcal superantigen Spe-C [50232]
        1. Streptococcus pyogenes [TaxId: 1314] [50233] (3) picpic
      9. Streptococcal superantigen Spe-H [50234]
        1. Streptococcus pyogenes [TaxId: 1314] [50235] (2) picpic
      10. Streptococcal superantigen Smez-2 [50236]
        1. Streptococcus pyogenes [TaxId: 1314] [50237] (2) picpic
      11. Streptococcal superantigen SSA [50238]
        1. Streptococcus pyogenes [TaxId: 1314] [50239] (10) picpic
      12. Streptococcal pyrogenic exotoxin A1 [50240]
        1. Streptococcus pyogenes [TaxId: 1314] [50241] (8) picpic
          SQ P08095
      13. Exotoxin 1 (SET1, Superantigen-like protein 7) [110190]
        1. Staphylococcus aureus [TaxId: 1280] [110191] (2) picpic
          SQ Q9ZFS5 36-231
      14. Streptococcal pyrogenic exotoxin Spe-J [110192]
        1. Streptococcus pyogenes [TaxId: 1314] [110193] (2) picpic
          SQ Q7BAE3
      15. Enterotoxin type I, SEI [159080]
        1. Staphylococcus aureus [TaxId: 1280] [159081] (1) picpic
          SQ Q52T95 4-86
  3. TIMP-like [50242] (3)
    link to SUPERFAMILY database - Superfamily
    1. Tissue inhibitor of metalloproteinases, TIMP [50243] (3)
      contains an irregular alpha+beta subdomain in the C-terminal extension
      1. TIMP-1 [50244]
        1. Human (Homo sapiens) [TaxId: 9606] [50245] (6) picpic
      2. TIMP-2 [50246]
        1. Human (Homo sapiens) [TaxId: 9606] [50247] (3) picpic
        2. Cow (Bos taurus) [TaxId: 9913] [50248] (3) picpic
    2. Netrin-like domain (NTR/C345C module) [89320] (2)
      Pfam 01759
      1. Procollagen c-proteinase enhancer protein PCOLCE [89321]
        1. Human (Homo sapiens) [TaxId: 9606] [89322] (1) picpic
      2. Complement C5 domain [117188]
        1. Human (Homo sapiens) [TaxId: 9606] [117189] (1) picpic
          SQ P01031 1530-1676 # structure of the C5a anaphylotoxin domain (679-751) is also known (scop_sp 47689)
    3. The laminin-binding domain of agrin [63767] (1)
      1. The laminin-binding domain of agrin [63768]
        1. Chicken (Gallus gallus) [TaxId: 9031] [63769] (3) picpic
          SQ Q90685 # ! Fragment
  4. Heme chaperone CcmE [82093] (1)
    link to SUPERFAMILY database - Superfamily
    1. Heme chaperone CcmE [82094] (2)
      1. Heme chaperone CcmE [82095]
        1. Escherichia coli [TaxId: 562] [82096] (1) picpic
        2. Shewanella putrefaciens [TaxId: 24] [82097] (2) picpic
  5. gp5 N-terminal domain-like [69255] (1)
    link to SUPERFAMILY database - Superfamily
    1. gp4 N-terminal domain-like [69256] (2)
      1. Tail-associated lysozyme gp5, N-terminal domain [69257]
        1. Bacteriophage T4 [TaxId: 10665] [69258] (1) picpic
      2. Hypothetical protein c3393 [159082]
        1. Escherichia coli o6 [TaxId: 217992] [159083] (1) picpic
          SQ Q8FED2 378-468
  6. Hypothetical protein YgiW [101756] (1)
    link to SUPERFAMILY database - Superfamily
    1. Hypothetical protein YgiW [101757] (1)
      Pfam 04076, Domain of unknown function DUF388
      1. Hypothetical protein YgiW [101758]
        1. Escherichia coli [TaxId: 562] [101759] (1) picpic
  7. Nucleic acid-binding proteins [50249] (16)
    link to SUPERFAMILY database - Superfamily
    1. Anticodon-binding domain [50250] (7)
      barrel, closed; n=5, S=10
      1. Aspartyl-tRNA synthetase (AspRS) [50251]
        this is N-terminal domain in prokaryotic enzymes and the first "visible" domain in eukaryotic enzymes
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [50252] (3) picpic
        2. Archaeon Pyrococcus kodakaraensis [TaxId: 311400] [50253] (1) picpic
        3. Thermus thermophilus, AspRS-2 [TaxId: 274] [89323] (1) picpic
          non-discriminating and archaeal-type enzyme
        4. Escherichia coli [TaxId: 562] [50254] (3) picpic
        5. Thermus thermophilus, AspRS-1 [TaxId: 274] [50255] (3) picpic
      2. Lysyl-tRNA synthetase (LysRS) [50256]
        1. Escherichia coli, gene lysS [TaxId: 562] [50257] (4) picpic
        2. Escherichia coli, gene lysU [TaxId: 562] [50258] (5) picpic
    2. RecG "wedge" domain [69259] (1)
      1. RecG "wedge" domain [69260]
        1. Thermotoga maritima [TaxId: 2336] [69261] (1) picpic
    3. DNA helicase RuvA subunit, N-terminal domain [50259] (3)
      barrel, closed; n=5, S=10
      1. DNA helicase RuvA subunit, N-terminal domain [50260]
        tetramer; binds Holliday junction
        1. Escherichia coli [TaxId: 562] [50261] (5) picpic
        2. Mycobacterium leprae [TaxId: 1769] [50262] (1) picpic
        3. Thermus thermophilus [TaxId: 274] [82098] (1) picpic
    4. Single strand DNA-binding domain, SSB [50263] (17)
      barrel, closed; n=5, S=10
      1. ssDNA-binding protein [50264]
        1. Human (Homo sapiens), mitochondria [TaxId: 9606] [50265] (4) picpic
          SQ Q04837
        2. Escherichia coli [TaxId: 562] [50266] (5) picpic
          SQ P02339
        3. Mycobacterium tuberculosis [TaxId: 1773] [101760] (4) picpic
        4. Deinococcus radiodurans [TaxId: 1299] [110194] (1) picpic
          SQ Q9RY51
      2. Archaeal ssDNA-binding protein [89324]
        similar to the domains of the Replication protein A
        1. Archaeon Sulfolobus solfataricus [TaxId: 2287] [89325] (1) picpic
      3. Replication protein A 70 KDa subunit (RPA70) [50267]
        duplication: consists of three domains of this fold; contains zinc-finger insert in the C-terminal domain, residues 479-511
        1. Human (Homo sapiens) [TaxId: 9606] [50268] (6) picpic
      4. Replication protein A 32 KDa subunit (RPA32) fragment [50269]
        1. Human (Homo sapiens) [TaxId: 9606] [50270] (10) picpic
      5. Replication protein A 14 KDa (RPA14) subunit [50271]
        1. Human (Homo sapiens) [TaxId: 9606] [50272] (10) picpic
      6. CDC13 ssDNA-binding domain [74948]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [74949] (2) picpic
      7. Telomere end binding protein alpha subunit [50273]
        duplication: consists of three domains of this fold
        1. Oxytricha nova [TaxId: 200597] [50274] (18) picpic
      8. Core domain of telomere end binding protein beta subunit [50275]
        1. Oxytricha nova [TaxId: 200597] [50276] (14) picpic
      9. Protection of telomeres protein 1, Pot1 [101761]
        1. Fission yeast (Schizosaccharomyces pombe) [TaxId: 4896] [101762] (2) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [117190] (1) picpic
          SQ Q9NUX5 6-299
      10. OB-fold domains of BRCA2 [82099]
        duplication: tandem repeat of three OB-fold domains
        1. Mouse (Mus musculus) [TaxId: 10090] [82100] (2) picpic
        2. Rat (Rattus norvegicus) [TaxId: 10116] [82101] (1) picpic
      11. Primosomal replication protein N, PriB [117191]
        1. Escherichia coli [TaxId: 562] [117192] (4) picpic
          SQ P07013
      12. Hypothetical protein At4g28440 (F20O9.120) [117193]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117194] (1) picpic
          SQ O49453 14-145
    5. Myf domain [50277] (7)
      1. Domain B2 of PheRS-beta, PheT [50278]
        1. Thermus thermophilus [TaxId: 274] [50279] (9) picpic
          identical sequence to Thermus aquaticus, TaxId: 271
      2. C-terminal domain of methionyl-tRNA synthetase, MetRS-CD [82102]
        1. Archaeon Pyrococcus abyssi [TaxId: 29292] [82103] (1) picpic
      3. EMAP II [50280]
        domain of the p43 protein
        1. Human (Homo sapiens) [TaxId: 9606] [50281] (3) picpic
      4. C-terminal domain of metazoan tyrosyl-tRNA synthetase, TyrRS [89326]
        EMAP II-like domain found in vertebrata and insect enzymes; free domain possesses a cytokine activity
        1. Human (Homo sapiens) [TaxId: 9606] [89327] (1) picpic
      5. Structure-specific tRNA-binding protein TRBP111 [89328]
        1. Escherichia coli [TaxId: 562] [89329] (1) picpic
          YgjH
        2. Aquifex aeolicus [TaxId: 63363] [101763] (1) picpic
          aq_422; putative methionyl-tRNA synthetase beta subunit
      6. TRBP111 homolog CsaA [63770]
        possesses export-related chaperone and tRNA-binding activities
        1. Thermus thermophilus [TaxId: 274] [63771] (1) picpic
    6. Cold shock DNA-binding domain-like [50282] (56)
      barrel, closed; n=5, S=8
      1. Major cold shock protein [50283]
        1. Escherichia coli [TaxId: 562] [50284] (2) picpic
        2. Bacillus subtilis [TaxId: 1423] [50285] (6) picpic
        3. Bacillus caldolyticus [TaxId: 1394] [50286] (8) picpic
        4. Thermotoga maritima [TaxId: 2336] [69262] (1) picpic
      2. Y-box protein 1 cold shock domain (YB1-CSD) [69263]
        1. Human (Homo sapiens) [TaxId: 9606] [69264] (1) picpic
      3. S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase [50287]
        1. Escherichia coli [TaxId: 562] [50288] (1) picpic
        2. Streptomyces antibioticus [TaxId: 1890] [50289] (1) picpic
      4. S1 domain of NusA [69265]
        1. Thermotoga maritima [TaxId: 2336] [69266] (2) picpic
        2. Mycobacterium tuberculosis [TaxId: 1773] [69267] (4) picpic
      5. C-terminal domain of RNA polymerase II subunit RBP7 (RpoE) [88670]
        1. Archaeon Methanococcus jannaschii [TaxId: 2190] [88671] (1) picpic
        2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [117195] (7) picpic
          SQ P34087
        3. Human (Homo sapiens) [TaxId: 9606] [141309] (4) picpic
          SQ P62487 78-171
      6. Translational initiation factor 1, IF1 [50290]
        1. Escherichia coli [TaxId: 562] [50291] (3) picpic
      7. Archaeal initiation factor-1a, aIF1a [63772]
        evolutionary link between IF1 and eIF1a
        1. Archaeon Methanococcus jannaschii [TaxId: 2190] [63773] (1) picpic
      8. Translation initiation factor-1a, eIF1a [50292]
        1. Human (Homo sapiens) [TaxId: 9606] [50293] (1) picpic
      9. Eukaryotic initiation factor 2alpha, eIF2alpha, N-terminal domain [74950]
        1. Human (Homo sapiens) [TaxId: 9606] [74951] (2) picpic
          SQ P05198
        2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [101764] (1) picpic
        3. Sulfolobus solfataricus [TaxId: 2287] [141310] (1) picpic
          SQ Q97Z79 1-84
      10. Viral structural mimic of eIF2alpha [74952]
        1. Vaccinia virus [TaxId: 10245] [74953] (1) picpic
        2. Myxoma virus, m156r [TaxId: 10273] [74954] (1) picpic
      11. Rho termination factor, RNA-binding domain [68910]
        1. Escherichia coli [TaxId: 562] [68911] (14) picpic
          SQ P03002
      12. C-terminal domain of eukaryotic initiation translation factor 5a (eIF5a) [50296]
        1. Archaeon Methanococcus jannaschii [TaxId: 2190] [50297] (2) picpic
        2. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [50298] (1) picpic
        3. Archaeon Pyrococcus horikoshii [TaxId: 53953] [82104] (1) picpic
        4. Leishmania infantum [TaxId: 5671] [110195] (1) picpic
          SQ Q9N9V6
        5. Leishmania mexicana [TaxId: 5665] [117196] (1) picpic
          SQ Q9N9V6 97% sequence identity
      13. C-terminal domain of eIF5a homologue (Hex1) [82105]
        1. Filamentous fungi (Neurospora crassa) [TaxId: 5141] [82106] (1) picpic
      14. N-terminal domain of ribosomal protein L2 [50299]
        incomplete OB-fold lacking the last strand
        1. Bacillus stearothermophilus [TaxId: 1422] [50300] (2) picpic
        2. Archaeon Haloarcula marismortui [TaxId: 2238] [50301] (40) picpic
          SQ P20276
          includes the N-terminal tail
        3. Thermus thermophilus [TaxId: 274] [159084] (5) picpic
          SQ Q72I07 1-125
        4. Deinococcus radiodurans [TaxId: 1299] [159085] (5) picpic
          SQ Q9RXJ9 33-127
        5. Escherichia coli [TaxId: 562] [159086] (27) picpic
          SQ P60422 3-124
      15. Ribosomal protein S12 [50302]
        1. Thermus thermophilus [TaxId: 274] [50303] (36) picpic
          SQ P17293
        2. Escherichia coli [TaxId: 562] [159087] (25) picpic
          SQ P0A7S3 1-123
      16. Ribosomal protein S17 [50304]
        1. Thermus thermophilus [TaxId: 274] [50305] (45) picpic
          SQ P24321
        2. Bacillus stearothermophilus [TaxId: 1422] [50306] (1) picpic
        3. Escherichia coli [TaxId: 562] [159088] (26) picpic
          SQ P02373 3-82
      17. Ribosomal protein S28e [101765]
        incomplete OB-fold lacking the last strand
        1. Archaeon Pyrococcus horikoshii [TaxId: 53953] [101766] (1) picpic
        2. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [101767] (1) picpic
      18. Elongation factor P middle and C-terminal domains [110196]
        duplication: contains two domains of this fold
        1. Thermus thermophilus HB8 [TaxId: 300852] [110197] (1) picpic
          SQ Q76G20
      19. S1-domain of Ribonuclease E [110198]
        1. Escherichia coli [TaxId: 562] [110199] (3) picpic
          SQ P21513 35-125
      20. Probable GTPase EngC (YjeQ), N-terminal domain [110200]
        1. Thermotoga maritima [TaxId: 2336] [110201] (1) picpic
          SQ Q9X242 # TM1717
        2. Bacillus subtilis [TaxId: 1423] [117197] (1) picpic
          SQ O34530
      21. Cold shock domain protein E1 (UNR) [117198]
        1. Human (Homo sapiens) [TaxId: 9606] [117199] (1) picpic
          SQ O75534 15-90
      22. S1-domain of RRP5 protein homolog (PDCD11, KIAA0185) [117200]
        1. Human (Homo sapiens) [TaxId: 9606] [117201] (1) picpic
          SQ Q14690 173-278
      23. Exoribonuclease 2, RNB [159089]
        RNase II; contains 3 S1-like domains in addition to an OB-fold embedded in the catalytic domain
        1. Escherichia coli [TaxId: 562] [159090] (18) picpic
          SQ P30850 1-82! SQ P30850 4-82! SQ P30850 5-82! SQ P30850 558-643! SQ P30850 558-644! SQ P30850 83-172
      24. S1-domain of exosome component 3 (RRP40) [159091]
        1. Saccharomyces cerevisiae [TaxId: 4932] [159092] (1) picpic
          SQ Q08285 62-151
        2. Human (Homo sapiens) [TaxId: 9606] [159093] (1) picpic
          SQ Q9NQT5 108-195
      25. Ribonuclease II family protein DR0020 [159094]
        1. Deinococcus radiodurans [TaxId: 1299] [159095] (4) picpic
          SQ Q9RYD0 404-461
      26. S1-domain of Ribosomal RNA-processing protein 4, RRP4 [159096]
        1. Human (Homo sapiens) [TaxId: 9606] [159097] (1) picpic
          SQ Q13868 73-167
      27. Exosome component 1, EXOSC1 [159098]
        3'-5' exoribonuclease CSL4 homolog
        1. Human (Homo sapiens) [TaxId: 9606] [159099] (1) picpic
          SQ Q9Y3B2 61-185
      28. S1-domain of exosome complex RNA-binding protein 1, ECR1 [159100]
        1. Aeropyrum pernix [TaxId: 56636] [159101] (1) picpic
          SQ Q9YC02 60-147
        2. Sulfolobus solfataricus [TaxId: 2287] [159102] (2) picpic
          SQ Q9UXC4 66-152
        3. Archaeoglobus fulgidus [TaxId: 2234] [159103] (3) picpic
          SQ O29758 53-135
      29. Exosome complex exonuclease RRP44 [159104]
        member or the RNase II family; contains 3 S1-like domains; two of them are in tandem N-terminally to the catalytic domain and one is C-terminally to the catalytic domain that also contains an OB-fold
        1. Saccharomyces cerevisiae [TaxId: 4932] [159105] (3) picpic
          SQ Q08162 252-399! SQ Q08162 400-494! SQ Q08162 911-998
      30. Tex S1-domain [159106]
        1. Pseudomonas aeruginosa [TaxId: 287] [159107] (3) picpic
          SQ Q9HTY8 637-730
    7. TRAM domain [101768] (3)
      Pfam 01938
      1. rRNA (Uracil-5-)-methyltransferase RumA, N-terminal domain [101769]
        1. Escherichia coli [TaxId: 562] [101770] (3) picpic
      2. Hypothetical protein MM1357 [141311]
        1. Methanosarcina mazei [TaxId: 2209] [141312] (1) picpic
          SQ Q8PX65 1-68
      3. Hypothetical protein MMP0076 [141313]
        1. Methanococcus maripaludis [TaxId: 39152] [141314] (1) picpic
          SQ Q6M142 1-69
    8. Hypothetical protein MTH1 (MT0001), insert domain [74955] (1)
      1. Hypothetical protein MTH1 (MT0001), insert domain [74956]
        1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [74957] (1) picpic
    9. DNA ligase/mRNA capping enzyme postcatalytic domain [50307] (6)
      1. RNA guanylyltransferase (mRNA capping enzyme) [50308]
        1. Chlorella virus PBCV-1 [TaxId: 10506] [50309] (3) picpic
      2. mRNA capping enzyme alpha subunit [89330]
        1. Yeast (Candida albicans) [TaxId: 5476] [89331] (1) picpic
      3. ATP-dependent DNA ligase [50310]
        1. Bacteriophage T7 [TaxId: 10760] [50311] (1) picpic
        2. Chlorella virus PBCV-1 [TaxId: 10506] [50312] (7) picpic
      4. NAD+-dependent DNA ligase [50313]
        1. Thermus filiformis [TaxId: 276] [50314] (2) picpic
      5. DNA ligase I (LIG1) [117202]
        1. Human (Homo sapiens) [TaxId: 9606] [117203] (1) picpic
          SQ P18858 262-901
    10. Phage ssDNA-binding proteins [50315] (5)
      barrel, open; n*=5, S*=8; the members' structures vary greater that those from cellular organisms
      1. Gene V protein [50316]
        1. Enterobacteria phage M13, including coliphage f1 [TaxId: 10870] [50317] (19) picpic
        2. Pseudomonas phage Pf3 [TaxId: 10872] [50318] (1) picpic
      2. Gene 32 protein (gp32) core [50319]
        contains a Zn-finger subdomain, res. 63-111
        1. Bacteriophage T4 [TaxId: 10665] [50320] (1) picpic
        2. Enterobacteria phage RB69 [TaxId: 12353] [159108] (3) picpic
          SQ Q7Y265 32-241
      3. gp2.5 [63774]
        1. Bacteriophage T7 [TaxId: 10760] [63775] (1) picpic
    11. DNA replication initiator (cdc21/cdc54) N-terminal domain [89332] (1)
      1. DNA replication initiator (cdc21/cdc54) N-terminal domain [89333]
        MCM complex protein; dodecamer assembly; includes the N-terminal all-alpha subdomain and inserted Zn-finger
        1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [89334] (1) picpic
    12. RNA polymerase subunit RBP8 [50321] (1)
      duplication; contains tandem repeat of two incomplete OB-folds; forms a single barrel; n=8, S=10
      1. RNA polymerase subunit RBP8 [50322]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [50323] (31) picpic
          SQ P20436
    13. RecO N-terminal domain-like [117204] (1)
      N-terminal part of Pfam 02565
      1. Recombinational repair protein RecO, N-terminal domain [117205]
        1. Deinococcus radiodurans [TaxId: 1299] [117206] (1) picpic
          SQ Q9RW50 # DR0819
    14. TIP49 domain [141315] (1)
      N-terminal part of Pfam 06068; the RuvA-like OB-fold domain in RuvB-like eukaryotic proteins
      1. RuvB-like 2 protein, RUVBL2 (TIP49b) [141316]
        1. Human (Homo sapiens) [TaxId: 9606] [141317] (1) picpic
          SQ Q9Y230 131-212
    15. SSO2064-like [159109] (1)
      Pfam 01796; DUF35; contains extra N-terminal zinc finger subdomain of the rubredoxin-like fold
      1. Hypothetical protein SSO2064 [159110]
        1. Sulfolobus solfataricus [TaxId: 2287] [159111] (2) picpic
          SQ Q97WQ4 8-144
    16. RNB domain-like [159112] (3)
      Pfam 00773; RNase II catalytic domain; decorated OB-fold domain with extra C-terminal structures forming the active site
      1. Exosome complex exonuclease RRP44 [159113]
        1. Saccharomyces cerevisiae [TaxId: 4932] [159114] (1) picpic
          SQ Q08162 495-910
      2. Ribonuclease II family protein DR0020 [159115]
        Includes extra N-terminal all-alpha subdomain
        1. Deinococcus radiodurans [TaxId: 1299] [159116] (4) picpic
          SQ Q9RYD0 3-403
      3. Exoribonuclease 2, RNB [159117]
        RNase II
        1. Escherichia coli [TaxId: 562] [159118] (6) picpic
          SQ P30850 173-557
  8. Inorganic pyrophosphatase [50324] (1)
    link to SUPERFAMILY database - Superfamily
    1. Inorganic pyrophosphatase [50325] (6)
      barrel, closed; n=5, S=8
      1. Inorganic pyrophosphatase [50326]
        eukaryotic enzyme has additional secondary structures at both N- and C-termini
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [50327] (16) picpic
        2. Archaeon Sulfolobus acidocaldarius [TaxId: 2285] [50328] (1) picpic
        3. Archaeon Pyrococcus horikoshii [TaxId: 53953] [101771] (1) picpic
        4. Escherichia coli [TaxId: 562] [50329] (17) picpic
        5. Thermus thermophilus [TaxId: 274] [50330] (1) picpic
        6. Pyrococcus furiosus [TaxId: 2261] [117207] (1) picpic
          SQ Q8U438
  9. MOP-like [50331] (3)
    link to SUPERFAMILY database - Superfamily
    1. Molybdate/tungstate binding protein MOP [50332] (2)
      1. Molybdate/tungstate binding protein MOP [50333]
        homohexamer: trimer of the C-terminal strand swapped dimers
        1. Sporomusa ovata [TaxId: 2378] [50334] (1) picpic
        2. Clostridium pasteurianum, MOP II [TaxId: 1501] [69270] (5) picpic
    2. BiMOP, duplicated molybdate-binding domain [50335] (2)
      duplication: tandem repeat of two OB-fold domains with swapped C-terminal strands
      1. Cytoplasmic molybdate-binding protein ModG [63776]
        1. Azotobacter vinelandii [TaxId: 354] [63777] (3) picpic
      2. C-terminal domain of molybdate-dependent transcriptional regulator ModE [63405]
        1. Escherichia coli [TaxId: 562] [50337] (5) picpic
    3. ABC-transporter additional domain [50338] (5)
      probably stems out from the biMOP domain
      1. Maltose transport protein MalK, C-terminal domain [63406]
        1. Archaeon Thermococcus litoralis [TaxId: 2265] [50340] (1) picpic
        2. Escherichia coli [TaxId: 562] [101772] (13) picpic
      2. Glucose transport protein GlcV, N-terminal domain [89335]
        1. Archaeon Sulfolobus solfataricus [TaxId: 2287] [89336] (5) picpic
      3. Hypothetical protein PH0022, C-terminal domain [117208]
        1. Pyrococcus horikoshii [TaxId: 53953] [117209] (2) picpic
          SQ O57758
      4. Sulfate/molybdate ABC transporter, ATP-binding protein [159119]
        1. Methanosarcina acetivorans [TaxId: 2214] [159120] (2) picpic
          SQ Q8TTZ3 230-348
  10. CheW-like [50341] (1)
    link to SUPERFAMILY database - Superfamily
    1. CheW-like [50342] (2)
      duplication: tandem repeat of two swapped domains, one with a canonical OB-fold topology and one with a circular permutation
      1. Histidine kinase CheA, C-terminal domain [50343]
        1. Thermotoga maritima [TaxId: 2336] [50344] (3) picpic
      2. Chemotaxis protein CheW [69271]
        1. Thermotoga maritima [TaxId: 2336] [69272] (3) picpic
  11. TM0957-like [141318] (1)
    extra N-terminal region and large insertion after strand 3 together form an alpha-helical subdomain
    link to SUPERFAMILY database - Superfamily
    1. TM0957-like [141319] (1)
      1. Hypothetical protein TM0957 [141320]
        1. Thermotoga maritima [TaxId: 2336] [141321] (4) picpic
          SQ Q9X052 39-214
  12. NfeD domain-like [141322] (1)
    close structural similarity to some members of the Nucleic acid-binding OB-fold proteins, possibly related to this superfamily
    link to SUPERFAMILY database - Superfamily
    1. NfeD domain-like [141323] (1)
      C-terminal part of Pfam 01957
      1. Hypothetical protein PH0471 [141324]
        NfeD short homolog
        1. Pyrococcus horikoshii [TaxId: 53953] [141325] (1) picpic
          SQ O58204 72-143
  13. BC4932-like [159121] (1)
    1. BC4932-like [159122] (2)
      Pfam 06486; DUF1093
      1. Uncharacterized protein BC2438 [159123]
        1. Bacillus cereus [TaxId: 1396] [159124] (1) picpic
          SQ Q813L1 22-129
      2. Uncharacterized protein BC4932 [159125]
        1. Bacillus cereus [TaxId: 1396] [159126] (1) picpic
          SQ Q812L6 22-117
  14. HupF/HypC-like [159127] (1)
    contains extra C-terminal helix packed against the beta-barrel side
    1. HupF/HypC-like [159128] (3)
      Pfam 01455
      1. Hydrogenase expression/formation protein HypC [159129]
        1. Escherichia coli [TaxId: 562] [159130] (1) picpic
          SQ P0AAM3 1-90
        2. Shewanella oneidensis [TaxId: 70863] [159131] (2) picpic
          SQ Q8EF93 1-76
        3. Thermococcus kodakaraensis [TaxId: 311400] [159132] (3) picpic
          SQ Q5JII0 2-72
  15. EutN/CcmL-like [159133] (1)
    homohexameric unit
    1. EutN/CcmL-like [159134] (3)
      Pfam 03319
      1. Ethanolamine utilization protein EutN [159135]
        1. Escherichia coli [TaxId: 562] [159136] (18) picpic
          SQ P0AEJ9 1-95
      2. Carboxysome shell protein [159137]
        Unidentified carboxysome polypeptide
        1. Thiobacillus neapolitanus [TaxId: 927] [159138] (5) picpic
          SQ O85043 1-82
      3. Carbon dioxide concentrating mechanism protein CcmL [159139]
        1. Synechocystis sp. (strain PCC 6803) [TaxId: 1148] [159140] (10) picpic
          SQ P72759 1-96
  16. HIN-2000 domain-like [159141] (1)
    duplication: tandem repeat of two OB-fold domains
    1. HIN-200/IF120x domain [159142] (1)
      Pfam 02760
      1. Gamma-interferon-inducible protein Ifi-16 [159143]
        1. Human (Homo sapiens) [TaxId: 9606] [159144] (8) picpic
          SQ Q16666 199-301! SQ Q16666 302-389
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk