Fold: SH3-like barrel

barrel, partly opened; n*=4, S*=8; meander
the last strand is interrupted by a turn of 3-10 helix

Lineage:

1. Root: scop
2. Class: All beta proteins [48724]
3. Fold: SH3-like barrel [50036]
   barrel, partly opened; n*=4, S*=8; meander
   the last strand is interrupted by a turn of 3-10 helix

Superfamilies:

1. C-terminal domain of transcriptional repressors [50037] (3)
   the N-terminal domains of these repressors bind DNA
   uperfamily
   1. Biotin repressor (BirA) [50038] (2)
   2. FeoA-like [50041] (4)
   3. Transcriptional repressor protein KorB [69242] (1)
2. SH3-domain [50044] (1)
   uperfamily
   1. SH3-domain [50045] (48)
3. Prokaryotic SH3-related domain [82057] (4)
   uperfamily
   1. GW domain [82058] (1)
   2. PhnA-like [141190] (2)
      Pfam 03831
   3. Spr N-terminal domain-like [141195] (1)
   4. Ply C-terminal domain-like [141198] (1)
      duplication: tandem repeat of two SH3-like domains swapped with the N-terminal strands; non-overlapping parts of sequence are covered by PfamB 062324 and PfamB 020199
4. Myosin S1 fragment, N-terminal domain [50084] (1)
   uperfamily
   1. Myosin S1 fragment, N-terminal domain [50085] (4)
5. Tudor/PWWP/MBT [63748] (4)
   uperfamily
   1. Tudor domain [63749] (7)
      Pfam 00567
   2. PWWP domain [69250] (6)
      includes the C-terminal all-alpha subdomain
   3. MBT repeat [89299] (4)
      Pfam 02820
      contains extended 'arm', N-terminal to the common fold core
   4. CPH domain [159021] (1)
6. Chromo domain-like [54160] (3)
   SH3-like barrel is capped by a C-terminal helix
   uperfamily
   1. "Histone-like" proteins from archaea [54161] (2)
   2. Chromo domain [54165] (10)
      lacks the SH3-like barrel first strand that can be complemented by bound peptide ligand; in shadow chromo domain the corresponding site is altered by insertion; similarity to the IL8-like fold
   3. Chromo barrel domain [117157] (3)
      typical SH3-like barrel fold; similar sequence motif to the canonical chromo domain
7. BAH domain [82061] (1)
   uperfamily
   1. BAH domain [82062] (1)
8. PAZ domain [101690] (1)
   uperfamily
   1. PAZ domain [101691] (5)
9. Cap-Gly domain [74924] (1)
   uperfamily
   1. Cap-Gly domain [74925] (12)
      Pfam 01302
10. Electron transport accessory proteins [50090] (4)
    uperfamily
    1. R67 dihydrofolate reductase [50091] (1)
    2. Photosystem I accessory protein E (PsaE) [50094] (4)
    3. Ferredoxin thioredoxin reductase (FTR), alpha (variable) chain [50098] (1)
    4. Nitrile hydratase beta chain [50101] (3)
       contains irregular array of helices in the N-terminal extension
11. Translation proteins SH3-like domain [50104] (7)
    many known members contain KOW motif
    uperfamily
    1. Ribosomal proteins L24p and L21e [50105] (5)
    2. eIF5a N-terminal domain-like [50110] (7)
    3. C-terminal domain of ribosomal protein L2 [50114] (5)
    4. N-utilization substance G protein NusG, C-terminal domain [82072] (2)
    5. SPT5 KOW domain-like [141242] (1)
       part of Pfam 00467
    6. Ribosomal protein L19 [141245] (3)
       Pfam 01245
    7. Ribosomal protein L14e [159031] (1)
       PfamB 032577
12. Cell growth inhibitor/plasmid maintenance toxic component [50118] (3)
    contains insert beta-sheet subdomain and C-terminal helix
    uperfamily
    1. CcdB [50119] (1)
    2. Kid/PemK [82075] (3)
    3. Rv2302-like [141248] (1)
       different orientation for the extra C-terminal helix relative the SH3-like barrel
13. Fumarylacetoacetate hydrolase, FAH, N-terminal domain [63433] (1)
    uperfamily
    1. Fumarylacetoacetate hydrolase, FAH, N-terminal domain [63434] (1)
       contains 5 short helices in the loop between the third and fourth strands
14. DNA-binding domain of retroviral integrase [50122] (1)
    uperfamily
    1. DNA-binding domain of retroviral integrase [50123] (3)
15. Hypothetical protein YfhH [101697] (1)
    contains extra N-terminal all-alpha subdomain
    uperfamily
    1. Hypothetical protein YfhH [101698] (1)
16. Kinase-associated protein B-like [141251] (1)
    contains extra C-terminal alpha-hairpin
    uperfamily
    1. Kinase-associated protein B-like [141252] (1)
17. YccV-like [141255] (1)
    contains extra C-terminal helix packed against barrel
    uperfamily
    1. YccV-like [141256] (1)
18. CarD-like [141259] (1)
    uperfamily
    1. CarD-like [141260] (1)
       Pfam 02559
19. Mib/herc2 domain-like [159034] (1)
    1. Mib/herc2 domain [159035] (1)
       Pfam 06701
20. YorP-like [159038] (1)
    1. YorP-like [159039] (1)
       Pfam 09629
21. Plus3-like [159042] (1)
    1. Plus3 [159043] (1)
       Pfam 03126

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk