Structural Classification of Proteins
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Family: EF-hand modules in multidomain proteins

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: EF Hand-like [47472]
    core: 4 helices; array of 2 hairpins, opened
  4. Superfamily: EF-hand [47473]
    Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
    link to SUPERFAMILY database - Superfamily
  5. Family: EF-hand modules in multidomain proteins [47547]

Protein Domains:

  1. Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!) [47548]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [47549] (10)
      1. 1qas picpicxrefxref
        1. region a:205-298 [17340] picpiclink
        2. region b:206-298 [17341] picpiclink
      2. 1djx picpicxrefxref
        complexed with act, ca, i3p; mutant
        1. region a:200-298 [17342] picpiclink
        2. region b:158-298 [17343] picpiclink
      3. 1djh picpicxrefxref
        complexed with act, ba; mutant
        1. region a:200-298 [17346] picpiclink
        2. region b:158-298 [17347] picpiclink
      4. 1djw picpicxrefxref
        complexed with act, ca, cip; mutant
        1. region a:200-298 [17344] picpiclink
        2. region b:158-298 [17345] picpiclink
      5. 1dji picpicxrefxref
        complexed with act, ca; mutant
        1. region a:200-298 [17348] picpiclink
        2. region b:158-298 [17349] picpiclink
      6. 1djg picpicxrefxref
        complexed with act, la; mutant
        1. region a:200-298 [17350] picpiclink
        2. region b:158-298 [17351] picpiclink
      7. 2isd picpicxrefxref
        complexed with act; mutant
        1. region a:200-298 [17352] picpiclink
        2. region b:158-298 [17353] picpiclink
      8. 1djy picpicxrefxref
        complexed with act, ca, i2p; mutant
        1. region a:200-298 [17356] picpiclink
        2. region b:158-298 [17357] picpiclink
      9. 1djz picpicxrefxref
        complexed with act, ca, ip2; mutant
        1. region a:200-298 [17358] picpiclink
        2. region b:158-298 [17359] picpiclink
      10. 1qat picpicxrefxref
        N-termini of both chains are disordered in the crystal structure
        complexed with sm
        1. region a:206-298 [17354] picpiclink
        2. region b:206-298 [17355] picpiclink
  2. Dystrophin [47559]
    probably lost calcium-binding function; contains extra helices in each domain
    1. Human (Homo sapiens) [TaxId: 9606] [47560] (2)
      1. 1eg3 picpicxref
        1. region a:85-209 [17376] picpiclink
        2. region a:210-306 [17377] picpiclink
      2. 1eg4 picpicxref
        1. region a:85-209 [17378] picpiclink
        2. region a:210-306 [17379] picpiclink
  3. Cbl [47561]
    1. Human (Homo sapiens) [TaxId: 9606] [47562] (12)
      1. 3bux picpicxrefxrefxrefxref
        automatically matched to d1b47a1
        1. region b:178-263 [155647] picpiclink
      2. 3bux picpicxrefxrefxrefxref
        automatically matched to d1b47a1
        1. region d:178-263 [155650] picpiclink
      3. 3buw picpicxrefxrefxrefxref
        automatically matched to d1b47a1
        1. region b:178-263 [155641] picpiclink
      4. 3buw picpicxrefxrefxrefxref
        automatically matched to d1b47a1
        1. region d:178-263 [155644] picpiclink
      5. 1yvh picpicxrefxref
        automatically matched to d1b47a1
        complexed with mg
        1. region a:178-263 [124096] picpiclink
      6. 3bun picpicxrefxref
        automatically matched to d1b47a1
        1. region b:178-263 [155626] picpiclink
      7. 3bum picpicxrefxref
        automatically matched to d1b47a1
        1. region b:178-263 [155623] picpiclink
      8. 2cbl picpicxrefxref
        complexed with ca
        1. region a:178-263 [17380] picpiclink
      9. 1b47 picpicxrefxref
        complexed with ca
        1. region a:178-263 [17381] picpiclink
        2. region b:178-263 [17382] picpiclink
        3. region c:178-263 [17383] picpiclink
      10. 3buo picpicxrefxrefxrefxref
        automatically matched to d1b47a1
        1. region b:178-263 [155629] picpiclink
      11. 3buo picpicxrefxrefxrefxref
        automatically matched to d1b47a1
        1. region d:178-263 [155632] picpiclink
      12. 1fbv picpicxrefxrefxrefxref
        complexed with so4, zn
        1. region a:178-263 [17384] picpiclink
  4. alpha-Actinin [63553]
    1. Human (Homo sapiens) [TaxId: 9606] [63554] (1)
      1. 1h8b picpic
        EF-hands 3&4 complexed with Z-repeat 7 from titin, chain B
        1. chain a [60736] picpiclink
  5. Nucleobindin 1 (CALNUC) [109825]
    1. Human (Homo sapiens) [TaxId: 9606] [109826] (1)
      SQ Q02818 228-326
      1. 1snl picpic
        1. chain a [105820] picpiclink
  6. Diacylglycerol kinase alpha, N-terminal domain [116905]
    contains two pairs of EF-hands, the modified first pair (res 25-109) does not bind calcium but retains the common fold
    1. Human (Homo sapiens) [TaxId: 9606] [116906] (1)
      SQ O95217 P23743 1-116
      1. 1tuz picpic
        structural genomics target
        1. chain a [112670] picpiclink
  7. DJ-1-binding protein, DJBP [140536]
    1. Human (Homo sapiens) [TaxId: 9606] [140537] (4)
      SQ Q5THR3 1160-1242
      1. 1wlz picpic
        5th EF-hand module
        1. region a:229-311 [121024] picpiclink
      2. 1wlz picpic
        automatically matched to 1WLZ A:229-311
        1. region b:229-310 [121025] picpiclink
      3. 1wlz picpic
        automatically matched to 1WLZ A:229-311
        1. region c:229-311 [121026] picpiclink
      4. 1wlz picpic
        automatically matched to 1WLZ A:229-311
        1. region d:229-311 [121027] picpiclink
  8. Phospholipase C-beta-2 [158478]
    1. Human (Homo sapiens) [TaxId: 9606] [158479] (2)
      SQ Q00722 142-311
      1. 2zkm picpicxrefxrefxref
        automatically matched to 2FJU B:142-311
        complexed with ca
        1. region x:142-311 [154587] picpiclink
      2. 2fju picpicxrefxrefxrefxref
        complexed with ca, gsp, mg
        1. region b:142-311 [145170] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk