Structural Classification of Proteins
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Family: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322]
    core: 4 helices; bundle; one loop crosses over one side of the bundle
  4. Superfamily: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47323]
    link to SUPERFAMILY database - Superfamily
  5. Family: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47324]

Protein Domains:

  1. Methionyl-tRNA synthetase (MetRS) [47325]
    this domain follows the Rossmann-fold catalytic domain of class I aaRS
    1. Thermus thermophilus [TaxId: 274] [47326] (4)
      1. 2d5b picpicxref
        automatically matched to d1a8h_1
        complexed with zn; mutant
        1. region a:349-500 [131268] picpiclink
      2. 1woy picpicxref
        automatically matched to d1a8h_1
        complexed with zn; mutant
        1. region a:349-500 [121130] picpiclink
      3. 2d54 picpicxref
        automatically matched to d1a8h_1
        complexed with zn; mutant
        1. region a:349-500 [131264] picpiclink
      4. 1a8h picpicxref
        complexed with zn
        1. region a:349-500 [16922] picpiclink
    2. Escherichia coli [TaxId: 562] [47327] (9)
      1. 1pfv picpicxrefxref
        complexed with 2fm, zn
        1. region a:389-550 [94660] picpiclink
      2. 1pfw picpicxrefxref
        complexed with mf3, zn
        1. region a:389-549 [94663] picpiclink
      3. 1p7p picpicxrefxref
        complexed with mph, zn
        1. region a:389-548 [94309] picpiclink
      4. 1pg2 picpicxref
        complexed with adn, met
        1. region a:389-550 [94671] picpiclink
      5. 1f4l picpicxrefxref
        complexed with met, zn
        1. region a:389-548 [59648] picpiclink
      6. 1pfu picpicxrefxref
        complexed with mpj, zn
        1. region a:389-550 [94657] picpiclink
      7. 1pfy picpicxrefxref
        complexed with msp, zn
        1. region a:389-550 [94666] picpiclink
      8. 1pg0 picpicxref
        complexed with mod
        1. region a:389-550 [94669] picpiclink
      9. 1qqt picpicxrefxref
        1. region a:389-548 [16923] picpiclink
    3. Pyrococcus abyssi [TaxId: 29292] [109792] (1)
      SQ Q9V011 1-606 # C-domain 616-722 is solved separately: 1MKH
      1. 1rqg picpicxrefxref
        complexed with zn
        1. region a:397-606 [105063] picpiclink
  2. Cysteinyl-tRNA synthetase (CysRS) [74709]
    contains extra C-terminal alpha+beta subdomain: [alpha(2)-beta(2)], ordered in the complex with tRNA
    1. Escherichia coli [TaxId: 562] [74710] (3)
      SQ P21888; extra C-terminal subdomain: 407-461
      1. 1u0b picpicxref
        complexed with zn
        1. region b:316-461 [112904] picpiclink
      2. 1li5 picpicxref
        complexed with zn
        1. region a:316-402 [73912] picpiclink
        2. region b:316-402 [73914] picpiclink
      3. 1li7 picpicxref
        complexed with cys, zn
        1. region a:316-402 [73917] picpiclink
        2. region b:316-402 [73919] picpiclink
  3. Isoleucyl-tRNA synthetase (IleRS) [47328]
    1. Thermus thermophilus [TaxId: 274] [47329] (3)
      1. 1ile picpicxrefxref
        complexed with zn
        1. region a:642-821 [16924] picpiclink
      2. 1jzs picpicxrefxref
        complexed with mrc, zn
        1. region a:642-821 [67880] picpiclink
      3. 1jzq picpicxrefxref
        complexed with ila, zn
        1. region a:642-821 [67869] picpiclink
    2. Staphylococcus aureus [TaxId: 1280] [47330] (3)
      contains additional alpha+beta and Zn-binding domains in the C-terminal extension
      1. 1qu2 picpicxrefxref
        protein/DNA complex; complexed with k, mo2, mo4, mo5, mo6, mrc, zn
        1. region a:645-917 [16925] picpiclink
      2. 1ffy picpicxrefxref
        protein/RNA complex; complexed with k, mo2, mo4, mo5, mo6, mrc, zn
        1. region a:645-917 [16926] picpiclink
      3. 1qu3 picpicxrefxref
        complexed with mrc, zn
        1. region a:645-881 [16927] picpiclink
  4. Valyl-tRNA synthetase (ValRS) [47331]
    includes additional alpha+beta (sub)domain at the C-terminus
    1. Thermus thermophilus [TaxId: 274] [47332] (3)
      1. 1ivs picpicxrefxrefxref
        complexed with vaa
        1. region a:579-796 [76856] picpiclink
        2. region b:579-796 [76860] picpiclink
      2. 1gax picpicxrefxrefxref
        protein/RNA complex; complexed with vaa, zn
        1. region a:579-796 [75843] picpiclink
        2. region b:579-796 [75845] picpiclink
      3. 1iyw picpicxrefxrefxref
        preliminary structure of ligand-free enzyme; CA-atoms only
        1. region a:579-796 [83808] picpiclink
        2. region b:579-796 [83812] picpiclink
  5. Arginyl-tRNA synthetase (ArgRS) [47333]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [47334] (3)
      1. 1f7u picpicxrefxref
        complexed with 1ma, 1mg, 2mg, 5mc, 5mu, arg, dhu, m2g, psu, so4
        1. region a:484-607 [59673] picpiclink
      2. 1bs2 picpicxrefxref
        1. region a:484-607 [16930] picpiclink
      3. 1f7v picpicxrefxref
        complexed with 1ma, 1mg, 2mg, 5mc, 5mu, dhu, m2g, psu
        1. region a:484-607 [59676] picpiclink
    2. Thermus thermophilus [TaxId: 274] [69007] (1)
      1. 1iq0 picpicxrefxref
        1. region a:467-592 [66257] picpiclink
  6. Leucyl-tRNA synthetase (LeuRS) [81746]
    1. Thermus thermophilus [TaxId: 274] [81747] (3)
      1. 1h3n picpicxrefxref
        The C-terminal region (residues 815-878) is invisible in the electron density
        complexed with leu, lms, so4, zn
        1. region a:687-814 [76641] picpiclink
      2. 1obc picpicxrefxref
        The C-terminal region (residues 815-878) is invisible in the electron density
        complexed with 2ad, leu, lms, nva, zn
        1. region a:687-814 [86764] picpiclink
      3. 1obh picpicxrefxref
        The C-terminal region (residues 815-878) is invisible in the electron density
        complexed with hg, lms, nva, so4
        1. region a:687-814 [86773] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk