Structural Classification of Proteins

Superfamily: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

: uperfamily

Lineage:

Root: scop
Class: All alpha proteins [46456]
Fold: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322]
core: 4 helices; bundle; one loop crosses over one side of the bundle
Superfamily: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47323]
uperfamily

Families:

Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47324] (10)
1. Methionyl-tRNA synthetase (MetRS) [47325]
  this domain follows the Rossmann-fold catalytic domain of class I aaRS
  1. Thermus thermophilus [TaxId: 274] [47326] (4)
    1. 2d5b
      automatically matched to d1a8h_1
      complexed with zn; mutant
      1. region a:349-500 [131268]
    2. 1woy
      automatically matched to d1a8h_1
      complexed with zn; mutant
      1. region a:349-500 [121130]
    3. 2d54
      automatically matched to d1a8h_1
      complexed with zn; mutant
      1. region a:349-500 [131264]
    4. 1a8h
      complexed with zn
      1. region a:349-500 [16922]
  2. Escherichia coli [TaxId: 562] [47327] (9)
    1. 1pfv
      complexed with 2fm, zn
      1. region a:389-550 [94660]
    2. 1pfw
      complexed with mf3, zn
      1. region a:389-549 [94663]
    3. 1p7p
      complexed with mph, zn
      1. region a:389-548 [94309]
    4. 1pg2
      complexed with adn, met
      1. region a:389-550 [94671]
    5. 1f4l
      complexed with met, zn
      1. region a:389-548 [59648]
    6. 1pfu
      complexed with mpj, zn
      1. region a:389-550 [94657]
    7. 1pfy
      complexed with msp, zn
      1. region a:389-550 [94666]
    8. 1pg0
      complexed with mod
      1. region a:389-550 [94669]
    9. 1qqt
      1. region a:389-548 [16923]
  3. Pyrococcus abyssi [TaxId: 29292] [109792] (1)
    SQ Q9V011 1-606 # C-domain 616-722 is solved separately: 1MKH
    1. 1rqg
      complexed with zn
      1. region a:397-606 [105063]
2. Cysteinyl-tRNA synthetase (CysRS) [74709]
  contains extra C-terminal alpha+beta subdomain: [alpha(2)-beta(2)], ordered in the complex with tRNA
  1. Escherichia coli [TaxId: 562] [74710] (3)
    SQ P21888; extra C-terminal subdomain: 407-461
    1. 1u0b
      complexed with zn
      1. region b:316-461 [112904]
    2. 1li5
      complexed with zn
      1. region a:316-402 [73912]
      2. region b:316-402 [73914]
    3. 1li7
      complexed with cys, zn
      1. region a:316-402 [73917]
      2. region b:316-402 [73919]
3. Isoleucyl-tRNA synthetase (IleRS) [47328]
  1. Thermus thermophilus [TaxId: 274] [47329] (3)
    1. 1ile
      complexed with zn
      1. region a:642-821 [16924]
    2. 1jzs
      complexed with mrc, zn
      1. region a:642-821 [67880]
    3. 1jzq
      complexed with ila, zn
      1. region a:642-821 [67869]
  2. Staphylococcus aureus [TaxId: 1280] [47330] (3)
    contains additional alpha+beta and Zn-binding domains in the C-terminal extension
    1. 1qu2
      protein/DNA complex; complexed with k, mo2, mo4, mo5, mo6, mrc, zn
      1. region a:645-917 [16925]
    2. 1ffy
      protein/RNA complex; complexed with k, mo2, mo4, mo5, mo6, mrc, zn
      1. region a:645-917 [16926]
    3. 1qu3
      complexed with mrc, zn
      1. region a:645-881 [16927]
4. Valyl-tRNA synthetase (ValRS) [47331]
  includes additional alpha+beta (sub)domain at the C-terminus
  1. Thermus thermophilus [TaxId: 274] [47332] (3)
    1. 1ivs
      complexed with vaa
      1. region a:579-796 [76856]
      2. region b:579-796 [76860]
    2. 1gax
      protein/RNA complex; complexed with vaa, zn
      1. region a:579-796 [75843]
      2. region b:579-796 [75845]
    3. 1iyw
      preliminary structure of ligand-free enzyme; CA-atoms only
      1. region a:579-796 [83808]
      2. region b:579-796 [83812]
5. Arginyl-tRNA synthetase (ArgRS) [47333]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [47334] (3)
    1. 1f7u
      complexed with 1ma, 1mg, 2mg, 5mc, 5mu, arg, dhu, m2g, psu, so4
      1. region a:484-607 [59673]
    2. 1bs2
      1. region a:484-607 [16930]
    3. 1f7v
      complexed with 1ma, 1mg, 2mg, 5mc, 5mu, dhu, m2g, psu
      1. region a:484-607 [59676]
  2. Thermus thermophilus [TaxId: 274] [69007] (1)
    1. 1iq0
      1. region a:467-592 [66257]
6. Leucyl-tRNA synthetase (LeuRS) [81746]
  1. Thermus thermophilus [TaxId: 274] [81747] (3)
    1. 1h3n
      The C-terminal region (residues 815-878) is invisible in the electron density
      complexed with leu, lms, so4, zn
      1. region a:687-814 [76641]
    2. 1obc
      The C-terminal region (residues 815-878) is invisible in the electron density
      complexed with 2ad, leu, lms, nva, zn
      1. region a:687-814 [86764]
    3. 1obh
      The C-terminal region (residues 815-878) is invisible in the electron density
      complexed with hg, lms, nva, so4
      1. region a:687-814 [86773]