Structural Classification of Proteins
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Family: DBL homology domain (DH-domain)

Pfam 00621

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: DBL homology domain (DH-domain) [48064]
    multihelical; core: 5-helical bundle
  4. Superfamily: DBL homology domain (DH-domain) [48065]
    link to SUPERFAMILY database - Superfamily
  5. Family: DBL homology domain (DH-domain) [48066]
    Pfam 00621

Protein Domains:

  1. Son of sevenless-1 (sos-1) [48067]
    1. Human (Homo sapiens) [TaxId: 9606] [48068] (3)
      SQ Q07889 189-1046
      1. 1dbh picpicxref
        1. region a:198-404 [18514] picpiclink
      2. 1xdv picpicxrefxref
        1. region a:200-404 [115180] picpiclink
        2. region b:200-404 [115183] picpiclink
      3. 1xd4 picpicxrefxref
        1. region a:200-404 [115149] picpiclink
        2. region b:200-404 [115152] picpiclink
  2. beta-pix [48069]
    1. Human (Homo sapiens) [TaxId: 9606] [48070] (1)
      1. 1by1 picpic
        1. chain a [18515] picpiclink
  3. RhoGEF Vav [48071]
    1. Mouse (Mus musculus) [TaxId: 10090] [48072] (1)
      1. 1f5x picpic
        autoinhibited
        1. chain a [18516] picpiclink
  4. GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [48073]
    1. Mouse (Mus musculus) [TaxId: 10090] [48074] (1)
      1. 1foe picpicxrefxref
        complexed with so4; mutant
        1. region a:1034-1239 [18517] picpiclink
        2. region c:1036-1239 [18518] picpiclink
        3. region e:1035-1239 [18519] picpiclink
        4. region g:1035-1239 [18520] picpiclink
  5. Dbl's big sister, Dbs [74743]
    1. Mouse (Mus musculus) [TaxId: 10090] [74744] (4)
      SQ Q64096 624-958 # 98% sequence identity; the rat sequence Q63406 region 499-833 is 100% identical to the PDB sequence
      1. 1kz7 picpicxrefxref
        complexed with mse; mutant
        1. region a:624-818 [73333] picpiclink
        2. region c:1624-1818 [73336] picpiclink
      2. 1kzg picpicxrefxref
        mutant
        1. region a:624-818 [73355] picpiclink
        2. region c:1624-1818 [73358] picpiclink
      3. 1lb1 picpicxrefxref
        mutant
        1. region a:624-818 [73784] picpiclink
        2. region c:624-818 [73787] picpiclink
        3. region e:624-818 [73790] picpiclink
        4. region g:624-818 [73793] picpiclink
      4. 1rj2 picpicxref
        1. region a:624-818 [104954] picpiclink
        2. region d:624-818 [104956] picpiclink
        3. region g:624-818 [104958] picpiclink
        4. region j:624-818 [104960] picpiclink
  6. GEF of intersectin [74745]
    1. Human (Homo sapiens) [TaxId: 9606] [74746] (1)
      1. 1ki1 picpicxrefxref
        complexed with so4; mutant
        1. region b:1229-1438 [72497] picpiclink
        2. region d:1229-1438 [72500] picpiclink
  7. Triple functional domain protein TRIO [109935]
    1. Human (Homo sapiens) [TaxId: 9606] [109936] (2)
      SQ O75962 1231-1535
      1. 1nty picpicxref
        1. region a:1231-1414 [103873] picpiclink
      2. 2nz8 picpicxrefxref
        automatically matched to d1ntya1
        1. region b:1231-1414 [138838] picpiclink
  8. Rho guanine nucleotide exchange factor 12 [109937]
    1. Human (Homo sapiens), gamma isoform [TaxId: 9606] [109938] (2)
      SQ Q9NZN5 766-1138
      1. 1txd picpicxref
        1. region a:766-999 [107422] picpiclink
      2. 1x86 picpicxrefxref
        complexed with po4; mutant
        1. region a:766-999 [109504] picpiclink
        2. region c:766-999 [109507] picpiclink
        3. region e:766-996 [109510] picpiclink
        4. region g:766-994 [109513] picpiclink
  9. Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [116957]
    1. Human (Homo sapiens) [TaxId: 9606] [116958] (1)
      SQ O15085 714-1081
      1. 1xcg picpicxrefxref
        mutant
        1. region a:714-941 [115120] picpiclink
        2. region e:714-941 [115123] picpiclink
  10. Rho guanine nucleotide exchange factor 9, Collybistin [158679]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [158680] (1)
      SQ Q9QX73 97-299
      1. 2dfk picpicxrefxrefxref
        complexed with gol, so4
        1. region a:37-239 [145077] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk