Family: HkH motif-containing C2H2 finger

putative dsRNA-specific zinc finger with a helix-kink-helix (HkH) motif; the kink results from the incompatibility of the cation-coordinating H-x5-H motif with a regular alpha-helix and contributes to RNA recognition

Lineage:

1. Root: scop
2. Class: Small proteins [56992]
   Usually dominated by metal ligand, heme, and/or disulfide bridges
3. Fold: beta-beta-alpha zinc fingers [57666]
   simple fold, consisting of the N-terminal beta-hairpin and C-terminal alpha-helical region; each part provides two zinc-coordinating residues with the observed sequences including C2H2, C2HC and CHHC
4. Superfamily: beta-beta-alpha zinc fingers [57667]
   uperfamily
5. Family: HkH motif-containing C2H2 finger [111436]
   putative dsRNA-specific zinc finger with a helix-kink-helix (HkH) motif; the kink results from the incompatibility of the cation-coordinating H-x5-H motif with a regular alpha-helix and contributes to RNA recognition

Protein Domains:

1. Spliceosomal protein U1C [111437]
   1. Human (Homo sapiens) [TaxId: 9606] [111438] (1)
      SQ P09234 1-61
      1. 2vrd
         complexed with zn
         1. region a:1-61 [153505]
2. Zinc finger protein 593, ZNF593 [144151]
   1. Human (Homo sapiens) [TaxId: 9606] [144152] (1)
      SQ O00488 28-94
      1. 1zr9
         complexed with zn
         1. region a:28-94 [125529]
3. dsRNA-binding protein ZFa (ZNF346, JAZ) [161154]
   1. African clawed frog (Xenopus laevis) [TaxId: 8355] [161155] (2)
      SQ Q8AVN9 2-73!SQ Q8AVN9 74-128
      1. 1zu1
         complexed with zn
         1. region a:2-73 [146026]
      2. 1zu1
         complexed with zn
         1. region a:74-128 [146027]
4. Zinc finger homeobox protein 4, ZFHX4 [161156]
   1. Human (Homo sapiens) [TaxId: 9606] [161157] (1)
      SQ Q9JJN9 2937-2984
      1. 2yrk
         complexed with zn
         1. region a:8-55 [153744]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk