Structural Classification of Proteins
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Fold: beta-beta-alpha zinc fingers

simple fold, consisting of the N-terminal beta-hairpin and C-terminal alpha-helical region; each part provides two zinc-coordinating residues with the observed sequences including C2H2, C2HC and CHHC

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: beta-beta-alpha zinc fingers [57666]
    simple fold, consisting of the N-terminal beta-hairpin and C-terminal alpha-helical region; each part provides two zinc-coordinating residues with the observed sequences including C2H2, C2HC and CHHC

Superfamilies:

  1. beta-beta-alpha zinc fingers [57667] (7)
    link to SUPERFAMILY database - Superfamily
    1. Classic zinc finger, C2H2 [57668] (30)
      1. ZIF268 [57669]
        duplication: consists of 3 fingers
        1. Mouse (Mus musculus) [TaxId: 10090] [57670] (14) picpic
      2. V(D)J recombination activating protein 1 (RAG1), dimerization domain [57671]
        1. Mouse (Mus musculus) [TaxId: 10090] [57672] (1) picpic
      3. Tramtrack protein (two zinc-finger peptide) [57673]
        1. Drosophila melanogaster [TaxId: 7227] [57674] (1) picpic
      4. ADR1 [57675]
        1. Synthetic, based on Saccharomyces cerevisiae sequence [57676] (5) picpic
      5. XFIN, third domain [57677]
        1. Xenopus laevis [TaxId: 8355] [57678] (1) picpic
      6. ZFY [57679]
        1. Human (Homo sapiens) [TaxId: 9606] [57680] (5) picpic
          SQ P08048 570-598
      7. SWI5 zinc-finger domains [57681]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [57682] (2) picpic
      8. Five-finger GLI1 [57683]
        1. Human (Homo sapiens) [TaxId: 9606] [57684] (1) picpic
      9. Enhancer binding protein [57685]
        duplication: consists of two Zn fingers
        1. Human (Homo sapiens) [TaxId: 9606] [57686] (3) picpic
      10. Transcription factor sp1 [57687]
        1. Human (Homo sapiens) [TaxId: 9606] [57688] (4) picpic
      11. Transactivation domain of cre-bp1/atf-2 [57689]
        1. Human (Homo sapiens) [TaxId: 9606] [57690] (1) picpic
      12. Ying-yang 1 (yy1, zinc finger domain) [57691]
        duplication: consists of 4 fingers
        1. Human (Homo sapiens) [TaxId: 9606] [57692] (1) picpic
      13. Transcription factor IIIA, TFIIIA [57693]
        duplication: consists of 6 fingers
        1. Xenopus laevis [TaxId: 8355] [57694] (9) picpic
      14. GAGA factor [57695]
        1. Drosophila melanogaster [TaxId: 7227] [57696] (2) picpic
      15. Kruppel-like factor 3, Bklf [103597]
        1. Mouse (Mus musculus) [TaxId: 10090] [103598] (3) picpic
      16. Zinc finger protein ZFPM1 (FOG-1) [111434]
        1. Mouse (Mus musculus) [TaxId: 10090] [111435] (1) picpic
          SQ O35615 328-360
      17. Zinc finger protein 295, ZNF295 [118267]
        1. Human (Homo sapiens) [TaxId: 9606] [118268] (1) picpic
          SQ Q9ULJ3 713-806
      18. Wilms' tumor protein, WT1 [118269]
        1. Human (Homo sapiens) [TaxId: 9606] [118270] (1) picpic
          SQ P19544 381-408
      19. Zinc finger protein 292, ZNF292 [144133]
        1. Human (Homo sapiens) [TaxId: 9606] [144134] (1) picpic
          SQ O60281 1340-1400
      20. Zinc finger protein 512, ZNF512 [144135]
        1. Human (Homo sapiens) [TaxId: 9606] [144136] (2) picpic
          SQ Q96ME7 142-194! SQ Q96ME7 195-224
      21. Zinc finger protein 462, ZNF462 [144137]
        1. Human (Homo sapiens) [TaxId: 9606] [144138] (1) picpic
          SQ Q96JM2 719-793
      22. Zinc finger protein 692, ZNF692 [144139]
        1. Human (Homo sapiens) [TaxId: 9606] [144140] (2) picpic
          SQ Q9BU19 328-357! SQ Q9BU19 358-393
      23. Zinc fingers and homeoboxes protein 1, ZHX1 [144141]
        1. Human (Homo sapiens) [TaxId: 9606] [144142] (2) picpic
          SQ Q9UKY1 60-95! SQ Q9UKY1 96-153
      24. Zinc finger protein 24 [144143]
        1. Human (Homo sapiens) [TaxId: 9606] [144144] (2) picpic
          SQ P17028 272-304! SQ P17028 305-330
      25. Zinc finger protein 297b [144145]
        1. Human (Homo sapiens) [TaxId: 9606] [144146] (2) picpic
          SQ O43298 370-422! SQ O43298 423-486
      26. GLI-Krueppel family member HKR3 [144147]
        ZBTB48
        1. Mouse (Mus musculus) [TaxId: 10090] [144148] (4) picpic
          SQ Q1H9T6 284-310! SQ Q1H9T6 311-338! SQ Q1H9T6 339-368! SQ Q1H9T6 369-394
      27. Zinc finger protein 64, ZFP68 [144149]
        1. Human (Homo sapiens) [TaxId: 9606] [144150] (5) picpic
          SQ Q9NPA5 174-199! SQ Q9NPA5 200-227! SQ Q9NPA5 228-256! SQ Q9NPA5 341-368! SQ Q9NPA5 369-397
      28. Transcriptional repressor CTCF [144153]
        1. Human (Homo sapiens) [TaxId: 9606] [144154] (4) picpic
          SQ P49711 399-434! SQ P49711 435-462! SQ P49711 515-550! SQ P49711 551-587
      29. Zinc finger and SCAN domain-containing protein 16, ZSCAN16 [144155]
        Zinc finger protein 435
        1. Human (Homo sapiens) [TaxId: 9606] [144156] (2) picpic
          SQ Q9H4T2 224-261! SQ Q9H4T2 262-288
      30. PATZ1 [161152]
        Zinc finger protein 278
        1. Human (Homo sapiens) [TaxId: 9606] [161153] (7) picpic
          SQ Q9HBE1 286-338! SQ Q9HBE1 350-384! SQ Q9HBE1 355-379! SQ Q9HBE1 380-409! SQ Q9HBE1 380-411! SQ Q9HBE1 407-445! SQ Q9HBE1 410-436
    2. Plant C2H2 finger (QALGGH zinc finger) [90198] (1)
      1. SUPERMAN zinc finger domain [90199]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [90200] (1) picpic
    3. C2HC finger [57697] (3)
      1. U-shaped transcription factor, different fingers [57698]
        1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [57699] (4) picpic
      2. Monocytic leukemia zinc finger protein Moz [103599]
        1. Human (Homo sapiens) [TaxId: 9606] [103600] (1) picpic
          this zinc finger is only a fragment of a bigger subdomain in the structure of functional HAT domain (scop_sp 143703)
      3. Cell growth regulating nucleolar protein LyaR [118271]
        1. Mouse (Mus musculus) [TaxId: 10090] [118272] (1) picpic
          SQ Q08288 1-66
    4. HkH motif-containing C2H2 finger [111436] (4)
      putative dsRNA-specific zinc finger with a helix-kink-helix (HkH) motif; the kink results from the incompatibility of the cation-coordinating H-x5-H motif with a regular alpha-helix and contributes to RNA recognition
      1. Spliceosomal protein U1C [111437]
        1. Human (Homo sapiens) [TaxId: 9606] [111438] (1) picpic
          SQ P09234 1-61
      2. Zinc finger protein 593, ZNF593 [144151]
        1. Human (Homo sapiens) [TaxId: 9606] [144152] (1) picpic
          SQ O00488 28-94
      3. dsRNA-binding protein ZFa (ZNF346, JAZ) [161154]
        1. African clawed frog (Xenopus laevis) [TaxId: 8355] [161155] (2) picpic
          SQ Q8AVN9 2-73!SQ Q8AVN9 74-128
      4. Zinc finger homeobox protein 4, ZFHX4 [161156]
        1. Human (Homo sapiens) [TaxId: 9606] [161157] (1) picpic
          SQ Q9JJN9 2937-2984
    5. CHHC finger [161158] (1)
      1. U11/U12 small nuclear ribonucleoprotein 48 kDa protein, U11-48K [161159]
        1. Human (Homo sapiens) [TaxId: 9606] [161160] (2) picpic
          SQ Q6IEG0 53-87
    6. variant C2H2 finger [118273] (1)
      contains extra C-terminal, alpha-helical subdomain
      1. Protein arginine N-methyltransferase 3 [118274]
        1. Mouse (Mus musculus) [TaxId: 10090] [118275] (1) picpic
          SQ Q922H1 38-145
    7. BED zinc finger [144157] (1)
      Pfam 02892; contains extra N-terminal and C-terminal helices bundled together with the core helix
      1. Zinc finger BED domain-containing protein 1 [144158]
        dREF homolog
        1. Human (Homo sapiens) [TaxId: 9606] [144159] (1) picpic
          SQ O96006 23-82
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk