Structural Classification of Proteins
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Family: Complement control module/SCR domain

Pfam 00084

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: Complement control module/SCR domain [57534]
    disulfide-rich all-beta fold
  4. Superfamily: Complement control module/SCR domain [57535]
    link to SUPERFAMILY database - Superfamily
  5. Family: Complement control module/SCR domain [57536]
    Pfam 00084

Protein Domains:

  1. Factor H, 15th and 16th modules [57537]
    1. Human (Homo sapiens) [TaxId: 9606] [57538] (3)
      1. 1hfi picpic
        15th module only
        1. chain a [44819] picpiclink
      2. 1hcc picpic
        16th module only
        1. chain a [44820] picpiclink
      3. 1hfh picpic
        both modules
        1. region a:1-63 [44821] picpiclink
        2. region a:64-120 [44822] picpiclink
  2. Complement control protein [57539]
    1. Vaccinia virus [TaxId: 10245] [57540] (15)
      SQ P10998
      a complement protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans
      1. 1g40 picpic
        1. region a:1-64 [44823] picpiclink
        2. region a:65-126 [44824] picpiclink
        3. region a:127-184 [44825] picpiclink
        4. region a:185-243 [44826] picpiclink
        5. region b:1-64 [44827] picpiclink
        6. region b:65-126 [44828] picpiclink
        7. region b:127-184 [44829] picpiclink
        8. region b:185-243 [44830] picpiclink
      2. 1y8e picpic
        automatically matched to d1g40a1
        complexed with svr
        1. region a:1-64 [122736] picpiclink
      3. 1y8e picpic
        automatically matched to d1e5ga1
        complexed with svr
        1. region a:65-126 [122737] picpiclink
      4. 1y8e picpic
        automatically matched to d1e5ga2
        complexed with svr
        1. region a:127-184 [122738] picpiclink
      5. 1y8e picpic
        automatically matched to d1rida4
        complexed with svr
        1. region a:185-244 [122739] picpiclink
      6. 1y8e picpic
        automatically matched to d1g40a1
        complexed with svr
        1. region b:2-64 [122740] picpiclink
      7. 1y8e picpic
        automatically matched to d1e5ga1
        complexed with svr
        1. region b:65-126 [122741] picpiclink
      8. 1y8e picpic
        automatically matched to d1e5ga2
        complexed with svr
        1. region b:127-184 [122742] picpiclink
      9. 1y8e picpic
        automatically matched to d1rida4
        complexed with svr
        1. region b:185-244 [122743] picpiclink
      10. 1rid picpic
        complexed with ids, sgn
        1. region a:1-64 [104943] picpiclink
        2. region a:65-126 [104944] picpiclink
        3. region a:127-184 [104945] picpiclink
        4. region a:185-244 [104946] picpiclink
        5. region b:1-64 [104947] picpiclink
        6. region b:65-126 [104948] picpiclink
        7. region b:127-184 [104949] picpiclink
        8. region b:185-244 [104950] picpiclink
      11. 1g44 picpic
        1. region a:1-64 [44831] picpiclink
        2. region a:65-125 [44832] picpiclink
        3. region a:127-184 [44833] picpiclink
        4. region a:185-243 [44834] picpiclink
        5. region b:1-64 [44835] picpiclink
        6. region b:65-125 [44836] picpiclink
        7. region b:127-184 [44837] picpiclink
        8. region b:185-243 [44838] picpiclink
        9. region c:1-64 [44839] picpiclink
        10. region c:65-125 [44840] picpiclink
        11. region c:127-183 [44841] picpiclink
        12. region c:185-243 [44842] picpiclink
      12. 1e5g picpic
        central cp module pair
        1. region a:7-68 [44843] picpiclink
        2. region a:69-126 [44844] picpiclink
      13. 1vve picpic
        1. region a:1-58 [44847] picpiclink
        2. region a:59-118 [44848] picpiclink
      14. 1vvd picpic
        1. region a:1-58 [44845] picpiclink
        2. region a:59-118 [44846] picpiclink
      15. 1vvc picpic
        1. region a:1-58 [44849] picpiclink
        2. region a:59-118 [44850] picpiclink
  3. CD46 (membrane cofactor protein, MCP) [57541]
    1. Human (Homo sapiens) [TaxId: 9606] [57542] (5)
      1. 2o39 picpicxrefxref
        automatically matched to d1ckla1
        complexed with bma, ca, nag
        1. region c:1-62 [138898] picpiclink
      2. 2o39 picpicxrefxref
        automatically matched to d1ckla2
        complexed with bma, ca, nag
        1. region c:63-126 [138899] picpiclink
      3. 2o39 picpicxrefxref
        automatically matched to d1ckla1
        complexed with bma, ca, nag
        1. region d:1-62 [138900] picpiclink
      4. 2o39 picpicxrefxref
        automatically matched to d1ckla2
        complexed with bma, ca, nag
        1. region d:63-126 [138901] picpiclink
      5. 1ckl picpic
        N-terminal two domains
        complexed with ca, cl, man, nag
        1. region a:1-62 [44851] picpiclink
        2. region a:63-126 [44852] picpiclink
        3. region b:1-62 [44853] picpiclink
        4. region b:63-126 [44854] picpiclink
        5. region c:1-62 [44855] picpiclink
        6. region c:63-126 [44856] picpiclink
        7. region d:1-62 [44857] picpiclink
        8. region d:63-126 [44858] picpiclink
        9. region e:1-62 [44859] picpiclink
        10. region e:63-126 [44860] picpiclink
        11. region f:1-62 [44861] picpiclink
        12. region f:63-126 [44862] picpiclink
  4. beta2-glycoprotein I [57543]
    consists of five modules with the C-terminal module fold being altered
    1. Human (Homo sapiens) [TaxId: 9606] [57544] (4)
      1. 1qub picpic
        complexed with man, nag
        1. region a:1-62 [44863] picpiclink
        2. region a:63-120 [44864] picpiclink
        3. region a:121-183 [44865] picpiclink
        4. region a:184-243 [44866] picpiclink
        5. region a:244-326 [44867] picpiclink
      2. 1c1z picpic
        1. region a:1-62 [44868] picpiclink
        2. region a:63-120 [44869] picpiclink
        3. region a:121-183 [44870] picpiclink
        4. region a:184-243 [44871] picpiclink
        5. region a:244-326 [44872] picpiclink
      3. 1g4f picpic
        fifth module
        1. chain a [44873] picpiclink
      4. 1g4g picpic
        fifth module
        1. chain a [44874] picpiclink
  5. Complement decay-accelerating factor (Daf, CD55) [90172]
    1. Human (Homo sapiens) [TaxId: 9606] [90173] (21)
      1. 1h03 picpic
        modules 3 and 4
        1. region p:5-66 [83411] picpiclink
        2. region p:67-129 [83412] picpiclink
        3. region q:5-66 [83413] picpiclink
        4. region q:67-129 [83414] picpiclink
      2. 1h04 picpic
        modules 3 and 4
        complexed with ni
        1. region p:5-66 [83415] picpiclink
        2. region p:67-129 [83416] picpiclink
      3. 1ok3 picpic
        intact protein
        complexed with act, gol, so4
        1. region a:1-64 [93208] picpiclink
        2. region a:65-128 [93209] picpiclink
        3. region a:129-190 [93210] picpiclink
        4. region a:191-254 [93211] picpiclink
        5. region b:2-64 [93212] picpiclink
        6. region b:65-128 [93213] picpiclink
        7. region b:129-190 [93214] picpiclink
        8. region b:191-254 [93215] picpiclink
      4. 1ojv picpic
        intact protein
        complexed with act, gol, so4
        1. region a:1-64 [93148] picpiclink
        2. region a:65-128 [93149] picpiclink
        3. region a:129-190 [93150] picpiclink
        4. region a:191-254 [93151] picpiclink
        5. region b:2-64 [93152] picpiclink
        6. region b:65-128 [93153] picpiclink
        7. region b:129-190 [93154] picpiclink
        8. region b:191-254 [93155] picpiclink
      5. 1ok1 picpic
        intact protein
        complexed with act, gol, so4
        1. region a:1-64 [93192] picpiclink
        2. region a:65-128 [93193] picpiclink
        3. region a:129-190 [93194] picpiclink
        4. region a:191-254 [93195] picpiclink
        5. region b:2-64 [93196] picpiclink
        6. region b:65-128 [93197] picpiclink
        7. region b:129-190 [93198] picpiclink
        8. region b:191-254 [93199] picpiclink
      6. 1ok2 picpic
        intact protein
        complexed with act, gol, so4
        1. region a:1-64 [93200] picpiclink
        2. region a:65-128 [93201] picpiclink
        3. region a:129-190 [93202] picpiclink
        4. region a:191-254 [93203] picpiclink
        5. region b:2-64 [93204] picpiclink
        6. region b:65-128 [93205] picpiclink
        7. region b:129-190 [93206] picpiclink
        8. region b:191-254 [93207] picpiclink
      7. 1ojw picpic
        intact protein
        complexed with gol, so4
        1. region a:2-64 [93156] picpiclink
        2. region a:65-128 [93157] picpiclink
        3. region a:129-190 [93158] picpiclink
        4. region a:191-253 [93159] picpiclink
        5. region b:3-64 [93160] picpiclink
        6. region b:65-128 [93161] picpiclink
        7. region b:129-190 [93162] picpiclink
        8. region b:191-253 [93163] picpiclink
      8. 1h2p picpic
        modules 3 and 4
        1. region p:5-66 [83466] picpiclink
        2. region p:67-129 [83467] picpiclink
      9. 1h2q picpic
        modules 3 and 4
        1. region p:5-66 [90548] picpiclink
        2. region p:67-129 [90549] picpiclink
      10. 1ojy picpic
        intact protein
        complexed with act, gol, so4
        1. region a:2-64 [93174] picpiclink
        2. region a:65-128 [93175] picpiclink
        3. region a:129-190 [93176] picpiclink
        4. region a:191-253 [93177] picpiclink
        5. region b:2-64 [93178] picpiclink
        6. region b:65-128 [93179] picpiclink
        7. region b:129-190 [93180] picpiclink
        8. region b:191-254 [93181] picpiclink
        9. region c:1-64 [93182] picpiclink
        10. region c:65-128 [93183] picpiclink
        11. region c:129-190 [93184] picpiclink
        12. region c:191-253 [93185] picpiclink
        13. region d:2-64 [93186] picpiclink
        14. region d:65-128 [93187] picpiclink
        15. region d:129-190 [93188] picpiclink
        16. region d:191-254 [93189] picpiclink
      11. 1uot picpic
        modules 3 and 4
        1. region p:5-66 [99704] picpiclink
        2. region p:67-129 [99705] picpiclink
      12. 1ok9 picpic
        intact protein
        complexed with act, cl, gol, pt, so4
        1. region a:1-64 [93238] picpiclink
        2. region a:65-128 [93239] picpiclink
        3. region a:129-190 [93240] picpiclink
        4. region a:191-254 [93241] picpiclink
        5. region b:1-64 [93242] picpiclink
        6. region b:65-128 [93243] picpiclink
        7. region b:129-190 [93244] picpiclink
        8. region b:191-254 [93245] picpiclink
      13. 1nwv picpic
        modules 2 and 3; a functionally active component of Daf
        1. region a:61-127 [86304] picpiclink
        2. region a:128-189 [86305] picpiclink
      14. 2c8i picpicxrefxref
        automatically matched to d1ojva1
        1. region e:2-63 [130105] picpiclink
      15. 2c8i picpicxrefxref
        automatically matched to d1nwva1
        1. region e:64-128 [130106] picpiclink
      16. 2c8i picpicxrefxref
        automatically matched to d1h03p1
        1. region e:129-190 [130107] picpiclink
      17. 2c8i picpicxrefxref
        automatically matched to d1ojva4
        1. region e:191-253 [130108] picpiclink
      18. 2qzd picpic
        automatically matched to d1ojva4
        1. region a:1191-1254 [151480] picpiclink
      19. 2qzh picpic
        automatically matched to d1nwva1
        1. region a:1061-1127 [151486] picpiclink
      20. 1upn picpicxref
        modules 3 and 4
        1. region e:5-66 [99764] picpiclink
        2. region e:67-129 [99765] picpiclink
      21. 2qzf picpic
        automatically matched to d1ojva1
        1. region a:1001-1062 [151481] picpiclink
  6. Complement receptor 1, cr1 [75680]
    1. Human (Homo sapiens) [TaxId: 9606] [75681] (3)
      1. 1ppq picpic
        module 16
        mutant
        1. chain a [94980] picpiclink
      2. 1gkn picpic
        modules 15 and 16
        mutant
        1. region a:897-960 [70229] picpiclink
        2. region a:961-1024 [70230] picpiclink
      3. 1gkg picpic
        modules 16 and 17
        mutant
        1. region a:957-1022 [70219] picpiclink
        2. region a:1023-1092 [70220] picpiclink
  7. Complement receptor 2, cr2 [64564]
    1. Human (Homo sapiens) [TaxId: 9606] [64565] (6)
      1. 1ly2 picpic
        complexed with nag
        1. region a:0-66 [74335] picpiclink
        2. region a:67-129 [74336] picpiclink
      2. 1ghq picpicxref
        complexed with C3D
        complexed with nag, zn; mutant
        1. region b:1-66 [60522] picpiclink
        2. region b:67-129 [60523] picpiclink
        3. region c:1-66 [60524] picpiclink
        4. region c:67-134 [60525] picpiclink
      3. 1w2r picpic
        automatically matched to d1ly2a1
        1. region a:6-69 [120602] picpiclink
      4. 1w2r picpic
        automatically matched to d1ghqc2
        1. region a:70-137 [120603] picpiclink
      5. 1w2s picpicxref
        automatically matched to d1ly2a1
        1. region b:6-69 [120605] picpiclink
      6. 1w2s picpicxref
        automatically matched to d1ghqc2
        1. region b:70-137 [120606] picpiclink
  8. Complement C1S protease domain [64566]
    1. Human (Homo sapiens) [TaxId: 9606] [64567] (1)
      1. 1elv picpicxref
        complexed with fuc, nag, nes, so4; mutant
        1. region a:342-409 [59455] picpiclink
  9. Complement C1R protease domains [75682]
    1. Human (Homo sapiens) [TaxId: 9606] [75683] (4)
      1. 1zjk picpicxrefxref
        automatically matched to d1gpza2
        mutant
        1. region a:311-363 [125150] picpiclink
      2. 1md8 picpicxref
        1. region a:358-433 [91246] picpiclink
      3. 1gpz picpicxref
        complexed with fuc, man, nag; mutant
        1. region a:290-357 [70303] picpiclink
        2. region a:358-433 [70304] picpiclink
        3. region b:290-357 [70306] picpiclink
        4. region b:358-433 [70307] picpiclink
      4. 1md7 picpicxref
        complexed with nag; mutant
        1. region a:358-433 [91244] picpiclink
  10. Mannan-binding lectin serine protease 2 (MASP-2) domains [111409]
    1. Human (Homo sapiens) [TaxId: 9606] [111410] (2)
      SQ O00187 366-686
      1. 1q3x picpicxref
        complexed with gol, na
        1. region a:366-440 [104527] picpiclink
        2. region b:366-440 [104529] picpiclink
      2. 1zjk picpicxrefxref
        automatically matched to d1q3xa2
        mutant
        1. region a:366-440 [125151] picpiclink
  11. GABA-B receptor 1 [118257]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [118258] (2)
      SQ Q9Z0U4 96-159
      1. 1srz picpic
        1. chain a [112110] picpiclink
      2. 1ss2 picpic
        1. chain a [112111] picpiclink
  12. Complement factor B [144115]
    contains tandemrepeat of three SCR (Sushi) domains
    1. Human (Homo sapiens) [TaxId: 9606] [144116] (3)
      SQ P00751 102-162! SQ P00751 163-224! SQ P00751 34-101
      1. 2ok5 picpicxref
        complexed with bma, gol, man, nag
        1. region a:138-199 [139125] picpiclink
      2. 2ok5 picpicxref
        complexed with bma, gol, man, nag
        1. region a:77-137 [139126] picpiclink
      3. 2ok5 picpicxref
        complexed with bma, gol, man, nag
        1. region a:9-76 [139127] picpiclink
  13. Interleukin-2 receptor alpha chain [144117]
    consists of two segment-swapped SCR domains
    1. Human (Homo sapiens) [TaxId: 9606] [144118] (8)
      SQ P01589 121-186! SQ P01589 124-186! SQ P01589 125-186! SQ P01589 22-85
      1. 2b5i picpicxrefxrefxrefxrefxref
        complexed with nag; mutant
        1. region d:1-64 [127900] picpiclink
      2. 2b5i picpicxrefxrefxrefxrefxref
        complexed with nag; mutant
        1. region d:103-165 [127901] picpiclink
      3. 2erj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        complexed with bma, fuc, nag; mutant
        1. region a:100-165 [132288] picpiclink
      4. 2erj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        complexed with bma, fuc, nag; mutant
        1. region a:1-64 [132289] picpiclink
      5. 2erj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2ERJ A:100-165
        complexed with bma, fuc, nag; mutant
        1. region e:100-165 [132295] picpiclink
      6. 2erj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2ERJ A:1-64
        complexed with bma, fuc, nag; mutant
        1. region e:1-64 [132296] picpiclink
      7. 1z92 picpicxref
        1. region b:1-64 [124738] picpiclink
      8. 1z92 picpicxref
        1. region b:104-165 [124739] picpiclink
  14. Interleukin-15 receptor subunit alpha [161139]
    1. Mouse (Mus musculus) [TaxId: 10090] [161140] (2)
      SQ Q60819 35-103
      1. 2psm picpicxrefxref
        complexed with bam
        1. region c:3-71 [149822] picpiclink
      2. 2psm picpicxrefxref
        automatically matched to 2PSM C:3-71
        complexed with bam
        1. region f:3-70 [149823] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [161141] (11)
      SQ Q13261 31-108! SQ Q13261 31-96
      1. 2z3q picpicxrefxref
        1. region b:1-78 [154003] picpiclink
      2. 2z3q picpicxrefxref
        automatically matched to 2Z3Q B:1-78
        1. region d:1-73 [154005] picpiclink
      3. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2Z3Q B:1-78
        complexed with gol
        1. region b:1-73 [154007] picpiclink
      4. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2Z3Q B:1-78
        complexed with gol
        1. region d:1-72 [154009] picpiclink
      5. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2Z3Q B:1-78
        complexed with gol
        1. region f:1-72 [154011] picpiclink
      6. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2Z3Q B:1-78
        complexed with gol
        1. region h:1-72 [154013] picpiclink
      7. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2Z3Q B:1-78
        complexed with gol
        1. region j:1-73 [154015] picpiclink
      8. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2Z3Q B:1-78
        complexed with gol
        1. region l:1-73 [154017] picpiclink
      9. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2Z3Q B:1-78
        complexed with gol
        1. region n:1-72 [154019] picpiclink
      10. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 2Z3Q B:1-78
        complexed with gol
        1. region p:1-71 [154021] picpiclink
      11. 2ers picpic
        1. region a:31-89 [146988] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk