Structural Classification of Proteins
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Superfamily: Complement control module/SCR domain

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: Complement control module/SCR domain [57534]
    disulfide-rich all-beta fold
  4. Superfamily: Complement control module/SCR domain [57535]
    link to SUPERFAMILY database - Superfamily

Families:

  1. Complement control module/SCR domain [57536] (15)
    Pfam 00084
    1. Factor H, 15th and 16th modules [57537]
      1. Human (Homo sapiens) [TaxId: 9606] [57538] (3) picpic
    2. Complement control protein [57539]
      1. Vaccinia virus [TaxId: 10245] [57540] (15) picpic
        SQ P10998
        a complement protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans
    3. CD46 (membrane cofactor protein, MCP) [57541]
      1. Human (Homo sapiens) [TaxId: 9606] [57542] (5) picpic
    4. beta2-glycoprotein I [57543]
      consists of five modules with the C-terminal module fold being altered
      1. Human (Homo sapiens) [TaxId: 9606] [57544] (4) picpic
    5. Complement decay-accelerating factor (Daf, CD55) [90172]
      1. Human (Homo sapiens) [TaxId: 9606] [90173] (21) picpic
    6. Complement receptor 1, cr1 [75680]
      1. Human (Homo sapiens) [TaxId: 9606] [75681] (3) picpic
    7. Complement receptor 2, cr2 [64564]
      1. Human (Homo sapiens) [TaxId: 9606] [64565] (6) picpic
    8. Complement C1S protease domain [64566]
      1. Human (Homo sapiens) [TaxId: 9606] [64567] (1) picpic
    9. Complement C1R protease domains [75682]
      1. Human (Homo sapiens) [TaxId: 9606] [75683] (4) picpic
    10. Mannan-binding lectin serine protease 2 (MASP-2) domains [111409]
      1. Human (Homo sapiens) [TaxId: 9606] [111410] (2) picpic
        SQ O00187 366-686
    11. GABA-B receptor 1 [118257]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [118258] (2) picpic
        SQ Q9Z0U4 96-159
    12. Complement factor B [144115]
      contains tandemrepeat of three SCR (Sushi) domains
      1. Human (Homo sapiens) [TaxId: 9606] [144116] (3) picpic
        SQ P00751 102-162! SQ P00751 163-224! SQ P00751 34-101
    13. Interleukin-2 receptor alpha chain [144117]
      consists of two segment-swapped SCR domains
      1. Human (Homo sapiens) [TaxId: 9606] [144118] (8) picpic
        SQ P01589 121-186! SQ P01589 124-186! SQ P01589 125-186! SQ P01589 22-85
    14. Interleukin-15 receptor subunit alpha [161139]
      1. Mouse (Mus musculus) [TaxId: 10090] [161140] (2) picpic
        SQ Q60819 35-103
      2. Human (Homo sapiens) [TaxId: 9606] [161141] (11) picpic
        SQ Q13261 31-108! SQ Q13261 31-96
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk