Structural Classification of Proteins

Superfamily: Complement control module/SCR domain

: uperfamily

Lineage:

Root: scop
Class: Small proteins [56992]
Usually dominated by metal ligand, heme, and/or disulfide bridges
Fold: Complement control module/SCR domain [57534]
disulfide-rich all-beta fold
Superfamily: Complement control module/SCR domain [57535]
uperfamily

Families:

Complement control module/SCR domain [57536] (15)
Pfam 00084
1. Factor H, 15th and 16th modules [57537]
  1. Human (Homo sapiens) [TaxId: 9606] [57538] (3)
    1. 1hfi
      15th module only
      1. chain a [44819]
    2. 1hcc
      16th module only
      1. chain a [44820]
    3. 1hfh
      both modules
      1. region a:1-63 [44821]
      2. region a:64-120 [44822]
2. Complement control protein [57539]
  1. Vaccinia virus [TaxId: 10245] [57540] (15)
    SQ P10998
    a complement protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans
    1. 1g40
      1. region a:1-64 [44823]
      2. region a:65-126 [44824]
      3. region a:127-184 [44825]
      4. region a:185-243 [44826]
      5. region b:1-64 [44827]
      6. region b:65-126 [44828]
      7. region b:127-184 [44829]
      8. region b:185-243 [44830]
    2. 1y8e
      automatically matched to d1g40a1
      complexed with svr
      1. region a:1-64 [122736]
    3. 1y8e
      automatically matched to d1e5ga1
      complexed with svr
      1. region a:65-126 [122737]
    4. 1y8e
      automatically matched to d1e5ga2
      complexed with svr
      1. region a:127-184 [122738]
    5. 1y8e
      automatically matched to d1rida4
      complexed with svr
      1. region a:185-244 [122739]
    6. 1y8e
      automatically matched to d1g40a1
      complexed with svr
      1. region b:2-64 [122740]
    7. 1y8e
      automatically matched to d1e5ga1
      complexed with svr
      1. region b:65-126 [122741]
    8. 1y8e
      automatically matched to d1e5ga2
      complexed with svr
      1. region b:127-184 [122742]
    9. 1y8e
      automatically matched to d1rida4
      complexed with svr
      1. region b:185-244 [122743]
    10. 1rid
      complexed with ids, sgn
      1. region a:1-64 [104943]
      2. region a:65-126 [104944]
      3. region a:127-184 [104945]
      4. region a:185-244 [104946]
      5. region b:1-64 [104947]
      6. region b:65-126 [104948]
      7. region b:127-184 [104949]
      8. region b:185-244 [104950]
    11. 1g44
      1. region a:1-64 [44831]
      2. region a:65-125 [44832]
      3. region a:127-184 [44833]
      4. region a:185-243 [44834]
      5. region b:1-64 [44835]
      6. region b:65-125 [44836]
      7. region b:127-184 [44837]
      8. region b:185-243 [44838]
      9. region c:1-64 [44839]
      10. region c:65-125 [44840]
      11. region c:127-183 [44841]
      12. region c:185-243 [44842]
    12. 1e5g
      central cp module pair
      1. region a:7-68 [44843]
      2. region a:69-126 [44844]
    13. 1vve
      1. region a:1-58 [44847]
      2. region a:59-118 [44848]
    14. 1vvd
      1. region a:1-58 [44845]
      2. region a:59-118 [44846]
    15. 1vvc
      1. region a:1-58 [44849]
      2. region a:59-118 [44850]
3. CD46 (membrane cofactor protein, MCP) [57541]
  1. Human (Homo sapiens) [TaxId: 9606] [57542] (5)
    1. 2o39
      automatically matched to d1ckla1
      complexed with bma, ca, nag
      1. region c:1-62 [138898]
    2. 2o39
      automatically matched to d1ckla2
      complexed with bma, ca, nag
      1. region c:63-126 [138899]
    3. 2o39
      automatically matched to d1ckla1
      complexed with bma, ca, nag
      1. region d:1-62 [138900]
    4. 2o39
      automatically matched to d1ckla2
      complexed with bma, ca, nag
      1. region d:63-126 [138901]
    5. 1ckl
      N-terminal two domains
      complexed with ca, cl, man, nag
      1. region a:1-62 [44851]
      2. region a:63-126 [44852]
      3. region b:1-62 [44853]
      4. region b:63-126 [44854]
      5. region c:1-62 [44855]
      6. region c:63-126 [44856]
      7. region d:1-62 [44857]
      8. region d:63-126 [44858]
      9. region e:1-62 [44859]
      10. region e:63-126 [44860]
      11. region f:1-62 [44861]
      12. region f:63-126 [44862]
4. beta2-glycoprotein I [57543]
  consists of five modules with the C-terminal module fold being altered
  1. Human (Homo sapiens) [TaxId: 9606] [57544] (4)
    1. 1qub
      complexed with man, nag
      1. region a:1-62 [44863]
      2. region a:63-120 [44864]
      3. region a:121-183 [44865]
      4. region a:184-243 [44866]
      5. region a:244-326 [44867]
    2. 1c1z
      1. region a:1-62 [44868]
      2. region a:63-120 [44869]
      3. region a:121-183 [44870]
      4. region a:184-243 [44871]
      5. region a:244-326 [44872]
    3. 1g4f
      fifth module
      1. chain a [44873]
    4. 1g4g
      fifth module
      1. chain a [44874]
5. Complement decay-accelerating factor (Daf, CD55) [90172]
  1. Human (Homo sapiens) [TaxId: 9606] [90173] (21)
    1. 1h03
      modules 3 and 4
      1. region p:5-66 [83411]
      2. region p:67-129 [83412]
      3. region q:5-66 [83413]
      4. region q:67-129 [83414]
    2. 1h04
      modules 3 and 4
      complexed with ni
      1. region p:5-66 [83415]
      2. region p:67-129 [83416]
    3. 1ok3
      intact protein
      complexed with act, gol, so4
      1. region a:1-64 [93208]
      2. region a:65-128 [93209]
      3. region a:129-190 [93210]
      4. region a:191-254 [93211]
      5. region b:2-64 [93212]
      6. region b:65-128 [93213]
      7. region b:129-190 [93214]
      8. region b:191-254 [93215]
    4. 1ojv
      intact protein
      complexed with act, gol, so4
      1. region a:1-64 [93148]
      2. region a:65-128 [93149]
      3. region a:129-190 [93150]
      4. region a:191-254 [93151]
      5. region b:2-64 [93152]
      6. region b:65-128 [93153]
      7. region b:129-190 [93154]
      8. region b:191-254 [93155]
    5. 1ok1
      intact protein
      complexed with act, gol, so4
      1. region a:1-64 [93192]
      2. region a:65-128 [93193]
      3. region a:129-190 [93194]
      4. region a:191-254 [93195]
      5. region b:2-64 [93196]
      6. region b:65-128 [93197]
      7. region b:129-190 [93198]
      8. region b:191-254 [93199]
    6. 1ok2
      intact protein
      complexed with act, gol, so4
      1. region a:1-64 [93200]
      2. region a:65-128 [93201]
      3. region a:129-190 [93202]
      4. region a:191-254 [93203]
      5. region b:2-64 [93204]
      6. region b:65-128 [93205]
      7. region b:129-190 [93206]
      8. region b:191-254 [93207]
    7. 1ojw
      intact protein
      complexed with gol, so4
      1. region a:2-64 [93156]
      2. region a:65-128 [93157]
      3. region a:129-190 [93158]
      4. region a:191-253 [93159]
      5. region b:3-64 [93160]
      6. region b:65-128 [93161]
      7. region b:129-190 [93162]
      8. region b:191-253 [93163]
    8. 1h2p
      modules 3 and 4
      1. region p:5-66 [83466]
      2. region p:67-129 [83467]
    9. 1h2q
      modules 3 and 4
      1. region p:5-66 [90548]
      2. region p:67-129 [90549]
    10. 1ojy
      intact protein
      complexed with act, gol, so4
      1. region a:2-64 [93174]
      2. region a:65-128 [93175]
      3. region a:129-190 [93176]
      4. region a:191-253 [93177]
      5. region b:2-64 [93178]
      6. region b:65-128 [93179]
      7. region b:129-190 [93180]
      8. region b:191-254 [93181]
      9. region c:1-64 [93182]
      10. region c:65-128 [93183]
      11. region c:129-190 [93184]
      12. region c:191-253 [93185]
      13. region d:2-64 [93186]
      14. region d:65-128 [93187]
      15. region d:129-190 [93188]
      16. region d:191-254 [93189]
    11. 1uot
      modules 3 and 4
      1. region p:5-66 [99704]
      2. region p:67-129 [99705]
    12. 1ok9
      intact protein
      complexed with act, cl, gol, pt, so4
      1. region a:1-64 [93238]
      2. region a:65-128 [93239]
      3. region a:129-190 [93240]
      4. region a:191-254 [93241]
      5. region b:1-64 [93242]
      6. region b:65-128 [93243]
      7. region b:129-190 [93244]
      8. region b:191-254 [93245]
    13. 1nwv
      modules 2 and 3; a functionally active component of Daf
      1. region a:61-127 [86304]
      2. region a:128-189 [86305]
    14. 2c8i
      automatically matched to d1ojva1
      1. region e:2-63 [130105]
    15. 2c8i
      automatically matched to d1nwva1
      1. region e:64-128 [130106]
    16. 2c8i
      automatically matched to d1h03p1
      1. region e:129-190 [130107]
    17. 2c8i
      automatically matched to d1ojva4
      1. region e:191-253 [130108]
    18. 2qzd
      automatically matched to d1ojva4
      1. region a:1191-1254 [151480]
    19. 2qzh
      automatically matched to d1nwva1
      1. region a:1061-1127 [151486]
    20. 1upn
      modules 3 and 4
      1. region e:5-66 [99764]
      2. region e:67-129 [99765]
    21. 2qzf
      automatically matched to d1ojva1
      1. region a:1001-1062 [151481]
6. Complement receptor 1, cr1 [75680]
  1. Human (Homo sapiens) [TaxId: 9606] [75681] (3)
    1. 1ppq
      module 16
      mutant
      1. chain a [94980]
    2. 1gkn
      modules 15 and 16
      mutant
      1. region a:897-960 [70229]
      2. region a:961-1024 [70230]
    3. 1gkg
      modules 16 and 17
      mutant
      1. region a:957-1022 [70219]
      2. region a:1023-1092 [70220]
7. Complement receptor 2, cr2 [64564]
  1. Human (Homo sapiens) [TaxId: 9606] [64565] (6)
    1. 1ly2
      complexed with nag
      1. region a:0-66 [74335]
      2. region a:67-129 [74336]
    2. 1ghq
      complexed with C3D
      complexed with nag, zn; mutant
      1. region b:1-66 [60522]
      2. region b:67-129 [60523]
      3. region c:1-66 [60524]
      4. region c:67-134 [60525]
    3. 1w2r
      automatically matched to d1ly2a1
      1. region a:6-69 [120602]
    4. 1w2r
      automatically matched to d1ghqc2
      1. region a:70-137 [120603]
    5. 1w2s
      automatically matched to d1ly2a1
      1. region b:6-69 [120605]
    6. 1w2s
      automatically matched to d1ghqc2
      1. region b:70-137 [120606]
8. Complement C1S protease domain [64566]
  1. Human (Homo sapiens) [TaxId: 9606] [64567] (1)
    1. 1elv
      complexed with fuc, nag, nes, so4; mutant
      1. region a:342-409 [59455]
9. Complement C1R protease domains [75682]
  1. Human (Homo sapiens) [TaxId: 9606] [75683] (4)
    1. 1zjk
      automatically matched to d1gpza2
      mutant
      1. region a:311-363 [125150]
    2. 1md8
      1. region a:358-433 [91246]
    3. 1gpz
      complexed with fuc, man, nag; mutant
      1. region a:290-357 [70303]
      2. region a:358-433 [70304]
      3. region b:290-357 [70306]
      4. region b:358-433 [70307]
    4. 1md7
      complexed with nag; mutant
      1. region a:358-433 [91244]
10. Mannan-binding lectin serine protease 2 (MASP-2) domains [111409]
  1. Human (Homo sapiens) [TaxId: 9606] [111410] (2)
    SQ O00187 366-686
    1. 1q3x
      complexed with gol, na
      1. region a:366-440 [104527]
      2. region b:366-440 [104529]
    2. 1zjk
      automatically matched to d1q3xa2
      mutant
      1. region a:366-440 [125151]
11. GABA-B receptor 1 [118257]
  1. Rat (Rattus norvegicus) [TaxId: 10116] [118258] (2)
    SQ Q9Z0U4 96-159
    1. 1srz
      1. chain a [112110]
    2. 1ss2
      1. chain a [112111]
12. Complement factor B [144115]
  contains tandemrepeat of three SCR (Sushi) domains
  1. Human (Homo sapiens) [TaxId: 9606] [144116] (3)
    SQ P00751 102-162! SQ P00751 163-224! SQ P00751 34-101
    1. 2ok5
      complexed with bma, gol, man, nag
      1. region a:138-199 [139125]
    2. 2ok5
      complexed with bma, gol, man, nag
      1. region a:77-137 [139126]
    3. 2ok5
      complexed with bma, gol, man, nag
      1. region a:9-76 [139127]
13. Interleukin-2 receptor alpha chain [144117]
  consists of two segment-swapped SCR domains
  1. Human (Homo sapiens) [TaxId: 9606] [144118] (8)
    SQ P01589 121-186! SQ P01589 124-186! SQ P01589 125-186! SQ P01589 22-85
    1. 2b5i
      complexed with nag; mutant
      1. region d:1-64 [127900]
    2. 2b5i
      complexed with nag; mutant
      1. region d:103-165 [127901]
    3. 2erj
      complexed with bma, fuc, nag; mutant
      1. region a:100-165 [132288]
    4. 2erj
      complexed with bma, fuc, nag; mutant
      1. region a:1-64 [132289]
    5. 2erj
      automatically matched to 2ERJ A:100-165
      complexed with bma, fuc, nag; mutant
      1. region e:100-165 [132295]
    6. 2erj
      automatically matched to 2ERJ A:1-64
      complexed with bma, fuc, nag; mutant
      1. region e:1-64 [132296]
    7. 1z92
      1. region b:1-64 [124738]
    8. 1z92
      1. region b:104-165 [124739]
14. Interleukin-15 receptor subunit alpha [161139]
  1. Mouse (Mus musculus) [TaxId: 10090] [161140] (2)
    SQ Q60819 35-103
    1. 2psm
      complexed with bam
      1. region c:3-71 [149822]
    2. 2psm
      automatically matched to 2PSM C:3-71
      complexed with bam
      1. region f:3-70 [149823]
  2. Human (Homo sapiens) [TaxId: 9606] [161141] (11)
    SQ Q13261 31-108! SQ Q13261 31-96
    1. 2z3q
      1. region b:1-78 [154003]
    2. 2z3q
      automatically matched to 2Z3Q B:1-78
      1. region d:1-73 [154005]
    3. 2z3r
      automatically matched to 2Z3Q B:1-78
      complexed with gol
      1. region b:1-73 [154007]
    4. 2z3r
      automatically matched to 2Z3Q B:1-78
      complexed with gol
      1. region d:1-72 [154009]
    5. 2z3r
      automatically matched to 2Z3Q B:1-78
      complexed with gol
      1. region f:1-72 [154011]
    6. 2z3r
      automatically matched to 2Z3Q B:1-78
      complexed with gol
      1. region h:1-72 [154013]
    7. 2z3r
      automatically matched to 2Z3Q B:1-78
      complexed with gol
      1. region j:1-73 [154015]
    8. 2z3r
      automatically matched to 2Z3Q B:1-78
      complexed with gol
      1. region l:1-73 [154017]
    9. 2z3r
      automatically matched to 2Z3Q B:1-78
      complexed with gol
      1. region n:1-72 [154019]
    10. 2z3r
      automatically matched to 2Z3Q B:1-78
      complexed with gol
      1. region p:1-71 [154021]
    11. 2ers
      1. region a:31-89 [146988]