Structural Classification of Proteins
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Fold: Complement control module/SCR domain

disulfide-rich all-beta fold

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: Complement control module/SCR domain [57534]
    disulfide-rich all-beta fold

Superfamilies:

  1. Complement control module/SCR domain [57535] (1)
    link to SUPERFAMILY database - Superfamily
    1. Complement control module/SCR domain [57536] (15)
      Pfam 00084
      1. Factor H, 15th and 16th modules [57537]
        1. Human (Homo sapiens) [TaxId: 9606] [57538] (3)
          1. 1hfi picpic
            15th module only
            1. chain a [44819] picpiclink
          2. 1hcc picpic
            16th module only
            1. chain a [44820] picpiclink
          3. 1hfh picpic
            both modules
            1. region a:1-63 [44821] picpiclink
            2. region a:64-120 [44822] picpiclink
      2. Complement control protein [57539]
        1. Vaccinia virus [TaxId: 10245] [57540] (15)
          SQ P10998
          a complement protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans
          1. 1g40 picpic
            1. region a:1-64 [44823] picpiclink
            2. region a:65-126 [44824] picpiclink
            3. region a:127-184 [44825] picpiclink
            4. region a:185-243 [44826] picpiclink
            5. region b:1-64 [44827] picpiclink
            6. region b:65-126 [44828] picpiclink
            7. region b:127-184 [44829] picpiclink
            8. region b:185-243 [44830] picpiclink
          2. 1y8e picpic
            automatically matched to d1g40a1
            complexed with svr
            1. region a:1-64 [122736] picpiclink
          3. 1y8e picpic
            automatically matched to d1e5ga1
            complexed with svr
            1. region a:65-126 [122737] picpiclink
          4. 1y8e picpic
            automatically matched to d1e5ga2
            complexed with svr
            1. region a:127-184 [122738] picpiclink
          5. 1y8e picpic
            automatically matched to d1rida4
            complexed with svr
            1. region a:185-244 [122739] picpiclink
          6. 1y8e picpic
            automatically matched to d1g40a1
            complexed with svr
            1. region b:2-64 [122740] picpiclink
          7. 1y8e picpic
            automatically matched to d1e5ga1
            complexed with svr
            1. region b:65-126 [122741] picpiclink
          8. 1y8e picpic
            automatically matched to d1e5ga2
            complexed with svr
            1. region b:127-184 [122742] picpiclink
          9. 1y8e picpic
            automatically matched to d1rida4
            complexed with svr
            1. region b:185-244 [122743] picpiclink
          10. 1rid picpic
            complexed with ids, sgn
            1. region a:1-64 [104943] picpiclink
            2. region a:65-126 [104944] picpiclink
            3. region a:127-184 [104945] picpiclink
            4. region a:185-244 [104946] picpiclink
            5. region b:1-64 [104947] picpiclink
            6. region b:65-126 [104948] picpiclink
            7. region b:127-184 [104949] picpiclink
            8. region b:185-244 [104950] picpiclink
          11. 1g44 picpic
            1. region a:1-64 [44831] picpiclink
            2. region a:65-125 [44832] picpiclink
            3. region a:127-184 [44833] picpiclink
            4. region a:185-243 [44834] picpiclink
            5. region b:1-64 [44835] picpiclink
            6. region b:65-125 [44836] picpiclink
            7. region b:127-184 [44837] picpiclink
            8. region b:185-243 [44838] picpiclink
            9. region c:1-64 [44839] picpiclink
            10. region c:65-125 [44840] picpiclink
            11. region c:127-183 [44841] picpiclink
            12. region c:185-243 [44842] picpiclink
          12. 1e5g picpic
            central cp module pair
            1. region a:7-68 [44843] picpiclink
            2. region a:69-126 [44844] picpiclink
          13. 1vve picpic
            1. region a:1-58 [44847] picpiclink
            2. region a:59-118 [44848] picpiclink
          14. 1vvd picpic
            1. region a:1-58 [44845] picpiclink
            2. region a:59-118 [44846] picpiclink
          15. 1vvc picpic
            1. region a:1-58 [44849] picpiclink
            2. region a:59-118 [44850] picpiclink
      3. CD46 (membrane cofactor protein, MCP) [57541]
        1. Human (Homo sapiens) [TaxId: 9606] [57542] (5)
          1. 2o39 picpicxrefxref
            automatically matched to d1ckla1
            complexed with bma, ca, nag
            1. region c:1-62 [138898] picpiclink
          2. 2o39 picpicxrefxref
            automatically matched to d1ckla2
            complexed with bma, ca, nag
            1. region c:63-126 [138899] picpiclink
          3. 2o39 picpicxrefxref
            automatically matched to d1ckla1
            complexed with bma, ca, nag
            1. region d:1-62 [138900] picpiclink
          4. 2o39 picpicxrefxref
            automatically matched to d1ckla2
            complexed with bma, ca, nag
            1. region d:63-126 [138901] picpiclink
          5. 1ckl picpic
            N-terminal two domains
            complexed with ca, cl, man, nag
            1. region a:1-62 [44851] picpiclink
            2. region a:63-126 [44852] picpiclink
            3. region b:1-62 [44853] picpiclink
            4. region b:63-126 [44854] picpiclink
            5. region c:1-62 [44855] picpiclink
            6. region c:63-126 [44856] picpiclink
            7. region d:1-62 [44857] picpiclink
            8. region d:63-126 [44858] picpiclink
            9. region e:1-62 [44859] picpiclink
            10. region e:63-126 [44860] picpiclink
            11. region f:1-62 [44861] picpiclink
            12. region f:63-126 [44862] picpiclink
      4. beta2-glycoprotein I [57543]
        consists of five modules with the C-terminal module fold being altered
        1. Human (Homo sapiens) [TaxId: 9606] [57544] (4)
          1. 1qub picpic
            complexed with man, nag
            1. region a:1-62 [44863] picpiclink
            2. region a:63-120 [44864] picpiclink
            3. region a:121-183 [44865] picpiclink
            4. region a:184-243 [44866] picpiclink
            5. region a:244-326 [44867] picpiclink
          2. 1c1z picpic
            1. region a:1-62 [44868] picpiclink
            2. region a:63-120 [44869] picpiclink
            3. region a:121-183 [44870] picpiclink
            4. region a:184-243 [44871] picpiclink
            5. region a:244-326 [44872] picpiclink
          3. 1g4f picpic
            fifth module
            1. chain a [44873] picpiclink
          4. 1g4g picpic
            fifth module
            1. chain a [44874] picpiclink
      5. Complement decay-accelerating factor (Daf, CD55) [90172]
        1. Human (Homo sapiens) [TaxId: 9606] [90173] (21)
          1. 1h03 picpic
            modules 3 and 4
            1. region p:5-66 [83411] picpiclink
            2. region p:67-129 [83412] picpiclink
            3. region q:5-66 [83413] picpiclink
            4. region q:67-129 [83414] picpiclink
          2. 1h04 picpic
            modules 3 and 4
            complexed with ni
            1. region p:5-66 [83415] picpiclink
            2. region p:67-129 [83416] picpiclink
          3. 1ok3 picpic
            intact protein
            complexed with act, gol, so4
            1. region a:1-64 [93208] picpiclink
            2. region a:65-128 [93209] picpiclink
            3. region a:129-190 [93210] picpiclink
            4. region a:191-254 [93211] picpiclink
            5. region b:2-64 [93212] picpiclink
            6. region b:65-128 [93213] picpiclink
            7. region b:129-190 [93214] picpiclink
            8. region b:191-254 [93215] picpiclink
          4. 1ojv picpic
            intact protein
            complexed with act, gol, so4
            1. region a:1-64 [93148] picpiclink
            2. region a:65-128 [93149] picpiclink
            3. region a:129-190 [93150] picpiclink
            4. region a:191-254 [93151] picpiclink
            5. region b:2-64 [93152] picpiclink
            6. region b:65-128 [93153] picpiclink
            7. region b:129-190 [93154] picpiclink
            8. region b:191-254 [93155] picpiclink
          5. 1ok1 picpic
            intact protein
            complexed with act, gol, so4
            1. region a:1-64 [93192] picpiclink
            2. region a:65-128 [93193] picpiclink
            3. region a:129-190 [93194] picpiclink
            4. region a:191-254 [93195] picpiclink
            5. region b:2-64 [93196] picpiclink
            6. region b:65-128 [93197] picpiclink
            7. region b:129-190 [93198] picpiclink
            8. region b:191-254 [93199] picpiclink
          6. 1ok2 picpic
            intact protein
            complexed with act, gol, so4
            1. region a:1-64 [93200] picpiclink
            2. region a:65-128 [93201] picpiclink
            3. region a:129-190 [93202] picpiclink
            4. region a:191-254 [93203] picpiclink
            5. region b:2-64 [93204] picpiclink
            6. region b:65-128 [93205] picpiclink
            7. region b:129-190 [93206] picpiclink
            8. region b:191-254 [93207] picpiclink
          7. 1ojw picpic
            intact protein
            complexed with gol, so4
            1. region a:2-64 [93156] picpiclink
            2. region a:65-128 [93157] picpiclink
            3. region a:129-190 [93158] picpiclink
            4. region a:191-253 [93159] picpiclink
            5. region b:3-64 [93160] picpiclink
            6. region b:65-128 [93161] picpiclink
            7. region b:129-190 [93162] picpiclink
            8. region b:191-253 [93163] picpiclink
          8. 1h2p picpic
            modules 3 and 4
            1. region p:5-66 [83466] picpiclink
            2. region p:67-129 [83467] picpiclink
          9. 1h2q picpic
            modules 3 and 4
            1. region p:5-66 [90548] picpiclink
            2. region p:67-129 [90549] picpiclink
          10. 1ojy picpic
            intact protein
            complexed with act, gol, so4
            1. region a:2-64 [93174] picpiclink
            2. region a:65-128 [93175] picpiclink
            3. region a:129-190 [93176] picpiclink
            4. region a:191-253 [93177] picpiclink
            5. region b:2-64 [93178] picpiclink
            6. region b:65-128 [93179] picpiclink
            7. region b:129-190 [93180] picpiclink
            8. region b:191-254 [93181] picpiclink
            9. region c:1-64 [93182] picpiclink
            10. region c:65-128 [93183] picpiclink
            11. region c:129-190 [93184] picpiclink
            12. region c:191-253 [93185] picpiclink
            13. region d:2-64 [93186] picpiclink
            14. region d:65-128 [93187] picpiclink
            15. region d:129-190 [93188] picpiclink
            16. region d:191-254 [93189] picpiclink
          11. 1uot picpic
            modules 3 and 4
            1. region p:5-66 [99704] picpiclink
            2. region p:67-129 [99705] picpiclink
          12. 1ok9 picpic
            intact protein
            complexed with act, cl, gol, pt, so4
            1. region a:1-64 [93238] picpiclink
            2. region a:65-128 [93239] picpiclink
            3. region a:129-190 [93240] picpiclink
            4. region a:191-254 [93241] picpiclink
            5. region b:1-64 [93242] picpiclink
            6. region b:65-128 [93243] picpiclink
            7. region b:129-190 [93244] picpiclink
            8. region b:191-254 [93245] picpiclink
          13. 1nwv picpic
            modules 2 and 3; a functionally active component of Daf
            1. region a:61-127 [86304] picpiclink
            2. region a:128-189 [86305] picpiclink
          14. 2c8i picpicxrefxref
            automatically matched to d1ojva1
            1. region e:2-63 [130105] picpiclink
          15. 2c8i picpicxrefxref
            automatically matched to d1nwva1
            1. region e:64-128 [130106] picpiclink
          16. 2c8i picpicxrefxref
            automatically matched to d1h03p1
            1. region e:129-190 [130107] picpiclink
          17. 2c8i picpicxrefxref
            automatically matched to d1ojva4
            1. region e:191-253 [130108] picpiclink
          18. 2qzd picpic
            automatically matched to d1ojva4
            1. region a:1191-1254 [151480] picpiclink
          19. 2qzh picpic
            automatically matched to d1nwva1
            1. region a:1061-1127 [151486] picpiclink
          20. 1upn picpicxref
            modules 3 and 4
            1. region e:5-66 [99764] picpiclink
            2. region e:67-129 [99765] picpiclink
          21. 2qzf picpic
            automatically matched to d1ojva1
            1. region a:1001-1062 [151481] picpiclink
      6. Complement receptor 1, cr1 [75680]
        1. Human (Homo sapiens) [TaxId: 9606] [75681] (3)
          1. 1ppq picpic
            module 16
            mutant
            1. chain a [94980] picpiclink
          2. 1gkn picpic
            modules 15 and 16
            mutant
            1. region a:897-960 [70229] picpiclink
            2. region a:961-1024 [70230] picpiclink
          3. 1gkg picpic
            modules 16 and 17
            mutant
            1. region a:957-1022 [70219] picpiclink
            2. region a:1023-1092 [70220] picpiclink
      7. Complement receptor 2, cr2 [64564]
        1. Human (Homo sapiens) [TaxId: 9606] [64565] (6)
          1. 1ly2 picpic
            complexed with nag
            1. region a:0-66 [74335] picpiclink
            2. region a:67-129 [74336] picpiclink
          2. 1ghq picpicxref
            complexed with C3D
            complexed with nag, zn; mutant
            1. region b:1-66 [60522] picpiclink
            2. region b:67-129 [60523] picpiclink
            3. region c:1-66 [60524] picpiclink
            4. region c:67-134 [60525] picpiclink
          3. 1w2r picpic
            automatically matched to d1ly2a1
            1. region a:6-69 [120602] picpiclink
          4. 1w2r picpic
            automatically matched to d1ghqc2
            1. region a:70-137 [120603] picpiclink
          5. 1w2s picpicxref
            automatically matched to d1ly2a1
            1. region b:6-69 [120605] picpiclink
          6. 1w2s picpicxref
            automatically matched to d1ghqc2
            1. region b:70-137 [120606] picpiclink
      8. Complement C1S protease domain [64566]
        1. Human (Homo sapiens) [TaxId: 9606] [64567] (1)
          1. 1elv picpicxref
            complexed with fuc, nag, nes, so4; mutant
            1. region a:342-409 [59455] picpiclink
      9. Complement C1R protease domains [75682]
        1. Human (Homo sapiens) [TaxId: 9606] [75683] (4)
          1. 1zjk picpicxrefxref
            automatically matched to d1gpza2
            mutant
            1. region a:311-363 [125150] picpiclink
          2. 1md8 picpicxref
            1. region a:358-433 [91246] picpiclink
          3. 1gpz picpicxref
            complexed with fuc, man, nag; mutant
            1. region a:290-357 [70303] picpiclink
            2. region a:358-433 [70304] picpiclink
            3. region b:290-357 [70306] picpiclink
            4. region b:358-433 [70307] picpiclink
          4. 1md7 picpicxref
            complexed with nag; mutant
            1. region a:358-433 [91244] picpiclink
      10. Mannan-binding lectin serine protease 2 (MASP-2) domains [111409]
        1. Human (Homo sapiens) [TaxId: 9606] [111410] (2)
          SQ O00187 366-686
          1. 1q3x picpicxref
            complexed with gol, na
            1. region a:366-440 [104527] picpiclink
            2. region b:366-440 [104529] picpiclink
          2. 1zjk picpicxrefxref
            automatically matched to d1q3xa2
            mutant
            1. region a:366-440 [125151] picpiclink
      11. GABA-B receptor 1 [118257]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [118258] (2)
          SQ Q9Z0U4 96-159
          1. 1srz picpic
            1. chain a [112110] picpiclink
          2. 1ss2 picpic
            1. chain a [112111] picpiclink
      12. Complement factor B [144115]
        contains tandemrepeat of three SCR (Sushi) domains
        1. Human (Homo sapiens) [TaxId: 9606] [144116] (3)
          SQ P00751 102-162! SQ P00751 163-224! SQ P00751 34-101
          1. 2ok5 picpicxref
            complexed with bma, gol, man, nag
            1. region a:138-199 [139125] picpiclink
          2. 2ok5 picpicxref
            complexed with bma, gol, man, nag
            1. region a:77-137 [139126] picpiclink
          3. 2ok5 picpicxref
            complexed with bma, gol, man, nag
            1. region a:9-76 [139127] picpiclink
      13. Interleukin-2 receptor alpha chain [144117]
        consists of two segment-swapped SCR domains
        1. Human (Homo sapiens) [TaxId: 9606] [144118] (8)
          SQ P01589 121-186! SQ P01589 124-186! SQ P01589 125-186! SQ P01589 22-85
          1. 2b5i picpicxrefxrefxrefxrefxref
            complexed with nag; mutant
            1. region d:1-64 [127900] picpiclink
          2. 2b5i picpicxrefxrefxrefxrefxref
            complexed with nag; mutant
            1. region d:103-165 [127901] picpiclink
          3. 2erj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
            complexed with bma, fuc, nag; mutant
            1. region a:100-165 [132288] picpiclink
          4. 2erj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
            complexed with bma, fuc, nag; mutant
            1. region a:1-64 [132289] picpiclink
          5. 2erj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to 2ERJ A:100-165
            complexed with bma, fuc, nag; mutant
            1. region e:100-165 [132295] picpiclink
          6. 2erj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to 2ERJ A:1-64
            complexed with bma, fuc, nag; mutant
            1. region e:1-64 [132296] picpiclink
          7. 1z92 picpicxref
            1. region b:1-64 [124738] picpiclink
          8. 1z92 picpicxref
            1. region b:104-165 [124739] picpiclink
      14. Interleukin-15 receptor subunit alpha [161139]
        1. Mouse (Mus musculus) [TaxId: 10090] [161140] (2)
          SQ Q60819 35-103
          1. 2psm picpicxrefxref
            complexed with bam
            1. region c:3-71 [149822] picpiclink
          2. 2psm picpicxrefxref
            automatically matched to 2PSM C:3-71
            complexed with bam
            1. region f:3-70 [149823] picpiclink
        2. Human (Homo sapiens) [TaxId: 9606] [161141] (11)
          SQ Q13261 31-108! SQ Q13261 31-96
          1. 2z3q picpicxrefxref
            1. region b:1-78 [154003] picpiclink
          2. 2z3q picpicxrefxref
            automatically matched to 2Z3Q B:1-78
            1. region d:1-73 [154005] picpiclink
          3. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to 2Z3Q B:1-78
            complexed with gol
            1. region b:1-73 [154007] picpiclink
          4. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to 2Z3Q B:1-78
            complexed with gol
            1. region d:1-72 [154009] picpiclink
          5. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to 2Z3Q B:1-78
            complexed with gol
            1. region f:1-72 [154011] picpiclink
          6. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to 2Z3Q B:1-78
            complexed with gol
            1. region h:1-72 [154013] picpiclink
          7. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to 2Z3Q B:1-78
            complexed with gol
            1. region j:1-73 [154015] picpiclink
          8. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to 2Z3Q B:1-78
            complexed with gol
            1. region l:1-73 [154017] picpiclink
          9. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to 2Z3Q B:1-78
            complexed with gol
            1. region n:1-72 [154019] picpiclink
          10. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
            automatically matched to 2Z3Q B:1-78
            complexed with gol
            1. region p:1-71 [154021] picpiclink
          11. 2ers picpic
            1. region a:31-89 [146988] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk