Structural Classification of Proteins
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Superfamily: Leech antihemostatic proteins

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: Knottins (small inhibitors, toxins, lectins) [57015]
    disulfide-bound fold; contains beta-hairpin with two adjacent disulfides
  4. Superfamily: Leech antihemostatic proteins [57262]
    link to SUPERFAMILY database - Superfamily

Families:

  1. Huristasin-like [57263] (3)
    1. Hirustasin [57264]
      1. Medicinal leech (Hirudo medicinalis) [TaxId: 6421] [57265] (3)
        1. 1bx7 picpic
          complexed with so4
          1. chain a [44355] picpiclink
        2. 1bx8 picpic
          complexed with so4
          1. chain a [44356] picpiclink
        3. 1hia picpicxref
          1. chain i [44357] picpiclink
          2. chain j [44358] picpiclink
    2. Bdellastasin [57266]
      1. Medicinal leech (Hirudo medicinalis) [TaxId: 6421] [57267] (3)
        1. 1eja picpicxref
          complexed with na
          1. chain b [59416] picpiclink
        2. 1c9p picpicxref
          complexed with ca, ias
          1. chain b [44359] picpiclink
        3. 1c9t picpicxref
          1. chain g [44360] picpiclink
          2. chain h [44361] picpiclink
          3. chain i [44362] picpiclink
          4. chain j [44363] picpiclink
          5. chain k [44364] picpiclink
          6. chain l [44365] picpiclink
    3. Factor Xa inhibitor antistasin [57268]
      duplication: consists of two similar domain
      1. Mexican leech (Haementeria officinalis) [TaxId: 6410] [57269] (1)
        1. 1skz picpic
          complexed with cl; mutant
          1. region a:7-58 [44366] picpiclink
          2. region a:59-110 [44367] picpiclink
  2. Hirudin-like [57270] (3)
    1. Hirudin [57271]
      1. Leech (Hirudo medicinalis) [TaxId: 6421] [57272] (8)
        1. 4htc picpicxref
          complexed with nag
          1. chain i [44368] picpiclink
        2. 3htc picpicxref
          CA-atoms only
          1. chain i [44369] picpiclink
        3. 1hrt picpicxref
          1. chain i [44370] picpiclink
        4. 1hic picpic
          1. chain a [44371] picpiclink
        5. 4hir picpic
          mutant
          1. chain a [44374] picpiclink
        6. 2hir picpic
          1. chain a [44372] picpiclink
        7. 5hir picpic
          1. chain a [44373] picpiclink
        8. 6hir picpic
          mutant
          1. chain a [44375] picpiclink
    2. Decorsin [57273]
      1. North american leech (Macrobdella decora) [TaxId: 6405] [57274] (1)
        1. 1dec picpic
          1. chain a [44376] picpiclink
    3. Haemadin [57275]
      1. Indian leech (Haemadipsa sylvestris) [TaxId: 13555] [57276] (1)
        1. 1e0f picpicxref
          1. chain i [44377] picpiclink
          2. chain j [44378] picpiclink
          3. chain k [44379] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk