Structural Classification of Proteins
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Protein: Thrombin from Human (Homo sapiens) [TaxId: 9606]

SQ P00734 331-361,364-421 ! SQ P00734 334-360 364-510 518-619 ! SQ P00734 328-620 ! SQ P00734 355-621 ! SQ P00734 328-620

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Trypsin-like serine proteases [50493]
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. Superfamily: Trypsin-like serine proteases [50494]
    link to SUPERFAMILY database - Superfamily
  5. Family: Eukaryotic proteases [50514]
  6. Protein: Thrombin [50531]
  7. Species: Human (Homo sapiens) [TaxId: 9606] [50532]
    SQ P00734 331-361,364-421 ! SQ P00734 334-360 364-510 518-619 ! SQ P00734 328-620 ! SQ P00734 355-621 ! SQ P00734 328-620

PDB Entry Domains:

  1. 1h8d picpic
    complexed with phw
    1. chain l,h [60737] picpiclink
  2. 1oyt picpic
    complexed with ca, fsn, na, sin
    1. chain l,h [87615] picpiclink
  3. 2bdy picpic
    automatically matched to d1jwta_
    complexed with na, unb
    1. region a:7-286 [128347] picpiclink
  4. 1c5l picpic
    complexed with ca, na
    1. chain l,h [26078] picpiclink
  5. 1aht picpic
    complexed with apa, sfo
    1. chain l,h [26079] picpiclink
  6. 1c5n picpic
    complexed with ca, esi, na
    1. chain l,h [26080] picpiclink
  7. 1o2g picpic
    complexed with 696, na, sty
    1. chain l,h [86595] picpiclink
  8. 1nm6 picpic
    complexed with l86
    1. chain a [91973] picpiclink
  9. 1h8i picpic
    complexed with phw
    1. chain l,h [60778] picpiclink
  10. 1doj picpic
    complexed with ar2, ch3, na, nag
    1. chain a [26081] picpiclink
  11. 1tom picpic
    complexed with min
    1. chain l,h [26082] picpiclink
  12. 1eb1 picpic
    complexed with alc, mmo, pro
    1. chain l,h [64892] picpiclink
  13. 1sl3 picpic
    complexed with 170
    1. chain a [105709] picpiclink
  14. 1ghx picpic
    complexed with bmz, ca, na, zn
    1. chain l,h [65204] picpiclink
  15. 1a3e picpic
    complexed with t16
    1. chain l,h [26086] picpiclink
  16. 1no9 picpic
    complexed with 4nd, nag
    1. chain l,h [92019] picpiclink
  17. 1ihs picpic
    complexed with pnl
    1. chain l,h [26092] picpiclink
  18. 1xmn picpic
    complexed with gol, ids, man, na, nag, sgn
    1. chain a,b [115495] picpiclink
    2. chain c,d [115496] picpiclink
    3. chain e,f [115497] picpiclink
    4. chain g,h [115498] picpiclink
  19. 1z71 picpic
    automatically matched to d1jwta_
    complexed with l17
    1. region a:1a-245 [124582] picpiclink
  20. 1k21 picpic
    complexed with ign, na, nag, tys
    1. chain l,h [72000] picpiclink
  21. 1k22 picpic
    complexed with mel, na, nag, tys
    1. chain l,h [72001] picpiclink
  22. 1a4w picpic
    complexed with 2ep, ans, kth, na
    1. chain l,h [26083] picpiclink
  23. 1a3b picpic
    complexed with t29
    1. chain l,h [26084] picpiclink
  24. 1gj5 picpic
    complexed with 130, na, sty
    1. chain l,h [70178] picpiclink
  25. 1qbv picpic
    1. chain l,h [26090] picpiclink
  26. 1jou picpic
    complexed with acy, gol, na, nag; mutant
    1. chain a,b [63218] picpiclink
    2. chain c,d [63219] picpiclink
    3. chain e,f [63220] picpiclink
  27. 1ai8 picpic
    complexed with t42
    1. chain l,h [26087] picpiclink
  28. 1ghw picpic
    complexed with bmz, his, na
    1. chain l,h [65203] picpiclink
  29. 1zrb picpic
    automatically matched to d1jwta_
    complexed with 062
    1. region a:1a-245 [125530] picpiclink
  30. 3c1k picpic
    automatically matched to d1jwta_
    complexed with t15
    1. region a:1a-246 [155866] picpiclink
  31. 1ba8 picpic
    complexed with nag, pms, ron
    1. chain a,b [26085] picpiclink
  32. 1c1u picpic
    complexed with bai, na, zn
    1. chain l,h [26091] picpiclink
  33. 1o5g picpic
    complexed with ca, cr9, na
    1. chain l,h [103889] picpiclink
  34. 1hbt picpic
    complexed with chx, paa
    1. chain l,h [26093] picpiclink
  35. 1de7 picpic
    complexed with ch2, na
    1. chain l,h [26095] picpiclink
    2. chain j,k [26096] picpiclink
  36. 1iht picpic
    complexed with fbe, ptl
    1. chain l,h [26094] picpiclink
  37. 1g32 picpic
    complexed with r11
    1. chain a,b [65120] picpiclink
  38. 1mu6 picpic
    complexed with cda
    1. chain a,b [91462] picpiclink
  39. 1mu8 picpic
    complexed with cdb
    1. chain a,b [91463] picpiclink
  40. 1ghv picpic
    complexed with 120, na
    1. chain l,h [65202] picpiclink
  41. 1gj4 picpic
    complexed with 132, na, sty
    1. chain l,h [70177] picpiclink
  42. 1bcu picpic
    complexed with prl
    1. chain l,h [26107] picpiclink
  43. 1g37 picpic
    complexed with 110
    1. chain a [60234] picpiclink
  44. 1mue picpic
    complexed with cdd
    1. chain a,b [91464] picpiclink
  45. 1nt1 picpic
    complexed with t76
    1. chain a [92101] picpiclink
  46. 1ay6 picpic
    complexed with hho, hmf
    1. chain l,h [26088] picpiclink
  47. 1ghy picpic
    complexed with 121, ca, na, zn
    1. chain l,h [65205] picpiclink
  48. 1vr1 picpic
    complexed with sfo
    1. chain l,h [26099] picpiclink
  49. 1eoj picpic
    complexed with bbs, cpi, doa
    1. chain a [26105] picpiclink
  50. 1ad8 picpic
    complexed with mdl, na
    1. chain l,h [26114] picpiclink
  51. 1ppb picpic
    complexed with ch2
    1. chain l,h [26089] picpiclink
  52. 1riw picpic
    complexed with na, nag, osc, so4
    1. chain a,b,c [111819] picpiclink
  53. 1c1w picpic
    complexed with bah, na, zn
    1. chain l,h [26104] picpiclink
  54. 1aix picpic
    complexed with t19
    1. chain l,h [26113] picpiclink
  55. 1g30 picpic
    complexed with t87
    1. chain a,b [65119] picpiclink
  56. 1eol picpic
    complexed with bbs, cpi, doa
    1. chain a [26126] picpiclink
  57. 1qur picpic
    complexed with abu, aph, nas, pip
    1. chain l,h [26118] picpiclink
  58. 1c5o picpic
    complexed with bam, na
    1. chain l,h [26097] picpiclink
  59. 1lhc picpic
    complexed with dp7
    1. chain l,h [26100] picpiclink
  60. 1ae8 picpic
    complexed with azl, nag
    1. chain l,h [26101] picpiclink
  61. 1d3d picpic
    complexed with bzt, na, nag
    1. chain a,b [26103] picpiclink
  62. 1ktt picpic
    complexed with c02
    1. chain a,b [68866] picpiclink
  63. 1qj1 picpic
    complexed with 166
    1. chain a,b [26111] picpiclink
  64. 1zgv picpic
    automatically matched to d1jwta_
    complexed with 501
    1. region a:1a-245 [125063] picpiclink
  65. 1d6w picpic
    complexed with aim, hmm, na, sml
    1. chain a [26098] picpiclink
  66. 1bb0 picpic
    complexed with 3ga, na, pms, ron
    1. chain a,b [26106] picpiclink
  67. 1uma picpic
    complexed with in2, nag, sfo
    1. chain l,h [26102] picpiclink
  68. 1afe picpic
    complexed with alz, nag
    1. chain l,h [26110] picpiclink
  69. 1d4p picpic
    complexed with bpp, na, nag
    1. chain a,b [26119] picpiclink
  70. 1c1v picpic
    complexed with bab, na, zn
    1. chain l,h [26121] picpiclink
  71. 1nu9 picpicxref
    complexed with hg, imd, mcr
    1. chain a [92199] picpiclink
    2. chain d [92202] picpiclink
  72. 1bhx picpic
    complexed with r56
    1. chain a,b,f [26143] picpiclink
  73. 1zgi picpic
    automatically matched to d1jwta_
    complexed with 382
    1. region a:1a-245 [125030] picpiclink
  74. 1a46 picpic
    complexed with bcy, na, oho, rng
    1. chain l,h [26108] picpiclink
  75. 1d3p picpic
    complexed with bt3, na, nag
    1. chain a,b [26117] picpiclink
  76. 1nu7 picpicxref
    complexed with hg, imd, mcr
    1. chain a,b [92189] picpiclink
    2. chain e,f [92190] picpiclink
  77. 1ca8 picpic
    complexed with 3ga, na, pms, ron
    1. chain a,b [26120] picpiclink
  78. 1nzq picpic
    complexed with 162, alc, sin, smf
    1. chain l,h [92386] picpiclink
  79. 1dx5 picpicxref
    complexed with ca, fmt, na, nag; mutant
    1. chain a,m [26155] picpiclink
    2. chain b,n [26156] picpiclink
    3. chain c,o [26157] picpiclink
    4. chain d,p [26158] picpiclink
  80. 1hxf picpic
    1. chain l,h [26115] picpiclink
  81. 1a5g picpic
    complexed with bic, eoa, na
    1. chain l,h [26112] picpiclink
  82. 1b5g picpic
    complexed with bcc, na, thz
    1. chain l,h [26109] picpiclink
  83. 1qj7 picpic
    complexed with gr1
    1. chain a,b [26133] picpiclink
  84. 7kme picpic
    complexed with na
    1. chain l,h [26124] picpiclink
  85. 1hah picpic
    complexed with nag, sfo
    1. chain l,h [26125] picpiclink
  86. 1tmt picpic
    complexed with nag
    1. chain l,h [26127] picpiclink
  87. 5gds picpic
    complexed with nag, nal
    1. chain l,h [26131] picpiclink
  88. 1xm1 picpic
    automatically matched to d1jwta_
    complexed with gah
    1. region a:1b-245 [122141] picpiclink
  89. 1hxe picpic
    complexed with rb
    1. chain l,h [26116] picpiclink
  90. 1awf picpic
    complexed with gr4
    1. chain l,h [26141] picpiclink
  91. 1qj6 picpic
    complexed with 167
    1. chain a,b [26144] picpiclink
  92. 1qhr picpic
    complexed with 157
    1. chain a,b [26151] picpiclink
  93. 1a61 picpic
    complexed with lom, mol, na
    1. chain l,h [26122] picpiclink
  94. 1tbz picpic
    complexed with bot, na
    1. chain l,h [26128] picpiclink
  95. 2thf picpic
    complexed with ch2, na; mutant
    1. chain a,b [26139] picpiclink
  96. 1lhe picpic
    complexed with di3
    1. chain l,h [26148] picpiclink
  97. 1ths picpic
    complexed with chx, sin
    1. chain l,h [26130] picpiclink
  98. 1thp picpic
    complexed with ch2; mutant
    1. chain a,b [26140] picpiclink
  99. 1fpc picpic
    complexed with ans, epi, so3
    1. chain l,h [26132] picpiclink
  100. 1dit picpic
    complexed with 2pp, cbx
    1. chain l,h [26136] picpiclink
  101. 1hai picpic
    complexed with ch2, nag
    1. chain l,h [26146] picpiclink
  102. 1nrr picpic
    complexed with ch2
    1. chain l,h [26147] picpiclink
  103. 1tmb picpic
    complexed with aht, sfn
    1. chain l,h [26138] picpiclink
  104. 1lhg picpic
    complexed with di5
    1. chain l,h [26149] picpiclink
  105. 1b7x picpic
    mutant
    1. chain a,b [26153] picpiclink
  106. 1kts picpic
    complexed with c24
    1. chain a,b [68865] picpiclink
  107. 1ook picpicxref
    complexed with cl, man, nag, tys; mutant
    1. chain a,b [87199] picpiclink
  108. 1a2c picpic
    complexed with na, oar, oph, rph
    1. chain l,h [26123] picpiclink
  109. 1abi picpic
    1. chain l,h [26137] picpiclink
  110. 2hgt picpic
    1. chain l,h [26142] picpiclink
  111. 1thr picpic
    1. chain l,h [26152] picpiclink
  112. 1fph picpic
    complexed with ch2
    1. chain l,h [26160] picpiclink
  113. 1lhd picpic
    complexed with di2
    1. chain l,h [26162] picpiclink
  114. 1o0d picpic
    complexed with 163, alc, sin, smf
    1. chain l,h [92392] picpiclink
  115. 1tq7 picpic
    complexed with ch2, nag, zn; mutant
    1. chain a,b [107203] picpiclink
  116. 8kme picpic
    complexed with cuc, na
    1. chain 1,2 [26129] picpiclink
  117. 1c4u picpic
    complexed with ih1, na
    1. chain 1,2 [26134] picpiclink
  118. 1hag picpic
    prethrombin 2
    complexed with nag, sfo
    1. chain e [26135] picpiclink
  119. 1c4v picpic
    complexed with ih2, na
    1. chain 1,2 [26145] picpiclink
  120. 1hgt picpic
    complexed with sfn
    1. chain l,h [26150] picpiclink
  121. 1nrs picpic
    complexed with sfn
    1. chain l,h [26154] picpiclink
  122. 1p8v picpicxref
    complexed with dfp, mes, nag, tys; mutant
    1. chain b,c [87984] picpiclink
  123. 1uvs picpic
    complexed with i11
    1. chain l,h [26174] picpiclink
  124. 1abj picpic
    complexed with ch2
    1. chain l,h [26161] picpiclink
  125. 4htc picpicxref
    complexed with nag
    1. chain l,h [26164] picpiclink
  126. 1dwc picpic
    complexed with mit
    1. chain l,h [26167] picpiclink
  127. 1tb6 picpicxref
    complexed with fuc, gu0, gu1, gu2, gu3, gu4, gu5, gu6, gu8, gu9, man, mpd, nag; mutant
    1. chain l,h [106737] picpiclink
  128. 1rd3 picpic
    complexed with fuc, gol, man, nag, po4; mutant
    1. chain a,b [97302] picpiclink
    2. chain c,d [97303] picpiclink
  129. 1dwe picpic
    complexed with ch2
    1. chain l,h [26173] picpiclink
  130. 1dwd picpic
    complexed with mid
    1. chain l,h [26179] picpiclink
  131. 1d9i picpic
    complexed with chn, hmm, na, sml
    1. chain a [26159] picpiclink
  132. 1dwb picpic
    complexed with ben
    1. chain l,h [26180] picpiclink
  133. 3hat picpic
    complexed with rng, so3
    1. chain l,h [26163] picpiclink
  134. 1tmu picpic
    complexed with ch2, nag, so3
    1. chain l,h [26165] picpiclink
  135. 1lhf picpic
    complexed with di4
    1. chain l,h [26166] picpiclink
  136. 1bmn picpic
    complexed with bm9
    1. chain l,h [26168] picpiclink
  137. 1d3q picpic
    complexed with bt2, na, nag
    1. chain a,b [26176] picpiclink
  138. 4thn picpic
    complexed with nag, nal
    1. chain l,h [26170] picpiclink
  139. 1bmm picpic
    complexed with bm2
    1. chain l,h [26169] picpiclink
  140. 1mh0 picpic
    anticoagulant slow form
    complexed with nag; mutant
    1. chain a [79110] picpiclink
    2. chain b [79111] picpiclink
  141. 1d3t picpic
    complexed with bt1, na, nag
    1. chain a,b [26177] picpiclink
  142. 1tq0 picpic
    mutant
    1. chain a,b [107196] picpiclink
    2. chain c,d [107197] picpiclink
  143. 1ny2 picpic
    complexed with tys
    1. chain 1,2 [86397] picpiclink
  144. 1c4y picpic
    complexed with ih3
    1. chain 1,2 [26172] picpiclink
  145. 1jwt picpic
    complexed with bli
    1. chain a [67398] picpiclink
  146. 3htc picpicxref
    CA-atoms only
    1. chain l,h [26175] picpiclink
  147. 1dm4 picpic
    1. chain a,b [26171] picpiclink
  148. 1e0f picpicxref
    1. chain a,d [26184] picpiclink
    2. chain b,e [26185] picpiclink
    3. chain c,f [26186] picpiclink
  149. 2hnt picpic
    1. chain l,c,e,f [26178] picpiclink
  150. 1hdt picpic
    complexed with alg, ch3, so3
    1. chain l,h [26183] picpiclink
  151. 1hlt picpic
    complexed with ch2
    1. chain l,h [26181] picpiclink
    2. chain j,k [26182] picpiclink
  152. 1awh picpic
    complexed with gr3
    1. chain a,b [26191] picpiclink
    2. chain c,d [26192] picpiclink
  153. 1hap picpic
    protein/DNA complex; complexed with ch2
    1. chain l,h [26187] picpiclink
  154. 1hao picpic
    protein/DNA complex; complexed with ch2
    1. chain l,h [26188] picpiclink
  155. 1sr5 picpicxref
    complexed with nag, nt1, nt2
    1. chain b,c [105951] picpiclink
  156. 1nrn picpic
    1. chain l,h [26190] picpiclink
  157. 2hpq picpicxref
    complexed with ch2
    1. chain l,h [26193] picpiclink
  158. 2hpp picpicxref
    complexed with ch2
    1. chain l,h [26194] picpiclink
  159. 1hut picpic
    protein/DNA complex; complexed with ch2
    1. chain l,h [26189] picpiclink
  160. 1nrp picpic
    1. chain l,h [26195] picpiclink
  161. 1nro picpic
    1. chain l,h [26196] picpiclink
  162. 1qvh picpicxrefxrefxref
    complexed with po4
    1. chain a,b [96419] picpiclink
    2. chain d,e [96420] picpiclink
  163. 1nrq picpic
    1. chain l,h [26197] picpiclink
  164. 1jmo picpicxref
    complex with a heparin cofactor II mutant
    1. chain l,h [77137] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk