Structural Classification of Proteins
home mail help root up expand collapse

Family: Eukaryotic proteases

Lineage:

  1. Root: scop
  2. Class: All beta proteins [48724]
  3. Fold: Trypsin-like serine proteases [50493]
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. Superfamily: Trypsin-like serine proteases [50494]
    link to SUPERFAMILY database - Superfamily
  5. Family: Eukaryotic proteases [50514]

Protein Domains:

  1. Trypsin(ogen) [50515]
    1. Cow (Bos taurus) [TaxId: 9913] [50516] (282) picpic
      SQ P00760
    2. Pig (Sus scrofa) [TaxId: 9823] [50517] (26) picpic
      SQ P00761 9-231 ! SQ P00761
    3. Rat (Rattus norvegicus) [TaxId: 10116] [50518] (33) picpic
    4. Human (Homo sapiens) [TaxId: 9606] [50519] (1) picpic
    5. Human (Homo sapiens), trypsin IV (brain isoform) [TaxId: 9606] [69283] (1) picpic
    6. North atlantic salmon (Salmo salar) [TaxId: 8030] [50520] (11) picpic
    7. Pacific chum salmon (Oncorhynchus keta) [TaxId: 8018] [82121] (1) picpic
    8. Mold (Fusarium oxysporum) [TaxId: 5507] [50521] (16) picpic
    9. Narrow-clawed crayfish (Pontastacus leptodactylus) [TaxId: 6717] [141385] (1) picpic
      SQ Q52V24 1-237
  2. (alpha,gamma)-chymotrypsin(ogen) [50522]
    1. Cow (Bos taurus) [TaxId: 9913] [50523] (62) picpic
      SQ P00766
    2. Rat (Rattus norvegicus) [TaxId: 10116] [89340] (1) picpic
    3. Red fire ant (Solenopsis invicta) [TaxId: 13686] [50524] (1) picpic
  3. Neuropsin [50525]
    1. Mouse (Mus musculus) [TaxId: 10090] [50526] (1) picpic
  4. Crab collagenase [50527]
    1. Atlantic sand fiddler crab (Uca pugilator) [TaxId: 6772] [50528] (1) picpic
  5. HL collagenase [50529]
    1. Common cattle grub (Hypoderma lineatum) [TaxId: 7389] [50530] (2) picpic
  6. Thrombin [50531]
    1. Human (Homo sapiens) [TaxId: 9606] [50532] (164) picpic
      SQ P00734 331-361,364-421 ! SQ P00734 334-360 364-510 518-619 ! SQ P00734 328-620 ! SQ P00734 355-621 ! SQ P00734 328-620
    2. Cow (Bos taurus) [TaxId: 9913] [50533] (26) picpic
      SQ P00734 333-622
  7. Procarboxypeptidase A-S6 subunit III (zymogen E) [50534]
    1. Cow (Bos taurus) [TaxId: 9913] [50535] (2) picpic
  8. Elastase [50536]
    1. Human (Homo sapiens) [TaxId: 9606] [50537] (7) picpic
    2. Pig (Sus scrofa) [TaxId: 9823] [50538] (94) picpic
    3. Salmon (Salmo salar) [TaxId: 8030] [50539] (1) picpic
    4. Worm (Eisenia fetida) [TaxId: 6396] [74973] (1) picpic
      fibrinolytic enzyme component A
  9. Enteropeptidase (enterokinase light chain) [50540]
    1. Cow (Bos taurus) [TaxId: 9913] [50541] (1) picpic
  10. Urokinase [50542]
    1. Human (Homo sapiens) [TaxId: 9606] [50543] (1) picpic
  11. Heparin binding protein, HBP [50544]
    multifunctional protein (synonym: CAP37, azurocidin)
    1. Human (Homo sapiens) [TaxId: 9606] [50545] (4) picpic
  12. Alpha tryptase I [89341]
    1. Human (Homo sapiens) [TaxId: 9606] [89342] (1) picpic
  13. beta-Tryptase [50546]
    ring-like tetramer with active sites facing a central pore
    1. Human (Homo sapiens) [TaxId: 9606] [50547] (33) picpic
  14. Cathepsin G [50548]
    1. Human (Homo sapiens) [TaxId: 9606] [50549] (4) picpic
  15. Coagulation factor VIIa [50550]
    1. Human (Homo sapiens) [TaxId: 9606] [50551] (35) picpic
      SQ P08709 213-466 ! SQ P08709 213-446
  16. Chymase (mast cell protease I) [89343]
    1. Human (Homo sapiens) [TaxId: 9606] [89344] (1) picpic
  17. Chymase II (mast cell proteinase II) [50552]
    1. Rat (Rattus rattus) [TaxId: 10117] [50553] (1) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [50554] (4) picpic
  18. Kallikrein A [50555]
    1. Pig (Sus scrofa) [TaxId: 9823] [50556] (3) picpic
  19. Kallikrein-13 [50572]
    1. Mouse (Mus musculus) [TaxId: 10090] [50573] (1) picpic
  20. Kallikrein 6 [74974]
    1. Human (Homo sapiens) [TaxId: 9606] [74975] (3) picpic
  21. Tonin [50557]
    1. Rat (Rattus rattus) [TaxId: 10117] [50558] (1) picpic
  22. 7S NGF protease subunits [50559]
    two pairs of homologous but non-identical chains
    1. Mouse (Mus musculus) [TaxId: 10090] [50560] (1) picpic
  23. Prostate specific antigen (PSA kallikrein) [82122]
    1. Horse (Equus caballus) [TaxId: 9796] [82123] (1) picpic
  24. Factor B [50561]
    1. Human (Homo sapiens) [TaxId: 9606] [50562] (4) picpic
      SQ P00751 268-764
  25. Factor D [50563]
    1. Human (Homo sapiens) [TaxId: 9606] [50564] (7) picpic
  26. Two-chain tissue plasminogen activator (TC)-T-PA [50565]
    1. Human (Homo sapiens) [TaxId: 9606] [50566] (2) picpic
  27. Single chain tissue plasminogen activator [50567]
    1. Human (Homo sapiens) [TaxId: 9606] [50568] (1) picpic
    2. Vampire bat (Desmodus rotundus) [TaxId: 9430] [50569] (1) picpic
  28. Venom serine protease [50570]
    1. Chinese green tree viper (Trimeresurus stejnegeri) [TaxId: 39682] [50571] (1) picpic
    2. Hundred-pace snake (Agkistrodon acutus) [TaxId: 36307] [110238] (2) picpic
      SQ Q9I8X1
  29. Coagulation factor IXa, protease domain [50583]
    1. Pig (Sus scrofa) [TaxId: 9823] [50584] (2) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [50585] (1) picpic
  30. Coagulation factor Xa, protease domain [50574]
    1. Human (Homo sapiens) [TaxId: 9606] [50575] (76) picpic
      SQ P00742 235-467
    2. Cow (Bos taurus) [TaxId: 9913] [50576] (1) picpic
  31. Coagulation factor Xa-trypsin chimera [50577]
    1. Synthetic, based on Homo sapiens sequence [50578] (1) picpic
      Xa: residues 16-121; trypsin: residues 122-246
  32. Complement C1S protease, catalytic domain [63789]
    1. Human (Homo sapiens) [TaxId: 9606] [63790] (1) picpic
  33. Complement C1R protease, catalytic domain [74976]
    1. Human (Homo sapiens) [TaxId: 9606] [74977] (5) picpic
  34. Activated protein c (autoprothrombin IIa) [50579]
    1. Human (Homo sapiens) [TaxId: 9606] [50580] (1) picpic
  35. Myeloblastin, PR3 [50581]
    1. Human (Homo sapiens) [TaxId: 9606] [50582] (1) picpic
  36. Urokinase-type plasminogen activator (LMW U-PA), catalytic domain [50586]
    1. Human (Homo sapiens) [TaxId: 9606] [50587] (49) picpic
      SQ P00749 156-178,179-424
  37. Plasmin(ogen), catalytic domain [50588]
    1. Human (Homo sapiens) [TaxId: 9606] [50589] (7) picpic
  38. Granzyme A [89345]
    1. Human (Homo sapiens) [TaxId: 9606] [89346] (2) picpic
  39. Granzyme B [50590]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [50591] (1) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [50592] (2) picpic
  40. Granzyme K [82124]
    1. Human (Homo sapiens) [TaxId: 9606] [82125] (2) picpic
  41. Duodenase [63791]
    new serine protease
    1. Cow (Bos taurus) [TaxId: 9913] [63792] (1) picpic
  42. Beta-acrosin [50593]
    1. Sheep (Ovis aries) [TaxId: 9940] [50594] (1) picpic
    2. Pig (Sus scrofa) [TaxId: 9823] [50595] (1) picpic
  43. Matriptase MTSP1 [69284]
    1. Human (Homo sapiens) [TaxId: 9606] [69285] (4) picpic
  44. Hepsin, catalytic domain [101813]
    1. Human (Homo sapiens) [TaxId: 9606] [101814] (4) picpic
      SQ P05981 163-417
  45. Hepatocyte growth factor, HGF [110239]
    1. Human (Homo sapiens) [TaxId: 9606] [110240] (2) picpic
      SQ P14210 495-728 ! SQ P14210 495-722
  46. Mannan-binding lectin serine protease 2 (MASP-2), catalytic domain [110241]
    1. Human (Homo sapiens) [TaxId: 9606] [110242] (2) picpic
      SQ O00187 366-686
  47. Coagulation factor XI [117237]
    1. Human (Homo sapiens) [TaxId: 9606] [117238] (4) picpic
      SQ P03951 388-624
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk