Structural Classification of Proteins
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Family: EGF-type module

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: Knottins (small inhibitors, toxins, lectins) [57015]
    disulfide-bound fold; contains beta-hairpin with two adjacent disulfides
  4. Superfamily: EGF/Laminin [57196]
    link to SUPERFAMILY database - Superfamily
  5. Family: EGF-type module [57197]

Protein Domains:

  1. Factor IX (IXa) [57198]
    1. Human (Homo sapiens) [TaxId: 9606] [57199] (7) picpic
    2. Pig (Sus scrofa) [TaxId: 9823] [57200] (31) picpic
  2. Coagulation factor VIIa [57201]
    1. Human (Homo sapiens) [TaxId: 9606] [57202] (19) picpic
      SQ P08709 108-202 ! SQ P08709 107-202
  3. E-selectin, EGF-domain [57203]
    1. Human (Homo sapiens) [TaxId: 9606] [57204] (5) picpic
  4. Factor X, N-terminal module [57205]
    1. Human (Homo sapiens) [TaxId: 9606] [57206] (75) picpic
      SQ P00742 127-178
    2. Cow (Bos taurus) [TaxId: 9913] [57207] (5) picpic
  5. Activated protein c (autoprothrombin IIa) [57208]
    1. Human (Homo sapiens) [TaxId: 9606] [57209] (1) picpic
  6. Prostaglandin H2 synthase-1, EGF-like module [57210]
    the rest of protein is heme-linked peroxidase, all-alpha fold
    1. Sheep (Ovis aries) [TaxId: 9940] [57211] (22) picpic
      SQ P05979 32-584
    2. Mouse (Mus musculus) [TaxId: 10090] [57212] (8) picpic
  7. P-selectin, EGF-domain [57213]
    1. Human (Homo sapiens) [TaxId: 9606] [57214] (1) picpic
  8. Epidermal growth factor, EGF [57215]
    1. Mouse (Mus musculus) [TaxId: 10090] [57216] (8) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [69939] (4) picpic
  9. Transforming growth factor alpha [57217]
    1. Human (Homo sapiens) [TaxId: 9606] [57218] (6) picpic
  10. Epiregulin, EGF-domain [103561]
    1. Human (Homo sapiens) [TaxId: 9606] [103562] (2) picpic
  11. Betacellulin-2 [75670]
    1. Human (Homo sapiens) [TaxId: 9606] [75671] (2) picpic
  12. Heparin-binding epidermal growth factor, HBEGF [57219]
    extracellular domain
    1. Human (Homo sapiens) [TaxId: 9606] [57220] (1) picpic
  13. Plasminogen activator (urokinase-type) [57221]
    1. Human (Homo sapiens) [TaxId: 9606] [57222] (12) picpic
  14. Heregulin-alpha, EGF-like domain [57223]
    1. Human (Homo sapiens) [TaxId: 9606] [57224] (4) picpic
  15. Thrombomodulin, different EGF-like domains [57225]
    1. Human (Homo sapiens) [TaxId: 9606] [57226] (6) picpic
  16. Fibrillin-1 [57227]
    duplication: contains 47 EFG-like domains
    1. Human (Homo sapiens) [TaxId: 9606] [57228] (8) picpic
  17. Mannose-binding protein associated serine protease 2, MASP2 [90141]
    EGF-like domain separates two CUB domains
    1. Rat (Rattus norvegicus) [TaxId: 10116] [90142] (1) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [111402] (1) picpic
      SQ O00187 17-181
  18. Complement C1S component [90143]
    1. Human (Homo sapiens) [TaxId: 9606] [90144] (1) picpic
  19. Complement protease C1R [57229]
    1. Human (Homo sapiens) [TaxId: 9606] [57230] (1) picpic
  20. Plasminogen activator (tissue-type), t-PA [57231]
    1. Human (Homo sapiens) [TaxId: 9606] [57232] (1) picpic
  21. Low density lipoprotein (LDL) receptor, different EGF domains [64539]
    1. Human (Homo sapiens) [TaxId: 9606] [64540] (7) picpic
      SQ P01130 272-353
  22. Neurogenic locus notch homolog protein 1, Notch1 [118243]
    1. Human (Homo sapiens) [TaxId: 9606] [118244] (4) picpic
      SQ P46531 411-526
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk