Structural Classification of Proteins
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Family: RNA-dependent RNA-polymerase

Lineage:

  1. Root: scop
  2. Class: Multi-domain proteins (alpha and beta) [56572]
    Folds consisting of two or more domains belonging to different classes
  3. Fold: DNA/RNA polymerases [56671]
    divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members
  4. Superfamily: DNA/RNA polymerases [56672]
    "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain
    link to SUPERFAMILY database - Superfamily
  5. Family: RNA-dependent RNA-polymerase [56694]

Protein Domains:

  1. Viral RNA polymerase [56695]
    1. Poliovirus type 1, strain Mahoney [TaxId: 12080] [56696] (13)
      SQ P03300 1748-2208
      1. 1ra6 picpic
        complexed with acy, cas; mutant
        1. chain a [104879] picpiclink
      2. 1ra7 picpic
        complexed with acy, cas, gtp; mutant
        1. chain a [104880] picpiclink
      3. 2im0 picpic
        automatically matched to d1ra6a_
        complexed with acy, cas, ctp, na; mutant
        1. region a:1-461 [137502] picpiclink
      4. 1rdr picpic
        complexed with ca
        1. chain a [43116] picpiclink
      5. 2im2 picpic
        automatically matched to d1ra6a_
        complexed with acy, cas, na, utp; mutant
        1. region a:1-461 [137504] picpiclink
      6. 1tql picpic
        complexed with acy, cas; mutant
        1. chain a [107235] picpiclink
      7. 2ilz picpic
        automatically matched to d1ra6a_
        complexed with acy, cas, gtp, mn, na; mutant
        1. region a:1-461 [137501] picpiclink
      8. 1raj picpic
        mutant
        1. chain a [104881] picpiclink
      9. 2ily picpic
        automatically matched to d1ra6a_
        complexed with acy, atp, cas, na; mutant
        1. region a:1-461 [137500] picpiclink
      10. 2im1 picpic
        automatically matched to d1ra6a_
        complexed with acy, cas, ctp, mn, na; mutant
        1. region a:1-461 [137503] picpiclink
      11. 2ijd picpicxrefxref
        automatically matched to d1ra6a_
        complexed with so4, zn; mutant
        1. region 1:184-644 [137475] picpiclink
      12. 2ijd picpicxrefxref
        automatically matched to d1ra6a_
        complexed with so4, zn; mutant
        1. region 2:184-644 [137477] picpiclink
      13. 2im3 picpic
        automatically matched to d1ra6a_
        complexed with acy, cas, mn, na, utp; mutant
        1. region a:1-461 [137505] picpiclink
    2. Hepatitis C virus [TaxId: 11103] [56697] (30)
      1. 1gx5 picpic
        complexed with gtp, mn, mse
        1. chain a [70682] picpiclink
      2. 2d3z picpic
        automatically matched to d1nhvb_
        complexed with fih
        1. region a:1-562 [131234] picpiclink
      3. 2d3z picpic
        automatically matched to d1nhvb_
        complexed with fih
        1. region b:1-562 [131235] picpiclink
      4. 1gx6 picpic
        complexed with mn, mse, utp
        1. chain a [70683] picpiclink
      5. 1c2p picpic
        1. chain a [43117] picpiclink
        2. chain b [43118] picpiclink
      6. 2d3u picpic
        automatically matched to d1nhvb_
        complexed with cct
        1. region a:1-562 [131232] picpiclink
      7. 2d3u picpic
        automatically matched to d1nhvb_
        complexed with cct
        1. region b:1-562 [131233] picpiclink
      8. 1nhu picpic
        complexed with 153
        1. chain a [85723] picpiclink
        2. chain b [85724] picpiclink
      9. 2hwi picpic
        automatically matched to d1c2pb_
        complexed with vrx
        1. region a:1-564 [136824] picpiclink
      10. 2hwi picpic
        automatically matched to d1c2pb_
        complexed with vrx
        1. region b:1-564 [136825] picpiclink
      11. 2d41 picpic
        automatically matched to d1nhvb_
        complexed with snh
        1. region a:1-562 [131236] picpiclink
      12. 2d41 picpic
        automatically matched to d1nhvb_
        complexed with snh
        1. region b:1-562 [131237] picpiclink
      13. 2o5d picpic
        automatically matched to d1c2pb_
        complexed with vr1
        1. region a:1-564 [138918] picpiclink
      14. 2o5d picpic
        automatically matched to d1c2pb_
        complexed with vr1
        1. region b:1-564 [138919] picpiclink
      15. 2gc8 picpic
        automatically matched to d1nhvb_
        complexed with 885
        1. region a:1-562 [134970] picpiclink
      16. 2gc8 picpic
        automatically matched to d1nhvb_
        complexed with 885
        1. region b:1-562 [134971] picpiclink
      17. 1nb4 picpic
        1. chain a [85509] picpiclink
        2. chain b [85510] picpiclink
      18. 2brk picpic
        automatically matched to d1csja_
        complexed with cmf, mn
        1. region a:1-531 [129001] picpiclink
      19. 2ijn picpic
        automatically matched to d1c2pb_
        complexed with 221
        1. region a:1-564 [137478] picpiclink
      20. 2ijn picpic
        automatically matched to d1c2pb_
        complexed with 221
        1. region b:1-564 [137479] picpiclink
      21. 2i1r picpic
        automatically matched to d1c2pb_
        complexed with vxr
        1. region a:1-564 [136986] picpiclink
      22. 2i1r picpic
        automatically matched to d1c2pb_
        complexed with vxr
        1. region b:1-564 [136987] picpiclink
      23. 1os5 picpic
        complexed with nh1; mutant
        1. chain a [93475] picpiclink
      24. 2hwh picpic
        automatically matched to d1c2pb_
        complexed with rna
        1. region a:1-564 [136822] picpiclink
      25. 2hwh picpic
        automatically matched to d1c2pb_
        complexed with rna
        1. region b:1-564 [136823] picpiclink
      26. 1nb6 picpic
        complexed with mn, utp
        1. chain a [85511] picpiclink
        2. chain b [85512] picpiclink
      27. 1csj picpic
        1. chain a [43120] picpiclink
        2. chain b [43121] picpiclink
      28. 1nhv picpic
        complexed with 154
        1. chain a [85725] picpiclink
        2. chain b [85726] picpiclink
      29. 1quv picpic
        1. chain a [43119] picpiclink
      30. 1nb7 picpic
        complexed with mn
        1. chain a [85513] picpiclink
        2. chain b [85514] picpiclink
    3. Rabbit hemorrhagic disease virus [TaxId: 11976] [69882] (2)
      1. 1khv picpic
        complexed with lu
        1. chain a [68627] picpiclink
        2. chain b [68628] picpiclink
      2. 1khw picpic
        complexed with mn
        1. chain a [68629] picpiclink
        2. chain b [68630] picpiclink
    4. Norwalk virus [TaxId: 11983] [103400] (3)
      1. 1sh0 picpic
        1. chain a [98876] picpiclink
        2. chain b [98877] picpiclink
      2. 1sh2 picpic
        1. chain a [98878] picpiclink
      3. 1sh3 picpic
        complexed with mg
        1. chain a [98879] picpiclink
        2. chain b [98880] picpiclink
    5. Bovine viral diarrhea virus [TaxId: 11099] [103401] (3)
      1. 1s48 picpic
        1. chain a [98475] picpiclink
      2. 1s49 picpic
        complexed with gtp
        1. chain a [98476] picpiclink
      3. 1s4f picpic
        1. chain a [98495] picpiclink
        2. chain b [98496] picpiclink
        3. chain c [98497] picpiclink
        4. chain d [98498] picpiclink
    6. Human rhinovirus 1B, HRV-1B [TaxId: 12129] [111299] (1)
      SQ P12916 1698-2157
      1. 1xr6 picpic
        complexed with k
        1. chain a [115865] picpiclink
    7. Human rhinovirus 16, HRV-16 [TaxId: 31708] [111300] (1)
      SQ Q82122 1694-2153
      1. 1xr7 picpic
        1. chain a [115866] picpiclink
        2. chain b [115867] picpiclink
    8. Human rhinovirus 14, HRV-14 [TaxId: 12131] [111301] (1)
      SQ P03303 1720-2179
      1. 1xr5 picpic
        complexed with sm
        1. chain a [115864] picpiclink
    9. Foot-and-mouth disease virus [TaxId: 12110] [111302] (10)
      SQ Q9QCE4 1858-2327
      1. 1u09 picpic
        1. chain a [107545] picpiclink
      2. 2e9t picpic
        automatically matched to d1u09a_
        complexed with 5fu, mg, ppv
        1. region a:1-474 [146733] picpiclink
      3. 2e9t picpic
        automatically matched to d1u09a_
        complexed with 5fu, mg, ppv
        1. region d:1-474 [146734] picpiclink
      4. 2e9z picpic
        automatically matched to d1u09a_
        complexed with mg, ppv, utp
        1. region a:1-476 [146753] picpiclink
      5. 1wne picpic
        complexed with mg
        1. chain a [109434] picpiclink
      6. 2ec0 picpic
        automatically matched to d1u09a_
        complexed with mg, ppv
        1. region a:1-470 [146776] picpiclink
      7. 2ec0 picpic
        automatically matched to d1u09a_
        complexed with mg, ppv
        1. region d:1-470 [146777] picpiclink
      8. 2f8e picpic
        automatically matched to d1u09a_
        complexed with mg, mn, u5p
        1. region x:1-474 [133121] picpiclink
      9. 2e9r picpic
        automatically matched to d1u09a_
        complexed with mg, rtp
        1. region x:1-476 [146732] picpiclink
      10. 2d7s picpic
        automatically matched to d1u09a_
        1. region a:1-474 [131326] picpiclink
    10. Avian infectious bursal disease virus [TaxId: 10995] [160955] (1)
      SQ Q9Q6Q5 31-804
      1. 2pgg picpic
        1. region a:31-804 [149462] picpiclink
  2. Reovirus polymerase lambda3 [82841]
    contains additional N-terminal domain (res. 1-380) and C-terminal "bracelet" domain (res. 891-1267)
    1. Reovirus [TaxId: 10891] [82842] (5)
      1. 1muk picpic
        1. chain a [79492] picpiclink
      2. 1n35 picpic
        elongation complex with four phosphodiester bonds formed
        complexed with ch1, mn
        1. chain a [79935] picpiclink
      3. 1mwh picpic
        complexed with gtg, mn
        1. chain a [79573] picpiclink
      4. 1n38 picpic
        elongation complex with one phosphodiester bond formed
        complexed with ch1, mn, u3h
        1. chain a [79958] picpiclink
      5. 1n1h picpic
        initiation complex
        complexed with ch1, g7m, gdp, gh3, mn
        1. chain a [79804] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk