Class: Multi-domain proteins (alpha and beta)

Folds consisting of two or more domains belonging to different classes

Lineage:

1. Root: scop
2. Class: Multi-domain proteins (alpha and beta) [56572]
   Folds consisting of two or more domains belonging to different classes

Folds:

1. Serpins [56573] (1)
   contains a cluster of helices and a beta-sandwich
   1. Serpins [56574] (1)
      uperfamily
2. FdhE-like [144019] (1)
   consists on the N-terminal five-helical bundle, a tandem repeat of two rubredoxin-like domains and the C-terminal helix packed together
   1. FdhE-like [144020] (1)
      uperfamily
3. FlhC-like [160929] (1)
   3 domains; d1 & d2 are similar three-helical bundles, with d1 containing an HTH motif; d3: zinc finger of a rubredoxin-like fold
   1. FlhC-like [160930] (1)
4. Replication terminator protein (Tus) [56595] (1)
   contains a cluster of helices and a beta-sandwich
   1. Replication terminator protein (Tus) [56596] (1)
      uperfamily
5. VPA0735-like [160934] (1)
   consists of a cluster of helices and two beta-sandwich domains of similar topology; probable duplication
   1. VPA0735-like [160935] (1)
6. 2-methylcitrate dehydratase PrpD [103377] (1)
   consists of an all-alpha and alpha+beta domains
   1. 2-methylcitrate dehydratase PrpD [103378] (1)
      uperfamily
7. Antivirulence factor [103382] (1)
   contains a helical bundle with a buried helix and an alpha+beta insert domain
   1. Antivirulence factor [103383] (1)
      uperfamily
8. Api92-like [160939] (1)
   2 domains; d1: [alpha+beta with similarity to ferredoxin-like fold]; d2: [6 helices, bundle, one buried central helix], inserted into d1
   1. Api92-like [160940] (1)
9. PH0156-like [160944] (1)
   2 (sub)domains; d1: [alpha/beta with central mixed beta-sheet, order: 23415876, similarity to the G protein but no P-loop]; d2: [all-alpha, 5 helices, provides dimerization interface]
   1. PH0156-like [160945] (1)
10. YacF-like [160949] (1)
    2 domains; d1: kinked four-helical bundle, inserted in d2: beta-sandwich of 7 strands in two sheets
    1. YacF-like [160950] (1)
       probable biological unit is a dimer
11. Virulence-associated V antigen [103387] (1)
    consists of an all-alpha and alpha+beta domains connected by antiparallel coiled coil
    1. Virulence-associated V antigen [103388] (1)
       uperfamily
12. Heme-dependent catalase-like [56633] (1)
    contains an (8,10) beta-barrel and an all-alpha domain
    1. Heme-dependent catalase-like [56634] (2)
       uperfamily
13. Acyl-CoA dehydrogenase NM domain-like [56644] (1)
    2 domains: (1) all-alpha: 5 helices; (2) contains an open beta-sheet barrel: n*=5, S*=8; complex topology
    1. Acyl-CoA dehydrogenase NM domain-like [56645] (2)
       flavoprotein: binds FAD; constituent families differ in the numbers of C-terminal domains (four-helical bundles)
       uperfamily
14. Carbohydrate phosphatase [56654] (1)
    N-terminal domain is an alpha+beta, C-terminal domain is an alpha/beta with mixed beta-sheet
    1. Carbohydrate phosphatase [56655] (2)
       uperfamily
15. DNA/RNA polymerases [56671] (1)
    divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members
    1. DNA/RNA polymerases [56672] (6)
       "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain
       uperfamily
16. beta and beta-prime subunits of DNA dependent RNA-polymerase [64483] (1)
    Multidomain subunits of complex domain organization
    1. beta and beta-prime subunits of DNA dependent RNA-polymerase [64484] (2)
       The catalytic site is formed by the association of two double-psi beta-barrel domains, one from each subunit
       uperfamily
17. Poly(A) polymerase catalytic subunit-like [160956] (1)
    3 domains; d1: all-alpha, contains HhH motif; d2: alpha+beta of nucleotidyltransferase fold (scop_cf 81302); d3: [alpha+beta; beta(3)-alpha-beta(3)-alpha(2); 3 layers: a/b/a; mixed beta-sheet of 6 strands, order 123654, strands 2 and 5 are antiparallel to the rest
    1. Poly(A) polymerase catalytic subunit-like [160957] (1)
       Central domain d2 is distantly related to the nucleotidyltransferase superfamily (scop_sf 81301)
18. Adenylylcyclase toxin (the edema factor) [81299] (1)
    3 domains: (1&2) alpha+beta, with domain 2 being inserted in domain 1; (3) all-alpha
    1. Adenylylcyclase toxin (the edema factor) [81298] (1)
       Domain 1 has topological and active site similarity to the Nucleotidyltransferases (eg. 1kny N-domain); domain 3 binds calmodulin
       uperfamily
19. Prokaryotic type I DNA topoisomerase [56711] (1)
    4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8
    1. Prokaryotic type I DNA topoisomerase [56712] (1)
       duplication: the protein chain passing through the domains 2-4 makes two structural repeats
       The active site is formed by the toprim and "winged helix" domains (domains 1 and 4); these two domains are also found in the type II topoisomerase (DNA gyrase A) and in the alpha subunit of topoisomerase IV
       uperfamily
20. Type II DNA topoisomerase [56718] (1)
    4 domains: (1) toprim alpha/beta; (2) "winged helix"-like; (3) alpha+beta; (4) all-alpha
    1. Type II DNA topoisomerase [56719] (1)
       uperfamily
21. DNA topoisomerase IV, alpha subunit [56725] (1)
    2 domains: (1) toprim alpha/beta; (2) "winged helix"-like
    1. DNA topoisomerase IV, alpha subunit [56726] (1)
       uperfamily
22. DNA primase core [56730] (1)
    2 domains: (1) alpha+beta; (2) toprim alpha/beta
    1. DNA primase core [56731] (2)
       uperfamily
23. Recombination protein RecR [111303] (1)
    consists of three domains: alpha-helical dimerisation domain (res. 1-53) with HhH motif; 'treble cleft' C4 zinc-finger domain (54-76); and Toprim domain (76-199; segment-swapped dimer)
    1. Recombination protein RecR [111304] (1)
       uperfamily
24. Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56740] (1)
    2 domains: alpha+beta and all-beta
    1. Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56741] (1)
       uperfamily
25. D-aminoacid aminotransferase-like PLP-dependent enzymes [56751] (1)
    2 domains: (1) alpha+beta: beta3-alpha2-beta2; (2) alpha/beta, a part of its mixed sheet forms barrel: n=6, S=8
    1. D-aminoacid aminotransferase-like PLP-dependent enzymes [56752] (1)
       uperfamily
26. HydB/Nqo4-like [56761] (1)
    3 domains: (1) all-alpha; (2&3) alpha+beta
    1. HydB/Nqo4-like [56762] (2)
       uperfamily
27. HydA/Nqo6-like [56769] (1)
    2 domains: (1) alpa/beta; (2) Fe-S cluster-bound
    1. HydA/Nqo6-like [56770] (2)
       uperfamily
28. Dehydroquinate synthase-like [56795] (1)
    2 domains: (1) alpha/beta of a Rossmann-fold topology, binds NAD (2) multihelical array
    1. Dehydroquinate synthase-like [56796] (2)
       uperfamily
29. Siroheme synthase middle domains-like [75614] (1)
    2 domains: (1) alpha+beta, 2 layers; (2) 3/4-helical bundle, right-handed twist, left-handed superhelix
    1. Siroheme synthase middle domains-like [75615] (1)
       uperfamily
30. Acetyl-CoA synthetase-like [56800] (1)
    4 domains: (1&2) duplication: share the same alpha/beta fold; (3) beta-barrel; (4) alpha+beta
    1. Acetyl-CoA synthetase-like [56801] (1)
       uperfamily
31. Ribosomal protein L1 [56807] (1)
    2 domains: (1) alpha+beta; (2) alpha/beta (interrupts domain 1)
    1. Ribosomal protein L1 [56808] (1)
       uperfamily
32. Release factor [75619] (1)
    4 domains: (1) 3-helical bundle; (2) alpha+beta of ferredoxin-like fold (3 and 4) alpha+beta of dsRDB-like fold
    1. Release factor [75620] (1)
       uperfamily
33. YaeB-like [118195] (1)
    2 domains; d1: [beta-barrel (n=6, S=10), similar to the Reductase/isomerase/elongation factor common domain fold (scop_cf 50412), provides homodimerisation interface]; d2: [alpha+beta (disordered)]
    1. YaeB-like [118196] (1)
       uperfamily
34. MalF N-terminal region-like [160963] (1)
    consists of 3 N-terminal transmembrane helices, an alpha+beta linker domain and a beta-barrel (n=7; S=8) with one overside loop
    1. MalF N-terminal region-like [160964] (1)
35. YebC-like [75624] (1)
    3 domains: (1) 3-helical bundle; (2 and 3 ) alpha+beta of different folds: domain 3 has a ferredoxin-like fold and is inserted in domain 2
    1. YebC-like [75625] (1)
       uperfamily
36. Cullin homology domain [75631] (1)
    3 domains: (1) 4-helical bundle; (2) alpha+beta; (3) "winged helix"-like
    1. Cullin homology domain [75632] (1)
       uperfamily
37. Sec1/munc18-like (SM) proteins [56814] (1)
    3 domains: (1 and 2) alpha+beta; (3) mostly alpha, inserted in domain 2
    1. Sec1/munc18-like (SM) proteins [56815] (1)
       uperfamily
38. Prismane protein-like [56820] (1)
    3 domains: (1) spectrin repeat-like 3-helical bundle; (2 and 3) alpha/beta: Rossmann-fold topology
    1. Prismane protein-like [56821] (3)
       uperfamily
39. Subunits of heterodimeric actin filament capping protein Capz [90095] (1)
    3 domains: (1) protozoan pheromone-like alpha-helical bundle; (2) rubredoxin-like domain lacking metal-binding site; (3) alpha+beta heterodimerisation domain: alpha-beta(5)-alpha
    1. Subunits of heterodimeric actin filament capping protein Capz [90096] (2)
       uperfamily
40. beta-lactamase/transpeptidase-like [56600] (1)
    contains a cluster of helices and an alpha+beta sandwich
    1. beta-lactamase/transpeptidase-like [56601] (3)
       uperfamily
41. Upper collar protein gp10 (connector protein) [56825] (1)
    2 domains: (1) alpha-helical bundle; (2) beta-barrel (n=5, S=8)
    1. Upper collar protein gp10 (connector protein) [56826] (1)
       uperfamily
42. AF1531-like [160974] (1)
    2 domains; d1: incomplete barrel similar to the OB-fold domain of ribosomal L2 protein, d2: six helices, array
    1. AF1531-like [160975] (1)
43. Phase 1 flagellin [64517] (1)
    3 domains: (1) alpha-helical bundle; (2&3) complex all-beta folds
    1. Phase 1 flagellin [64518] (1)
       uperfamily
44. 39 kda initiator binding protein, IBP39, C-terminal domains [103408] (1)
    2 closely associated domains: (1) all-alpha, EF-hand like; (2) alpha+beta, Frataxin-like
    1. 39 kda initiator binding protein, IBP39, C-terminal domains [103409] (1)
       uperfamily
45. AF1104-like [111320] (1)
    2 domains; d1: [all-alpha; 3-helical bundle, similar to the immunoglobulin/albumin-binding domain-like fold (scop_cf 46996)]; d2: [alpha/beta; 3 layers, a/b/a; 6-stranded mixed beta-sheet, order: 321456, strand 6 is antiparallel to the rest]
    1. AF1104-like [111321] (1)
       uperfamily
46. SSO1389-like [160979] (1)
    2 domains; d1: [alpha/beta, central parallel beta-sheet of 6 strands, order 321456, Rossmann-like]; d2: [alpha+beta, cluster of helices and a small 4-stranded beta-sheet]
    1. SSO1389-like [160980] (1)
47. Urocanase [111325] (1)
    3 domains; d1: alpha+beta [alpha(2)-beta(3); mixed sheet: 213]; d2: alpha/beta of the NAD(P)-binding Rossmann-fold superfamily (scop_sf 51735, most similar to scop_fa 51883 and scop_fa 51736); d3: alpha+beta of the glutamine synthetase/guanido kinase fold (scop_cf 55930); d1 and d3 form a single beta-sheet
    1. Urocanase [111326] (1)
       uperfamily
48. NAD kinase/diacylglycerol kinase-like [111330] (1)
    2 domains: d1 [alpha/beta; related to the PFK N-terminal domain (scop_sf 53784)]; d2 [all-beta; atypical beta-sandwich made of 4 structural repeats of beta(3) unit]
    1. NAD kinase/diacylglycerol kinase-like [111331] (2)
       uperfamily
49. QueA-like [111336] (1)
    2 domains; d1 (1-64,174-335) [alpha/beta; 3 layers, a/b/a; mixed beta sheet of 9 strands, order: 219863457; strands 1, 5 and 8 are antiparallel to the rest]; d2 (65-142) [all-beta; barrel, closed (n=6, S=10); greek-key; topologically similar to the split barrel fold (scop_cf 50474)
    1. QueA-like [111337] (1)
       uperfamily
50. CbiD-like [111341] (1)
    2 domains; (1) alpha+beta (res 1-192), a circularly permuted rS5 domain 2-like fold (scop_cf 54210); (2) alpha/beta with parallel beta-sheet of 4 strands, order 2134
    1. CbiD-like [111342] (1)
       uperfamily
51. Rap/Ran-GAP [111346] (1)
    consists of two domains; d1: alpha+beta (78-190; alpha-beta(4)-alpha-beta-alpha; 3 layers; antiparallel beta-sheet of 5 strands; order 51234); d2: alpha/beta similar to the G-domain fold (191-381; scop_fa 52592)
    1. Rap/Ran-GAP [111347] (1)
       uperfamily
52. Vacuolar ATP synthase subunit C [118202] (1)
    2 alpha+beta (sub)domains [each has a ferredoxin-like fold; scop_cf 54861], connected with 3-helical bundle; duplication: two repeats of beta-alpha-beta-[alpha coiled-coil]-beta-alpha-beta motif
    1. Vacuolar ATP synthase subunit C [118203] (1)
       uperfamily
53. Thermophilic metalloprotease-like [144051] (1)
    consists of two domains; d1: alpha/beta (3 layers, a/b/a; parralel beta-sheet, order 2134); d2: pseudo beta-barrel capped by helices
    1. Thermophilic metalloprotease-like [144052] (1)
       uperfamily
54. ImpE-like [144058] (1)
    consists of two domains; d1: right-handed superhelix of five helices; d2: pseudo beta-barrel containing structurally similar part to the "Histone-like" proteins from archaea (scop_fa 54161)
    1. ImpE-like [144059] (1)
       uperfamily
55. CV3147-like [160990] (1)
    2 domains; d1: [alpha/beta; 3 layers, a/b/a, mixed beta-sheet of 8 strands, order 12543876, strands 1, 7 and 8 are antiparallel to the rest]; d2: [pseudo beta-barrel of 6 strands, meander]
    1. CV3147-like [160991] (1)
56. Heme iron utilization protein-like [144063] (1)
    2 domains; d1 - 3-helical bundle similar to the homeodomain-like fold; d2 - 6-stranded beta-barrel capped by two helices at one end, similar topology to the PH-like fold
    1. Heme iron utilization protein-like [144064] (2)
       uperfamily
57. HI0933 insert domain-like [160995] (1)
    2 domains; d1: barrel, closed, n=6, S=12, greek-key; d2: four-helical bundle, inserted in d1
    1. HI0933 insert domain-like [160996] (1)
58. NSP3 homodimer [69902] (1)
    2 domains: (1) all-alpha, (2) alpha+beta; asymmetric homodimer with each domain intertwining with its counterpart
    1. NSP3 homodimer [69903] (1)
       uperfamily
59. E2F-DP heterodimerization region [144073] (1)
    heterodimeric fold with the N-terminal long helices of both chains forming a parallel coiled coil and their C-terminal folded beta-hairpins interlocking together in a beta-sandwich
    1. E2F-DP heterodimerization region [144074] (2)
       uperfamily
60. Membrane penetration protein mu1 [69907] (1)
    4 domains: three intertwined predominately alpha domains and one jelly-roll beta-sandwich
    1. Membrane penetration protein mu1 [69908] (1)
       uperfamily
61. Flu NP-like [161002] (1)
    consists of alpha+beta and all-alpha domains; biological unit is a trimer
    1. flu NP-like [161003] (1)
62. Viral glycoprotein ectodomain-like [161007] (1)
    complex fold; contains three rigid, mostly-beta domains and an alpha-helical region, acting as a conformatiomal switch ("fusion stalk")
    1. Viral glycoprotein ectodomain-like [161008] (2)
63. Reovirus inner layer core protein p3 [56830] (1)
    large protein without apparent domain division; has a number of all-alpha regions and one all beta domain near the C-end
    1. Reovirus inner layer core protein p3 [56831] (2)
       uperfamily
64. L-A virus major coat protein [82855] (1)
    large protein without apparent domain division
    1. L-A virus major coat protein [82856] (1)
       uperfamily
65. Major capsid protein VP5 [103416] (1)
    large protein without apparent domain division
    1. Major capsid protein VP5 [103417] (1)
       uperfamily
66. Viral ssDNA binding protein [118207] (1)
    2 domains; d1: [large alpha+beta domain subdivided into the 'head', 'neck' and 'shoulders' regions; in the 'neck', there is an OB-fold interrupted by large insertions]; d2: [all-alpha, 6 helices; orthogonal array]
    1. Viral ssDNA binding protein [118208] (1)
       uperfamily

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk