Structural Classification of Proteins
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Fold: Thioesterase/thiol ester dehydrase-isomerase

core: beta-alpha-beta(4); 2 layers: alpha/beta

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Thioesterase/thiol ester dehydrase-isomerase [54636]
    core: beta-alpha-beta(4); 2 layers: alpha/beta

Superfamilies:

  1. Thioesterase/thiol ester dehydrase-isomerase [54637] (8)
    link to SUPERFAMILY database - Superfamily
    1. 4HBT-like [54638] (18)
      Pfam 03061
      1. 4-hydroxybenzoyl-CoA thioesterase [54639]
        1. Pseudomonas sp., CBS-3 [TaxId: 306] [54640] (4) picpic
      2. Hypothetical protein YbaW [89900]
        1. Escherichia coli [TaxId: 562] [89901] (1) picpic
      3. Hypothetical protein YbgC [102901]
        1. Escherichia coli [TaxId: 562] [102902] (1) picpic
      4. Putative acyl-coa thioester hydrolase HI0827 [102903]
        1. Haemophilus influenzae [TaxId: 727] [102904] (2) picpic
      5. Acyl-CoA hydrolase BH0798 [117883]
        1. Bacillus halodurans [TaxId: 86665] [117884] (1) picpic
          SQ Q9KEQ1
      6. Hypothetical protein PP0301 [143144]
        1. Pseudomonas putida [TaxId: 303] [143145] (1) picpic
          SQ Q88R33 1-156
      7. Hypothetical protein XCC1147 [143146]
        1. Xanthomonas campestris pv. campestris [TaxId: 340] [143147] (1) picpic
          SQ Q8PBH4 5-122
      8. Probable acyl-CoA hydrolase AGR_L_2016 [143148]
        1. Agrobacterium tumefaciens [TaxId: 358] [143149] (6) picpic
          SQ Q7CTE6 147-262! SQ Q7CTE6 9-143
      9. Probable thioesterase TTHA1846 [143150]
        1. Thermus thermophilus [TaxId: 274] [143151] (4) picpic
          SQ Q5SH84 1-132
      10. Probable thioesterase TTHA0908 [143152]
        1. Thermus thermophilus [TaxId: 274] [143153] (4) picpic
          SQ Q5SJV0 1-132
      11. Hypothetical protein Jann_1972 [143154]
        1. Jannaschia sp. CCS1 [TaxId: 290400] [143155] (2) picpic
          SQ Q28QX3 3-161
      12. Hypothetical protein SSO2295 [143156]
        1. Archaeon Sulfolobus solfataricus [TaxId: 2287] [143157] (4) picpic
          SQ Q97WD2 1-134
      13. Hypothetical thioesterase PA5185 [143158]
        1. Pseudomonas aeruginosa [TaxId: 287] [143159] (25) picpic
          SQ Q9HU04 5-146
      14. Hypothetical protein PMT2055 [143160]
        1. Prochlorococcus marinus [TaxId: 1219] [143161] (1) picpic
          SQ Q7V4A7 1-144
      15. Hypothetical protein PA2801 [143162]
        1. Pseudomonas aeruginosa [TaxId: 287] [143163] (1) picpic
          SQ Q9I042 5-134
      16. Acyl-coa hydrolase BC2038 [143164]
        1. Bacillus cereus [TaxId: 1396] [143165] (3) picpic
          SQ Q81EE4 8-171
      17. Hypothetical protein Jann0674 [160180]
        1. Jannaschia sp. ccs1 [TaxId: 290400] [160181] (2) picpic
          SQ Q28UM1 1-143
      18. GK1870 orthologue [160182]
        Predicted 4-hydroxybenzoyl-CoA thioesterase
        1. Bacillus stearothermophilus [TaxId: 1422] [160183] (4) picpic
          SQ Q5KYT1 1-131
    2. beta-Hydroxydecanol thiol ester dehydrase [54641] (1)
      contains two additional beta-strands in the N-terminal extension
      1. beta-Hydroxydecanol thiol ester dehydrase [54642]
        1. Escherichia coli [TaxId: 562] [54643] (4) picpic
    3. Acyl-CoA thioesterase [54644] (2)
      duplication: consists of two domains of this fold
      1. Thioesterase II (TesB) [54645]
        1. Escherichia coli [TaxId: 562] [54646] (1) picpic
      2. Peroxisomal long-chain acyl-CoA thioesterase 1, TES1 [143166]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [143167] (4) picpic
          SQ P41903 13-116
    4. MaoC-like [82636] (7)
      1. (R)-specific enoyl-CoA hydratase [82637]
        involved in polyhydroxyalkanoate (PHA) biosynthesis
        1. Aeromonas caviae [TaxId: 648] [82638] (1) picpic
      2. Monoamine oxidase regulatory protein [102905]
        1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [102906] (1) picpic
      3. 2-enoyl-coa hydratase domain of multifunctional peroxisomal hydratase-dehydrogenase-epimerase [102907]
        duplication: consists of two MaoC-like domains; there is a greater structural divergence in the N-terminal domain
        1. Yeast (Candida tropicalis) [TaxId: 5482] [102908] (2) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [143168] (24) picpic
          SQ P51659 326-479! SQ P51659 480-605
          the structure of N-terminal, SDR domain is also known, PDB entry 1ZBQ
      4. Hypothetical protein Rv0216/MT0226 [143169]
        duplication: consists of two MaoC-like domains
        1. Mycobacterium tuberculosis [TaxId: 1773] [143170] (2) picpic
          SQ P96398 186-337! SQ P96398 8-185
      5. Hypothetical protein AF1124 [143171]
        1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [143172] (3) picpic
          SQ O29141 6-159
      6. Hypothetical protein Rv0130 [143173]
        1. Mycobacterium tuberculosis [TaxId: 1773] [143174] (2) picpic
          SQ P96807 2-150
    5. PaaI/YdiI-like [89902] (16)
      1. Phenylacetic acid degradation protein PaaI [89903]
        1. Escherichia coli [TaxId: 562] [89904] (3) picpic
        2. Thermus thermophilus [TaxId: 274] [102909] (26) picpic
      2. Hypothetical protein HI1161 [89905]
        1. Haemophilus influenzae [TaxId: 727] [89906] (10) picpic
      3. Hypothetical protein YdiI [102910]
        1. Escherichia coli [TaxId: 562] [102911] (3) picpic
      4. Hypothetical protein YbdB [102912]
        1. Escherichia coli [TaxId: 562] [102913] (1) picpic
      5. 4-hydroxybenzoyl CoA thioesterase [102914]
        1. Arthrobacter sp., strain su [TaxId: 1667] [102915] (3) picpic
      6. Hypothetical protein PH1136 [102916]
        1. Archaeon Pyrococcus horikoshii [TaxId: 53953] [102917] (1) picpic
      7. Putative thioesterase SO4397 [110898]
        1. Shewanella oneidensis [TaxId: 70863] [110899] (1) picpic
          SQ Q8E989
      8. Hypothetical protein PA5026 [110900]
        1. Pseudomonas aeruginosa [TaxId: 287] [110901] (1) picpic
          SQ Q9HUE3
      9. Hypothetical protein PA5202 [143175]
        1. Pseudomonas aeruginosa [TaxId: 287] [143176] (2) picpic
          SQ Q9HTY7 4-129
      10. Hypothetical protein CC3309 [143177]
        1. Caulobacter crescentus [TaxId: 155892] [143178] (1) picpic
          SQ Q9A395 12-153
      11. Hypothetical protein Them2 [143179]
        1. Mouse (Mus musculus) [TaxId: 10090] [143180] (2) picpic
          SQ Q9CQR4 13-139
        2. Human (Homo sapiens) [TaxId: 9606] [143181] (12) picpic
          SQ Q9NPJ3 19-139! SQ Q9NPJ3 3-138
      12. Hypothetical protein PA1835 [143182]
        1. Pseudomonas aeruginosa [TaxId: 287] [143183] (2) picpic
          SQ Q9I2R0 1-145
      13. Transcription factor FapR, C-terminal domain [143184]
        1. Bacillus subtilis [TaxId: 1423] [143185] (6) picpic
          SQ O34835 66-186! SQ O34835 73-183
      14. Hypothetical protein RHA1_ro05818 [160184]
        includes two extra N-terminal helices forming an interlocking four-helical bundle in the dimer
        1. Rhodococcus sp. RHA1 [TaxId: 101510] [160185] (3) picpic
          SQ Q0S4E1 7-209
    6. FabZ-like [110902] (2)
      1. (3R)-hydroxymyristoyl ACP dehydrase FabZ [110903]
        1. Pseudomonas aeruginosa [TaxId: 287] [110904] (1) picpic
          SQ Q9HXY7
        2. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [143186] (8) picpic
          SQ Q965D7 84-229! SQ Q965D7 94-229
    7. TTHA0967-like [143187] (2)
      contains extra C-terminal helix
      1. Hypothetical protein TTHA0967 [143188]
        1. Thermus thermophilus [TaxId: 274] [143189] (4) picpic
          SQ Q5SJP1 1-138
      2. Uncharacterized protein TM0581 [160186]
        1. Thermotoga maritima [TaxId: 2336] [160187] (8) picpic
          SQ Q9WZ50 1-130
    8. Acyl-ACP thioesterase-like [143190] (2)
      Pfam 01643; duplication: consists of two 4HBT-like domains
      1. Acyl-ACP thioesterase [143191]
        1. Bacteroides thetaiotaomicron [TaxId: 818] [143192] (2) picpic
          SQ Q8A611 1-149! SQ Q8A611 150-257
      2. Putative oleoyl-ACP thioesterase LP0708 [160188]
        1. Lactobacillus plantarum [TaxId: 1590] [160189] (4) picpic
          SQ Q88YP1 150-258! SQ Q88YP1 3-149
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk