Structural Classification of Proteins
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Fold: ADP-ribosylation

unusual fold

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: ADP-ribosylation [56398]
    unusual fold

Superfamilies:

  1. ADP-ribosylation [56399] (7)
    link to SUPERFAMILY database - Superfamily
    1. ADP-ribosylating toxins [56400] (12)
      1. Heat-labile toxin, A-chain [56401]
        1. Escherichia coli, type IB [TaxId: 562] [56402] (9) picpic
        2. Escherichia coli, type IIB [TaxId: 562] [56403] (1) picpic
      2. Diphtheria toxin, N-terminal domain [56404]
        1. Corynebacterium diphtheriae [TaxId: 1717] [56405] (7) picpic
      3. Exotoxin A, C-terminal domain [56406]
        1. Pseudomonas aeruginosa [TaxId: 287] [56407] (21) picpic
      4. Pertussis toxin, S1 subunit [56408]
        1. Bordetella pertussis [TaxId: 520] [56409] (3) picpic
      5. Cholera toxin [56410]
        1. Vibrio cholerae [TaxId: 666] [56411] (9) picpic
      6. Vegetative insecticidal protein 2 (VIP2) [56412]
        duplication: consists of two domains of this fold, the second of which is catalytic
        1. Bacillus cereus [TaxId: 1396] [56413] (2) picpic
      7. Enzymatic component (Ia) of iota-toxin [82812]
        mammalian-targeted relative of VIP2; C-terminal domain is catalytic, N-terminal domain interacts with Ib (binding component)
        1. Clostridium perfringens [TaxId: 1502] [82813] (4) picpic
      8. Exoenzyme c3 [56414]
        1. Clostridium botulinum [TaxId: 1491] [56415] (14) picpic
          SQ P15879 41-251
        2. Staphylococcus aureus [TaxId: 1280] [103338] (2) picpic
        3. Clostridium botulinum C bacteriophage [TaxId: 12336] [118161] (2) picpic
          SQ Q00901 44-244
      9. Anthrax toxin lethal factor, middle domain [69845]
        includes an all-alpha insert subdomain
        1. Bacillus anthracis [TaxId: 1392] [69846] (10) picpic
    2. Ecto-ART [82814] (1)
      the two disulfide bridges and N-terminal alpha helices are characteristic for all ecto-ARTs
      1. Eukaryotic mono-ADP-ribosyltransferase ART2.2 [82815]
        NAD glycohydrolase and auto-ADP-ribosylation activity
        1. Rat (Rattus norvegicus) [TaxId: 10116] [82816] (6) picpic
    3. Poly(ADP-ribose) polymerase, C-terminal domain [56416] (3)
      1. Poly(ADP-ribose) polymerase, C-terminal domain [56417]
        1. Chicken (Gallus gallus) [TaxId: 9031] [56418] (7) picpic
        2. Mouse (Mus musculus) [TaxId: 10090] [82817] (1) picpic
        3. Human (Homo sapiens) [TaxId: 9606] [103339] (8) picpic
          SQ P09874 661-1010
    4. AvrPphF ORF2, a type III effector [111257] (1)
      shares the common structural core with other families; unknown function
      1. AvrPphF ORF2, a type III effector [111258]
        1. Pseudomonas syringae pv. phaseolicola [TaxId: 319] [111259] (1) picpic
          SQ Q9K2L5 29-204
    5. Tpt1/KptA [118162] (1)
      Pfam 01885; contains extra N-terminal domain similar to the "winged helix" DNA-binding domain (scop_sf 46785)
      1. Probable RNA 2'-phosphotransferase KptA [118163]
        1. Aeropyrum pernix [TaxId: 56636] [118164] (1) picpic
          SQ Q9YFP5 37-216; d1: (1-76); d2: (88-182)
    6. BC2332-like [143947] (1)
      minimized common structural core with two large, mainly helical insertions on one side forming dimerization "domain"
      1. Hypothetical protein BC2332 [143948]
        1. Bacillus cereus [TaxId: 1396] [143949] (2) picpic
          SQ Q81DM5 2-195
    7. CC0527-like [143950] (1)
      Pfam 06108; DUF952
      1. Hypothetical protein CC0527 [143951]
        1. Caulobacter crescentus [TaxId: 155892] [143952] (3) picpic
          SQ Q9AAR9 2-114
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk