Structural Classification of Proteins
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Family: DNA gyrase/MutL, N-terminal domain

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873]
    8-stranded mixed beta-sheet; 2 layers: alpha/beta
  4. Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874]
    link to SUPERFAMILY database - Superfamily
  5. Family: DNA gyrase/MutL, N-terminal domain [55879]

Protein Domains:

  1. DNA gyrase B [55880]
    1. Escherichia coli [TaxId: 562] [55881] (3)
      1. 1ei1 picpicxref
        complexed with anp, gol, so4; mutant
        1. region a:2-220 [41104] picpiclink
        2. region b:402-620 [41105] picpiclink
      2. 1kzn picpic
        complexed with clorobiocin
        complexed with cbn
        1. chain a [73373] picpiclink
      3. 1aj6 picpic
        novobiocin-resistant mutant complexed with novobiocin
        1. chain a [41106] picpiclink
    2. Thermus thermophilus [TaxId: 274] [75534] (1)
      1. 1kij picpicxref
        complexed with fmt, nov
        1. region a:9-220 [72515] picpiclink
        2. region b:9-220 [72517] picpiclink
  2. DNA topoisomerase II [103226]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [103227] (2)
      1. 1pvg picpicxref
        complexed with anp, mg
        1. region a:7-245 [95162] picpiclink
        2. region b:8-245 [95164] picpiclink
      2. 1qzr picpicxref
        complexed with anp, cdx, mg
        1. region a:7-245 [96660] picpiclink
        2. region b:8-245 [96662] picpiclink
  3. Topoisomerase IV subunit B [103228]
    1. Escherichia coli [TaxId: 562] [103229] (2)
      1. 1s14 picpic
        complexed with nov
        1. chain a [98329] picpiclink
        2. chain b [98330] picpiclink
      2. 1s16 picpicxref
        complexed with anp, mg, so4
        1. region a:1004-1216 [98332] picpiclink
        2. region b:2004-2216 [98334] picpiclink
  4. DNA mismatch repair protein MutL [55882]
    1. Escherichia coli [TaxId: 562] [55883] (6)
      1. 1b63 picpicxref
        complexed with anp, edo, mg
        1. region a:-2-216 [41107] picpiclink
      2. 1nhi picpicxref
        complexed with anp, edo, k, mg
        1. region a:-2-216 [85719] picpiclink
      3. 1b62 picpicxref
        complexed with adp, mg
        1. region a:1-216 [41108] picpiclink
      4. 1nhj picpicxref
        complexed with anp, mg, na; mutant
        1. region a:-2-216 [85721] picpiclink
      5. 1nhh picpicxref
        complexed with anp, edo, mg, rb
        1. region a:-2-216 [85717] picpiclink
      6. 1bkn picpicxref
        1. region a:20-216 [41109] picpiclink
        2. region b:420-616 [41110] picpiclink
  5. DNA mismatch repair protein PMS2 [69800]
    1. Human (Homo sapiens) [TaxId: 9606] [69801] (3)
      1. 1h7s picpicxref
        1. region a:29-231 [65706] picpiclink
        2. region b:33-231 [65708] picpiclink
      2. 1ea6 picpicxref
        complexed with adp, mg
        1. region a:27-231 [64872] picpiclink
        2. region b:27-231 [64874] picpiclink
      3. 1h7u picpicxref
        complexed with atg, mg
        1. region a:31-231 [65710] picpiclink
        2. region b:32-231 [65712] picpiclink
  6. Topoisomerase VI-B subunit [82778]
    contains an H2TH domain inserted after this domain and before the second family-specific domain
    1. Archaeon Sulfolobus shibatae [TaxId: 2286] [82779] (10)
      1. 2hkj picpicxrefxref
        automatically matched to d1mx0a3
        complexed with dms, mg, rdc
        1. region a:10-228 [136555] picpiclink
      2. 1z5b picpicxrefxrefxrefxref
        automatically matched to d1mx0a3
        complexed with adp, alf, mg, so4
        1. region a:9-228 [124466] picpiclink
      3. 1z5b picpicxrefxrefxrefxref
        automatically matched to d1mx0a3
        complexed with adp, alf, mg, so4
        1. region b:9-228 [124469] picpiclink
      4. 1z59 picpicxrefxref
        automatically matched to d1mx0a3
        complexed with adp, mg
        1. region a:9-228 [124457] picpiclink
      5. 1mu5 picpicxrefxref
        complexed with ca
        1. region a:10-228 [79474] picpiclink
      6. 1z5c picpicxrefxrefxrefxref
        automatically matched to d1mx0a3
        complexed with adp, mg, po4
        1. region a:9-228 [124472] picpiclink
      7. 1z5c picpicxrefxrefxrefxref
        automatically matched to d1mx0a3
        complexed with adp, mg, po4
        1. region b:9-228 [124475] picpiclink
      8. 1z5a picpicxrefxrefxrefxref
        automatically matched to d1mx0a3
        complexed with adp, mg
        1. region a:9-228 [124460] picpiclink
      9. 1z5a picpicxrefxrefxrefxref
        automatically matched to d1mx0a3
        complexed with adp, mg
        1. region b:9-228 [124463] picpiclink
      10. 1mx0 picpicxrefxref
        complexed with anp, mg, mse, na
        1. region a:4-228 [79620] picpiclink
        2. region b:4-228 [79623] picpiclink
        3. region c:4-228 [79626] picpiclink
        4. region d:4-228 [79629] picpiclink
        5. region e:4-228 [79632] picpiclink
        6. region f:4-228 [79635] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk