Structural Classification of Proteins
home mail help root up expand collapse

Superfamily: Class II aaRS and biotin synthetases

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Class II aaRS and biotin synthetases [55680]
    contains large mixed beta-sheet
  4. Superfamily: Class II aaRS and biotin synthetases [55681]
    link to SUPERFAMILY database - Superfamily

Families:

  1. Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain [55682] (28)
    1. Seryl-tRNA synthetase (SerRS) [55683]
      1. Thermus thermophilus, strain hb27 [TaxId: 274] [55684] (4) picpic
    2. Lysyl-tRNA synthetase (LysRS) [55685]
      contains an insertion of LEM/SAP-like HeH motif, residues 337-379
      1. Escherichia coli, gene lysU [TaxId: 562] [55686] (5) picpic
      2. Escherichia coli, gene lysS [TaxId: 562] [55687] (2) picpic
    3. Histidyl-tRNA synthetase (HisRS) [55688]
      1. Escherichia coli [TaxId: 562] [55689] (7) picpic
      2. Staphylococcus aureus [TaxId: 1280] [55690] (1) picpic
      3. Thermus thermophilus [TaxId: 274] [55691] (3) picpic
      4. Archaeon Thermoplasma acidophilum [TaxId: 2303] [143637] (2) picpic
        SQ Q9HLX5 3-329
    4. Glycyl-tRNA synthetase (GlyRS) [55692]
      1. Thermus thermophilus [TaxId: 274] [55693] (3) picpic
    5. Threonyl-tRNA synthetase (ThrRS) [55694]
      1. Escherichia coli [TaxId: 562] [55695] (5) picpic
      2. Staphylococcus aureus [TaxId: 1280] [103154] (2) picpic
    6. Aspartyl-tRNA synthetase (AspRS) [55696]
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [55697] (3) picpic
      2. Archaeon Pyrococcus kodakaraensis [TaxId: 311400] [55698] (1) picpic
      3. Thermus thermophilus, AspRS-2 [TaxId: 274] [90008] (1) picpic
        non-discriminating and archaeal-type enzyme
      4. Escherichia coli [TaxId: 562] [55699] (3) picpic
      5. Thermus thermophilus, AspRS-1 [TaxId: 274] [55700] (3) picpic
    7. Phenyl-tRNA synthetase (PheRS) alpha subunit, PheS [55701]
      1. Thermus thermophilus [TaxId: 274] [55702] (9) picpic
        identical sequence to Thermus aquaticus, TaxId: 271
    8. Phenyl-tRNA synthetase (PheRS) beta subunit, PheT, central domain [55703]
      this domain is non-catalytic
      1. Thermus thermophilus [TaxId: 274] [55704] (9) picpic
        identical sequence to Thermus aquaticus, TaxId: 271
    9. Glycyl-tRNA synthetase (GlyRS) alpha chain [75504]
      1. Thermotoga maritima [TaxId: 2336] [75505] (1) picpic
        TM0216
    10. Alanyl-tRNA synthetase (AlaRS) [103155]
      1. Aquifex aeolicus [TaxId: 63363] [103156] (7) picpic
    11. Prolyl-tRNA synthetase (ProRS) [64347]
      1. Thermus thermophilus [TaxId: 274] [64348] (4) picpic
      2. Arhaeon (Methanothermobacter thermautotrophicus) [TaxId: 145262] [90009] (4) picpic
      3. Archaeon (Methanocaldococcus jannaschii) [TaxId: 2190] [90010] (1) picpic
    12. The aaRS-like accessory subunit of mitochondrial polymerase gamma, N-terminal domain [64349]
      1. Mouse (Mus musculus) [TaxId: 10090] [64350] (2) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [143638] (4) picpic
        SQ Q9UHN1 66-355
    13. Asparagine synthetase [55705]
      1. Escherichia coli [TaxId: 562] [55706] (2) picpic
    14. Hypothetical protein PF1951 [103157]
      1. Archaeon Pyrococcus furiosus [TaxId: 2261] [103158] (1) picpic
        AspRS-related protein
    15. ATP phosphoribosyltransferase regulatory subunit HisZ [118058]
      shares histidine-binding site with the HisRS catalytic domain
      1. Thermotoga maritima [TaxId: 2336] [118059] (1) picpic
        SQ Q9X0D3
      2. Lactococcus lactis [TaxId: 1358] [143639] (8) picpic
        SQ Q02147 6-323
  2. Biotin holoenzyme synthetase [55707] (2)
    1. Biotin repressor/biotin holoenzyme synthetase, catalytic (central) domain [55708]
      this structure contains an SH2-like fold
      1. Escherichia coli [TaxId: 562] [55709] (5) picpic
    2. Biotin--[acetyl-CoA-carboxylase] ligase catalytic domain [143640]
      1. Archaeon Pyrococcus horikoshii [TaxId: 53953] [143641] (28) picpic
        SQ O57883 1-188
  3. LplA-like [143642] (6)
    part of Pfam 03099
    1. Lipoyltransferase LipB [143643]
      1. Mycobacterium tuberculosis [TaxId: 1773] [143644] (1) picpic
        SQ Q10404 1-216
    2. LplA-like protein SP1160, N-terminal domain [143645]
      1. Streptococcus pneumoniae [TaxId: 1313] [143646] (1) picpic
        SQ Q97QP1 1-241
    3. Lipoate-protein ligase A [160604]
      1. Streptococcus agalactiae [TaxId: 1311] [160605] (1) picpic
        SQ Q3D8N4 2-270
      2. Thermoplasma acidophilum [TaxId: 2303] [160606] (11) picpic
        SQ Q9HKT1 1-257
    4. Two-domain LplA, N-terminal domain [160607]
      1. Escherichia coli [TaxId: 562] [160608] (6) picpic
        SQ P32099 1-246
    5. Hypothetical protein BH3822 [160609]
      1. Bacillus halodurans [TaxId: 86665] [160610] (1) picpic
        SQ Q9K6A7 12-276
  4. PH0223-like [160611] (1)
    Pfam 04017; DUF366
    1. Uncharacterized protein PH0223 [160612]
      1. Pyrococcus horikoshii [TaxId: 53953] [160613] (6) picpic
        SQ O57962 3-190
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk