Structural Classification of Proteins
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Fold: Homing endonuclease-like

alpha-beta(2)-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Homing endonuclease-like [55603]
    alpha-beta(2)-alpha-beta(2)-alpha; 2 layers: a/b; antiparallel sheet 1243

Superfamilies:

  1. Glucose permease domain IIB [55604] (1)
    link to SUPERFAMILY database - Superfamily
    1. Glucose permease domain IIB [55605] (1)
      1. Glucose permease domain IIB [55606]
        1. Escherichia coli [TaxId: 562] [55607] (4)
          there are differences in secondary structure packing between the two NMR-determined structures
          1. 3bp8 picpicxrefxrefxrefxrefxrefxref
            automatically matched to d1ibaa_
            complexed with act, zn
            1. region c:13-87 [155469] picpiclink
          2. 3bp8 picpicxrefxrefxrefxrefxrefxref
            automatically matched to d1ibaa_
            complexed with act, zn
            1. region d:13-87 [155470] picpiclink
          3. 1o2f picpicxref
            complexed with po3
            1. chain b [86594] picpiclink
          4. 1iba picpic
            1. chain a [40567] picpiclink
  2. Homing endonucleases [55608] (2)
    link to SUPERFAMILY database - Superfamily
    1. Group I mobile intron endonuclease [55609] (5)
      contains two extra helices in the C-terminal extension
      1. DNA endonuclease I-CreI [55610]
        1. Chlamydomonas reinhardtii [TaxId: 3055] [55611] (13)
          SQ P05725 2-154 ! SQ P05725
          1. 1t9i picpic
            complexed with ca, na; mutant
            1. chain a [112360] picpiclink
            2. chain b [112361] picpiclink
          2. 1g9z picpic
            DNA product complex with magnesium
            complexed with mg
            1. chain a [60408] picpiclink
            2. chain b [60409] picpiclink
          3. 1n3f picpic
            complexed with ca
            1. chain a [85299] picpiclink
            2. chain b [85300] picpiclink
            3. chain g [85301] picpiclink
            4. chain h [85302] picpiclink
          4. 2o7m picpic
            automatically matched to d1bp7a_
            1. region a:2-153 [148668] picpiclink
          5. 2o7m picpic
            automatically matched to d1bp7a_
            1. region b:2-153 [148669] picpiclink
          6. 1t9j picpic
            mutant
            1. chain a [112362] picpiclink
            2. chain b [112363] picpiclink
          7. 1g9y picpic
            DNA substrate complex with calcium
            complexed with ca
            1. chain a [60406] picpiclink
            2. chain b [60407] picpiclink
          8. 1n3e picpic
            complexed with ca, na
            1. chain a [85295] picpiclink
            2. chain b [85296] picpiclink
            3. chain g [85297] picpiclink
            4. chain h [85298] picpiclink
          9. 1u0c picpic
            complexed with mg
            1. chain a [112906] picpiclink
            2. chain b [112907] picpiclink
          10. 1u0d picpic
            1. chain a [112908] picpiclink
            2. chain b [112909] picpiclink
          11. 1bp7 picpic
            protein/DNA complex; complexed with ca
            1. chain a [40568] picpiclink
            2. chain b [40569] picpiclink
            3. chain c [40570] picpiclink
            4. chain d [40571] picpiclink
          12. 1af5 picpic
            mutant
            1. chain a [40572] picpiclink
          13. 1mow picpicxref
            chimera with the I-dmoI N-domain
            complexed with gol, mg, so4
            1. region a:100-252 [79360] picpiclink
            2. region d:600-752 [79362] picpiclink
            3. region g:1100-1250 [79364] picpiclink
            4. region j:1600-1752 [79366] picpiclink
      2. DNA endonuclease I-dmoI [55612]
        duplication: contains tandem repeat of this fold
        1. Archaeon Desulfurococcus mobilis [TaxId: 2274] [55613] (2)
          1. 1b24 picpic
            1. region a:7-99 [40573] picpiclink
            2. region a:100-179 [40574] picpiclink
          2. 1mow picpicxref
            chimera of N-domain with I-CreI
            complexed with gol, mg, so4
            1. region a:5-99 [79361] picpiclink
            2. region d:505-599 [79363] picpiclink
            3. region g:1007-1098 [79365] picpiclink
            4. region j:1506-1599 [79367] picpiclink
      3. DNA endonuclease I-MsoI [90006]
        1. Monomastix sp. cl-1997 [TaxId: 141716] [90007] (1)
          1. 1m5x picpic
            complexed with ca
            1. chain a [84844] picpiclink
            2. chain b [84845] picpiclink
      4. DNA endonuclease I-AniI [103141]
        duplication: contains tandem repeat of this fold
        1. Aspergillus nidulans [TaxId: 162425] [103142] (1)
          synonym: Emericella nidulans
          1. 1p8k picpic
            complexed with mg
            1. region z:1-125 [94361] picpiclink
            2. region z:126-254 [94362] picpiclink
      5. DNA endonuclease I-SceI [118055]
        duplication: contains tandem repeat of this fold
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [118056] (1)
          SQ P03882
          1. 1r7m picpic
            complexed with ca
            1. region a:3-120 [111713] picpiclink
            2. region a:121-225 [111714] picpiclink
            3. region b:303-420 [111715] picpiclink
            4. region b:421-525 [111716] picpiclink
    2. Intein endonuclease [55614] (2)
      duplication: contains tandem repeat of this fold
      1. VMA1-derived endonuclease (VDE) PI-SceI [55615]
        homing endonuclease with protein splicing activity
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [55616] (7)
          SQ P17255 284-737
          1. 1jva picpicxref
            mutant
            1. region a:464-581 [77176] picpiclink
            2. region a:582-698 [77177] picpiclink
            3. region b:464-581 [77179] picpiclink
            4. region b:582-698 [77180] picpiclink
          2. 1ef0 picpicxref
            complexed with zn
            1. region a:181-298 [40577] picpiclink
            2. region a:299-415 [40578] picpiclink
            3. region b:181-298 [40579] picpiclink
            4. region b:299-415 [40580] picpiclink
          3. 1dfa picpicxref
            1. region a:181-298 [40575] picpiclink
            2. region a:299-415 [40576] picpiclink
          4. 1vde picpicxref
            1. region a:181-298 [40581] picpiclink
            2. region a:299-415 [40582] picpiclink
            3. region b:181-298 [40583] picpiclink
            4. region b:299-415 [40584] picpiclink
          5. 1um2 picpicxref
            mutant
            1. region a:464-581 [107947] picpiclink
            2. region a:582-698 [107948] picpiclink
            3. region b:464-581 [107950] picpiclink
            4. region b:582-698 [107951] picpiclink
          6. 1lwt picpicxref
            complexed with mse
            1. region a:181-298 [78279] picpiclink
            2. region a:299-415 [78280] picpiclink
          7. 1lws picpicxref
            complexed with ca, mse
            1. region a:181-298 [78276] picpiclink
            2. region a:299-415 [78277] picpiclink
      2. PI-Pfui intein [55617]
        1. Archaeon Pyrococcus furiosus [TaxId: 2261] [55618] (1)
          1. 1dq3 picpicxrefxref
            complexed with zn
            1. region a:129-226 [40585] picpiclink
            2. region a:227-335 [40586] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk