Structural Classification of Proteins
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Family: FAD/NAD-linked reductases, dimerisation (C-terminal) domain

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: CO dehydrogenase flavoprotein C-domain-like [55423]
    core: beta(3,4)-alpha(3); alpha+beta sandwich
  4. Superfamily: FAD/NAD-linked reductases, dimerisation (C-terminal) domain [55424]
    both first two domains are of same beta/beta/alpha fold
    link to SUPERFAMILY database - Superfamily
  5. Family: FAD/NAD-linked reductases, dimerisation (C-terminal) domain [55425]

Protein Domains:

  1. Glutathione reductase [55426]
    1. Human (Homo sapiens) [TaxId: 9606] [55427] (17)
      1. 3grs picpicxref
        complexed with fad
        1. region a:364-478 [40152] picpiclink
      2. 1dnc picpicxref
        complexed with fad, gtt, po4
        1. region a:364-478 [40153] picpiclink
      3. 1gsn picpicxref
        complexed with fad, gtt, po4
        1. region a:364-478 [40154] picpiclink
      4. 1xan picpicxref
        complexed with fad, hxp
        1. region a:364-478 [40156] picpiclink
      5. 1grb picpicxref
        complexed with fad, nad, ndp, po4
        1. region a:364-478 [40155] picpiclink
      6. 1gra picpicxref
        complexed with fad, gsh, ndp
        1. region a:364-478 [40157] picpiclink
      7. 1k4q picpicxref
        complexed with fad, niy
        1. region a:364-478 [68142] picpiclink
      8. 1gre picpicxref
        complexed with fad, gsh, po4
        1. region a:364-478 [40158] picpiclink
      9. 1grg picpicxref
        complexed with cec, fad, po4
        1. region a:364-478 [40159] picpiclink
      10. 1grf picpicxref
        complexed with cnm, fad, po4
        1. region a:364-478 [40160] picpiclink
      11. 1bwc picpicxref
        complexed with aj3, cl, fad
        1. region a:364-478 [40161] picpiclink
      12. 4gr1 picpicxref
        complexed with fad, po4, rgs
        1. region a:364-478 [40162] picpiclink
      13. 5grt picpicxref
        complexed with fad, ts4; mutant
        1. region a:364-478 [40164] picpiclink
      14. 3grt picpicxref
        complexed with fad, ts2; mutant
        1. region a:364-478 [40163] picpiclink
      15. 1grt picpicxref
        complexed with fad; mutant
        1. region a:364-478 [40165] picpiclink
      16. 2grt picpicxref
        complexed with fad, gds; mutant
        1. region a:364-478 [40166] picpiclink
      17. 4grt picpicxref
        complexed with fad, ts3; mutant
        1. region a:364-478 [40167] picpiclink
    2. Plasmodium falciparum [TaxId: 5833] [89990] (1)
      1. 1onf picpicxref
        complexed with fad
        1. region a:377-495 [87143] picpiclink
    3. Escherichia coli [TaxId: 562] [55428] (4)
      1. 1ges picpicxref
        complexed with fad; mutant
        1. region a:336-450 [40168] picpiclink
        2. region b:336-450 [40169] picpiclink
      2. 1ger picpicxref
        complexed with fad
        1. region a:336-450 [40170] picpiclink
        2. region b:336-450 [40171] picpiclink
      3. 1get picpicxref
        complexed with fad, nap
        1. region a:336-450 [40172] picpiclink
        2. region b:336-450 [40173] picpiclink
      4. 1geu picpicxref
        complexed with fad, nad; mutant
        1. region a:336-450 [40174] picpiclink
        2. region b:336-450 [40175] picpiclink
  2. Trypanothione reductase [55429]
    1. Crithidia fasciculata [TaxId: 5656] [55430] (6)
      1. 1fec picpicxref
        complexed with fad
        1. region a:358-485 [40176] picpiclink
        2. region b:358-486 [40177] picpiclink
      2. 1feb picpicxref
        complexed with fad
        1. region a:358-487 [40178] picpiclink
        2. region b:358-484 [40179] picpiclink
      3. 1fea picpicxref
        complexed with fad
        1. region a:358-487 [40180] picpiclink
        2. region b:358-484 [40181] picpiclink
        3. region c:358-487 [40182] picpiclink
        4. region d:358-484 [40183] picpiclink
      4. 2tpr picpicxref
        complexed with fad
        1. region a:358-482 [40184] picpiclink
        2. region b:358-482 [40185] picpiclink
      5. 1typ picpicxref
        complexed with fad, gsh, nap, spd
        1. region a:359-487 [40186] picpiclink
        2. region b:359-487 [40187] picpiclink
      6. 1tyt picpicxref
        complexed with fad
        1. region a:359-487 [40188] picpiclink
        2. region b:359-487 [40189] picpiclink
    2. Trypanosoma cruzi [TaxId: 5693] [55431] (6)
      1. 1aog picpicxref
        complexed with fad, mae
        1. region a:358-487 [40190] picpiclink
        2. region b:358-487 [40191] picpiclink
      2. 1bzl picpicxref
        1. region a:358-487 [40192] picpiclink
        2. region b:358-487 [40193] picpiclink
      3. 1gxf picpicxref
        complexed with fad, mae, qum
        1. region a:358-488 [90529] picpiclink
        2. region b:358-488 [90532] picpiclink
      4. 1nda picpicxrefxrefxrefxrefxref
        complexed with fad
        1. region a:358-484 [40194] picpiclink
        2. region b:358-484 [40195] picpiclink
      5. 1nda picpicxrefxrefxrefxrefxref
        duplicate of 1NDA A:358-484
        complexed with fad
        1. region c:358-484 [118566] picpiclink
      6. 1nda picpicxrefxrefxrefxrefxref
        duplicate of 1NDA A:358-484
        complexed with fad
        1. region d:358-484 [118569] picpiclink
  3. Mammalian thioredoxin reductase [64329]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [64330] (1)
      1. 1h6v picpicxref
        complexed with fad, ndp; mutant
        1. region a:367-499 [60695] picpiclink
        2. region b:367-495 [60698] picpiclink
        3. region c:367-495 [60701] picpiclink
        4. region d:367-495 [60704] picpiclink
        5. region e:367-499 [60707] picpiclink
        6. region f:367-499 [60710] picpiclink
  4. Apoptosis-inducing factor (AIF) [75489]
    contains a large loop insertion in this domain
    1. Human (Homo sapiens) [TaxId: 9606] [75490] (1)
      1. 1m6i picpicxref
        complexed with fad
        1. region a:478-608 [74535] picpiclink
    2. Mouse (Mus musculus) [TaxId: 10090] [75491] (1)
      1. 1gv4 picpicxref
        complexed with fad
        1. region a:478-610 [70591] picpiclink
        2. region b:478-610 [70594] picpiclink
  5. NADH peroxidase [55432]
    1. Enterococcus faecalis [TaxId: 1351] [55433] (8)
      1. 1nhp picpicxref
        complexed with fad, so4; mutant
        1. region a:322-447 [40196] picpiclink
      2. 1nhs picpicxref
        complexed with cyo, fad, so4; mutant
        1. region a:322-447 [40199] picpiclink
      3. 1nhq picpicxref
        complexed with fad, so4; mutant
        1. region a:322-447 [40197] picpiclink
      4. 1nhr picpicxref
        complexed with fad, so4; mutant
        1. region a:322-447 [40198] picpiclink
      5. 1npx picpicxref
        complexed with cyo, fad
        1. region a:322-447 [40200] picpiclink
      6. 2npx picpicxref
        complexed with cyo, fad, nad
        1. region a:322-447 [40201] picpiclink
      7. 1f8w picpicxref
        complexed with fad; mutant
        1. region a:322-447 [40202] picpiclink
      8. 1joa picpicxref
        complexed with fad
        1. region a:322-447 [40203] picpiclink
  6. NADH-dependent ferredoxin reductase, BphA4 [55434]
    1. Pseudomonas sp., KKS102 [TaxId: 306] [55435] (2)
      1. 1d7y picpicxref
        complexed with fad
        1. region a:309-405 [40204] picpiclink
      2. 1f3p picpicxref
        complexed with fad, nad
        1. region a:309-405 [59634] picpiclink
  7. Putidaredoxin reductase [103115]
    1. Pseudomonas putida [TaxId: 303] [103116] (2)
      1. 1q1r picpicxref
        complexed with fad
        1. region a:320-422 [95602] picpiclink
        2. region b:320-422 [95605] picpiclink
      2. 1q1w picpicxref
        complexed with fad
        1. region a:320-423 [95611] picpiclink
        2. region b:320-423 [95614] picpiclink
  8. Dihydrolipoamide dehydrogenase [55436]
    1. Pseudomonas putida [TaxId: 303] [55437] (1)
      1. 1lvl picpicxref
        complexed with fad, nad
        1. region a:336-458 [40205] picpiclink
    2. Pseudomonas fluorescens [TaxId: 294] [55438] (1)
      1. 1lpf picpicxref
        complexed with fad
        1. region a:349-472 [40206] picpiclink
        2. region b:349-472 [40207] picpiclink
    3. Azotobacter vinelandii [TaxId: 354] [55439] (1)
      1. 3lad picpicxref
        complexed with fad
        1. region a:349-472 [40208] picpiclink
        2. region b:349-472 [40209] picpiclink
    4. Bacillus stearothermophilus [TaxId: 1422] [55440] (1)
      1. 1ebd picpicxrefxref
        complexed with fad
        1. region a:347-461 [40210] picpiclink
        2. region b:347-461 [40211] picpiclink
    5. Neisseria meningitidis [TaxId: 487] [55441] (2)
      1. 1ojt picpicxref
        complexed with fad
        1. region a:471-598 [40212] picpiclink
      2. 1bhy picpicxref
        complexed with fad
        1. region a:471-598 [40213] picpiclink
    6. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [64331] (3)
      1. 1v59 picpicxrefxrefxrefxref
        automatically matched to d1jeha3
        complexed with fad, nad, po4
        1. region a:356-478 [119840] picpiclink
      2. 1v59 picpicxrefxrefxrefxref
        automatically matched to d1jeha3
        complexed with fad, nad, po4
        1. region b:356-478 [119843] picpiclink
      3. 1jeh picpicxref
        complexed with fad
        1. region a:356-478 [62914] picpiclink
        2. region b:356-478 [62917] picpiclink
    7. Garden pea (Pisum sativum) [TaxId: 3888] [55442] (1)
      1. 1dxl picpicxref
        complexed with fad
        1. region a:348-470 [40214] picpiclink
        2. region b:348-470 [40215] picpiclink
        3. region c:348-470 [40216] picpiclink
        4. region d:348-470 [40217] picpiclink
    8. Mycobacterium tuberculosis [TaxId: 1773] [118041] (1)
      SQ O53355
      1. 1xdi picpicxref
        complexed with fad
        1. region a:349-466 [115161] picpiclink
        2. region b:349-466 [115163] picpiclink
  9. NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase [82726]
    1. Xanthobacter sp., py2 [TaxId: 35809] [82727] (6)
      1. 1mo9 picpicxref
        complexed with fad, kpc
        1. region a:384-523 [79343] picpiclink
        2. region b:384-523 [79346] picpiclink
      2. 2c3c picpicxrefxrefxrefxref
        automatically matched to d1mo9a3
        complexed with acn, com, fad, nap
        1. region a:384-523 [129727] picpiclink
      3. 2c3c picpicxrefxrefxrefxref
        automatically matched to d1mo9a3
        complexed with acn, com, fad, nap
        1. region b:384-523 [129730] picpiclink
      4. 2c3d picpicxrefxrefxrefxref
        automatically matched to d1mo9a3
        complexed with com, fad
        1. region a:384-523 [129733] picpiclink
      5. 2c3d picpicxrefxrefxrefxref
        automatically matched to d1mo9a3
        complexed with com, fad
        1. region b:384-523 [129736] picpiclink
      6. 1mok picpicxref
        complexed with fad
        1. region a:384-523 [79349] picpiclink
        2. region b:384-523 [79352] picpiclink
        3. region c:384-523 [79355] picpiclink
        4. region d:384-523 [79358] picpiclink
  10. Flavocytochrome c sulfide dehydrogenase, FCSD, flavin-binding subunit [55443]
    rudiment "interface" domain of smaller size; beta(3)-alpha
    1. Purple phototrophic bacterium (Chromatium vinosum) [TaxId: 1049] [55444] (1)
      1. 1fcd picpicxrefxref
        complexed with fad, hem
        1. region a:328-401 [40218] picpiclink
        2. region b:328-401 [40219] picpiclink
  11. NADH oxidase /nitrite reductase [118042]
    1. Pyrococcus furiosus [TaxId: 2261] [118043] (1)
      SQ Q8U1K9
      1. 1xhc picpicxref
        Structural genomics target
        complexed with fad
        1. region a:290-351 [115294] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk