Structural Classification of Proteins
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Superfamily: FAD/NAD-linked reductases, dimerisation (C-terminal) domain

both first two domains are of same beta/beta/alpha fold
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: CO dehydrogenase flavoprotein C-domain-like [55423]
    core: beta(3,4)-alpha(3); alpha+beta sandwich
  4. Superfamily: FAD/NAD-linked reductases, dimerisation (C-terminal) domain [55424]
    both first two domains are of same beta/beta/alpha fold
    link to SUPERFAMILY database - Superfamily

Families:

  1. FAD/NAD-linked reductases, dimerisation (C-terminal) domain [55425] (22)
    1. Glutathione reductase [55426]
      1. Human (Homo sapiens) [TaxId: 9606] [55427] (17)
        1. 3grs picpicxref
          complexed with fad
          1. region a:364-478 [40152] picpiclink
        2. 1dnc picpicxref
          complexed with fad, gtt, po4
          1. region a:364-478 [40153] picpiclink
        3. 1gsn picpicxref
          complexed with fad, gtt, po4
          1. region a:364-478 [40154] picpiclink
        4. 1xan picpicxref
          complexed with fad, hxp
          1. region a:364-478 [40156] picpiclink
        5. 1grb picpicxref
          complexed with fad, nad, ndp, po4
          1. region a:364-478 [40155] picpiclink
        6. 1gra picpicxref
          complexed with fad, gsh, ndp
          1. region a:364-478 [40157] picpiclink
        7. 1k4q picpicxref
          complexed with fad, niy
          1. region a:364-478 [68142] picpiclink
        8. 1gre picpicxref
          complexed with fad, gsh, po4
          1. region a:364-478 [40158] picpiclink
        9. 1grg picpicxref
          complexed with cec, fad, po4
          1. region a:364-478 [40159] picpiclink
        10. 1grf picpicxref
          complexed with cnm, fad, po4
          1. region a:364-478 [40160] picpiclink
        11. 1bwc picpicxref
          complexed with aj3, cl, fad
          1. region a:364-478 [40161] picpiclink
        12. 4gr1 picpicxref
          complexed with fad, po4, rgs
          1. region a:364-478 [40162] picpiclink
        13. 5grt picpicxref
          complexed with fad, ts4; mutant
          1. region a:364-478 [40164] picpiclink
        14. 3grt picpicxref
          complexed with fad, ts2; mutant
          1. region a:364-478 [40163] picpiclink
        15. 1grt picpicxref
          complexed with fad; mutant
          1. region a:364-478 [40165] picpiclink
        16. 2grt picpicxref
          complexed with fad, gds; mutant
          1. region a:364-478 [40166] picpiclink
        17. 4grt picpicxref
          complexed with fad, ts3; mutant
          1. region a:364-478 [40167] picpiclink
      2. Plasmodium falciparum [TaxId: 5833] [89990] (1)
        1. 1onf picpicxref
          complexed with fad
          1. region a:377-495 [87143] picpiclink
      3. Escherichia coli [TaxId: 562] [55428] (4)
        1. 1ges picpicxref
          complexed with fad; mutant
          1. region a:336-450 [40168] picpiclink
          2. region b:336-450 [40169] picpiclink
        2. 1ger picpicxref
          complexed with fad
          1. region a:336-450 [40170] picpiclink
          2. region b:336-450 [40171] picpiclink
        3. 1get picpicxref
          complexed with fad, nap
          1. region a:336-450 [40172] picpiclink
          2. region b:336-450 [40173] picpiclink
        4. 1geu picpicxref
          complexed with fad, nad; mutant
          1. region a:336-450 [40174] picpiclink
          2. region b:336-450 [40175] picpiclink
    2. Trypanothione reductase [55429]
      1. Crithidia fasciculata [TaxId: 5656] [55430] (6)
        1. 1fec picpicxref
          complexed with fad
          1. region a:358-485 [40176] picpiclink
          2. region b:358-486 [40177] picpiclink
        2. 1feb picpicxref
          complexed with fad
          1. region a:358-487 [40178] picpiclink
          2. region b:358-484 [40179] picpiclink
        3. 1fea picpicxref
          complexed with fad
          1. region a:358-487 [40180] picpiclink
          2. region b:358-484 [40181] picpiclink
          3. region c:358-487 [40182] picpiclink
          4. region d:358-484 [40183] picpiclink
        4. 2tpr picpicxref
          complexed with fad
          1. region a:358-482 [40184] picpiclink
          2. region b:358-482 [40185] picpiclink
        5. 1typ picpicxref
          complexed with fad, gsh, nap, spd
          1. region a:359-487 [40186] picpiclink
          2. region b:359-487 [40187] picpiclink
        6. 1tyt picpicxref
          complexed with fad
          1. region a:359-487 [40188] picpiclink
          2. region b:359-487 [40189] picpiclink
      2. Trypanosoma cruzi [TaxId: 5693] [55431] (6)
        1. 1aog picpicxref
          complexed with fad, mae
          1. region a:358-487 [40190] picpiclink
          2. region b:358-487 [40191] picpiclink
        2. 1bzl picpicxref
          1. region a:358-487 [40192] picpiclink
          2. region b:358-487 [40193] picpiclink
        3. 1gxf picpicxref
          complexed with fad, mae, qum
          1. region a:358-488 [90529] picpiclink
          2. region b:358-488 [90532] picpiclink
        4. 1nda picpicxrefxrefxrefxrefxref
          complexed with fad
          1. region a:358-484 [40194] picpiclink
          2. region b:358-484 [40195] picpiclink
        5. 1nda picpicxrefxrefxrefxrefxref
          duplicate of 1NDA A:358-484
          complexed with fad
          1. region c:358-484 [118566] picpiclink
        6. 1nda picpicxrefxrefxrefxrefxref
          duplicate of 1NDA A:358-484
          complexed with fad
          1. region d:358-484 [118569] picpiclink
    3. Mammalian thioredoxin reductase [64329]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [64330] (1)
        1. 1h6v picpicxref
          complexed with fad, ndp; mutant
          1. region a:367-499 [60695] picpiclink
          2. region b:367-495 [60698] picpiclink
          3. region c:367-495 [60701] picpiclink
          4. region d:367-495 [60704] picpiclink
          5. region e:367-499 [60707] picpiclink
          6. region f:367-499 [60710] picpiclink
    4. Apoptosis-inducing factor (AIF) [75489]
      contains a large loop insertion in this domain
      1. Human (Homo sapiens) [TaxId: 9606] [75490] (1)
        1. 1m6i picpicxref
          complexed with fad
          1. region a:478-608 [74535] picpiclink
      2. Mouse (Mus musculus) [TaxId: 10090] [75491] (1)
        1. 1gv4 picpicxref
          complexed with fad
          1. region a:478-610 [70591] picpiclink
          2. region b:478-610 [70594] picpiclink
    5. NADH peroxidase [55432]
      1. Enterococcus faecalis [TaxId: 1351] [55433] (8)
        1. 1nhp picpicxref
          complexed with fad, so4; mutant
          1. region a:322-447 [40196] picpiclink
        2. 1nhs picpicxref
          complexed with cyo, fad, so4; mutant
          1. region a:322-447 [40199] picpiclink
        3. 1nhq picpicxref
          complexed with fad, so4; mutant
          1. region a:322-447 [40197] picpiclink
        4. 1nhr picpicxref
          complexed with fad, so4; mutant
          1. region a:322-447 [40198] picpiclink
        5. 1npx picpicxref
          complexed with cyo, fad
          1. region a:322-447 [40200] picpiclink
        6. 2npx picpicxref
          complexed with cyo, fad, nad
          1. region a:322-447 [40201] picpiclink
        7. 1f8w picpicxref
          complexed with fad; mutant
          1. region a:322-447 [40202] picpiclink
        8. 1joa picpicxref
          complexed with fad
          1. region a:322-447 [40203] picpiclink
    6. NADH-dependent ferredoxin reductase, BphA4 [55434]
      1. Pseudomonas sp., KKS102 [TaxId: 306] [55435] (2)
        1. 1d7y picpicxref
          complexed with fad
          1. region a:309-405 [40204] picpiclink
        2. 1f3p picpicxref
          complexed with fad, nad
          1. region a:309-405 [59634] picpiclink
    7. Putidaredoxin reductase [103115]
      1. Pseudomonas putida [TaxId: 303] [103116] (2)
        1. 1q1r picpicxref
          complexed with fad
          1. region a:320-422 [95602] picpiclink
          2. region b:320-422 [95605] picpiclink
        2. 1q1w picpicxref
          complexed with fad
          1. region a:320-423 [95611] picpiclink
          2. region b:320-423 [95614] picpiclink
    8. Dihydrolipoamide dehydrogenase [55436]
      1. Pseudomonas putida [TaxId: 303] [55437] (1)
        1. 1lvl picpicxref
          complexed with fad, nad
          1. region a:336-458 [40205] picpiclink
      2. Pseudomonas fluorescens [TaxId: 294] [55438] (1)
        1. 1lpf picpicxref
          complexed with fad
          1. region a:349-472 [40206] picpiclink
          2. region b:349-472 [40207] picpiclink
      3. Azotobacter vinelandii [TaxId: 354] [55439] (1)
        1. 3lad picpicxref
          complexed with fad
          1. region a:349-472 [40208] picpiclink
          2. region b:349-472 [40209] picpiclink
      4. Bacillus stearothermophilus [TaxId: 1422] [55440] (1)
        1. 1ebd picpicxrefxref
          complexed with fad
          1. region a:347-461 [40210] picpiclink
          2. region b:347-461 [40211] picpiclink
      5. Neisseria meningitidis [TaxId: 487] [55441] (2)
        1. 1ojt picpicxref
          complexed with fad
          1. region a:471-598 [40212] picpiclink
        2. 1bhy picpicxref
          complexed with fad
          1. region a:471-598 [40213] picpiclink
      6. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [64331] (3)
        1. 1v59 picpicxrefxrefxrefxref
          automatically matched to d1jeha3
          complexed with fad, nad, po4
          1. region a:356-478 [119840] picpiclink
        2. 1v59 picpicxrefxrefxrefxref
          automatically matched to d1jeha3
          complexed with fad, nad, po4
          1. region b:356-478 [119843] picpiclink
        3. 1jeh picpicxref
          complexed with fad
          1. region a:356-478 [62914] picpiclink
          2. region b:356-478 [62917] picpiclink
      7. Garden pea (Pisum sativum) [TaxId: 3888] [55442] (1)
        1. 1dxl picpicxref
          complexed with fad
          1. region a:348-470 [40214] picpiclink
          2. region b:348-470 [40215] picpiclink
          3. region c:348-470 [40216] picpiclink
          4. region d:348-470 [40217] picpiclink
      8. Mycobacterium tuberculosis [TaxId: 1773] [118041] (1)
        SQ O53355
        1. 1xdi picpicxref
          complexed with fad
          1. region a:349-466 [115161] picpiclink
          2. region b:349-466 [115163] picpiclink
    9. NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase [82726]
      1. Xanthobacter sp., py2 [TaxId: 35809] [82727] (6)
        1. 1mo9 picpicxref
          complexed with fad, kpc
          1. region a:384-523 [79343] picpiclink
          2. region b:384-523 [79346] picpiclink
        2. 2c3c picpicxrefxrefxrefxref
          automatically matched to d1mo9a3
          complexed with acn, com, fad, nap
          1. region a:384-523 [129727] picpiclink
        3. 2c3c picpicxrefxrefxrefxref
          automatically matched to d1mo9a3
          complexed with acn, com, fad, nap
          1. region b:384-523 [129730] picpiclink
        4. 2c3d picpicxrefxrefxrefxref
          automatically matched to d1mo9a3
          complexed with com, fad
          1. region a:384-523 [129733] picpiclink
        5. 2c3d picpicxrefxrefxrefxref
          automatically matched to d1mo9a3
          complexed with com, fad
          1. region b:384-523 [129736] picpiclink
        6. 1mok picpicxref
          complexed with fad
          1. region a:384-523 [79349] picpiclink
          2. region b:384-523 [79352] picpiclink
          3. region c:384-523 [79355] picpiclink
          4. region d:384-523 [79358] picpiclink
    10. Flavocytochrome c sulfide dehydrogenase, FCSD, flavin-binding subunit [55443]
      rudiment "interface" domain of smaller size; beta(3)-alpha
      1. Purple phototrophic bacterium (Chromatium vinosum) [TaxId: 1049] [55444] (1)
        1. 1fcd picpicxrefxref
          complexed with fad, hem
          1. region a:328-401 [40218] picpiclink
          2. region b:328-401 [40219] picpiclink
    11. NADH oxidase /nitrite reductase [118042]
      1. Pyrococcus furiosus [TaxId: 2261] [118043] (1)
        SQ Q8U1K9
        1. 1xhc picpicxref
          Structural genomics target
          complexed with fad
          1. region a:290-351 [115294] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk