Structural Classification of Proteins
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Family: Interleukin 8-like chemokines

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: IL8-like [54116]
    beta(3)-alpha
  4. Superfamily: Interleukin 8-like chemokines [54117]
    form dimers with different dimerisation modes
    link to SUPERFAMILY database - Superfamily
  5. Family: Interleukin 8-like chemokines [54118]

Protein Domains:

  1. Interleukin-8, IL-8 [54119]
    1. Human (Homo sapiens) [TaxId: 9606] [54120] (9)
      1. 3il8 picpic
        1. chain a [37356] picpiclink
      2. 1icw picpic
        mutant
        1. chain a [37357] picpiclink
        2. chain b [37358] picpiclink
      3. 1qe6 picpic
        complexed with so4; mutant
        1. chain a [37359] picpiclink
        2. chain b [37360] picpiclink
        3. chain c [37361] picpiclink
        4. chain d [37362] picpiclink
      4. 1ilp picpic
        complexed with ace, hex, nh2; mutant
        1. chain a [37363] picpiclink
        2. chain b [37364] picpiclink
      5. 2il8 picpic
        1. chain a [37371] picpiclink
        2. chain b [37372] picpiclink
      6. 1ilq picpic
        complexed with ace, hex, nh2; mutant
        1. chain a [37367] picpiclink
        2. chain b [37368] picpiclink
      7. 1il8 picpic
        1. chain a [37365] picpiclink
        2. chain b [37366] picpiclink
      8. 1ikm picpic
        complexed with ch3; mutant
        1. chain a [37370] picpiclink
      9. 1ikl picpic
        monomeric mutant
        1. chain a [37369] picpiclink
  2. Platelet factor 4, PF4 [54121]
    1. Cow (Bos taurus) [TaxId: 9913] [54122] (1)
      1. 1plf picpic
        complexed with tcn
        1. chain a [37373] picpiclink
        2. chain b [37374] picpiclink
        3. chain c [37375] picpiclink
        4. chain d [37376] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [54123] (6)
      1. 1f9r picpic
        mutant
        1. chain a [90484] picpiclink
        2. chain b [90485] picpiclink
        3. chain c [90486] picpiclink
        4. chain d [90487] picpiclink
      2. 1f9q picpic
        1. chain a [90480] picpiclink
        2. chain b [90481] picpiclink
        3. chain c [90482] picpiclink
        4. chain d [90483] picpiclink
      3. 1f9s picpic
        mutant
        1. chain a [90488] picpiclink
        2. chain b [90489] picpiclink
        3. chain c [90490] picpiclink
        4. chain d [90491] picpiclink
      4. 1rhp picpic
        1. chain a [37377] picpiclink
        2. chain b [37378] picpiclink
        3. chain c [37379] picpiclink
        4. chain d [37380] picpiclink
      5. 1pfm picpic
        PF4-M2 chimeric mutant
        1. chain a [37385] picpiclink
        2. chain b [37386] picpiclink
        3. chain c [37387] picpiclink
        4. chain d [37388] picpiclink
      6. 1pfn picpic
        PF4-M2 chimeric mutant
        1. chain a [37381] picpiclink
        2. chain b [37382] picpiclink
        3. chain c [37383] picpiclink
        4. chain d [37384] picpiclink
  3. IP-10/CXCL10 [82573]
    1. Human (Homo sapiens) [TaxId: 9606] [82574] (4)
      1. 1o7z picpic
        1. chain a [86660] picpiclink
        2. chain b [86661] picpiclink
      2. 1o80 picpic
        1. chain a [86662] picpiclink
        2. chain b [86663] picpiclink
      3. 1o7y picpic
        complexed with so4
        1. chain a [86656] picpiclink
        2. chain b [86657] picpiclink
        3. chain c [86658] picpiclink
        4. chain d [86659] picpiclink
      4. 1lv9 picpic
        complexed with mle
        1. chain a [78233] picpiclink
  4. Melanoma growth stimulating activity (MGSA) [54124]
    1. Human (Homo sapiens) [TaxId: 9606] [54125] (3)
      1. 1mgs picpic
        1. chain a [37389] picpiclink
        2. chain b [37390] picpiclink
      2. 1msh picpic
        mutant
        1. chain a [37393] picpiclink
        2. chain b [37394] picpiclink
      3. 1msg picpic
        mutant
        1. chain a [37391] picpiclink
        2. chain b [37392] picpiclink
  5. IL-8/MGSA chimeric protein CIL-8M [54126]
    IL-8: residues 1-53; MGSA: residues 54-72
    1. Human (Homo sapiens) [TaxId: 9606] [54127] (1)
      1. 1rod picpic
        1. chain a [37395] picpiclink
        2. chain b [37396] picpiclink
  6. Macrophage inflammatory protein, MIP [54128]
    has different dimerisation mode
    1. Human (Homo sapiens), 1-beta [TaxId: 9606] [54129] (3)
      1. 1hun picpic
        1. chain a [37399] picpiclink
        2. chain b [37400] picpiclink
      2. 1hum picpic
        1. chain a [37397] picpiclink
        2. chain b [37398] picpiclink
      3. 1je4 picpic
        monomeric variant
        mutant
        1. chain a [66590] picpiclink
    2. Human (Homo sapiens), 1-alpha [TaxId: 9606] [54130] (2)
      1. 1b50 picpic
        mutant
        1. chain a [37401] picpiclink
        2. chain b [37402] picpiclink
      2. 1b53 picpic
        mutant
        1. chain a [37403] picpiclink
        2. chain b [37404] picpiclink
    3. Human (Homo sapiens), ccl20/mip-3a [TaxId: 9606] [75340] (4)
      1. 1m8a picpic
        complexed with ioh
        1. chain a [74579] picpiclink
        2. chain b [74580] picpiclink
      2. 2hci picpic
        automatically matched to d1m8aa_
        complexed with peg, so3, so4
        1. region a:5-65 [136336] picpiclink
      3. 2hci picpic
        automatically matched to d1m8aa_
        complexed with peg, so3, so4
        1. region b:5-65 [136337] picpiclink
      4. 2jyo picpic
        automatically matched to d1m8aa_
        1. region a:5-65 [148241] picpiclink
    4. Mouse (Mus musculus), ccl20/mip-3a [TaxId: 10090] [64214] (1)
      1. 1ha6 picpic
        1. chain a [60875] picpiclink
    5. Kaposi's sarcoma-associated herpesvirus, VMIP-II [TaxId: 37296] [54131] (10)
      anti-HIV chemokine
      1. 2fht picpic
        automatically matched to d1hhva_
        1. region a:4-71 [133504] picpiclink
      2. 1cm9 picpic
        1. chain a [37405] picpiclink
        2. chain b [37406] picpiclink
      3. 2fj2 picpic
        automatically matched to d1hhva_
        1. region a:4-71 [133543] picpiclink
      4. 2fj2 picpic
        automatically matched to d1hhva_
        1. region b:5-71 [133544] picpiclink
      5. 2fj2 picpic
        automatically matched to d1hhva_
        1. region c:4-71 [133545] picpiclink
      6. 2fj2 picpic
        automatically matched to d1hhva_
        1. region d:5-71 [133546] picpiclink
      7. 1vmp picpic
        1. chain a [37407] picpiclink
      8. 1hfn picpic
        1. chain a [37408] picpiclink
      9. 1hhv picpic
        1. chain a [90625] picpiclink
      10. 1hfg picpic
        1. chain a [37409] picpiclink
  7. RANTES (regulated upon activation, normal T-cell expressed and secreted) [54132]
    has different dimerisation mode
    1. Human (Homo sapiens) [TaxId: 9606] [54133] (9)
      SQ P13501 25-91
      1. 1b3a picpic
        synthetic, total chemical synthesis
        complexed with aop, so4
        1. chain a [37410] picpiclink
        2. chain b [37411] picpiclink
      2. 1eqt picpic
        complexed with so4
        1. chain a [37412] picpiclink
        2. chain b [37413] picpiclink
      3. 1u4p picpic
        complexed with acy; mutant
        1. chain a [113022] picpiclink
        2. chain b [113023] picpiclink
      4. 1u4l picpic
        complexed with acy, h1s
        1. chain a [113017] picpiclink
        2. chain b [113018] picpiclink
      5. 1u4m picpic
        complexed with acy, h3s
        1. chain a [113019] picpiclink
        2. chain b [113020] picpiclink
      6. 1u4r picpic
        complexed with so4; mutant
        1. chain a [113030] picpiclink
        2. chain b [113031] picpiclink
        3. chain c [113032] picpiclink
        4. chain d [113033] picpiclink
      7. 1rtn picpic
        1. chain a [37414] picpiclink
        2. chain b [37415] picpiclink
      8. 1rto picpic
        1. chain a [37416] picpiclink
        2. chain b [37417] picpiclink
      9. 1hrj picpic
        1. chain a [37418] picpiclink
        2. chain b [37419] picpiclink
  8. Monocyte chemoattractant protein-1 (MCP-1, MCAF) [54134]
    1. Human (Homo sapiens) [TaxId: 9606] [54135] (9)
      1. 1dok picpic
        complexed with so4; mutant
        1. chain a [37420] picpiclink
        2. chain b [37421] picpiclink
      2. 2nz1 picpicxrefxrefxref
        automatically matched to d1ml0d_
        mutant
        1. region d:9-71 [148524] picpiclink
      3. 2nz1 picpicxrefxrefxref
        automatically matched to d1ml0d_
        mutant
        1. region e:9-71 [148525] picpiclink
      4. 2nz1 picpicxrefxrefxref
        automatically matched to d1ml0d_
        mutant
        1. region y:9-71 [148527] picpiclink
      5. 1dol picpic
        mutant
        1. chain a [37422] picpiclink
      6. 2bdn picpicxrefxref
        automatically matched to d1doma_
        1. region a:4-71 [128341] picpiclink
      7. 1ml0 picpicxref
        mutant
        1. chain d [79254] picpiclink
      8. 1don picpic
        1. chain a [37423] picpiclink
        2. chain b [37424] picpiclink
      9. 1dom picpic
        1. chain a [37425] picpiclink
        2. chain b [37426] picpiclink
  9. Monocyte chemoattractant protein-2 (MCP-2) [54136]
    1. Human (Homo sapiens) [TaxId: 9606] [54137] (1)
      1. 1esr picpic
        mutant
        1. chain a [37427] picpiclink
  10. CC chemokine I-309 [54138]
    1. Human (Homo sapiens) [TaxId: 9606] [54139] (1)
      1. 1el0 picpic
        1. chain a [37428] picpiclink
  11. Eotaxin [54140]
    1. Human (Homo sapiens) [TaxId: 9606] [54141] (2)
      1. 2eot picpic
        1. chain a [37430] picpiclink
      2. 1eot picpic
        1. chain a [37429] picpiclink
  12. Eotaxin-2 [54142]
    1. Human (Homo sapiens) [TaxId: 9606] [54143] (2)
      1. 1eih picpic
        1. chain a [37431] picpiclink
      2. 1eig picpic
        1. chain a [37432] picpiclink
  13. Eotaxin-3 [75341]
    1. Human (Homo sapiens) [TaxId: 9606] [75342] (2)
      1. 1g2t picpic
        1. chain a [70150] picpiclink
      2. 1g2s picpic
        1. chain a [70149] picpiclink
  14. Lymphotactin [69632]
    1. Human (Homo sapiens) [TaxId: 9606] [69633] (2)
      1. 1j8i picpic
        1. chain a [66438] picpiclink
      2. 1j9o picpic
        1. chain a [66460] picpiclink
  15. Monocyte chemoattractant protein-3 (MCP-3) [54144]
    1. Human (Homo sapiens) [TaxId: 9606] [54145] (2)
      1. 1bo0 picpic
        1. chain a [37433] picpiclink
      2. 1ncv picpic
        1. chain a [37434] picpiclink
        2. chain b [37435] picpiclink
  16. Chemokine domain of fractalkine [54146]
    1. Human (Homo sapiens) [TaxId: 9606] [54147] (2)
      1. 1f2l picpic
        1. chain a [37436] picpiclink
        2. chain b [37437] picpiclink
        3. chain c [37438] picpiclink
        4. chain d [37439] picpiclink
      2. 1b2t picpic
        1. chain a [37440] picpiclink
  17. Platelet basic protein, PBP [54148]
    synonym: Small inducible cytokine B7; Neutrophil-activating peptide-2 (NAP-2), Connective tissue activating peptide-III (CTAP-III)
    1. Human (Homo sapiens) [TaxId: 9606] [54149] (3)
      1. 1tvx picpic
        mutant
        1. chain a [37441] picpiclink
        2. chain b [37442] picpiclink
        3. chain c [37443] picpiclink
        4. chain d [37444] picpiclink
      2. 1f9p picpic
        complexed with esa
        1. chain a [90479] picpiclink
      3. 1nap picpic
        mutant
        1. chain a [37445] picpiclink
        2. chain b [37446] picpiclink
        3. chain c [37447] picpiclink
        4. chain d [37448] picpiclink
  18. Stromal cell-derived factor-1 (SDF-1) [54150]
    1. Human (Homo sapiens) [TaxId: 9606] [54151] (7)
      1. 2j7z picpic
        automatically matched to d1sdf__
        1. region a:1-67 [138131] picpiclink
      2. 2j7z picpic
        automatically matched to d1sdf__
        1. region b:1-67 [138132] picpiclink
      3. 1qg7 picpic
        complexed with so4
        1. chain a [37449] picpiclink
        2. chain b [37450] picpiclink
      4. 1a15 picpic
        complexed with so4; mutant
        1. chain a [37451] picpiclink
        2. chain b [37452] picpiclink
      5. 1vmc picpic
        automatically matched to d1sdf__
        1. region a:8-67 [120065] picpiclink
      6. 1sdf picpic
        1. chain a [37453] picpiclink
      7. 2sdf picpic
        1. chain a [37454] picpiclink
  19. Macrophage inflammatory protein-2 [54152]
    1. Mouse (Mus musculus) [TaxId: 10090] [54153] (1)
      1. 1mi2 picpic
        1. chain a [37455] picpiclink
        2. chain b [37456] picpiclink
  20. Chemokine hcc-2 (macrophage inflammatory protein-5) [54154]
    1. Human (Homo sapiens) [TaxId: 9606] [54155] (1)
      1. 2hcc picpic
        1. chain a [37457] picpiclink
  21. Gro beta [54156]
    1. Human (Homo sapiens) [TaxId: 9606] [54157] (1)
      1. 1qnk picpic
        1. chain a [37458] picpiclink
        2. chain b [37459] picpiclink
  22. Myeloid progenitor inhibitory factor-1 (MPIF-1) [64215]
    1. Human (Homo sapiens) [TaxId: 9606] [64216] (1)
      1. 1g91 picpic
        1. chain a [60389] picpiclink
  23. Thymus and activation-regulated chemokine, TRAC [102730]
    1. Human (Homo sapiens) [TaxId: 9606] [102731] (2)
      1. 1nr4 picpic
        complexed with so4
        1. chain a [92077] picpiclink
        2. chain b [92078] picpiclink
        3. chain c [92079] picpiclink
        4. chain d [92080] picpiclink
        5. chain e [92081] picpiclink
        6. chain f [92082] picpiclink
        7. chain g [92083] picpiclink
        8. chain h [92084] picpiclink
      2. 1nr2 picpic
        1. chain a [92075] picpiclink
        2. chain b [92076] picpiclink
  24. Small inducible cytokine b11 (CXCL11/I-TAC) [102732]
    1. Human (Homo sapiens) [TaxId: 9606] [102733] (1)
      1. 1rjt picpic
        1. chain a [97581] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk