Structural Classification of Proteins

Fold: Nucleotidyltransferase

: core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: Nucleotidyltransferase [81302]
core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123

Superfamilies:

Nucleotidyltransferase [81301] (14)
uperfamily
1. Catalytic subunit of bi-partite nucleotidyltransferase [102932] (3)
  insert X in the core is an alpha-helix; minimal nucleotidyltransferase fold
  1. Hypothetical protein HI0073 [102933]
    nucleotide binding subunit of the HI0073/HI0074 nucleotidyltransferase (see 1jog)
    1. Haemophilus influenzae [TaxId: 727] [102934] (1)
  2. Unnamed putative nucleotidyltransferase [102935]
    1. Thermus thermophilus [TaxId: 274] [102936] (1)
      SQ P83814 # 100% identical to SQ Q72I47 (TTC1285)
  3. Putative nucleotidyltransferase AF0614 [143232]
    1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [143233] (2)
      SQ O29641 1-90
2. Kanamycin nucleotidyltransferase (KNTase), N-terminal domain [56708] (1)
  insert X in the core is a beta-strand ; mixed 4-stranded sheet, order: 1243
  1. Kanamycin nucleotidyltransferase (KNTase), N-terminal domain [56709]
    1. Staphylococcus aureus [TaxId: 1280] [56710] (2)
3. Poly(A) polymerase, PAP, N-terminal domain [81589] (2)
  insert X in the core is an alpha-beta(2) unit; mixed 5-stranded sheet, order: 12543
  1. Poly(A) polymerase, PAP, N-terminal domain [81588]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [81586] (7)
    2. Cow (Bos taurus) [TaxId: 9913] [81587] (3)
      SQ P25500 18-497
4. 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain [102937] (1)
  similar overall structure to the first two domains of poly(A) polymerase, PAP
  1. 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain [102938]
    1. Pig (Sus scrofa) [TaxId: 9823] [102939] (1)
5. Archaeal tRNA CCA-adding enzyme catalytic domain [102940] (1)
  similar overall structure to poly(A) polymerase, PAP
  1. tRNA nucleotidyltransferase, N-terminal domain [102941]
    1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [102942] (28)
      SQ O28126
6. DNA polymerase beta-like [81300] (5)
  insert X in the core is an alpha-beta(2) unit; mixed 5-stranded sheet, order: 12543; contains extra C-terminal alpha+beta subdomain
  1. DNA polymerase beta, catalytic (31 kD) fragment [81578]
    1. Human (Homo sapiens) [TaxId: 9606] [81574] (107)
      SQ P06746
    2. Rat (Rattus norvegicus) [TaxId: 10116] [81576] (18)
  2. Terminal deoxynucleotidyl transferase [81581]
    1. Mouse (Mus musculus) [TaxId: 10090] [81580] (3)
  3. DNA polymerase lambda [102943]
    1. Human (Homo sapiens) [TaxId: 9606] [102944] (24)
  4. DNA polymerase X [69885]
    1. African swine fever virus [TaxId: 10497] [69886] (2)
7. Poly A polymerase head domain-like [82661] (3)
  overlaps with the N-terminal part of Pfam 01743; this family is distinct from eukaryotic PAPs
  insert X in the core is an alpha-beta(2) unit; contains two extra C-terminal strands; mixed 7-stranded sheet, order: 7612543
  1. tRNA CCA-adding enzyme, head domain [82662]
    1. Bacillus stearothermophilus [TaxId: 1422] [82663] (3)
    2. Human (Homo sapiens), mitochondrial [TaxId: 9606] [89924] (1)
  2. Poly A polymerase PcnB [110931]
    1. Aquifex aeolicus [TaxId: 63363] [110932] (1)
      SQ O66728 443-824
8. RelA/SpoT domain [102945] (2)
  Pfam 04607; ppGpp-synthetase
  1. Stringent response-like protein RelA domain 2 [102946]
    1. Streptococcus equisimilis [TaxId: 119602] [102947] (1)
  2. Putative GTP pyrophosphokinase SP1097 [143234]
    1. Streptococcus pneumoniae [TaxId: 1313] [143235] (2)
      SQ Q97QV1 1-203
9. GlnE-like domain [110933] (1)
  Pfam 03710; Pfam coverage excludes the extra N-terminal subdomain but includes a short segment of the next domain 2
  1. Glutamine synthase adenylyltransferase GlnE, N-terminal domain [110934]
    includes extra N-terminal all-alpha subdomain (2-61) structurally similar to the PABP domain (scop_fa 63571)
    1. Escherichia coli [TaxId: 562] [110935] (1)
      SQ P30870 1-437
10. RNA editing terminal uridyl transferase 2, RET2, catalytic domain [143236] (1)
  contains insert domain of a ferredoxin-like fold
  1. RNA editing terminal uridyl transferase 2, TUTase 2, RET2 [143237]
    1. Trypanosoma brucei [TaxId: 5691] [143238] (1)
      SQ Q86MV5 30-288
11. TM1012-like [143239] (1)
  insert X in the core is an alpha-beta(2) unit; contains extra C-terminal structures; mixed 7-stranded sheet, order: 6712543;
  1. Hypothetical protein TM1012 [143240]
    1. Thermotoga maritima [TaxId: 2336] [143241] (2)
      SQ Q9X0A5 1-157! SQ Q9X0A5 2-157
12. Iojap/YbeB-like [160252] (2)
  Pfam 02410, probably has evolved a different function; closer relationship to the GrpB-like family
  1. Hypothetical protein CV0518 [160253]
    1. Chromobacterium violaceum [TaxId: 536] [160254] (2)
      SQ Q7P0P8 1-120
  2. Uncharacterized protein BH1328 [160255]
    1. Bacillus halodurans [TaxId: 86665] [160256] (2)
      SQ Q9KD89 2-114
13. AadK N-terminal domain-like [160257] (1)
  N-terminal part of Pfam 04439; Streptomycin adenylyltransferase; insert X is alpha-beta(2) unit; overall domain architecture is similar to Kanamycin nucleotidyltransferase
  1. Aminoglycoside 6-adenylyltransferase AadK [160258]
    1. Bacillus subtilis [TaxId: 1423] [160259] (1)
      SQ P17585 1-135
14. GrpB-like [160260] (1)
  Pfam 04229, different set of active-site residues
  1. Hypothetical protein GrpB [160261]
    1. Enterococcus faecalis [TaxId: 1351] [160262] (1)
      SQ Q837C3 4-170