Structural Classification of Proteins
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Family: Double-stranded RNA-binding domain (dsRBD)

Pfam 00035

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: dsRBD-like [54767]
    alpha-beta(3)-alpha; 2 layers: alpha/beta
  4. Superfamily: dsRNA-binding domain-like [54768]
    link to SUPERFAMILY database - Superfamily
  5. Family: Double-stranded RNA-binding domain (dsRBD) [54769]
    Pfam 00035

Protein Domains:

  1. Double-stranded RNA-binding protein A, second dsRBD [54770]
    1. Xenopus laevis [TaxId: 8355] [54771] (1)
      1. 1di2 picpic
        complexed with dsRNA
        1. chain a [38780] picpiclink
        2. chain b [38781] picpiclink
  2. Staufen, domain III [54772]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [54773] (2)
      1. 1ekz picpic
        1. chain a [38783] picpiclink
      2. 1stu picpic
        CASP1
        1. chain a [38782] picpiclink
  3. dsRNA-dependent protein kinase pkr [54774]
    contains tandem repeat of two dsRBD
    1. Human (Homo sapiens) [TaxId: 9606] [54775] (1)
      1. 1qu6 picpic
        1. region a:1-90 [38784] picpiclink
        2. region a:91-179 [38785] picpiclink
    2. Mouse (Mus musculus) [TaxId: 10090] [143201] (2)
      SQ Q03963 1-85! SQ Q03963 96-181
      1. 1x49 picpic
        1st dsRBD
        1. region a:8-92 [121682] picpiclink
      2. 1x48 picpic
        2nd dsRBD
        1. region a:8-83 [121681] picpiclink
  4. RNase III, C-terminal domain [54776]
    1. Thermotoga maritima [TaxId: 2336] [82644] (1)
      1. 1o0w picpicxref
        CASP5
        1. region a:168-236 [80752] picpiclink
        2. region b:168-237 [80754] picpiclink
    2. Aquifex aeolicus [TaxId: 63363] [102927] (19)
      1. 2nug picpicxrefxref
        automatically matched to d1rc7a2
        complexed with mg
        1. region a:151-218 [148453] picpiclink
      2. 2nug picpicxrefxref
        automatically matched to d1rc7a2
        complexed with mg
        1. region b:151-220 [148455] picpiclink
      3. 2ez6 picpicxrefxref
        automatically matched to d1rc7a2
        complexed with mg; mutant
        1. region a:151-220 [132617] picpiclink
      4. 2ez6 picpicxrefxref
        automatically matched to d1rc7a2
        complexed with mg; mutant
        1. region b:151-220 [132619] picpiclink
      5. 1rc7 picpicxref
        complexed with trs; mutant
        1. region a:151-220 [97290] picpiclink
      6. 1yz9 picpicxrefxref
        automatically matched to d1rc7a2
        complexed with so4; mutant
        1. region a:151-220 [124272] picpiclink
      7. 1yz9 picpicxrefxref
        automatically matched to d1rc7a2
        complexed with so4; mutant
        1. region b:151-220 [124274] picpiclink
      8. 1yyk picpicxrefxref
        automatically matched to d1rc7a2
        complexed with trs
        1. region a:151-220 [124219] picpiclink
      9. 1yyk picpicxrefxref
        automatically matched to d1rc7a2
        complexed with trs
        1. region b:151-220 [124221] picpiclink
      10. 2nuf picpicxrefxref
        automatically matched to d1rc7a2
        complexed with mg
        1. region a:151-220 [148449] picpiclink
      11. 2nuf picpicxrefxref
        automatically matched to d1rc7a2
        complexed with mg
        1. region b:151-220 [148451] picpiclink
      12. 1yyo picpicxrefxref
        automatically matched to d1rc7a2
        complexed with trs; mutant
        1. region a:151-220 [124245] picpiclink
      13. 1yyo picpicxrefxref
        automatically matched to d1rc7a2
        complexed with trs; mutant
        1. region b:151-220 [124247] picpiclink
      14. 2nue picpicxrefxref
        automatically matched to d1rc7a2
        1. region a:151-220 [148445] picpiclink
      15. 2nue picpicxrefxref
        automatically matched to d1rc7a2
        1. region b:151-220 [148447] picpiclink
      16. 1yyw picpicxrefxrefxrefxref
        automatically matched to d1rc7a2
        1. region a:151-220 [124257] picpiclink
      17. 1yyw picpicxrefxrefxrefxref
        automatically matched to d1rc7a2
        1. region b:151-220 [124259] picpiclink
      18. 1yyw picpicxrefxrefxrefxref
        automatically matched to d1rc7a2
        1. region c:151-219 [124261] picpiclink
      19. 1yyw picpicxrefxrefxrefxref
        automatically matched to d1rc7a2
        1. region d:151-220 [124263] picpiclink
    3. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110913] (3)
      SQ Q02555 364-447 ! SQ Q02555 366-453 ! SQ Q02555 363-443
      1. 1t4o picpic
        1. chain a [106425] picpiclink
        2. chain b [106426] picpiclink
      2. 1t4n picpic
        1. chain a [106424] picpiclink
      3. 1t4l picpic
        1. chain b [106423] picpiclink
  5. staufen homolog 2 [110914]
    1. Mouse (Mus musculus) [TaxId: 10090] [110915] (1)
      SQ Q9D5N7 3-78
      1. 1uhz picpic
        Structural genomics target
        1. chain a [107855] picpiclink
  6. ATP-dependent RNA helicase A, Dhx9 [117901]
    formerly hypothetical protein bab28848
    1. Mouse (Mus musculus) [TaxId: 10090] [117902] (2)
      SQ O70133 4-89, 168-262
      1. 1whq picpic
        Structural genomics target; 1st dsRBD
        1. chain a [114649] picpiclink
      2. 1uil picpic
        Structural genomics target; 2nd dsRDB
        1. chain a [113255] picpiclink
  7. tRNA-dihydrouridine synthase 2-like, Dus2l (2310016k04Rik) [117903]
    1. Mouse (Mus musculus) [TaxId: 10090] [117904] (1)
      SQ Q9D7B1 350-464
      1. 1whn picpic
        Structural genomics target
        1. chain a [114648] picpiclink
  8. dsRNA-specific editase 1 [143202]
    duplication: contains two dsRBD domains
    1. Rat (Rattus norvegicus) [TaxId: 10116] [143203] (2)
      SQ P51400 231-301! SQ P51400 74-146
      1. 2b7t picpic
        1st dsRBD
        1. region a:1-73 [128055] picpiclink
      2. 2b7v picpic
        2nd dsRBD
        1. region a:1-71 [128056] picpiclink
  9. Interferon-inducible double stranded RNA-dependent protein kinase activator A [143204]
    1. Human (Homo sapiens) [TaxId: 9606] [143205] (1)
      SQ O75569 32-104
      1. 2dix picpic
        1. region a:7-79 [131534] picpiclink
  10. Dgcr8 protein [143206]
    1. Human (Homo sapiens) [TaxId: 9606] [143207] (1)
      SQ Q8WYQ5 502-586
      1. 1x47 picpic
        1. region a:8-92 [121680] picpiclink
  11. TAR RNA-binding protein 2 [143208]
    duplication: contains three dsRBD
    1. Human (Homo sapiens) [TaxId: 9606] [143209] (1)
      SQ Q15633 150-225
      1. 2cpn picpic
        2nd dsRBD
        1. region a:150-225 [130703] picpiclink
  12. Spermatid perinuclear RNA-binding protein [143210]
    1. Human (Homo sapiens) [TaxId: 9606] [143211] (1)
      SQ Q96SI9 378-461
      1. 2dmy picpic
        2nd dsRBD
        1. region a:8-91 [131576] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk