Structural Classification of Proteins

Superfamily: Zn-dependent exopeptidases

: core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest
uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: Phosphorylase/hydrolase-like [53162]
core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops
Superfamily: Zn-dependent exopeptidases [53187]
core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest
uperfamily

Families:

Pancreatic carboxypeptidases [53188] (10)
1. Carboxypeptidase A [53189]
  1. Cow (Bos taurus) [TaxId: 9913] [53190] (30)
  2. Pig (Sus scrofa) [TaxId: 9823] [53191] (1)
  3. Human (Homo sapiens) [TaxId: 9606] [53192] (7)
  4. Cotton bollworm (Helicoverpa armigera) [TaxId: 29058] [75247] (1)
2. Carboxypeptidase B [53193]
  1. Pig (Sus scrofa) [TaxId: 9823] [53194] (54)
  2. Human (Homo sapiens) [TaxId: 9606] [75248] (2)
  3. Cow (Bos taurus) [TaxId: 9913] [53195] (1)
  4. Corn earworm (Helicoverpa zea) [TaxId: 7113] [142511] (2)
    SQ Q3T905 117-428
3. Carboxypeptidase D, catalytic domain [53196]
  1. Crested duck (Lophonetta specularioides) [TaxId: 8836] [53197] (2)
4. Carboxypeptidase M, catalytic domain [102504]
  1. Human (Homo sapiens) [TaxId: 9606] [102505] (1)
Carboxypeptidase T [53198] (1)
1. Carboxypeptidase T [53199]
  1. Thermoactinomyces vulgaris [TaxId: 2026] [53200] (1)
Leucine aminopeptidase, C-terminal domain [53201] (2)
1. Leucine aminopeptidase, C-terminal domain [53202]
  1. Cow (Bos taurus) [TaxId: 9913] [53203] (9)
  2. Escherichia coli, PepA [TaxId: 562] [75249] (1)
Bacterial dinuclear zinc exopeptidases [53204] (19)
1. Aminopeptidase [53205]
  1. Aeromonas proteolytica [TaxId: 671] [53206] (13)
    SQ Q01693
    synonym: Vibrio proteolyticus
  2. Streptomyces griseus [TaxId: 1911] [53207] (11)
2. Aminopeptidase PepV [82450]
  unspecific amino dipeptidase
  1. Lactobacillus delbrueckii [TaxId: 1584] [82451] (1)
3. Carboxypeptidase G2, catalytic domain [53208]
  1. Pseudomonas sp., strain rs-16 [TaxId: 306] [53209] (1)
4. Peptidase T (tripeptidase), catalytic domain [75250]
  1. Salmonella typhimurium [TaxId: 90371] [75251] (1)
  2. Escherichia coli [TaxId: 562] [102506] (1)
5. Peptidase-like beta-alanine synthase, catalytic domain [102507]
  1. Yeast (Saccharomyces kluyveri) [TaxId: 4934] [102508] (2)
6. Succinyl-diaminopimelate desuccinylase, catalytic domain [102509]
  1. Neisseria meningitidis [TaxId: 487] [102510] (1)
7. Aminoacylase-1, catalytic domain [102511]
  1. Human (Homo sapiens) [TaxId: 9606] [102512] (1)
8. Hypothetical protein YsdC, catalytic domain [102513]
  contains insert beta-barrel domain
  1. Bacillus subtilis [TaxId: 1423] [102514] (1)
9. Putative endoglucanase TM1048, catalytic domain [102515]
  contains insert beta-barrel domain
  1. Thermotoga maritima [TaxId: 2336] [102516] (1)
10. Frv operon protein FrvX, catalytic domain [117659]
  1. Pyrococcus horikoshii [TaxId: 53953] [117660] (3)
    SQ O59196 # PH1527
11. Probable aminopeptidase ApeA [117661]
  contains insert beta-barrel domain
  1. Borrelia burgdorferi [TaxId: 139] [117662] (1)
    SQ Q45055
12. IAA-amino acid hydrolase, catalytic domain [117663]
  1. Mouse-ear cress (Arabidopsis thaliana) [TaxId: 3702] [117664] (2)
    SQ P54970 37-428
13. Deblocking aminopeptidase YhfE [142512]
  contains insert beta-barrel domain
  1. Bacillus cereus [TaxId: 1396] [142513] (16)
    SQ Q81HB5 3-73,187-348
    BC0901
14. Allantoate amidohydrolase AllC catalytic domain [142514]
  1. Escherichia coli [TaxId: 562] [142515] (4)
    SQ P77425 2-210,328-411
15. Endoglucanase TM1049 [142516]
  1. Thermotoga maritima [TaxId: 2336] [142517] (1)
    SQ Q9X0D9 1-64,149-339
16. Protein YxeP [142518]
  1. Bacillus subtilis [TaxId: 1423] [142519] (2)
    SQ P54955 4-177,293-379
17. Aminopeptidase YpdE [142520]
  1. Shigella flexneri [TaxId: 623] [142521] (6)
    SQ Q83K87 1-66,148-345
    hypothetical protein SF2450 (PDB)/SF2449.1 (UniProt)
FolH catalytic domain-like [53210] (2)
1. Transferrin receptor ectodomain, protease-like domain [53211]
  1. Human (Homo sapiens) [TaxId: 9606] [53212] (4)
2. Glutamate carboxypeptidase II FOLH1 [142522]
  Folate hydrolase 1, FolH homologue
  1. Human (Homo sapiens) [TaxId: 9606] [142523] (17)
    SQ Q04609 57-117,351-593
N-acetylmuramoyl-L-alanine amidase-like [102517] (2)
1. N-acetylmuramoyl-L-alanine amidase CwlV [102518]
  1. Paenibacillus polymyxa [TaxId: 1406] [102519] (1)
2. Endolysin Ply, catalytic domain [142524]
  1. Bacteriophage Psa [TaxId: 171618] [142525] (1)
    SQ Q8W5Y8 1-180
AstE/AspA-like [142526] (6)
Pfam 04952; Succinylglutamate desuccinylase / Aspartoacylase family; contains extra C-terminal domain, new variant of the Barrel-sandwich hybrid fold (scop_cf 51229)
1. Succinylglutamate desuccinylase AstE [142527]
  1. Vibrio cholerae [TaxId: 666] [142528] (1)
    SQ Q9KSL4 3-342
  2. Vibrio parahaemolyticus [TaxId: 670] [142529] (2)
    SQ Q87Q40 4-342
  3. Escherichia coli [TaxId: 562] [142530] (2)
    SQ P76215 1-322
  4. Chromobacterium violaceum [TaxId: 536] [142531] (1)
    SQ Q7NU26 2-332
2. Aspartoacylase AspA [159649]
  1. Rat (Rattus norvegicus) [TaxId: 10116] [159650] (1)
    SQ Q6AZ03 4-310
  2. Human (Homo sapiens) [TaxId: 9606] [159651] (1)
    SQ P45381 9-310
Glutaminyl-peptide cyclotransferase-like [142532] (1)
part of Pfam 04389
1. Glutaminyl-peptide cyclotransferase, QPCT [142533]
  Glutaminyl cyclase
  1. Human (Homo sapiens) [TaxId: 9606] [142534] (16)
    SQ Q16769 33-361
FGase-like [159652] (2)
Pfam 05013; N-formylglutamate amidohydrolase
1. N-formylglutamate amidohydrolase [159653]
  1. Ralstonia eutropha [TaxId: 106590] [159654] (2)
    SQ Q46VW8 10-289
2. Hypothetical protein Atu2144 [159655]
  1. Agrobacterium tumefaciens [TaxId: 358] [159656] (8)
    SQ Q8UDI1 6-257