Structural Classification of Proteins
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Superfamily: Thioredoxin-like

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Thioredoxin fold [52832]
    core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest
  4. Superfamily: Thioredoxin-like [52833]
    link to SUPERFAMILY database - Superfamily

Families:

  1. Thioltransferase [52834] (31) picpic
  2. PDI-like [52849] (6) picpic
    duplication: contains two tandem repeats of this fold
  3. Calsequestrin [52855] (1) picpic
    duplication: contains three tandem repeats of this fold
  4. DsbA-like [100953] (4) picpic
    contains an all-alpha subdomain insertion
  5. Glutathione S-transferase (GST), N-terminal domain [52862] (44) picpic
  6. Phosducin [52888] (2) picpic
  7. ERP29 N domain-like [52892] (2) picpic
  8. spliceosomal protein U5-15Kd [52895] (1) picpic
  9. SH3BGR (SH3-binding, glutamic acid-rich protein-like) [102446] (1) picpic
    related to glutaredoxin 1 (GRX1) but lacks both conserved cysteine residues
  10. KaiB-like [102449] (2) picpic
    Pfam 07689; contains members with alternative folds
  11. DsbC/DsbG C-terminal domain-like [52898] (3) picpic
    elaborated common fold
  12. Glutathione peroxidase-like [52901] (42) picpic
  13. Thioredoxin-like 2Fe-2S ferredoxin [52918] (1) picpic
  14. ArsC-like [69518] (3) picpic
    Pfam 03960
  15. Txnl5-like [110612] (2) picpic
    Pfam 06110
  16. YuzD-like [117605] (1) picpic
    Pfam 07315
  17. YKR049C-like [142395] (1) picpic
    Pfam 07955; DUF1687; contains an all-alpha insert subdomain
  18. Atu2684-like [142398] (1) picpic
    Pfam 06764; DUF1223; contains extra C-terminal domain of Immunoglobulin-like fold (scop_cf 48725), intimately associated with the N-terminal thioredixin-like domain and contributing to the active site
  19. HyaE-like [142401] (2) picpic
    Pfam 07449; have evolved a different function; contains no conserved cysteine residues
  20. NQO2-like [142405] (1) picpic
    complex I 24 kDa subunit; contains 2Fe-2S cluster in the active site; includes extra N-terminal four-helical bundle
  21. Mitochondrial ribosomal protein L51/S25/CI-B8 domain [142408] (1) picpic
    Pfam 05047; "minimalized" version of the thioredoxin-like fold; variable positions for cysteine residues in the putative active site
  22. Selenoprotein W-related [142411] (3) picpic
    Pfam 05169; "minimalized" version of the thioredoxin-like fold
  23. UAS domain [159589] (1) picpic
    SMART 00594
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk