Structural Classification of Proteins
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Family: Thioltransferase

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Thioredoxin fold [52832]
    core: 3 layers, a/b/a; mixed beta-sheet of 4 strands, order 4312; strand 3 is antiparallel to the rest
  4. Superfamily: Thioredoxin-like [52833]
    link to SUPERFAMILY database - Superfamily
  5. Family: Thioltransferase [52834]

Protein Domains:

  1. Thioredoxin [52835]
    1. Escherichia coli [TaxId: 562] [52836] (31)
      SQ P00274 ! SQ P00581
      1. 2trx picpic
        complexed with cu, mpd
        1. chain a [32719] picpiclink
        2. chain b [32720] picpiclink
      2. 1keb picpic
        complexed with cu; mutant
        1. chain a [77341] picpiclink
        2. chain b [77342] picpiclink
      3. 2tir picpic
        complexed with cu; mutant
        1. chain a [32721] picpiclink
      4. 1x9m picpicxrefxref
        complexed with 2dt, 8fg, mg; mutant
        1. chain b [115001] picpiclink
      5. 1tk5 picpicxrefxref
        complexed with 1pe, ddg, mes, mg, so4
        1. chain b [107076] picpiclink
      6. 1tho picpic
        complexed with cu; mutant
        1. chain a [32722] picpiclink
      7. 1t7p picpicxrefxref
        protein/DNA complex; complexed with 2da, dg3, mg; mutant
        1. chain b [32723] picpiclink
      8. 1x9w picpicxrefxref
        complexed with 2dt, mg; mutant
        1. chain b [115010] picpiclink
      9. 1sl2 picpicxrefxref
        complexed with 2da, dad, mg, ttd; mutant
        1. chain b [105708] picpiclink
      10. 1tkd picpicxrefxref
        complexed with 1pe, 8og, d3t, doc, mes, mg, so4
        1. chain b [107088] picpiclink
      11. 1skr picpicxrefxref
        complexed with 2da, dad, mg; mutant
        1. chain b [105686] picpiclink
      12. 1sl1 picpicxrefxref
        complexed with 2da, mg, ttd; mutant
        1. chain b [105705] picpiclink
      13. 1tk0 picpicxrefxref
        complexed with 1pe, 8og, dct, ddg, mes, mg, so4; mutant
        1. chain b [107065] picpiclink
      14. 1tk8 picpicxrefxref
        complexed with 1pe, 2da, 8og, d3t, mes, mg, so4
        1. chain b [107081] picpiclink
      15. 1sks picpicxrefxref
        complexed with 2dt, mg, ttd; mutant
        1. chain b [105689] picpiclink
      16. 1skw picpicxrefxref
        complexed with 2dt, mg; mutant
        1. chain b [105696] picpiclink
      17. 1txx picpic
        active-site variant
        complexed with cu; mutant
        1. chain a [32724] picpiclink
      18. 2bto picpicxrefxrefxrefxref
        automatically matched to d1xoa__
        complexed with gtp
        1. region t:23-125 [129156] picpiclink
      19. 1t8e picpicxrefxref
        complexed with 2dt, dct, mes, mg, pg4, so4
        1. chain b [112318] picpiclink
      20. 2h6x picpic
        automatically matched to d1xoa__
        complexed with mpd
        1. region a:3-107 [136205] picpiclink
      21. 2h6x picpic
        automatically matched to d1xoa__
        complexed with mpd
        1. region b:3-107 [136206] picpiclink
      22. 1x9s picpicxrefxref
        complexed with 2dt, mg; mutant
        1. chain b [115007] picpiclink
      23. 1zyq picpicxrefxref
        automatically matched to d1xoa__
        complexed with 8og, dad, ddg, mg; mutant
        1. region b:3-107 [125848] picpiclink
      24. 2ajq picpic
        automatically matched to d1xoa__
        complexed with 2dt; mutant
        1. region b:3-107 [126890] picpiclink
      25. 2ajq picpic
        automatically matched to d1xoa__
        complexed with 2dt; mutant
        1. region i:3-107 [126891] picpiclink
      26. 1f6m picpicxref
        complexed with 3aa, fad; mutant
        1. chain c [32725] picpiclink
        2. chain d [32726] picpiclink
        3. chain g [32727] picpiclink
        4. chain h [32728] picpiclink
      27. 1srx picpic
        CA-atoms only
        1. chain a [32729] picpiclink
      28. 1xoa picpic
        1. chain a [32731] picpiclink
      29. 1sl0 picpicxrefxref
        complexed with 2dt, dad, mg; mutant
        1. chain b [105699] picpiclink
        2. chain d [105702] picpiclink
      30. 1xob picpic
        1. chain a [90400] picpiclink
      31. 1oaz picpicxrefxref
        insertion mutant
        1. chain a [92741] picpiclink
        2. chain b [92742] picpiclink
    2. Anabaena sp., pcc 7120 [TaxId: 1167] [52837] (1)
      thioredoxin H
      1. 1thx picpic
        1. chain a [32732] picpiclink
    3. Chlamydomonas reinhardtii [TaxId: 3055] [52838] (4)
      1. 1ep7 picpic
        1. chain a [64905] picpiclink
        2. chain b [64906] picpiclink
      2. 1ep8 picpic
        mutant
        1. chain a [64907] picpiclink
        2. chain b [64908] picpiclink
      3. 1tof picpic
        1. chain a [32733] picpiclink
      4. 1dby picpic
        1. chain a [32734] picpiclink
    4. Alicyclobacillus acidocaldarius, formerly Bacillus acidocaldarius [TaxId: 405212] [52839] (4)
      SQ P80579
      1. 1nw2 picpic
        complexed with act, cac, zn; mutant
        1. chain a [92215] picpiclink
        2. chain b [92216] picpiclink
        3. chain c [92217] picpiclink
        4. chain d [92218] picpiclink
        5. chain e [92219] picpiclink
        6. chain f [92220] picpiclink
        7. chain g [92221] picpiclink
        8. chain h [92222] picpiclink
      2. 1nsw picpic
        mutant
        1. chain a [92097] picpiclink
        2. chain b [92098] picpiclink
        3. chain c [92099] picpiclink
        4. chain d [92100] picpiclink
      3. 1quw picpic
        1. chain a [32735] picpiclink
      4. 1rqm picpic
        mutant
        1. chain a [105068] picpiclink
    5. Spinach (Spinacia oleracea), thioredoxin F [TaxId: 3562] [52840] (2)
      1. 1f9m picpic
        short form
        1. chain a [32736] picpiclink
        2. chain b [32737] picpiclink
      2. 1faa picpic
        long form
        mutant
        1. chain a [32738] picpiclink
    6. Spinach (Spinacia oleracea), thioredoxin M [TaxId: 3562] [52841] (3)
      1. 1fb6 picpic
        1. chain a [32739] picpiclink
        2. chain b [32740] picpiclink
      2. 1fb0 picpic
        1. chain a [32741] picpiclink
        2. chain b [32742] picpiclink
      3. 1gl8 picpic
        1. chain a [65290] picpiclink
    7. Human (Homo sapiens) [TaxId: 9606] [52842] (26)
      1. 2ifq picpic
        automatically matched to d1auc__
        complexed with eoh, snc
        1. region a:1-105 [137343] picpiclink
      2. 2ifq picpic
        automatically matched to d1auc__
        complexed with eoh, snc
        1. region b:1-105 [137344] picpiclink
      3. 2ifq picpic
        automatically matched to d1auc__
        complexed with eoh, snc
        1. region c:1-105 [137345] picpiclink
      4. 2hsh picpic
        automatically matched to d1erv__
        complexed with po4; mutant
        1. region a:1-105 [136724] picpiclink
      5. 2hxk picpic
        automatically matched to d1auc__
        complexed with eoh, snc
        1. region a:1-105 [136853] picpiclink
      6. 2hxk picpic
        automatically matched to d1auc__
        complexed with eoh, snc
        1. region b:1-105 [136854] picpiclink
      7. 2hxk picpic
        automatically matched to d1auc__
        complexed with eoh, snc
        1. region c:1-105 [136855] picpiclink
      8. 1erv picpic
        mutant
        1. chain a [32743] picpiclink
      9. 2iiy picpic
        automatically matched to d1auc__
        complexed with snc
        1. region a:1-105 [137443] picpiclink
      10. 1ert picpic
        1. chain a [32744] picpiclink
      11. 1erw picpic
        mutant
        1. chain a [32745] picpiclink
      12. 1aiu picpic
        mutant
        1. chain a [32746] picpiclink
      13. 1auc picpic
        1. chain a [32747] picpiclink
      14. 1eru picpic
        1. chain a [32748] picpiclink
      15. 1cqg picpic
        mutant
        1. chain a [32756] picpiclink
      16. 1cqh picpic
        mutant
        1. chain a [32749] picpiclink
      17. 1trv picpic
        mutant
        1. chain a [32759] picpiclink
      18. 1trw picpic
        mutant
        1. chain a [32750] picpiclink
      19. 1tru picpic
        mutant
        1. chain a [32758] picpiclink
      20. 1mdk picpic
        mutant
        1. chain a [32752] picpiclink
      21. 1mdj picpic
        mutant
        1. chain a [32751] picpiclink
      22. 1trs picpic
        mutant
        1. chain a [32753] picpiclink
      23. 1mdi picpic
        mutant
        1. chain a [32755] picpiclink
      24. 4trx picpic
        1. chain a [32754] picpiclink
      25. 3trx picpic
        1. chain a [32757] picpiclink
      26. 1m7t picpic
        human-escherichia coli thioredoxin chimera
        1. chain a [78745] picpiclink
    8. Trypanosoma brucei [TaxId: 5691] [102430] (1)
      1. 1r26 picpic
        1. chain a [96847] picpiclink
    9. Malarial parasite (Plasmodium falciparum) [TaxId: 5833] [102431] (1)
      1. 1syr picpic
        structural genomics
        1. chain a [99028] picpiclink
        2. chain b [99029] picpiclink
        3. chain c [99030] picpiclink
        4. chain d [99031] picpiclink
        5. chain e [99032] picpiclink
        6. chain f [99033] picpiclink
        7. chain g [99034] picpiclink
        8. chain h [99035] picpiclink
        9. chain i [99036] picpiclink
        10. chain j [99037] picpiclink
        11. chain k [99038] picpiclink
        12. chain l [99039] picpiclink
    10. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [110603] (1)
      SQ P29448 #
      1. 1xfl picpic
        Structural genomics target
        1. chain a [109586] picpiclink
    11. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [117589] (4)
      SQ Q9V429
      1. 1xwa picpic
        complexed with cd, cl
        1. chain a [116116] picpiclink
        2. chain b [116117] picpiclink
        3. chain c [116118] picpiclink
        4. chain d [116119] picpiclink
      2. 1xwb picpic
        complexed with cd
        1. chain a [116120] picpiclink
        2. chain b [116121] picpiclink
        3. chain c [116122] picpiclink
        4. chain d [116123] picpiclink
      3. 1xwc picpic
        1. chain a [116124] picpiclink
      4. 1xw9 picpic
        1. chain a [116112] picpiclink
        2. chain b [116113] picpiclink
        3. chain c [116114] picpiclink
        4. chain d [116115] picpiclink
    12. European aspen (Populus tremula), thioredoxin H [TaxId: 113636] [117590] (1)
      SQ Q8S3L3
      1. 1ti3 picpic
        1. chain a [112429] picpiclink
  2. Glutaredoxin (Grx, thioltransferase) [52843]
    1. Bacteriophage T4 [TaxId: 10665] [52844] (4)
      1. 1aba picpic
        complexed with mes; mutant
        1. chain a [32760] picpiclink
      2. 1aaz picpic
        complexed with cd
        1. chain a [32761] picpiclink
        2. chain b [32762] picpiclink
      3. 1de1 picpic
        1. chain a [32763] picpiclink
      4. 1de2 picpic
        1. chain a [32764] picpiclink
    2. Escherichia coli [TaxId: 562] [52845] (4)
      1. 1ego picpic
        1. chain a [32767] picpiclink
      2. 1egr picpic
        1. chain a [32765] picpiclink
      3. 1qfn picpic
        mixed disulfide bond with ribonucleotide reductase b1 fragment
        1. chain a [32768] picpiclink
      4. 1grx picpic
        complexed with gtt; mutant
        1. chain a [32766] picpiclink
    3. Escherichia coli, Grx3 [TaxId: 562] [52846] (2)
      1. 1fov picpic
        mutant
        1. chain a [32770] picpiclink
      2. 3grx picpic
        complexed with gtt; mutant
        1. chain a [32769] picpiclink
    4. Pig (Sus scrofa) [TaxId: 9823] [52847] (1)
      1. 1kte picpic
        1. chain a [32771] picpiclink
    5. Human (Homo sapiens) [TaxId: 9606] [52848] (2)
      1. 1jhb picpic
        1. chain a [32772] picpiclink
      2. 1b4q picpic
        1. chain a [32773] picpiclink
  3. C-terminal, Grx domain of Hybrid-Prx5 [89700]
    1. Haemophilus influenzae [TaxId: 727] [89701] (1)
      HI0572
      1. 1nm3 picpicxref
        complexed with mse, so4
        1. region a:166-239 [85866] picpiclink
        2. region b:166-241 [85868] picpiclink
  4. Glutaredoxin-like NRDH-redoxin [64052]
    1. Escherichia coli [TaxId: 562] [64053] (1)
      1. 1h75 picpic
        1. chain a [60716] picpiclink
    2. Corynebacterium ammoniagenes [TaxId: 1697] [102432] (1)
      1. 1r7h picpic
        segment-swapped dimer
        1. chain a [97196] picpiclink
        2. chain b [97197] picpiclink
  5. MJ0307, thioredoxin/glutaredoxin-like protein [64054]
    single-domain PDI
    1. Archaeon Methanococcus jannaschii [TaxId: 2190] [64055] (1)
      1. 1fo5 picpic
        1. chain a [59922] picpiclink
  6. MTH807, thioredoxin/glutaredoxin-like protein [102433]
    behaves as true thioredoxin; probable MJ0307 ortholog
    1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [102434] (1)
      1. 1nho picpic
        1. chain a [91885] picpiclink
  7. MTH985, a thioredoxin [69512]
    1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [69513] (1)
      1. 1ilo picpic
        1. chain a [66205] picpiclink
  8. Thioredoxin-like protein, N-terminal domain [64056]
    1. Human (Homo sapiens) [TaxId: 9606] [64057] (1)
      1. 1gh2 picpic
        1. chain a [60515] picpiclink
  9. Thiol:disulfide interchange protein DsbD, C-terminal domain (DsbD-gamma) [102435]
    1. Escherichia coli [TaxId: 562] [102436] (8)
      1. 2fwh picpic
        automatically matched to d1uc7a_
        complexed with iod, peg
        1. region a:428-544 [134242] picpiclink
      2. 2fwg picpic
        automatically matched to d1uc7a_
        1. region a:428-543 [134241] picpiclink
      3. 2fwf picpic
        automatically matched to d1uc7a_
        complexed with iod, na
        1. region a:428-546 [134240] picpiclink
      4. 2fwe picpic
        automatically matched to d1uc7a_
        complexed with iod, na, ni
        1. region a:428-546 [134239] picpiclink
      5. 1uc7 picpic
        disulfide-linked complex with the N-terminal domain
        1. chain a [99163] picpiclink
        2. chain b [99164] picpiclink
      6. 1vrs picpicxrefxref
        automatically matched to d1se1a2
        mutant
        1. region d:428-545 [120481] picpiclink
      7. 1vrs picpicxrefxref
        automatically matched to d1se1a2
        mutant
        1. region e:428-543 [120482] picpiclink
      8. 1vrs picpicxrefxref
        automatically matched to d1se1a2
        mutant
        1. region f:428-545 [120483] picpiclink
  10. Thioredoxin-like protein p19, TLP19 [110604]
    1. Human (Homo sapiens) [TaxId: 9606] [110605] (1)
      SQ O95881 23-172
      1. 1sen picpic
        Structural genomics target
        complexed with cl, pt
        1. chain a [105465] picpiclink
  11. Hypothetical protein XCC2852 [110606]
    1. Xanthomonas campestris [TaxId: 339] [110607] (2)
      SQ Q8P6W3
      1. 1ttz picpic
        1. chain a [107309] picpiclink
      2. 1xpv picpic
        Structural genomics target
        1. chain a [115808] picpiclink
  12. Thioredoxin-like protein 2 [117591]
    1. Mouse (Mus musculus) [TaxId: 10090] [117592] (1)
      SQ Q9CQM9 241-336
      1. 1wik picpic
        Structural genomics target
        1. chain a [114675] picpiclink
  13. Thioredoxin-like structure containing protein C330018D20Rik [117593]
    1. Mouse (Mus musculus) [TaxId: 10090] [117594] (1)
      SQ Q9CWB7 21-107
      1. 1wjk picpic
        Structural genomics target
        1. chain a [114700] picpiclink
  14. Hypothetical protein PA1234 [142353]
    1. Pseudomonas aeruginosa [TaxId: 287] [142354] (1)
      SQ Q9I4A4 1-166
      1. 1z6n picpic
        complexed with mg
        1. region a:1-166 [124530] picpiclink
  15. Bacterocin transport accessory protein Bta [142355]
    1. Streptococcus pneumoniae [TaxId: 1313] [142356] (1)
      SQ Q97PU4 1-115
      1. 1zma picpic
        complexed with fmt
        1. region a:1-115 [125354] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk