Structural Classification of Proteins
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Family: Dual specificity phosphatase-like

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: (Phosphotyrosine protein) phosphatases II [52798]
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
  4. Superfamily: (Phosphotyrosine protein) phosphatases II [52799]
    share with the family I the common active site structure with a circularly permuted topology
    link to SUPERFAMILY database - Superfamily
  5. Family: Dual specificity phosphatase-like [52800]

Protein Domains:

  1. VH1-related dual-specificity phosphatase, VHR [52801]
    1. Human (Homo sapiens) [TaxId: 9606] [52802] (2)
      1. 1vhr picpic
        complexed with epe, so4
        1. chain a [32651] picpiclink
        2. chain b [32652] picpiclink
      2. 1j4x picpic
        complexed with phosphopeptide
        complexed with ahp; mutant
        1. chain a [66392] picpiclink
  2. Mapk phosphatase [52803]
    1. Human (Homo sapiens), pyst1 (mkp3) [TaxId: 9606] [52804] (1)
      1. 1mkp picpic
        complexed with cl, mpd; mutant
        1. chain a [32654] picpiclink
    2. Human (Homo sapiens), pac-1 [TaxId: 9606] [75232] (1)
      1. 1m3g picpic
        mutant
        1. chain a [84783] picpiclink
  3. Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain [52818]
    1. Human (Homo sapiens) [TaxId: 9606] [52819] (1)
      1. 1d5r picpicxref
        1. region a:14-187 [32697] picpiclink
  4. Proline directed phosphatase CDC14b2 [89698]
    duplication: consists of two structurally similar domains with the catalytic site being in the C-terminal domain
    1. Human (Homo sapiens) [TaxId: 9606] [89699] (3)
      1. 1ohe picpic
        complexed with ace, sep
        1. region a:42-198 [87013] picpiclink
        2. region a:199-380 [87014] picpiclink
      2. 1ohc picpic
        1. region a:42-198 [87009] picpiclink
        2. region a:199-380 [87010] picpiclink
      3. 1ohd picpic
        complexed with wo4
        1. region a:42-198 [87011] picpiclink
        2. region a:199-379 [87012] picpiclink
  5. Protein tyrosine phosphatase type IVa [102418]
    1. Human (Homo sapiens), pr-3 [TaxId: 9606] [102419] (2)
      SQ O75365 1-162 # 99% sequence identity
      1. 1v3a picpic
        1. chain a [113499] picpiclink
      2. 1r6h picpic
        1. chain a [97150] picpiclink
    2. Human (Homo sapiens), pr-1 [TaxId: 9606] [117578] (1)
      SQ Q93096 9-160
      1. 1rxd picpic
        Structural genomics target
        1. chain a [111959] picpiclink
        2. chain b [111960] picpiclink
        3. chain c [111961] picpiclink
  6. mRNA capping enzyme, triphosphatase domain [64047]
    1. Mouse (Mus musculus) [TaxId: 10090] [64048] (2)
      1. 1i9s picpic
        complexed with cac, ipa, mo6, so4
        1. chain a [62099] picpiclink
      2. 1i9t picpic
        complexed with cac, ipa, mo6, so4
        1. chain a [62100] picpiclink
  7. Kinase associated phosphatase (kap) [64049]
    1. Human (Homo sapiens) [TaxId: 9606] [64050] (2)
      1. 1fpz picpic
        complexed with so4; mutant
        1. chain a [59976] picpiclink
        2. chain b [59977] picpiclink
        3. chain c [59978] picpiclink
        4. chain d [59979] picpiclink
        5. chain e [59980] picpiclink
        6. chain f [59981] picpiclink
      2. 1fq1 picpicxref
        complexed with atp, mg; mutant
        1. chain a [59982] picpiclink
  8. Putative phosphatase At1g05000 [117579]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117580] (3)
      SQ Q9ZVN4 52-201
      1. 1xri picpic
        complexed with so4
        1. chain a [115879] picpiclink
        2. chain b [115880] picpiclink
      2. 2q47 picpic
        automatically matched to d1xria_
        complexed with so4
        1. region a:52-202 [139827] picpiclink
      3. 2q47 picpic
        automatically matched to d1xria_
        complexed with so4
        1. region b:52-202 [139828] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk