Structural Classification of Proteins

Superfamily: HAD-like

: usually contains an insertion (sub)domain after strand 1
uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: HAD-like [56783]
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456
Superfamily: HAD-like [56784]
usually contains an insertion (sub)domain after strand 1
uperfamily

Families:

Probable phosphatase YrbI [69467] (1)
the insertion subdomain is a beta-hairpin involved into tetramerisation
1. Probable phosphatase YrbI [69468]
  1. Haemophilus influenzae, HI1679 [TaxId: 727] [69469] (2)
    1. 1k1e
      complexed with co, gol, hg, mes, so4
      1. chain a [67995]
      2. chain b [67996]
      3. chain c [67997]
      4. chain d [67998]
      5. chain e [67999]
      6. chain f [68000]
      7. chain g [68001]
      8. chain h [68002]
      9. chain i [68003]
      10. chain j [68004]
      11. chain k [68005]
      12. chain l [68006]
    2. 1j8d
      complexed with gol
      1. chain a [66433]
      2. chain b [66434]
      3. chain c [66435]
      4. chain d [66436]
HAD-related [56785] (3)
the insertion subdomain is a 4-helical bundle
1. L-2-Haloacid dehalogenase, HAD [56786]
  1. Pseudomonas sp., strain YL [TaxId: 306] [56787] (4)
    1. 1zrn
      complexed with acy; mutant
      1. chain a [43323]
    2. 1zrm
      complexed with bua; mutant
      1. chain a [43324]
    3. 1jud
      1. chain a [43325]
    4. 1qh9
      complexed with dla
      1. chain a [43326]
  2. Xanthobacter autotrophicus [TaxId: 280] [56788] (4)
    1. 1qq5
      complexed with fmt
      1. chain a [43327]
      2. chain b [43328]
    2. 1qq7
      complexed with cl
      1. chain a [43329]
      2. chain b [43330]
    3. 1qq6
      complexed with asm, cl
      1. chain a [43333]
      2. chain b [43334]
    4. 1aq6
      complexed with fmt
      1. chain a [43331]
      2. chain b [43332]
2. Hypothetical protein PH0459 [142133]
  1. Archaeon Pyrococcus horikoshii [TaxId: 53953] [142134] (1)
    SQ O58216 1-230
    1. 1x42
      1. region a:1-230 [121677]
beta-Phosphoglucomutase-like [75173] (9)
the insertion subdomain is a 4-helical bundle
1. beta-Phosphoglucomutase [75174]
  1. Lactococcus lactis [TaxId: 1358] [75175] (8)
    1. 1o08
      complexed with g16, mg; mutant
      1. chain a [86525]
    2. 1o03
      complexed with g16, mg; mutant
      1. chain a [86507]
    3. 1zol
      automatically matched to d1lvha_
      complexed with mg
      1. region a:1-219 [125452]
    4. 1z4o
      automatically matched to d1lvha_
      complexed with gl1, mg
      1. region a:1-219 [124440]
    5. 1z4o
      automatically matched to d1lvha_
      complexed with gl1, mg
      1. region b:1-219 [124441]
    6. 1z4n
      automatically matched to d1lvha_
      complexed with gl1, mg
      1. region a:1-219 [124438]
    7. 1z4n
      automatically matched to d1lvha_
      complexed with gl1, mg
      1. region b:1-216 [124439]
    8. 1lvh
      phosphorylated enzyme
      complexed with asq, mg; mutant
      1. chain a [74282]
      2. chain b [74283]
2. Phosphatase YniC [110504]
  1. Escherichia coli [TaxId: 562] [110505] (1)
    SQ P77247
    1. 1te2
      Structural genomics target
      complexed with 2pl, ca
      1. chain a [106792]
      2. chain b [106793]
3. Phosphoglycolate phosphatase [142135]
  1. Lactobacillus plantarum [TaxId: 1590] [142136] (1)
    SQ Q88YA8 1-207
    1. 2hdo
      complexed with po4
      1. region a:1-207 [136345]
4. N-acylneuraminate-9-phosphatase NANP [142137]
  1. Mouse (Mus musculus) [TaxId: 10090] [142138] (1)
    SQ Q9CPT3 1-247
    1. 2gfh
      complexed with cl, edo, na, po4
      1. region a:1-247 [135096]
5. Hypothetical protein SP2064 [142139]
  1. Streptococcus pneumoniae [TaxId: 1313] [142140] (4)
    SQ Q97NG6 3-206
    1. 2go7
      complexed with cl, mg
      1. region a:3-206 [135434]
    2. 2go7
      automatically matched to 2GO7 A:3-206
      complexed with cl, mg
      1. region b:3-204 [135435]
    3. 2go7
      automatically matched to 2GO7 A:3-206
      complexed with cl, mg
      1. region c:3-204 [135436]
    4. 2go7
      automatically matched to 2GO7 A:3-206
      complexed with cl, mg
      1. region d:3-205 [135437]
6. Hypothetical protein Atu0790 [142141]
  1. Agrobacterium tumefaciens [TaxId: 358] [142142] (1)
    SQ Q8UH93 3-224
    1. 2fdr
      complexed with mg
      1. region a:3-224 [133319]
7. Phosphoglycolate phosphatase Gph [142143]
  1. Haemophilus somnus [TaxId: 731] [142144] (2)
    SQ Q0I1W8 1-224
    1. 2hsz
      complexed with act, cl, unl
      1. region a:1-224 [136726]
    2. 2hsz
      automatically matched to 2HSZ A:1-224
      complexed with act, cl, unl
      1. region b:1-224 [136727]
8. predicted phosphatase SP0104 [142145]
  1. Streptococcus pneumoniae [TaxId: 1313] [142146] (1)
    SQ Q97T51 1-210
    1. 2ah5
      1. region a:1-210 [126742]
9. Hypothetical protein CT1708 [142147]
  1. Chlorobium tepidum [TaxId: 1097] [142148] (1)
    SQ Q8KBS5 2-229
    1. 2hcf
      complexed with cl, mg
      1. region a:2-229 [136333]
YihX-like [56789] (3)
the insertion subdomain is a 4-helical bundle
1. Epoxide hydrolase, N-terminal domain [56790]
  has a lipid phosphatase activity
  1. Mouse (Mus musculus) [TaxId: 10090] [56791] (4)
    1. 1cr6
      1. region a:4-225 [43337]
      2. region b:4-225 [43338]
    2. 1cqz
      1. region a:4-225 [43339]
      2. region b:4-225 [43340]
    3. 1ek1
      complexed with ciu
      1. region a:4-225 [43335]
      2. region b:4-225 [43336]
    4. 1ek2
      complexed with cdu
      1. region a:4-225 [43341]
      2. region b:4-225 [43342]
  2. Human (Homo sapiens) [TaxId: 9606] [102303] (6)
    1. 1zd3
      automatically matched to d1vj5a1
      complexed with 15p, mg, nc4, po4
      1. region a:2-224 [124930]
    2. 1vj5
      complexed with ciu, mg, p6g, po4
      1. region a:2-225 [100799]
    3. 1s8o
      complexed with p6g
      1. region a:4-225 [98736]
    4. 1zd4
      automatically matched to d1vj5a1
      complexed with mg, nc6, po4
      1. region a:2-224 [124932]
    5. 1zd5
      automatically matched to d1vj5a1
      complexed with mg, nc7, po4
      1. region a:2-224 [124934]
    6. 1zd2
      automatically matched to d1vj5a1
      complexed with mg, nc3, po4
      1. region p:2-224 [124928]
2. Putative phosphatase YihX [142149]
  1. Escherichia coli [TaxId: 562] [142150] (1)
    SQ P0A8Y3 1-197
    1. 2b0c
      complexed with g1p, mg
      1. region a:8-204 [127633]
Phosphonoacetaldehyde hydrolase-like [56792] (2)
the insertion subdomain is a 4-helical bundle
1. Phosphonoacetaldehyde hydrolase [56793]
  1. Bacillus cereus [TaxId: 1396] [56794] (6)
    SQ O31156
    1. 1swv
      complexed with mg; mutant
      1. chain a [112134]
      2. chain b [112135]
    2. 1sww
      complexed with mg, poa; mutant
      1. chain a [112136]
      2. chain b [112137]
    3. 1rql
      complexed with mg, vso
      1. chain a [97750]
      2. chain b [97751]
    4. 1rqn
      complexed with mg
      1. chain a [97752]
      2. chain b [97753]
    5. 1rdf
      complexed with esa, mg; mutant
      1. chain a [104884]
      2. chain b [104885]
      3. chain c [104886]
      4. chain d [104887]
      5. chain e [104888]
      6. chain f [104889]
    6. 1fez
      complexed with mg, wo4
      1. chain a [43343]
      2. chain b [43344]
      3. chain c [43345]
      4. chain d [43346]
2. Putative hydrolase SP0805 [142151]
  1. Streptococcus pneumoniae [TaxId: 1313] [142152] (1)
    SQ Q97RK1 4-190
    1. 2fi1
      complexed with ca
      1. region a:4-190 [133508]
Phosphoserine phosphatase [64511] (2)
the insertion subdomain is a 4-helical bundle
1. Phosphoserine phosphatase [64512]
  1. Archaeon Methanococcus jannaschii [TaxId: 2190] [64513] (6)
    1. 1j97
      Phospho-aspartyl intermediate analogue
      complexed with bfd, mg, po4
      1. chain a [62753]
      2. chain b [62754]
    2. 1l7m
      PI complex
      complexed with mg, mse, po4
      1. chain a [73664]
      2. chain b [73665]
    3. 1l7n
      complexed with af3, alf, mg, mse, so4
      1. chain a [73666]
      2. chain b [73667]
    4. 1f5s
      complexed with mg, po4
      1. chain a [59656]
      2. chain b [59657]
    5. 1l7p
      complex with substrate
      complexed with mse, po4, sep; mutant
      1. chain a [73670]
      2. chain b [73671]
    6. 1l7o
      complexed with acy, mse, zn; mutant
      1. chain a [73668]
      2. chain b [73669]
  2. Human (Homo sapiens) [TaxId: 9606] [89645] (3)
    1. 1nnl
      complexed with ca, cl
      1. chain a [85906]
      2. chain b [85907]
    2. 1l8l
      complexed with apo; mutant
      1. chain a [84562]
      2. chain b [84563]
    3. 1l8o
      complexed with po4, ser; mutant
      1. chain a [84566]
      2. chain b [84567]
5'(3')-deoxyribonucleotidase (dNT-2) [82382] (1)
the insertion subdomain is a 4-helical bundle; dephosphorylates dUMP and dTMP
1. 5'(3')-deoxyribonucleotidase (dNT-2) [82383]
  1. Human (Homo sapiens) [TaxId: 9606] [82384] (12)
    1. 1q92
      complexed with drm, gol, mg
      1. chain a [96250]
    2. 1q91
      complexed with dpb, mg, po4
      1. chain a [96249]
    3. 1z4k
      automatically matched to 1Z4I A:34-227
      complexed with mg, t3p; mutant
      1. region a:34-227 [124435]
    4. 1mh9
      complexed with mg, po4
      1. chain a [79118]
    5. 1z4j
      automatically matched to 1Z4I A:34-227
      complexed with gol, mg, u2p; mutant
      1. region a:34-227 [124434]
    6. 1z4m
      automatically matched to 1Z4I A:34-227
      complexed with gol, mg, u5p; mutant
      1. region a:34-227 [124437]
    7. 2jau
      automatically matched to d1z4ia1
      complexed with atm, mg, po4; mutant
      1. region a:34-227 [147952]
    8. 1z4l
      automatically matched to 1Z4I A:34-227
      complexed with mg, tmp; mutant
      1. region a:34-227 [124436]
    9. 1z4i
      complexed with gol, mg, ump; mutant
      1. region a:34-227 [124433]
    10. 2jaw
      automatically matched to d1z4ia1
      complexed with bvp, mg; mutant
      1. region a:34-227 [147953]
    11. 1z4p
      automatically matched to 1Z4I A:34-227
      complexed with dgp, mg; mutant
      1. region x:34-227 [124442]
    12. 1z4q
      automatically matched to 1Z4I A:34-227
      complexed with d4m, mg; mutant
      1. region a:34-227 [124443]
Homoserine kinase ThrH [102304] (1)
the insertion subdomain is a rudiment 4-helical bundle
1. Homoserine kinase ThrH [102305]
  1. Pseudomonas aeruginosa [TaxId: 287] [102306] (2)
    1. 1rku
      complexed with edo, mg
      1. chain a [97627]
      2. chain b [97628]
    2. 1rkv
      complexed with edo, mg, po4
      1. chain a [97629]
      2. chain b [97630]
Class B acid phosphatase, AphA [102307] (2)
the insertion subdomain is a helical hairpin
1. Class B acid phosphatase, AphA [102308]
  1. Escherichia coli [TaxId: 562] [102309] (15)
    SQ P32697 27-237
    1. 2b82
      automatically matched to d1n8na_
      complexed with adn, mg, po4
      1. region a:4-212 [128057]
    2. 2b82
      automatically matched to d1n8na_
      complexed with adn, mg, po4
      1. region b:4-212 [128058]
    3. 1rmt
      complexed with adn, mg
      1. chain a [111888]
      2. chain b [111889]
      3. chain c [111890]
      4. chain d [111891]
    4. 2heg
      automatically matched to d1rmta_
      complexed with bfd, mg
      1. region a:3-212 [147269]
    5. 2heg
      automatically matched to d1rmta_
      complexed with bfd, mg
      1. region b:3-212 [147270]
    6. 2hf7
      automatically matched to d1rmta_
      complexed with af3, mg
      1. region a:3-212 [147276]
    7. 2hf7
      automatically matched to d1rmta_
      complexed with af3, mg
      1. region b:3-212 [147277]
    8. 1n8n
      complexed with au3
      1. chain a [91706]
    9. 1rmy
      complexed with dcz, mg, po4
      1. chain a [111894]
      2. chain b [111895]
    10. 2g1a
      automatically matched to d1n8na_
      complexed with 5hg, mg
      1. region a:4-212 [134514]
    11. 2g1a
      automatically matched to d1n8na_
      complexed with 5hg, mg
      1. region b:4-212 [134515]
    12. 2b8j
      automatically matched to d1n8na_
      complexed with adn, au, au3, mg, po4, spm
      1. region a:4-212 [128074]
    13. 2b8j
      automatically matched to d1n8na_
      complexed with adn, au, au3, mg, po4, spm
      1. region b:4-212 [128075]
    14. 1rmq
      complexed with co, os
      1. chain a [111886]
      2. chain b [111887]
    15. 1n9k
      complexed with br, mg
      1. chain a [91732]
      2. chain b [91733]
  2. Salmonella typhimurium [TaxId: 90371] [142153] (12)
    SQ P58683 30-237
    1. 1z5g
      complexed with mg, po4
      1. region a:7-214 [124476]
    2. 1z5g
      automatically matched to 1Z5G A:7-214
      complexed with mg, po4
      1. region b:7-214 [124477]
    3. 1z5g
      automatically matched to 1Z5G A:7-214
      complexed with mg, po4
      1. region c:7-214 [124478]
    4. 1z5g
      automatically matched to 1Z5G A:7-214
      complexed with mg, po4
      1. region d:7-214 [124479]
    5. 1z88
      complexed with mg; mutant
      1. region a:7-214 [124691]
    6. 1z88
      automatically matched to 1Z88 A:7-214
      complexed with mg; mutant
      1. region b:7-214 [124692]
    7. 1z88
      automatically matched to 1Z88 A:7-214
      complexed with mg; mutant
      1. region c:7-214 [124693]
    8. 1z88
      automatically matched to 1Z88 A:7-214
      complexed with mg; mutant
      1. region d:7-214 [124694]
    9. 1z5u
      automatically matched to 1Z5G A:7-214
      complexed with cmp, mg
      1. region a:7-214 [124493]
    10. 1z5u
      automatically matched to 1Z5G A:7-214
      complexed with cmp, mg
      1. region b:7-214 [124494]
    11. 1z5u
      automatically matched to 1Z5G A:7-214
      complexed with cmp, mg
      1. region c:7-214 [124495]
    12. 1z5u
      automatically matched to 1Z5G A:7-214
      complexed with cmp, mg
      1. region d:7-214 [124496]
Hypothetical protein MW1667 (SA1546) [102310] (1)
the insertion subdomain is multi-helical
1. Hypothetical protein MW1667 (SA1546) [102311]
  1. Staphylococcus aureus [TaxId: 1280] [102312] (1)
    1. 1qyi
      structural genomics; NESG target ZR25
      1. chain a [96595]
phosphatase domain of polynucleotide kinase [82385] (2)
no insertion subdomains
1. Polynucleotide kinase, phosphatase domain [82386]
  1. Bacteriophage T4 [TaxId: 10665] [82387] (16)
    1. 1ltq
      complexed with adp, dms, mse
      1. region a:153-301 [78208]
    2. 1rrc
      complexed with adp, ca, dms
      1. region a:153-301 [97789]
    3. 1rc8
      complexed with adp, ca, dms
      1. region a:153-301 [97291]
    4. 2ia5
      automatically matched to d1ltqa1
      complexed with ars, mg, so4
      1. region a:153-301 [137133]
    5. 2ia5
      automatically matched to d1ltqa1
      complexed with ars, mg, so4
      1. region b:153-301 [137135]
    6. 2ia5
      automatically matched to d1ltqa1
      complexed with ars, mg, so4
      1. region c:153-301 [137137]
    7. 2ia5
      automatically matched to d1ltqa1
      complexed with ars, mg, so4
      1. region d:153-301 [137139]
    8. 2ia5
      automatically matched to d1ltqa1
      complexed with ars, mg, so4
      1. region e:153-301 [137141]
    9. 2ia5
      automatically matched to d1ltqa1
      complexed with ars, mg, so4
      1. region f:153-301 [137143]
    10. 2ia5
      automatically matched to d1ltqa1
      complexed with ars, mg, so4
      1. region g:153-301 [137145]
    11. 2ia5
      automatically matched to d1ltqa1
      complexed with ars, mg, so4
      1. region h:153-301 [137147]
    12. 2ia5
      automatically matched to d1ltqa1
      complexed with ars, mg, so4
      1. region i:153-301 [137149]
    13. 2ia5
      automatically matched to d1ltqa1
      complexed with ars, mg, so4
      1. region j:153-301 [137151]
    14. 2ia5
      automatically matched to d1ltqa1
      complexed with ars, mg, so4
      1. region k:153-301 [137153]
    15. 2ia5
      automatically matched to d1ltqa1
      complexed with ars, mg, so4
      1. region l:153-301 [137155]
    16. 1rpz
      complexed with adp, ca, dms
      1. region a:153-301 [97720]
2. 5' polynucleotide kinase-3' phosphatase, middle domain [142154]
  1. Mouse (Mus musculus) [TaxId: 10090] [142155] (2)
    SQ Q9JLV6 144-338
    1. 1yj5
      complexed with so4
      1. region a:144-338 [123380]
    2. 1yj5
      automatically matched to 1YJ5 A:144-338
      complexed with so4
      1. region b:144-338 [123382]
Predicted hydrolases Cof [82388] (13)
contains an alpha+beta subdomain inserted into a new site after strand 3
1. Phosphoglycolate phosphatase, PGPase [82389]
  1. Archaeon Thermoplasma acidophilum [TaxId: 2303] [82390] (2)
    1. 1l6r
      structural genomics
      complexed with ca, fmt
      1. chain a [77768]
      2. chain b [77769]
    2. 1kyt
      structural genomics; MCSG target APC014
      complexed with ca, mse; mutant
      1. chain a [77631]
      2. chain b [77632]
  2. Pyrococcus horikoshii [TaxId: 53953] [117502] (1)
    SQ O50129 # PH1421
    1. 1wr8
      Structural genomics target
      complexed with act
      1. chain a [114836]
      2. chain b [114837]
2. Hypothetical protein YwpJ [89646]
  1. Bacillus subtilis [TaxId: 1423] [89647] (1)
    1. 1nrw
      structural genomics
      complexed with ca, mse, po4
      1. chain a [86128]
3. Hypothetical protein TM0651 [102313]
  1. Thermotoga maritima [TaxId: 2336] [102314] (1)
    1. 1nf2
      structural genomics
      complexed with mg, so4
      1. chain a [91849]
      2. chain b [91850]
      3. chain c [91851]
4. Hypothetical protein YidA [102315]
  1. Escherichia coli [TaxId: 562] [102316] (1)
    1. 1rkq
      structural genomics; NYSGRC target T1436
      complexed with cl, mo3
      1. chain a [97621]
      2. chain b [97622]
5. Sugar phosphatase SupH (YbiV) [117503]
  1. Escherichia coli [TaxId: 562] [117504] (3)
    SQ P75792
    1. 1rlm
      complexed with gol, mg; mutant
      1. chain a [111860]
      2. chain b [111861]
      3. chain c [111862]
      4. chain d [111863]
    2. 1rlo
      complexed with bfd, gol, mg; mutant
      1. chain a [111864]
      2. chain b [111865]
      3. chain c [111866]
      4. chain d [111867]
    3. 1rlt
      complexed with act, af3, gol, mg; mutant
      1. chain a [111868]
      2. chain b [111869]
      3. chain c [111870]
      4. chain d [111871]
6. Putative mannosyl-3-phosphoglycerate phosphatase MPGP (YedP) [117505]
  1. Escherichia coli [TaxId: 562] [117506] (1)
    SQ P76329 4-235
    1. 1xvi
      Structural genomics target
      complexed with 1pe, pg4, pge, so4
      1. chain a [116088]
      2. chain b [116089]
  2. Archaeon Pyrococcus horikoshii [TaxId: 53953] [142156] (2)
    SQ O58690 1-243
    1. 1wzc
      complexed with mg, po4; mutant
      1. region a:1-243 [121491]
    2. 1wzc
      automatically matched to 1WZC A:1-243
      complexed with mg, po4; mutant
      1. region b:1-243 [121492]
7. Sugar-phosphate phosphatase BT4131 [142157]
  1. Bacteroides thetaiotaomicron [TaxId: 818] [142158] (3)
    SQ Q8A090 2-261
    1. 2rbk
      automatically matched to d1ymqa1
      complexed with mg, vn4
      1. region a:2-261 [151850]
    2. 2rb5
      automatically matched to d1ymqa1
      complexed with mg, wo6
      1. region a:2-261 [151843]
    3. 1ymq
      complexed with mg, so4
      1. region a:2-261 [123707]
8. Phosphomannomutase 2 [142159]
  1. Human (Homo sapiens) [TaxId: 9606] [142160] (2)
    SQ O15305 4-246
    1. 2amy
      complexed with edo, gly
      1. region a:4-246 [127026]
    2. 2q4r
      automatically matched to 2AMY A:4-246
      complexed with edo, gly
      1. region a:4-246 [139876]
9. Phosphomannomutase 1 [142161]
  1. Human (Homo sapiens) [TaxId: 9606] [142162] (2)
    SQ Q92871 12-256
    1. 2fue
      automatically matched to 2FUC A:12-256
      complexed with m1p, mg
      1. region a:13-256 [134119]
    2. 2fuc
      complexed with mg
      1. region a:12-256 [134116]
10. Sucrose-phosphatase Slr0953 [142163]
  1. Synechocystis sp. pcc 6803 [TaxId: 1148] [142164] (9)
    SQ P74325 1-244
    1. 1s2o
      complexed with mg
      1. region a:1-244 [118846]
    2. 2b1q
      automatically matched to 1S2O A:1-244
      complexed with mg, tre
      1. region a:1-244 [127673]
    3. 2b1r
      automatically matched to 1S2O A:1-244
      complexed with cbi, mg
      1. region a:1-244 [127674]
    4. 1tj5
      automatically matched to 1S2O A:1-244
      complexed with mg, po4, suc
      1. region a:1-244 [119285]
    5. 1u2s
      automatically matched to 1S2O A:1-244
      complexed with glc, mg
      1. region a:1-244 [119485]
    6. 2d2v
      automatically matched to 1S2O A:1-244
      complexed with mal, mg
      1. region a:1-244 [131189]
    7. 1tj4
      automatically matched to 1S2O A:1-244
      complexed with mg, suc
      1. region a:1-244 [119284]
    8. 1tj3
      automatically matched to 1S2O A:1-244
      complexed with mg
      1. region a:1-244 [119283]
    9. 1u2t
      automatically matched to 1S2O A:1-244
      complexed with sup
      1. region a:1-244 [119486]
11. PFL1270w orthologue [142165]
  1. Plasmodium vivax [TaxId: 5855] [142166] (4)
    SQ Q8I5F4 11-293
    1. 2b30
      complexed with ca, cl
      1. region a:18-300 [127759]
    2. 2b30
      automatically matched to 2B30 A:18-300
      complexed with ca, cl
      1. region b:18-300 [127760]
    3. 2b30
      automatically matched to 2B30 A:18-300
      complexed with ca, cl
      1. region c:18-300 [127761]
    4. 2b30
      automatically matched to 2B30 A:18-300
      complexed with ca, cl
      1. region d:18-300 [127762]
NagD-like [102317] (6)
duplication: consists of two segment-swapped domains of this fold; this results in the insertion of a circularly permuted domain after strand 3, analogously to the Cof family
1. Hypothetical protein TM1742 [102318]
  putative NagD protein
  1. Thermotoga maritima [TaxId: 2336] [102319] (2)
    1. 1vjr
      structural genomics
      complexed with cl, ni
      1. chain a [100832]
    2. 1pw5
      structural genomics,
      complexed with nag, so4
      1. chain a [95199]
2. Putative phosphatase SMU.1415c [117507]
  1. Streptococcus mutans [TaxId: 1309] [117508] (1)
    SQ Q8DTD6
    1. 1wvi
      Structural genomics target
      1. chain a [114915]
      2. chain b [114916]
      3. chain c [114917]
      4. chain d [114918]
3. Hypothetical protein SPy1043 [142167]
  1. Streptococcus pyogenes [TaxId: 1314] [142168] (1)
    SQ Q99ZW4 2-254
    1. 1ys9
      mutant
      1. region a:2-254 [123965]
4. NagD [142169]
  1. Escherichia coli [TaxId: 562] [142170] (1)
    SQ P0AF24 1-250
    1. 2c4n
      complexed with mg, po4
      1. region a:1-250 [129837]
5. Putative hydrolase SP1407 [142171]
  1. Streptococcus pneumoniae [TaxId: 1313] [142172] (1)
    SQ Q97Q24 3-255
    1. 1ydf
      complexed with mg
      1. region a:4-256 [122996]
6. Putative hydrolase EF1188 [142173]
  1. Enterococcus faecalis [TaxId: 1351] [142174] (2)
    SQ Q836C7 4-256
    1. 1yv9
      complexed with po4
      1. region a:4-256 [124089]
    2. 1yv9
      automatically matched to 1YV9 A:4-256
      complexed with po4
      1. region b:4-256 [124090]
Meta-cation ATPase, catalytic domain P [81656] (2)
interrupted by a large insertion, domain N
1. Calcium ATPase, catalytic domain P [81655]
  1. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [81654] (17)
    SQ P04191
    1. 1wpg
      complexed with adp, mf4, mg, na, tg1
      1. region a:344-360,a:600-750 [114807]
      2. region b:344-360,b:600-750 [114811]
      3. region c:344-360,c:600-750 [114815]
      4. region d:344-360,d:600-750 [114819]
    2. 2zbf
      automatically matched to d1iwoa2
      complexed with ace, bef, mg, tg1
      1. region a:344-360,a:600-750 [154314]
    3. 2zbd
      automatically matched to d1iwoa2
      complexed with ace, adp, alf, ca, mg, pc1
      1. region a:344-360,a:600-750 [154302]
    4. 2zbg
      automatically matched to d1iwoa2
      complexed with ace, alf, mg, tg1
      1. region a:344-360,a:600-750 [154318]
    5. 1su4
      complexed with ca, na
      1. region a:344-360,a:600-750 [98994]
    6. 1t5s
      complexed with acp, ca, k, mg
      1. region a:344-360,a:600-750 [106474]
    7. 3b9b
      automatically matched to d1iwoa2
      complexed with bef, mg, na
      1. region a:344-360,a:600-750 [154995]
    8. 1vfp
      complexed with acp, ca, mg
      1. region a:344-360,a:600-750 [108577]
      2. region b:344-360,b:600-750 [108581]
    9. 1t5t
      complexed with adp, alf, ca, k, mg
      1. region a:344-360,a:600-750 [106478]
    10. 3b9r
      automatically matched to d1iwoa2
      complexed with acp, alf, k, mg
      1. region a:344-360,a:600-750 [155015]
    11. 3b9r
      automatically matched to d1iwoa2
      complexed with acp, alf, k, mg
      1. region b:344-360,b:600-750 [155019]
    12. 1xp5
      complexed with alf, k, mg, tg1
      1. region a:344-360,a:600-750 [115731]
    13. 1wpe
      complexed with adp, af3, ca, mg
      1. region a:344-360,a:600-750 [114803]
    14. 1iwo
      Structure in the absence of calcium ions
      complexed with tg1
      1. region a:344-360,a:600-750 [75855]
      2. region b:344-360,b:600-750 [75859]
    15. 2zbe
      automatically matched to d1iwoa2
      complexed with ace, bef, mg
      1. region a:344-360,a:600-750 [154306]
    16. 2zbe
      automatically matched to d1iwoa2
      complexed with ace, bef, mg
      1. region b:344-360,b:600-750 [154310]
    17. 1kju
      Structure in the e2 state
      1. region a:344-360,a:600-750 [75893]
2. Cation-transporting ATPase [142175]
  1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [142176] (3)
    SQ O29777 416-434,548-663
    1. 2b8e
      1. region a:416-434,a:548-663 [128068]
    2. 2b8e
      automatically matched to 2B8E A:416-434,A:548-663
      1. region b:416-434,b:548-663 [128070]
    3. 2b8e
      automatically matched to 2B8E A:416-434,A:548-663
      1. region c:416-434,c:548-663 [128072]
Trehalose-phosphatase [110506] (1)
Pfam 02358; contains an insert alpha+beta subdomain; similar overall fold to the Cof family
1. Trehalose-6-phosphate phosphatase related protein [110507]
  1. Archaeon Thermoplasma acidophilum [TaxId: 2303] [110508] (1)
    SQ Q9HIW7
    1. 1u02
      Structural genomics target
      complexed with gol, mg, na
      1. chain a [107538]
NLI interacting factor-like phosphatase [110509] (1)
Pfam 03031; NIF; the insertion subdomain is a 3-stranded beta-sheet;
1. Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, NRAMP1 [110510]
  1. Human (Homo sapiens) [TaxId: 9606] [110511] (2)
    SQ Q9GZU7 76-256
    1. 1ta0
      complexed with bfd, cit, mg
      1. chain a [106729]
    2. 1t9z
      complexed with cit, mg; mutant
      1. chain a [106728]
Magnesium-dependent phosphatase-1, Mdp1 [117509] (1)
the insertion subdomain is a 3-stranded beta-sheet different from the NIF family
1. Magnesium-dependent phosphatase-1, Mdp1 [117510]
  1. Mouse (Mus musculus) [TaxId: 10090] [117511] (2)
    SQ Q9D967
    1. 1u7p
      complexed with mg, wo4
      1. chain a [113095]
      2. chain b [113096]
      3. chain c [113097]
      4. chain d [113098]
    2. 1u7o
      complexed with act
      1. chain a [113094]
Hypothetical protein VC0232 [117512] (1)
contains a deletion in the common fold; segment-swapped tetramer
1. Hypothetical protein VC0232 [117513]
  1. Vibrio cholerae [TaxId: 666] [117514] (1)
    SQ Q9KVB4
    1. 1xpj
      Structural genomics target
      complexed with hg, tar
      1. chain a [115739]
      2. chain b [115740]
      3. chain c [115741]
      4. chain d [115742]
Histidinol phosphatase-like [142177] (3)
no insertion subdomains
1. Histidine biosynthesis bifunctional protein HisB, phosphatase domain [142178]
  1. Escherichia coli [TaxId: 562] [142179] (10)
    SQ Q9S5G5 3-163
    1. 2fpw
      automatically matched to 2FPR A:3-163
      complexed with ca, phd, zn
      1. region a:3-163 [133927]
    2. 2fpw
      automatically matched to 2FPR A:3-163
      complexed with ca, phd, zn
      1. region b:4-163 [133928]
    3. 2fpr
      complexed with br, mg, na, zn
      1. region a:3-163 [133919]
    4. 2fpr
      automatically matched to 2FPR A:3-163
      complexed with br, mg, na, zn
      1. region b:4-163 [133920]
    5. 2fpx
      automatically matched to 2FPR A:3-163
      complexed with mg, so4, zn
      1. region a:3-163 [133929]
    6. 2fpx
      automatically matched to 2FPR A:3-163
      complexed with mg, so4, zn
      1. region b:4-163 [133930]
    7. 2fpu
      automatically matched to 2FPR A:3-163
      complexed with cl, hso, mg, zn
      1. region a:3-163 [133924]
    8. 2fpu
      automatically matched to 2FPR A:3-163
      complexed with cl, hso, mg, zn
      1. region b:4-163 [133925]
    9. 2fps
      automatically matched to 2FPR A:3-163
      complexed with ca, cl, zn
      1. region a:3-163 [133921]
    10. 2fps
      automatically matched to 2FPR A:3-163
      complexed with ca, cl, zn
      1. region b:4-163 [133922]
2. Hypothetical protein Mll2559 [159532]
  1. Mesorhizobium loti [TaxId: 381] [159533] (1)
    SQ Q98I56 8-216
    1. 2o2x
      complexed with gol
      1. region a:8-216 [148564]
3. D,D-heptose 1,7-bisphosphate phosphatase GmhB [159534]
  1. Escherichia coli [TaxId: 562] [159535] (4)
    SQ P63228 4-185
    1. 2gmw
      complexed with zn
      1. region a:24-205 [147137]
    2. 2gmw
      automatically matched to 2GMW A:24-205
      complexed with zn
      1. region b:24-205 [147138]
    3. 3esq
      automatically matched to 2GMW A:24-205
      complexed with ca, zn
      1. region a:24-205 [158196]
    4. 3esr
      automatically matched to 2GMW A:24-205
      complexed with ca, po4, zn
      1. region a:24-205 [158197]
MtnX-like [142180] (1)
Pfam 06888; the insertion subdomain is a rudiment 4-helical bundle
1. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase MtnX [142181]
  1. Bacillus subtilis [TaxId: 1423] [142182] (2)
    SQ O31667 2-227
    1. 2fea
      complexed with edo, mg, zn
      1. region a:2-227 [133327]
    2. 2fea
      automatically matched to 2FEA A:2-227
      complexed with edo, mg, zn
      1. region b:3-226 [133328]
Pyrimidine 5'-nucleotidase (UMPH-1) [142183] (2)
Pfam 05822; the insertion subdomain is a rudiment 4-helical bundle
1. Cytosolic 5'-nucleotidase III [142184]
  1. Human (Homo sapiens) [TaxId: 9606] [142185] (2)
    SQ Q9H0P0 64-336
    1. 2vkq
      automatically matched to d2cn1a1
      complexed with bef, mg
      1. region a:14-286 [153228]
    2. 2cn1
      1. region a:14-286 [130633]
  2. Mouse (Mus musculus) [TaxId: 10090] [159536] (1)
    SQ Q9D020 7-297
    1. 2bdu
      complexed with epe
      1. region a:7-297 [146135]
Enolase-phosphatase E1 [142186] (2)
the insertion subdomain is a 4-helical bundle
1. Protein UTR4 [142187]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [142188] (4)
    SQ P32626 17-241
    1. 2g80
      complexed with gol, mg, pe4
      1. region a:17-241 [134741]
    2. 2g80
      automatically matched to 2G80 A:17-241
      complexed with gol, mg, pe4
      1. region b:18-241 [134742]
    3. 2g80
      automatically matched to 2G80 A:17-241
      complexed with gol, mg, pe4
      1. region c:18-241 [134743]
    4. 2g80
      automatically matched to 2G80 A:17-241
      complexed with gol, mg, pe4
      1. region d:18-241 [134744]
2. E-1 enzyme [142189]
  1. Human(Homo sapiens) [TaxId: 9606] [142190] (2)
    SQ Q9UHY7 4-256
    1. 1zs9
      complexed with mg
      1. region a:4-256 [125600]
    2. 1yns
      automatically matched to 1ZS9 A:4-256
      complexed with hpo, mg
      1. region a:4-256 [123754]
5' nucleotidase-like [142191] (1)
Pfam 05761; the insertion domain cosists of 3-helical bundle and a pseudo beta-barrel; contains extra C-terminal long alpha hairpin subdomain (scop_cf 46556)
1. Cytosolic IMP-GMP specific 5'-nucleotidase [142192]
  1. Legionella pneumophila [TaxId: 446] [142193] (1)
    SQ Q5ZZB6 2-459
    1. 2bde
      complexed with so4
      1. region a:2-459 [128335]
AF1437-like [159537] (1)
the insertion subdomain is a rudiment 4-helical bundle; extra alpha-hairpin insertion after strand 3
1. Hypothetical protein AF1437 [159538]
  1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [159539] (1)
    SQ O28835 1-308
    1. 1y8a
      complexed with mg
      1. region a:1-308 [145913]
BT0820-like [159540] (1)
PfamB 073209; deletion in the common fold; segment-swapped dimer
1. Hypothetical protein BT0820 [159541]
  1. Bacteroides thetaiotaomicron [TaxId: 818] [159542] (1)
    SQ Q8A9J5 1-122
    1. 2obb
      complexed with mg
      1. region a:1-122 [148715]